Investigating combinatorial approaches in virtual screening on human inducible 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFKFB3): A case study for small molecule kinases

Analytical Biochemistry

Volumn 418, Issue 1, 2011, Pages 143-148

  Crochet, Robert B ^a   Cavalier, Michael C ^a   Seo, Minsuh ^a   Kim, Jeong Do ^a   Yim, Young Sun ^a   Park, Seung Jong ^a,b   Lee, Yong Hwan ^a  

^a LOUISIANA STATE UNIVERSITY   (United States)

^b Louisiana State University   (United States)

Author keywords

6 Phosphofructo 2 kinase fructose 2,6 bisphosphatase; Cancer; Computational biology; Drug discovery; Enrichment factors; Fructose 2,6 bisphosphate; Glycolysis; PFKFB3; Small molecule kinases; Software evaluation molecular docking; Warburg

Indexed keywords

CHEMOTHERAPY; COMPUTER SOFTWARE SELECTION AND EVALUATION; DATABASE SYSTEMS; DISEASES; MOLECULES; PHARMACODYNAMICS;

6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE; CANCER; COMPUTATIONAL BIOLOGY; DRUG DISCOVERY; ENRICHMENT FACTORS; GLYCOLYSIS; MOLECULAR DOCKING; PFKFB3; SMALL MOLECULES; WARBURG;

ENZYMES;

6 PHOSPHOFRUCTO 2 KINASE; ADENOSINE TRIPHOSPHATE; FRUCTOSE 2,6 BISPHOSPHATASE; FRUCTOSE 6 PHOSPHATE; HUMAN INDUCIBLE 6 PHOSPHOFRUCTO 2 KINASE/FRUCTOSE 2,6 BISPHOSPHATASE; UNCLASSIFIED DRUG;

ACCURACY; ARTICLE; CANCER CHEMOTHERAPY; COMBINATORIAL CHEMISTRY; COMPETITIVE INHIBITION; CONTROLLED STUDY; DRUG SCREENING; ENZYME ACTIVITY; ENZYME STRUCTURE; GLYCOLYSIS; HIGH THROUGHPUT SCREENING; HUMAN; MOLECULAR DOCKING; PHARMACOPHORE; PRIORITY JOURNAL; STEADY STATE; STRUCTURE BASE DOCKING; VIRTUAL SCREENING;

EID: 80052262774     PISSN: 00032697     EISSN: 10960309     Source Type: Journal    
DOI: 10.1016/j.ab.2011.06.035     Document Type: Article

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