Increased lifespan in hyposulfatemic NaS1 null mice

Experimental Gerontology

Volumn 46, Issue 10, 2011, Pages 833-835

  Markovich, Daniel ^a   Ku, Mei Chun ^a   Muslim, Dzaidenny ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

Ageing; Cancer; Hyposulfatemia; Longevity; Sulfate; Transporter

Indexed keywords

CATALASE; DECAY ACCELERATING FACTOR; MESSENGER RNA; SIRTUIN 1; SULFATE;

AGE DISTRIBUTION; AGING; ANIMAL EXPERIMENT; ANIMAL GENETICS; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD LEVEL; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME DEFICIENCY; FEMALE; GENETIC ASSOCIATION; HISTOLOGY; HOMEOSTASIS; HYPOSULFATEMIA; LIFE EXTENSION; LONGEVITY; MALE; MOUSE; MOUSE STRAIN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SEX RATIO; SURVIVAL RATE; TUMOR DIAGNOSIS;

AGING; ANIMALS; CATION TRANSPORT PROTEINS; FEMALE; HOMEOSTASIS; LIVER; LONGEVITY; MALE; MICE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SODIUM; SULFATES;

MAMMALIA; MUS;

EID: 80052271898     PISSN: 05315565     EISSN: 18736815     Source Type: Journal    
DOI: 10.1016/j.exger.2011.05.008     Document Type: Article

References (20)

1. Aebi H. Catalase in vitro. Methods Enzymol. 1984, 105:121-126.
2. Beck L., Markovich D. The mouse Na(+)-sulfate cotransporter gene Nas1. Cloning, tissue distribution, gene structure, chromosomal assignment, and transcriptional regulation by vitamin D. J. Biol. Chem. 2000, 275:11880-11890.
3. Braeckman B.P., Vanfleteren J.R. Genetic control of longevity in C. elegans. Exp. Gerontol. 2007, 42:90-98.
4. Brown-Borg H.M., Rakoczy S.G. Catalase expression in delayed and premature aging mouse models. Exp. Gerontol. 2000, 35:199-212.
5. Chen P.L., Chen Y.M., Bookstein R., Lee W.H. Genetic mechanisms of tumor suppression by the human p53 gene. Science 1990, 250:1576-1580.
6. Dawson P.A., Beck L., Markovich D. Hyposulfatemia, growth retardation, reduced fertility and seizures in mice lacking a functional NaSi-1 gene. Proc. Natl. Acad. Sci. U.S.A. 2003, 100:13704-13709.
7. Dawson P.A., Gardiner B., Grimmond S., Markovich D. Transcriptional profile reveals altered hepatic lipid and cholesterol metabolism in hyposulfatemic NaS1 null mice. Physiol. Genomics 2006, 26:116-124.
8. Glatt H., Engelke C.E., Pabel U., Teubner W., Jones A.L., Coughtrie M.W., Andrae U., Falany C.N., Meinl W. Sulfotransferases: genetics and role in toxicology. Toxicol. Lett. 2000, 112-113:341-348.
9. Jackson S.G., McCandless E.L. Simple, rapid, turbidometric determination of inorganic sulfate and/or protein. Anal. Biochem. 1978, 90:802-808.
10. Lee A., Beck L., Markovich D. The human renal sodium sulfate cotransporter (SLC13A1; hNaSi-1) cDNA and gene: organization, chromosomal localization, and functional characterization. Genomics 2000, 70:354-363.
11. Lee S., Dawson P.A., Hewavitharana A.K., Shaw P.N., Markovich D. Disruption of NaS1 sulfate transport function in mice leads to enhanced acetaminophen-induced hepatotoxicity. Hepatology 2006, 43:1241-1247.
12. Leibiger I.B., Berggren P.O. Sirt1: a metabolic master switch that modulates lifespan. Nat. Med. 2006, 12:34-36.
13. Longo V.D., Finch C.E. Evolutionary medicine: from dwarf model systems to healthy centenarians. Science 2003, 299:1342-1346.
14. Mahlknecht U., Bucala R., Hoelzer D., Verdin E. High resolution physical mapping of human HDAC3, a potential tumor suppressor gene in the 5q31 region. Cytogenet. Cell. Genet. 1999, 86:237-239.
15. Markovich D. Physiological roles and regulation of mammalian sulfate transporters. Physiol. Rev. 2001, 81:1499-1533.
16. Markovich D., Aronson P.S. Specificity and regulation of renal sulfate transporters. Annu. Rev. Physiol. 2007, 69:361-375.
17. Markovich D., Murer H. The SLC13 gene family of sodium sulphate/carboxylate cotransporters. Pflugers Arch. 2004, 447:594-602.
18. Markovich D., Forgo J., Stange G., Biber J., Murer H. Expression cloning of rat renal Na+/SO4(2-) cotransport. Proc. Natl. Acad. Sci. U.S.A. 1993, 90:8073-8077.
19. Rogina B., Reenan R.A., Nilsen S.P., Helfand S.L. Extended life-span conferred by cotransporter gene mutations in Drosophila. Science 2000, 290:2137-2140.
20. Walter C.A., Zhou Z.Q., Manguino D., Ikeno Y., Reddick R., Nelson J., Intano G., Herbert D.C., McMahan C.A., Hanes M. Health span and life span in transgenic mice with modulated DNA repair. Ann. N.Y. Acad. Sci. 2001, 928:132-140.