Defining the disconnect between in vitro models and human arrhythmogenic disease: Context matters

Circulation

Volumn 124, Issue 9, 2011, Pages 993-995

  Sturm, Amy C ^a,b   Mohler, Peter J ^a,b  

^a OHIO STATE UNIVERSITY   (United States)

^b THE OHIO STATE UNIVERSITY WEXNER MEDICAL CENTER   (United States)

Author keywords

Editorial; genetic testing; genetic variation; genetics; ion channels; polymorphism, genetic

Indexed keywords

ASPARAGINE; ASPARTIC ACID; CONNEXIN 40; SODIUM CHANNEL NAV1.5;

AMINO ACID SUBSTITUTION; ARRHYTHMOGENESIS; BRADYCARDIA; BRUGADA SYNDROME; CATHETER ABLATION; CONGESTIVE CARDIOMYOPATHY; DEFIBRILLATOR; DISEASE SEVERITY; DNA POLYMORPHISM; ELECTROCARDIOGRAM; GENE EXPRESSION; GENETIC SCREENING; GENETIC VARIABILITY; HEART ARRHYTHMIA; HEART ATRIUM FIBRILLATION; HEART ATRIUM FLUTTER; HEART CONDUCTION; HEART LEFT VENTRICLE FAILURE; HEART MUSCLE CONDUCTION DISTURBANCE; HEART RIGHT VENTRICLE FAILURE; HEART VENTRICLE TACHYCARDIA; HETEROLOGOUS EXPRESSION; HUMAN; IN VITRO STUDY; MISSENSE MUTATION; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN MODIFICATION; REVIEW; SICK SINUS SYNDROME; SINUS NODE DYSFUNCTION; SYNCOPE;

ANIMALS; ATRIAL FLUTTER; CARDIOMYOPATHY, DILATED; HUMANS; MALE; MUTATION, MISSENSE; SICK SINUS SYNDROME; SODIUM CHANNELS;

EID: 80052282193     PISSN: 00097322     EISSN: 15244539     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.111.051466     Document Type: Review

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