Pathomechanisms of photoaged skin

Textbook of Aging Skin

Volumn , Issue , 2010, Pages 101-107

  Krutmann, Jean ^a  

^a HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 80052333547     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-3-540-89656-2_10     Document Type: Chapter

References (36)

1. Berneburg M, Plettenberg H, Krutmann J. Photoaging of human skin. Photodermatol Photoimmunol Photomed. 2000;16:239-244.
2. BrashD, Rudolph J, Simon J, Lin A, McKenna G, Baden H, Halperin A, Pontenm JA. Role for sunlight in skin cancer: UV-induced p53 mutations in squamous cell carcinoma. Proc Natl Aacad Sci USA. 1998;88:10124-10128.
3. Hart RW, Setlow RB. Correlation between deoxyribonucleic acid excision-repair and life-span in a number of mammalian species. Proc Natl Acad Sci USA. 1974;71:2169-2173.
4. Vijg J. Somatic mutations and aging: A re-evaluation. Mutat Res. 2000;447:117-135.
5. Berneburg M, Grether-Beck S, Kurten V, Ruzicka T, Briviba K, Sies H, Krutmann J. Singlet oxygen mediates the UVA-induced generation of the photoaging-associated mitochondrial common deletion. J Biol Chem. 1999;274:15345-15349.
6. DiMauro S, Schon EA. Mitochondrial respiratory-chain diseases. N Engl J Med. 2003;348:2656-2668.
7. Wallace DC. Mitochondrial genetics: A paradigm for aging and degenerative diseases? Science. 1992;256:628-632.
8. Berneburg M, Gattermann N, Stege H, Grewe M, Vogelsang K, Ruzicka T, Krutmann J. Chronically ultraviolet-exposed human skin shows a higher mutation frequency of mitochondrial DNA as compared to unexposed skin and the hematopoietic system. Photochem Photobiol. 1997;66:271-275.
9. Birch-Machin MA, Tindall M, Turner R, Haldane F, Rees JL. Mitochondrial DNA deletions in human skin reflect photo-rather than chronologic aging. J Invest Dermatol. 1998;110:149-152.
10. Yang JH, Lee HC, Wei YH. Photoageing-associated mitochondrial DNA length mutations in human skin. Arch Dermatol Res. 1995;287:641-648.
11. Koch H, Wittern KP, Bergemann J. In human keratinocytes the common deletion reflects donor variabilities rather than chronologic aging and can be induced by ultraviolet A irradiation. J Invest Dermatol. 2001;117:892-897.
12. Berneburg M, Plettenberg H, Medve-Konig K, Pfahlberg A, Gers-Barlag H, Gefeller O, Krutmann J. Induction of the photoagingassociated mitochondrial common deletion in vivo in normal human skin. J Invest Dermatol. 2004;12:1277-1283.
13. Jacobs HT. The mitochondrial theory of aging: Dead or alivé. Aging Cell. 2003;2:11-17.
14. Trifunovic A, Wredenberg A, Falkenberg M, Spelbrink JN, Rovio AT, Bruder E, Bohlooly YM, Gidlof S, Oldfors A, Wibom R, Tornell J. Jacobs HT, Larsson NG. Premature ageing in mice expressing defective mitochondrial DNA polymerase. Nature. 2004;429: 417-423.
15. Berneburg M, Gremmel T, Kurten V, Schroeder P, Hertel I, Mikecz AV, Wild S, Chen M, Declercq L, Matsui M, Ruzicka T, Krutmann J. Creatine supplementation normalizes mutagenesis of mitochondrial DNA as well as functional consequences. J Invest Dermatol. 2005;125:213-220.
16. Schroeder P, Gremmel T, Berneburg M, Krutmann J. Partial depletion of mitochondrial DNA from human skin fibroblasts induces a gene expression profile reminiscent of photoaged skin. J Invest Dermatol. 2008;128:2297-2303.
17. Majora M, Wittkampf T, Schuermann B, Grether-Beck S, Schroeder P, Krutmann J. Increased expression of lysyl oxidase and production of reactive oxygen species in fibroblasts with deletions of the mitochondrial DNA leads to increased contractile strength in collagen lattices. Am J Pathol. 2009(in revision).
18. Smith JG, Davidson EA, Sams WM, Clark RD. Alterations in human dermal connective tissue with age and chronic sun damage. J Invest Dermatol. 1962;39:347-350.
19. Braverman M, Fonferko E. Studies in cutaneous aging: I. The elastic fibre network. J Invest Dermatol. 1982;78: 434-443.
20. Talwar HS, Griffioth CEM, Fisher GJ, Hamilton TA, Voorhees JJ. Reduced type I and type III procollagens in photodamaged adult human skin. J Invest Dermatol. 1995;105:285-290.
21. Fisher GJ, Talwar HS, Lin J, et al. Retinoic acid inhibits induction of c-jun protein by ultraviolet radiation that occurs subsequent to activation of mitogen-activated protein kinase pathways in human skin in vivo. J Clin Invest. 1998;101:1432-1440.
22. Scharffetter-Kochanek K, Brenneisen P, Wenk J, et al. Photoaging of the skin: From phenotype to mechanisms. Exp Gerontol. 2000;35: 307-316.
23. Wenk J, Brenneisen P, Meewes C, Wlaschek M, Peters T, Blaudschun R, Ma W, Kuhr L, Schneider L, Scharffetter-Kochanek K. UVinduced oxidative stress and photoaging. Curr Probl Dermatol. 2001;29:83-94.
24. Dong KK, Damaghi N, Picart SD, Markova NG, Obayashi K, Okano Y, Masaki H, Grether-Beck S, Krutmann J, Smiles KA, Yarosh DB. UV-induced DNA damage initiates release of MMP-1 in human skin. Exp Dermatol. 2008;17:1037-1044.
25. Fisher GJ, Wang ZQ, Datta SC, Varani J, Kang S, Voorhees JJ. Pathophysiology of premature skin aging induced by ultraviolet light. N Engl J Med. 1997;337:1419-1428.
26. Fisher G, Datta S, Wang Z, Li X, Quan T, Chung J, Kang S, Voorhees J. c-Jun dependent inhibition of cutaneous procollagen transcription following ultraviolet irradiation is reversed by all-trans retinoid acid. J Clin Invest. 2000;106:661-668.
27. Varani J, Schuger L, Dame MK, Leonhard Ch, Fligiel SEG, Kang S, Fisher GJ, Vorhees JJ. Reduced fibroblast interaction with intact collagen as a mechanism for depressed collagen synthesis in photodamaged skin. J Invest Dermatol. 2004;122: 1471-1479.
28. Braverman M, Fonfrko E. Studies in cutaneous aging: II. The microvasculature. J Invest Dermatol. 1982;73:59-66.
29. Kligman AM. Perspectives and problems in cutaneous gerontology. J Invest Dermatol. 1979;73:39-46.
30. Bielenberg DR, Bucana CD, Sanchez R, Donawho CK, Kripke ML, Fidler IJ. Molecular regulation of UVB-induced angiogenesis. J Invest Dermatol. 1998;111:864-872.
31. Yano K, Ouira H, Detmar M. Targeted over expression of the angiogenesis inhibitor thrombospondin-1 in the epidermis of transgenic mice prevents ultraviolet-B-induced angiogenesis and cutaneous photodamage. J Invest Dermatol. 2002;118: 800-805.
32. Lavker RM, Kligman A. Chronic heliodermatitis: A morphologic evaluation of chronic actinic dermal damage with emphasis on the role of mast cells. J Invest Dermatol. 1988;90:325-330.
33. DeLeo VA, Dawes L, Jackson R. Density of Langerhans cells (LC) in normal versus chronic actinically damaged skin (CADS) of humans. J Invest Dermatol. 1981;76:330-334.
34. Levine RL, Stadtman ER. Oxidative modification of protein during ageing. Exp Gerontol. 2001;36:1495-1502.
35. Sander CS, Chang H, Salzmann S, Muller CS, Ekanayake-Mudiyanselage S, Elsner P, Thiele JJ. Photoaging is associated with protein oxidation in human skin in vivo. J Invest Dermatol. 2002;118:618-625.
36. Schroeder P, Krutmann J. Role of mitochondria in photoageing of human skin: The defective powerhouse model. J Invest Dermatol Symp P. 2009;in press.