Smad expression during kidney development

American Journal of Physiology - Renal Physiology

Volumn 286, Issue 4 55-4, 2004, Pages

  Vrljicak, P ^a,b   Myburgh, D ^a   Ryan, A K ^a,b   Van Rooijen, M A ^c   Mummery, C L ^c   Gupta, I R ^a,b  

^a MCGILL UNIVERSITY   (Canada)

^b MONTREAL CHILDREN S HOSPITAL   (Canada)

^c HUBRECHT INSTITUTE   (Netherlands)

Author keywords

MRNA; Transforming growth factor signaling

Indexed keywords

SMAD PROTEIN; SMAD1 PROTEIN; SMAD2 PROTEIN; SMAD3 PROTEIN; SMAD4 PROTEIN; SMAD5 PROTEIN; SMAD6 PROTEIN; SMAD7 PROTEIN; SMAD8 PROTEIN; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL FATE; CONTROLLED STUDY; EMBRYO; EMBRYO DEVELOPMENT; GENE EXPRESSION; IN SITU HYBRIDIZATION; KIDNEY DEVELOPMENT; KIDNEY INTERSTITIUM; KIDNEY MEDULLA; MESENCHYME; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

EID: 1642290120     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.00152.2003     Document Type: Article

References (49)

1. Al-Awqati Q and Goldberg M. Architectural pattens in branching morphogenesis in the kidney. Kidney Int 54: 1832-1842, 1998.
2. Attisano L and Wrana J. Signal transduction by the TGF-β superfamily. Science 296: 1646-1647, 2002.
3. Barasch J, Yang J, Ware C, Taga T, Yoshida K, Erdjument-Bromage H, Tempst P, Parravicini E, Malach S, Aranoff T, and Oliver J. Mesenchymal to epithelial conversion in rat metanephros is induced by LIF. Cell 99: 377-386, 1999.
4. Chang H, Huylebroeck D, Verschueren K, Guo Q, Matzuk M, and Zwijsen A. Smad5 knockout mice die at mid-gestation due to multiple embryonic and extraembryonic defects. Development 126: 1631-1642, 1999.
5. Chen R, Cancan H, Morinelli T, Trojanowska M, and Richard V P. Blockade of the effects of TGF-β on mesangial cells by overexpression of Smad7. J Am Soc Nephrol 13: 887-893, 2002.
6. Choi M, Liu A, and Ballermann B. Differential expression of transforming growth factor-β receptors in rat kidney development. Am J Physiol Renal Physiol 273: F386-F395, 1997.
7. 1 in rat metanephric development. Kidney Int 59: 1641-1653, 2001.
8. Dewulf N, Verschueren K, Lonnoy O, Moren A, Grimsby S, Van deSpiegle K, Miyazono K, Huylebroeck D, and ten Dijke P. Distinct spatial and temporal expression patterns of two type I receptors for bone morphogenetic proteins during mouse embryogenesis. Endocrinology 136: 2652-2663, 1995.
9. Dudley A, Lyons K, and Robertson E. A requirement for bone morphogenetic protein-7 during development of the mammalian kidney and eye. Genes Dev 9: 2795-2807, 1995.
10. Dudley A and Robertson E. Overlapping expression domains of bone morphogenetic protein family members potentially account for limited tissue defects in BMP7 deficient embryos. Dev Dyn 208: 349-362, 1997.
11. Dunn N, Winnier G, Hargett L, Schrick J, Fogo A, and Hogan B. Haploinsufficient phenotypes in Bmp4 heterozygous null mice and modificaton by mutations in Gli3 and A1x4. Dev Biol 188: 235-247, 1997.
12. Gupta I, Piscione T, Grisaru S, Phan T, Macias-Silva M, Zhou X, Whiteside C, Wrana J, and Rosenblum N. Protein kinase A is a negative regulator of renal branching morphogenesis and modulates inhibitory and stimulatory bone morphogenetic proteins. J Biol Chem 274: 26305-26314, 1999.
13. Hanyu A, Ishidou Y, Ebisawa T, Shimanuki T, Imamura T, and Miyazono K. The N domain of Smad7 is essential for specific inhibition of transforming growth factor-β signaling. J Cell Biol 155: 1017-1027, 2001.
14. Hata A, Lagna G, Massague J, and Hemmati-Brivanlou A. Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor. Genes Dev 12: 186-197, 1998.
15. Hatini V, Huh S, Herzlinger D, Soares V, and Lai E. Essential role of stromal mesenchyme in kidney morphogenesis revealed by targeted disruption of winged helix transcription factor BF-2. Genes Dev 10: 1467-1478, 1996.
16. Hayashi H, Abdollah S, Qiu Y, Cai J, Xu YY, Grinnell B, Richardson M, Topper J, Gimbrone M, Wrana J, and Falb D. The MAD-related protein Smad7 associates with the TGFβ receptor and functions as an antagonist of TGFβ signaling. Cell 89: 1165-1173, 1997.
17. Hellmich H, Kos L, Cho E, Mahon K, and Zimmer A. Embryonic expression of glial cell-line derived neurotrophic factor (GDNF) suggests multiple developmental roles in neural differentiation and epithelial-mesenchymal interactions. Mech Dev 54: 95-105, 1996.
18. Hogan B. Bone morphogenetic proteins: multifunctional regulators of vertebrate development. Genes Dev 10: 1580-1594, 1996.
19. Imamura T, Takase M, Nishihara A, Oeda E, Hanai J, Kawabata M, and Miyazono K. Smad6 inhibits signalling by the TGF-β superfamily. Nature 389: 623-626, 1997.
20. Itoh S, Itoh F, Goumans MJ, and ten Dijke P. Signaling of transforming growth factor-family members through Smad proteins (Abstract). Eur J Biochem 267: 6954, 2000.
21. Kispert A, Vainio S, and McMahon A. Wnt-4 is a mesenchymal signal for epithelial transformation of metanephric mesenchyme in the developing kidney. Development 125: 4225-4234, 1998.
22. Luo G, Hofmann C, Bronckers A, Sohocki M, Bradley A, and Karsenty G. BMP-7 is an inducer of nephrogenesis, and is also required for eye development and skeletal patterning. Genes Dev 9: 2808-2820, 1995.
23. Martinez G, Loveland K, Clark A, Dziadek M, and Bertram J. Expression of bone morphogenetic protein receptors in the developing mouse metanephros. Exp Nephrol 9: 372-379, 2001.
24. Mendelsohn C, Batourina E, Fung S, Gilbert T, and Dodd J. Stromal cells mediate retinoid-dependent functions essential for renal development. Development 126: 1139-1148, 1999.
25. Miyazaki Y, Oshima K, Fogo A, Hogan B, and Ichikawa I. Bone morphogenetic protein 4 regulates the budding site and elongation of the mouse ureter. J Clin Invest 105: 863-873, 2000.
26. Moustakas A, Souchelnytskyi S, and Heldin CH. Smad regulation in TGF-β signal transduction. J Cell Sci 114: 4359-4369, 2001.
27. Nakao A, Afrakhte M, Moren A, Nakayama T, Christian J, Heuchel R, Itoh S, Kawabata M, Heldin NE, Heldin CH, and ten Dijke P. Identification of Smad7, a TGFβ-inducible antagonist of TGF-β signalling. Nature 389: 631-635, 1997.
28. Oxburgh L and Robertson E. Dynamic regulation of Smad expression during mesenchyme to epithelium transition in the metanephric kidney. Mech Dev 112: 207-211, 2002.
29. Pachnis V, Mankoo B, and Costantini F. Expression of the c-ret proto-oncogene during mouse embryogenesis. Development 119: 1005-1017, 1993.
30. Piscione TD, Yager TD, Gupta IR, Grinfeld B, Pei Y, Attisano L, Wrana JL, and Rosenblum ND. BMP-2 and OP-1 exert direct and opposite effects on renal branching morphogenesis. Am J Physiol Renal Physiol 273: F961-F975, 1997.
31. Plisov S, Yoshino K, Dove L, Higinbotham K, Rubin J, and Perantoni A. TGFB LIF and FGF2 cooperate to induce nephrogenesis. Development 128: 1045-1057, 2001.
32. Quaggin S, Schwartz L, Cui S, Igarashi P, Deimling J, Post M, and Rossant J. The basic-helix-loop-helix protein Pod1 is critically important for kidney and lung organogenesis. Development 126: 5771-5783, 1999.
33. Quaggin S, Vanden Heuvel G, and Igarashi P. Pod-1, a mesoderm-specific helix-loop-helix protein expressed in mesenchymal and glomerular epithelial cells in the developing kidney. Mech Dev 71: 37-48, 1998.
34. Raatikainen-Ahokas A, Hytonen M, Tenhunen A, Sainio K, and Sariola H. BMP-4 affects the differentiation of metanephric mesenchyme and reveals an early anterior-posterior axis of the embryonic kidney. Dev Dyn 217: 146-158, 2000.
35. Ritvos O, Tuuri T, Eramaa M, Sainio K, Hilden K, Saxen L, and Gilbert S. Activin disrupts epithelial branching morphogenesis in developing glandular organs of the mouse. Mech Dev 50: 229-245, 1995.
36. Rogers S, Ryan G, and Hammerman M. Metanephric transforming growth factor-α is required for renal organogenesis in vitro. Am J Physiol Renal Fluid Electrolyte Physiol 262: F533-F539, 1992.
37. 1 regulates nephrogenesis in vitro. Am J Physiol Renal Fluid Electrolyte Physiol 264: F996-F1002, 1993.
38. Saxen L. Organogenesis of the Kidney. Cambridge, UK: Cambridge University Press, 1987.
39. Schiffer M, Bitzer M, Roberts I, Kopp J, t. Peter D, Mundel P, and Bottinger E. Apoptosis in podocytes induced by TGF-β and Smad7. J Clin Invest 108: 807-816, 2001.
40. Schnaper H, Hayashida T, Hubchak S, and Poncelet AC. TGF-β signal transduction and mesangial cell fibrogenesis. Am J Physiol Renal Physiol 284: F243-F284, 2003.
41. Sirard C, de la Pompa JL, Elia A, Itie A, Mirtsos C, Cheung A, Hahn S, Wakeham A, Schwartz L, Kern SE, Rossant J, and Mak TW. The tumor suppressor gene Smad 4/Dpc4 is required for gastrulation and later for anterior development of the mouse embryo. Genes Dev 12: 107-119, 1998.
42. Tremblay KD, Dunn NR, and Robertson EJ. Mouse embryos lacking Smadl signals display defects in extra-embryonic tissues and germ cell formation. Development 128: 3609-3621, 2001.
43. Uchida K, Nitta K, Kobayashi H, Kawachi H, Shimizu F, Yumura W, and Nihei H. Localization of Smad6 and Smad7 in the rat kidney and their regulated expression in the anti-Thy-1 nephritis. Mol Cell Biol Res Commun 4: 98-105, 2000.
44. Vukicevic S, Kopp J, Luyten F, and Sampath T. Induction of nephrogenic mesenchyme by osteogenic protein I (bone morphogenetic protein 7). Proc Natl Acad Sci USA 93: 9021-9026, 1996.
45. Weinstein M, Yang X, Li C, Xu X, Gotay J, and Deng CX. Failure of egg cylinder elongation and mesoderm induction in mouse embryos lacking the tumor suppressor smad2. Proc Natl Acad Sci USA 95: 9378-9383, 1998.
46. Whitman M. Feedback from inhibitory SMADS. Nature 389: 549-551, 1997.
47. Wilkinson D. Essential Developmental Biology: A Practical Approach. Oxford, UK: Oxford University Press, 1993.
48. Yang X, Li C, Xu X, and Deng C. The tumor suppressor SMAD4/DPC4 is essential for epiblast proliferation and mesoderm induction in mice. Proc Natl Acad Sci USA 95: 3667-3672, 1998.
49. Zhao GQ. Consequences of knocking out BMP signaling in the mouse. Genesis 43-56, 2003.