ATM-mediated phosphorylation activates the tumor-suppressive function of B56γ-PP2A

Oncogene

Volumn 30, Issue 35, 2011, Pages 3755-3765

  Shouse, G P ^a   Nobumori, Y ^a   Panowicz, M J ^a   Liu, X ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

ATM; B56 ; MDM2; p53; PP2A

Indexed keywords

ATM PROTEIN; PHOSPHOPROTEIN PHOSPHATASE 2A; PHOSPHOPROTEIN PHOSPHATASE 2A B56DELTA; PHOSPHOPROTEIN PHOSPHATASE 2A B56GAMMA2; PHOSPHOPROTEIN PHOSPHATASE 2A B56GAMMA3; PROTEIN MDM2; PROTEIN P53; UNCLASSIFIED DRUG;

ARTICLE; CANCER INHIBITION; CELL GROWTH; CELL PROLIFERATION; CONTROLLED STUDY; DEPHOSPHORYLATION; DNA DAMAGE; DOWN REGULATION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN PHOSPHORYLATION; PROTEIN STABILITY; UBIQUITINATION; UPREGULATION;

CELL CYCLE PROTEINS; CELL LINE, TUMOR; DNA DAMAGE; DNA-BINDING PROTEINS; DOWN-REGULATION; HUMANS; PHOSPHORYLATION; PROTEIN PHOSPHATASE 2; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS C-MDM2; SERINE; THREONINE; TUMOR SUPPRESSOR PROTEIN P53; TUMOR SUPPRESSOR PROTEINS;

ATAXIA TELANGIECTASIA;

EID: 80052282497     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2011.95     Document Type: Article

References (24)

1. Ahn J-H, McAvoy T, Rakhilin SV, Nishi A, Greengard P, Nairn AC. (2007). Protein kinase A activates protein phosphatase 2A by phosphorylation of the B56d subunit. Proc Natl Acad Sci USA 104: 2979-2984. (Pubitemid 46327989)
2. Arnold HK, Sears RC. (2006). Protein phosphatase 2A regulatory subunit B56a associates with c-Myc and negatively regulates c-Myc accumulation. Mol Cell Biol 26: 2832-2844.
3. Canman CE, Lim D-S, Cimprich KA, Taya Y, Tamai K, Sakaguchi K et al. (1998). Activation of the ATM kinase by ionizing radiation and phosphorylation of p53. Science 281: 1677-1679. (Pubitemid 28435584)
4. Eichorn PJA, Creyghton MP, Bernards R. (2009). Protein phosphatase 2A regulatory subunits and cancer. Biochim Biophys Acta 1795: 1-15.
5. Hickson I, Zhao Y, Richardson CJ, Green SJ, Martin NMB, Orr AI et al. (2004). Identification and characterization of a novel specific inhibitor of the Ataxia-Telangiectasia Mutated kinase ATM. Cancer Res 64: 9152-9159. (Pubitemid 39665530)
6. Janssens V, Longin S, Goris J. (2008). PP2A holoenzyme assembly: in cauda venenum (the sting is in the tail). Trends Biochem Sci 33: 113-121.
7. Kim ST, Lim DS, Canman CE, Kastan MB. (1999). Substrate specificities and identification of putative substrates of ATM kinase family members. J Biol Chem 274: 37538-37543. (Pubitemid 30026807)
8. Li H-H, Cai X, Shouse GP, Piluso LG, Liu X. (2007). A specific PP2A regulatory subunit, B56g, mediates DNA damage-induced depho-sphorylation of p53 at Thr55. EMBO 26: 402-411. (Pubitemid 46160941)
9. Lim D-S, Kim S-T, Xu B, Maser RS, Lin J, Petrini JHJ et al. (2000). ATM phosphorylates p95/nbs1 in a S-phase checkpoint pathway. Nature 404: 613-617. (Pubitemid 30205060)
10. Margolis SS, Perry JA, Forester CM, Nutt LK, Guo MJ, Jardim MJ et al. (2006). Role for the PP2A/B56d phosphatase in regulating 14-3-3 release from Cdc25 to control mitosis. Cell 127: 759-763.
11. Mumby M. (2007). PP2A: unveiling a reluctant tumor suppressor. Cell 130: 21-24. (Pubitemid 47031327)
12. Muneer S, Ramalingam V, Wyatt R, Schultz RA, Minna JD, Kamibayashi C. (2002). Genomic organization and mapping of the gene encoding the PP2A B56gamma regulatory subunit. Genomics 79: 344-348. (Pubitemid 34211942)
13. Nousiainen M, Sillje HHW, Sauer G, Nigg EA, Korner R. (2006). Phosphoproteome analysis of the human mitotic spindle. Proc Natl Acad Sci USA 103: 5391-5396.
14. Okamoto K, Li H, Jensen MR, Zhang T, Tava Y, Thorgeirsson SS et al. (2002). Cyclin G recruits PP2A to dephosphorylate MDM2. Mol Cell 9: 761-771. (Pubitemid 34454888)
15. O'Neill T, Dwyer AJ, Ziv Y, Chan DW, Lees-Miller SP. (2000). Utilization of oriented peptide libraries to identify substrate motifs selected by ATM. J Biol Chem 275: 22719-22727. (Pubitemid 30646153)
16. Ortega-Lazaro JC, del Mazo J. (2003). Expression of the B56delta subunit of protein phosphatase 2A and Mea1 in mouse spermato-genesis: identification of a new B56gamma subunit (B56gamma4) specifically expressed in testis. Cytogenet Genome Res 103: 345-351. (Pubitemid 38446000)
17. Shouse GP, Cai X, Liu X. (2008). Serine 15 phosphorylation of p53 directs its interaction with B56g and the tumor suppressor activity of B56g-specific protein phosphatase 2A. Mol Cell Biol 28: 448-456.
18. Shouse GP, Nobumori Y, Liu X. (2010). A B56g mutation in lung cancer disrupts the p53-dependent tumor suppressor function of protein phosphatase 2A. Oncogene 29: 3933-3941.
19. Silverstein AM, Barrow CA, Davis AJ, Mumby MC. (2002). Actions of PP2A on the MAP kinase pathway and apoptosis are mediated by distinct regulatory subunits. Proc Natl Acad Sci USA 99: 4221-4226. (Pubitemid 34285967)
20. Sontag E. (2001). Protein phosphatase 2A: the Trojan horse of cellular signaling. Cell Signal 13: 7-16. (Pubitemid 32222967)
21. Strack S, Ruediger R, Walter G, Dagda RK, Barwacz CA, Cribbs JT. (2002). Protein phosphatase 2A holoenzyme assembly, identification of contacts between b-family regulatory and scaffolding A subunits. J Biol Chem 277: 20750-20755. (Pubitemid 34967380)
22. Virshup D, Shenolikar S. (2009). From promiscuity to precision: protein phosphatases get a makeover. Mol Cell 33: 537-545.
23. Westermarck J, Hahn WC. (2008). Multiple pathways regulated by the tumor suppressor PP2A in transformation. Trends Mol Med 14: 152-160.
24. Yeh E, Cunningham M, Arnold H, Chasse D, Monteith T, Ivaldi G et al. (2004). A signaling pathway controlling c-Myc degradation that impacts oncogenic transformation of human cells. Nat Cell Biol 6: 308-318. (Pubitemid 38584820)