E-cadherin as a prognostic marker in human serous carcinomas of the ovary: An immunohistochemical analysis

Archives of Gynecology and Obstetrics

Volumn 284, Issue 2, 2011, Pages 437-443

  Dian, Darius ^a   Brüning, Ansgar ^a   Mylonas, Ioannis ^a  

^a UNIVERSITY OF MUNICH   (Germany)

Author keywords

E cadherin; Immunohistochemistry; Prognosis; Serous ovarian cancer; Survival

Indexed keywords

TUMOR MARKER; UVOMORULIN;

ADULT; AGED; ARTICLE; CANCER CHEMOTHERAPY; CANCER GRADING; CANCER STAGING; CANCER SURVIVAL; CARCINOGENESIS; CAUSE SPECIFIC SURVIVAL; CONTROLLED STUDY; CYTOREDUCTIVE SURGERY; DISEASE ASSOCIATION; DISEASE MARKER; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYMPH NODE DISSECTION; LYMPH NODE METASTASIS; OVARY CARCINOMA; OVERALL SURVIVAL; PROGNOSIS; PROGRESSION FREE SURVIVAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; TUMOR DIFFERENTIATION;

ADULT; AGED; AGED, 80 AND OVER; BIOLOGICAL MARKERS; CADHERINS; CARCINOMA; DISEASE-FREE SURVIVAL; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; KAPLAN-MEIER ESTIMATE; MIDDLE AGED; OVARIAN NEOPLASMS;

EID: 80052305732     PISSN: 09320067     EISSN: 14320711     Source Type: Journal    
DOI: 10.1007/s00404-010-1657-0     Document Type: Article

References (41)

1. Colombo N, Van Gorp T, Parma G, Amant F, Gatta G, Sessa C, Vergote I (2006) Ovarian cancer. Crit Rev Oncol Hematol 60(2):159-179. doi:10.1016/j.critrevonc.2006.03.004 (Pubitemid 44636248)
2. International Agency for Research on Cancer I. Descriptive Epidemiology Group of IARC (2008) GLOBOCAN 2002 database. http://www-dep.iarc.fr/2
3. National Cancer Institute (2006) SEER Surveillance, Epidemiology and End Results: SEER Cancer Statistics Review, 1975-2003. http://seer.cancer.gov/csr/ 1975-2003/3
4. Abaid LN, Goldstein BH, Lopez KL, Micha JP, Brown JV, 3rd, Rettenmaier MA, Markman M (2010) The prognostic signiWcance of optimal debulking in the setting of a complete clinical response for advanced ovarian carcinoma patients receiving maintenance chemotherapy. Arch Gynecol Obstet. doi:10.1007/s00404-010- 1571-5
5. Heintz AP, Odicino F, Maisonneuve P, Beller U, Benedet JL, Creasman WT, Ngan HY, Pecorelli S (2003) Carcinoma of the ovary. Int J Gynaecol Obstet 83(Suppl):1135-1166
6. Lenhard SM, Bufe A, Kumper C, Stieber P, Mayr D, Hertlein L, Kirschenhofer A, Friese K, Burges A (2009) Relapse and survival in early-stage ovarian cancer. Arch Gynecol Obstet 280(1):71-77. doi:10.1007/s00404-008-0877-z
7. Munstedt K, Hackethal A, Eskef K, Hrgovic I, Franke FE (2009) Prognostic relevance of granulocyte colony-stimulating factor in ovarian carcinomas. Arch Gynecol Obstet. doi:10.1007/s00404- 009-1319-2
8. Miyazawa M, Yasuda M, Fujita M, Hirasawa T, Kajiwara H, Hirabayashi K, Ogane N, Shimizu M, Asanuma H, Murakami M, Takekoshi S, Mikami M, Osamura RY (2009) Association of hypoxia-inducible factor-1 expression with histology in epithelial ovarian tumors: a quantitative analysis of HIF-1. Arch Gynecol Obstet 279(6):789-796. doi:10.1007/s00404-008-0816-z
9. Gungor T, Kanat-Pektas M, Sucak A, Mollamahmutoglu L (2009) The role of thrombocytosis in prognostic evaluation of epithelial ovarian tumors. Arch Gynecol Obstet 279(1):53-56. doi:10.1007/ s00404-008-0673-9
10. Hogdall EV, Christensen L, Kjaer SK, Blaakaer J, Kjaerbye- Thygesen A, Gayther S, Jacobs IJ, Hogdall CK (2007) CA125 expression pattern, prognosis and correlation with serum CA125 in ovarian tumor patients From The Danish "MALOVA" Ovarian Cancer Study. Gynecol Oncol 104(3):508-515
11. Li J, Dowdy S, Tipton T, Podratz K, Lu WG, Xie X, Jiang SW (2009) HE4 as a biomarker for ovarian and endometrial cancer management. Expert Rev Mol Diagn 9(6):555-566. doi:10.1586/ erm.09.39
12. Zorn KK, Tian C, McGuire WP, Hoskins WJ, Markman M, Muggia FM, Rose PG, Ozols RF, Spriggs D, Armstrong DK (2009) The prognostic value of pretreatment CA 125 in patients with advanced ovarian carcinoma : a Gynecologic Oncology Group study. Cancer. doi:10.1002/cncr.24084
13. Birchmeier W, Hulsken J, Behrens J ((1995)) E-cadherin as an invasion suppressor. Ciba Found Symp 189:124-136 (discussion 136-141, 174-126)
14. Birchmeier W, Behrens J (1994) Cadherin expression in carcinomas: role in the formation of cell junctions and the prevention of invasiveness. Biochim Biophys Acta 1198(1):11-26 (Pubitemid 24159061)
15. Brinck U, Jacobs S, Neuss M, Tory K, Rath W, Kulle B, Fuzesi L (2004) DiVuse growth pattern aVects E-cadherin expression in invasive breast cancer. Anticancer Res 24(4):2237-2242 (Pubitemid 39166301)
16. Berx G, Van Roy F (2001) The E-cadherin-catenin complex: an important gatekeeper in breast cancer tumorigenesis and malignant progression. Breast Cancer Res 3(5):289-293 (Pubitemid 32851157)
17. Yalta T, Atay L, Atalay F, Caydere M, Gonultas M, Ustun H (2009) E-cadherin expression in endometrial malignancies: comparison between endometrioid and non-endometrioid carcinomas. J Int Med Res 37(1):163-168
18. Scholten AN, Aliredjo R, Creutzberg CL, Smit VT (2006) Combined E-cadherin, alpha-catenin, and beta-catenin expression is a favorable prognostic factor in endometrial carcinoma. Int J Gynecol Cancer 16(3):1379-1385 (Pubitemid 43886773)
19. Stawerski P, Wagrowska-Danilewicz M, Stasikowska O, Gottwald L, Danilewicz M (2008) Immunoexpression of betacatenin- E-cadherin complex in primary serous ovarian tumors. Pol J Pathol 59(1):27-32 (Pubitemid 351628139)
20. Blechschmidt K, Sassen S, Schmalfeldt B, Schuster T, HoXer H, Becker KF (2008) The E-cadherin repressor Snail is associated with lower overall survival of ovarian cancer patients. Br J Cancer 98(2):489-495. doi:6604115[pii]10.1038/ sj.bjc.6604115 (Pubitemid 351161237)
21. Faleiro-Rodrigues C, Macedo-Pinto I, Pereira D, Lopes CS (2004) Prognostic value of E-cadherin immunoexpression in patients with primary ovarian carcinomas. Ann Oncol 15(10):1535-1542. doi:10.1093/annonc/mdh38715/10/1535 (Pubitemid 39409745)
22. Imai T, Horiuchi A, Shiozawa T, Osada R, Kikuchi N, Ohira S, Oka K, Konishi I (2004) Elevated expression of E-cadherin and alpha-, beta-, and gamma-catenins in metastatic lesions compared with primary epithelial ovarian carcinomas. Hum Pathol 35(12):1469-1476 (Pubitemid 40017986)
23. Marques FR, Fonsechi-Carvasan GA, De Angelo Andrade LA, Bottcher-Luiz F (2004) Immunohistochemical patterns for alphaand beta-catenin, E- and N-cadherin expression in ovarian epithelial tumors. Gynecol Oncol 94(1):16-24 (Pubitemid 38950493)
24. Voutilainen KA, Anttila MA, Sillanpaa SM, Ropponen KM, Saarikoski SV, Juhola MT, Kosma VM (2006) Prognostic signiWcance of E-cadherin-catenin complex in epithelial ovarian cancer. J Clin Pathol 59:460-467
25. Yuecheng Y, Hongmei L, Xiaoyan X (2006) Clinical evaluation of E-cadherin expression and its regulation mechanism in epithelial ovarian cancer. Clin Exp Metastasis 23(1):65-74. doi:10.1007/ s10585-006-9020-3 (Pubitemid 44576780)
26. Faleiro-Rodrigues C, Macedo-Pinto I, Pereira D, Ferreira VM, Lopes CS (2004) Association of E-cadherin and beta-catenin immunoexpression with clinicopathologic features in primary ovarian carcinomas. Hum Pathol 35(6):663-669 (Pubitemid 38881075)
27. Burges A, Bruning A, Dannenmann C, Blankenstein T, Jeschke U, Shabani N, Friese K, Mylonas I (2010) Prognostic signiWcance of estrogen receptor alpha and beta expression in human serous carcinomas of the ovary. Arch Gynecol Obstet 281(3):511-517. doi:10.1007/s00404-009-1185-y
28. Dannenmann C, Shabani N, Friese K, Jeschke U, Mylonas I, Bruning A (2008) The metastasis-associated gene MTA1 is upregulated in advanced ovarian cancer, represses ERbeta, and enhances expression of oncogenic cytokine GRO. Cancer Biol Ther 7(9):1460-1467
29. Anonymous (1989) FIGO stages (announcements)-revision. Gynecol Oncol 35 125-127
30. Mylonas I, Worbs S, Shabani N, Kuhn C, Kunze S, Schulze S, Dian D, Gingelmaier A, Schindlbeck C, Bruning A, Sommer H, Jeschke U, Friese K (2009) Inhibin-alpha subunit is an independent prognostic parameter in human endometrial carcinomas: analysis of inhibin/activin-alpha, -betaA and -betaB subunits in 302 cases. Eur J Cancer 45(7):1304-1314. doi:10.1016/j.ejca. 2009.01.008
31. Shabani N, Kuhn C, Kunze S, Schulze S, Mayr D, Dian D, Gingelmaier A, Schindlbeck C, Willgeroth F, Sommer H, Jeschke U, Friese K, Mylonas I (2007) Prognostic signiWcance of oestrogen receptor alpha (ERalpha) and beta (ERbeta), progesterone receptor A (PR-A) and B (PR-B) in endometrial carcinomas. Eur J Cancer 43(16):2434-2444. doi:10.1016/j.ejca.2007.08.014 (Pubitemid 350001248)
32. Kaplan EL, Meier P (1958) Nonparametric estimation from incomplete observations. J Am Stat Assoc 53:457-481
33. Perez-Moreno M, Jamora C, Fuchs E (2003) Sticky business: orchestrating cellular signals at adherens junctions. Cell 112:535-548 (Pubitemid 36263085)
34. Darai E, Scoazec JY, Walker-Combrouze F, Mlika-Cabanne N, Feldmann G, Madelenat P, Potet F (1997) Expression of cadherins in benign, borderline, and malignant ovarian epithelial tumors: a clinicopathologic study of 60 cases. Hum Pathol 28:922-928 (Pubitemid 27355552)
35. Fujioka T, Takebayashi Y, Kihana T, Kusanagi Y, Hamada K, Ochi H, Uchida T, Fukumoto M, Ito M (2001) Expression of E-cadherin and beta-catenin in primary and peritoneal metastatic ovarian carcinoma. Oncol Rep 8(2):249-255 (Pubitemid 33758073)
36. Patel IS, Madan P, Getsios S, Bertrand MA, MacCalman CD (2003) Cadherin switching in ovarian cancer progression. Int J Cancer 106(2):172-177. doi:10.1002/ijc.11086 (Pubitemid 36835168)
37. Sundfeldt K, Piontkewitz Y, Ivarsson K, Nilsson O, Hellberg P, Brannstrom M, Janson PO, Enerback S, Hedin L (1997) E-cadherin expression in human epithelial ovarian cancer and normal ovary. Int J Cancer 74(3):275-280. doi:10.1002/(SICI) 1097-0215(19970620)74:33.0.CO;2-W (Pubitemid 27321795)
38. Behrens J, Mareel MM, Van Roy FM, Birchmeier W (1989) Dissecting tumor cell invasion: epithelial cells acquire invasive properties after the loss of uvomorulin-mediated cell-cell adhesion. J Cell Biol 108(6):2435-2447 (Pubitemid 19168932)
39. Frixen UH, Behrens J, Sachs M, Eberle G, Voss B, Warda A, Lochner D, Birchmeier W (1991) E-cadherin-mediated cell-cell adhesion prevents invasiveness of human carcinoma cells. J Cell Biol 113(1):173-185 (Pubitemid 21909684)
40. Veatch AL, Carson LF, Ramakrishnan S (1994) DiVerential expression of the cell-cell adhesion molecule E-cadherin in ascites and solid human ovarian tumor cells. Int J Cancer 58(3):393-399 (Pubitemid 24254650)
41. Auersperg N, Pan J, Grove BD, Peterson T, Fisher J, Maines- Bandiera S, Somasiri A, Roskelley CD (1999) E-cadherin induces mesenchymal-to-epithelial transition in human ovarian surface epithelium. Proc Natl Acad Sci USA 96(11):6249-6254 (Pubitemid 29256651)