Gas bioengineering using hemoglobin-vesicles for versatile clinical applications

Current Pharmaceutical Design

Volumn 17, Issue 22, 2011, Pages 2352-2359

  Sakai, Hiromi ^a,b   Takeoka, Shinji ^a,b   Kobayashi, Koichi ^c  

^a Waseda University   (Singapore)

^b WASEDA UNIVERSITY   (Japan)

^c KEIO UNIVERSITY   (Japan)

Author keywords

Blood substitutes; Hemodynamics; Liposome; Microcirculation

Indexed keywords

BLOOD SUBSTITUTE; CARBON MONOXIDE; HEME; HEMOGLOBIN; HEMOGLOBIN BASED OXYGEN CARRIER; LIPOSOME; NITRIC OXIDE; OXYGEN; OXYHEMOGLOBIN; UNCLASSIFIED DRUG;

ARTICLE; ARTIFICIAL CELL; ARTIFICIAL MEMBRANE; BIOENGINEERING; BLEEDING; BLOOD TRANSFUSION; BRAIN OXYGEN CONSUMPTION; CHEMICAL BINDING; CHEMICAL ENGINEERING; CHEMICAL REACTION; DIFFUSION; ENCAPSULATION; ERYTHROCYTE; EXTRACORPOREAL OXYGENATION; FLUID FLOW; FLUID RESUSCITATION; GAS BIOENGINEERING; GAS PERMEABILITY; HEMODYNAMICS; HEMOGLOBIN VESICLE; LIPID VESICLE; MICROCIRCULATION; OXIDATION; PHOSPHOLIPID BILAYER; PHOTOLYSIS; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; RADIOSENSITIZATION; SHOCK; SOLID TUMOR; SPECTROPHOTOMETRY; STOPPED FLOW RAPID SCAN SPECTROPHOTOMETRY; TISSUE OXYGENATION;

ANIMALS; BLOOD SUBSTITUTES; CARBON MONOXIDE; CLINICAL MEDICINE; HEMOGLOBINS; HUMANS; MODELS, BIOLOGICAL; NITRIC OXIDE; OXYGEN; SHOCK, HEMORRHAGIC;

EID: 80052255046     PISSN: 13816128     EISSN: 18734286     Source Type: Journal    
DOI: 10.2174/138161211797052637     Document Type: Article

References (61)

1. Tsuchida E (ed.), Artificial Red Cells. John Wiley & Sons. Chichester, 1995.
2. Vandegriff K, Winslow RM. Haemoglobin-based blood substitutes. Chem Industry 1991; 14: 497-504.
3. Natanson C, Kern SJ, Lurie P, Banks SM, Wolfe SM. Cell-free hemoglobin-based blood substitutes and risk of myocardial infarction and death: a meta-analysis. JAMA 2008; 299: 2304-12.
4. Tsuchida E, Sou K, Nakagawa A, Sakai H, Komatsu T, Kobayashi K. Artificial oxygen carriers, hemoglobin vesicles and albumin- hemes, based on bioconjugate chemistry. Bioconjug Chem 2009; 20: 1419-40.
5. Chang TMS. Blood substitutes based on modified hemoglobin prepared by encapsulation or crosslinking: An overview. Biomater Artif Cells Immobilization Biotechnol 1991; 20: 159-82.
6. Bangham AD, Horne RW. Negative staining of phospholipids and their structure modification by surface-active agents as observed in the electron microscope. J Mol Biol 1964; 8: 660-8.
7. Djordjevich L, Miller IF. Lipid encapsulated hemoglobin as a synthetic erythrocyte. 1977; 36: 567.
8. Gaber BP, Yager P, Sheridan JP, Chang EL. Encapsulation of hemoglobin in phospholipid vesicles. FEBS Lett 1983; 153: 285-8.
9. Djordjevich L, Ivankovich AD. Liposomes as carriers of hemoglobin, In: Liposomes as Drug Carriers. G. Gregoriadis (Ed.). John Wiley & Sons 1988; Chapter 39, pp.551-67.
10. Hunt CA, Burnette RR, MacGregor RD, et al. Synthesis and evaluation of prototypal artificial red cells. Science 1985; 230: 1165-8.
11. Sakai H, Sou K, Tsuchida E. Hemoglobin-vesicles as an artificial oxygen carrier. Methods Enzymol 2009; 465: 363-83.
12. 99mTc-labeled liposome-encapsulated hemoglobin in an anesthetized rabbit. Proc Natl Acad Sci USA 1991; 88: 10976-80.
13. Szebeni J, Fontana JL, Wassef NM, et al. Hemodynamic changes induced by liposomes and liposome-encapsulated hemoglobin in pigs: a model for pseudoallergic cardiopulmonary reactions to liposomes. Role of complement and inhibition by soluble CR1 and anti-C5a antibody. Circulation 1999; 99: 2302-9.
14. Tsuchida E (Ed.), Blood substitutes: Present and future perspectives, Elsevier, Chichester, 1998.
15. Yamazaki M, Aeba R, Yozu R, Kobayashi K. Use of hemoglobin vesicles during cardiopulmonary bypass priming prevents neurocognitive decline in rats. Circulation 2006; 114(1 Suppl): I220-5.
16. Sakai H, Masada Y, Horinouchi H, et al. Hemoglobin-vesicles suspended in recombinant human serum albumin for resuscitation from hemorrhagic shock in anesthetized rats. Crit Care Med 2004; 32: 539-45.
17. Sakai H, Seishi Y, Obata Y, et al. Fluid resuscitation with artificial oxygen carriers in hemorrhaged rats: Profiles of hemoglobin- vesicle degradation and hematopoiesis for 14 days. Shock 2009; 31: 192-200.
18. Taguchi K, Maruyama T, Iwao Y, et al. Pharmacokinetics of single and repeated injection of hemoglobin-vesicles in hemorrhagic shock rat model. J Control Release 2009; 136: 232-9.
19. Taguchi K, Ogaki S, Watanabe H, et al. Fluid resuscitation with hemoglobin-vesicles prevents Escherichia coli growth via complement activation in a hemorrhagic shock rat model. J Pharmacol Exp Ther 2011; 337: 201-8.
20. Goda N, Suzuki K, Naito M, et al. Distribution of heme oxygenase isoforms in rat liver. Topographic basis for carbon monoxide- mediated microvascular relaxation. J Clin Invest 1998; 101: 604-12.
21. Verdu EF, Bercik P, Huang XX, et al. The role of luminal factors in the recovery of gastric function and behavioral changes after chronic Helicobacter pylori infection. Am J Physiol Gastrointest Liver Physiol 2008; 295: G664-70.
22. Komatsu H, Furuya T, Sato N, et al. Effect of hemoglobin vesicle, a cellular-type artificial oxygen carrier, on middle cerebral artery occlusion- and arachidonic acid-induced stroke models in rats. Neurosci Lett 2007; 421: 121-5.
23. Plock JA, Tromp AE, Contaldo C, et al. Hemoglobin vesicles reduce hypoxia-related inflammation in critically ischemic hamster flap tissue. Crit Care Med 2007; 35: 899-905.
24. Plock JA, Rafatmehr N, Sinovcic D, et al. Hemoglobin vesicles improve wound healing and tissue survival in critically ischemic skin in mice. Am J Physiol Heart Circ Physiol 2009; 297: H905-10.
25. Cabrales P, Sakai H, Tsai AG, Takeoka S, Tsuchida E, Intaglietta M. Oxygen transport by low and normal oxygen affinity hemoglobin vesicles in extreme hemodilution. Am J Physiol Heart Circ Physiol 2005; 288: H1885-92.
26. Yamamoto M, Izumi Y, Horinouchi H, et al. Systemic administration of hemoglobin vesicle elevates tumor tissue oxygen tension and modifies tumor response to irradiation. J Surg Res 2009; 151: 48-54.
27. Sakai H, Horinouchi H, Tsuchida E, Kobayashi K. Hemoglobin vesicles and red blood cells as carriers of carbon monoxide prior to oxygen for resuscitation after hemorrhagic shock in a rat model. Shock 2009; 31: 507-14.
28. 15O-oxygen using hemoglobin-containing liposome vesicles and its application for measurement of brain oxygen consumption by PET. Nucl Med Biol 2010; 37: 77-83.
29. Sakai H, Sato A, Takeoka S, Tsuchida E. Mechanism of flocculate formation of highly concentrated phospholipid vesicles suspended in a series of water-soluble biopolymers. Biomacromolecules 2009; 10: 2344-50.
30. Sakai H, Miyagawa N, Horinouchi H, et al. Intravenous infusion of Hb-vesicles (artificial oxygen carriers) after repetitive blood exchange with a series of plasma expanders (water-soluble biopolymers) in a rat model. Polymers Adv Technol 2011 (in press) (DOI: 10.1002/pat.1964).
31. Sakai H, Sato A, Takeoka S, Tsuchida E. Rheological properties of hemoglobin vesicles (artificial oxygen carriers) suspended in a series of plasma-substitute solutions, Langmuir 2007; 23: 8121-8.
32. Sou K, Klipper R, Goins B, Tsuchida E, Phillips WT. Circulation kinetics and organ distribution of Hb vesicles developed as a red blood cell substitute. J Pharmacol Exp Ther 2005; 312: 702-9.
33. Sakai H, Horinouchi H, Tomiyama K, et al. Hemoglobin-vesicles as oxygen carriers: influence on phagocytic activity and histopathological changes in reticuloendothelial system. Am J Pathol 2001; 159: 1079-88.
34. Taguchi K, Urata Y, Anraku M, et al. Pharmacokinetic study of enclosed hemoglobin and outer lipid component after the administration of hemoglobin-vesicles as an artificial oxygen carrier. Drug Metab Disposit 2009; 37: 1456-63.
35. 50 Hb vesicles in transiently occluded arterioles of the hamster window model. Am J Physiol Heart Circ Physiol. 2005; 288: H2897-903.
36. 2 carriers determine constriction of resistance arteries and hypertension. Am J Physiol Heart Circ Physiol 2000; 279: H908-15.
37. Sakai H, Hamada K, Takeoka S, Nishide H, Tsuchida E. Functional evaluation of hemoglobin- and lipidheme vesicles as red cell substitutes. Polymers Adv Technol 1996; 7: 639-44.
38. Vaughn MW, Huang KT, Kuo L, Liao JC. Erythrocytes possess an intrinsic barrier to nitric oxide consumption. J Biol Chem 2000; 275: 2342-8.
39. Sakai H, Sato A, Masuda K, Takeoka S, Tsuchida E. Encapsulation of concentrated hemoglobin solution in phospholipid vesicles retards the reaction with NO, but not CO, by intracellular diffusion barrier. J Biol Chem 2008; 283: 1508-17.
40. Sakai H, Sato A, Sobolewski P, et al. NO and CO binding profiles of hemoglobin vesicles as artificial oxygen carriers. Biochim Biophys Acta 2008; 1784: 1441-7.
41. Rudolph AS, Sulpizio A, Hieble P, et al. Liposome encapsulation attenuates hemoglobin-induced vasoconstriction in rabbit arterial segments. J Appl Physiol 1997; 82: 1826-35.
42. Harder DR, Narayaran J, Birks EK, et al. Identification of a putative microvascular oxygen sensor. Circ Res 1996; 79: 54-61.
43. McCarthy MR, Vandegriff KD, Winslow RM. The role of facilitated diffusion in oxygen transport by cell-free hemoglobins: implications for the design of hemoglobin-based oxygen carriers. Biophys Chem 2001; 92: 103-17.
44. Olson JS, Foley EW, Rogge C, Tsai AL, Doyle MP, Lemon DD. No scavenging and the hypertensive effect of hemoglobin-based blood substitutes. Free Radic Biol Med 2004; 36: 685-97.
45. Rohlfs RJ, Bruner E, Chiu A, et al. Arterial blood pressure responses to cell-free hemoglobin solutions and the reaction with nitric oxide. J Biol Chem 1998; 273: 12128-34.
46. 2 release from Hb vesicles evaluated using an artificial, narrow O2-permeable tube: comparison with RBCs and acellular Hbs. Am J Physiol Heart Circ Physiol 2003; 285: H2543-51.
47. Page TC, Light WR, McKay CB, Hellums JD. Oxygen transport by erythrocyte/hemoglobin solution mixtures in an in vitro capillary as a model of hemoglobin-based oxygen carrier performance. Microvasc Res 1998; 55: 54-66.
48. 2-release when perfused through narrow gas-permeable tubes. Am J Physiol Heart Circ Physiol 2010; 298: H956-65.
49. Ryter SW, Alam J, Choi AM. Heme oxygenase-1/carbon monoxide: from basic science to therapeutic applications. Physiol Rev 2006; 86: 583-650.
50. Morita T, Perrella MA, Lee ME, Kourembanas S. Smooth muscle cell-derived carbon monoxide is a regulator of vascular cGMP. Proc Natl Acad Sci USA 1995; 92: 1475-9.
51. Motterlini R, Clark JE, Foresti R, Sarathchandra P, Mann BE, Green CJ. Carbon monoxide-releasing molecules: characterization of biochemical and vascular activities. Circ Res 2002; 90: e17-24.
52. Motterlini R, Otterbein LE. The therapeutic potential of carbon monoxide. Nat Rev Drug Discov 2010; 9: 728-43.
53. Morse D, Pischke SE, Zhou Z, et al. Suppression of inflammatory cytokine production by carbon monoxide involves the JNK pathway and AP-1. J Biol Chem 2003; 278: 36993-8.
54. Cabrales P, Tsai AG, Intaglietta M. Hemorrhagic shock resuscitation with carbon monoxide saturated blood. Resuscitation 2007; 72: 306-18.
55. Jaeschke H, Farhood A. Neutrophil and Kupffer cell-induced oxidant stress and ischemia-reperfusion injury in rat liver. Am J Physiol Gastroenterol Liver Physiol 1991; 260: G355-62.
56. Vandegriff KD, Young MA, Lohman J, et al. CO-MP4, a polyethylene glycol-conjugated haemoglobin derivative and carbon monoxide carrier that reduces myocardial infarct size in rats. Br J Pharmacol 2008; 154: 1649-61.
57. Sakai H, Tsuchida E. Hemoglobin-vesicles for a transfusion alternative and targeted oxygen delivery. J Liposome Res 2007; 17: 227-35.
58. 2 therapeutics. Am J Physiol Heart Circ Physiol 2003; 285: H1411-9.
59. Rameez S, Alosta H, Palmer AF. Biocompatible and biodegradable polymersome encapsulated hemoglobin: a potential oxygen carrier. Bioconjug Chem 2008; 19: 1025-32.
60. Zhao J, Liu CS, Yuan Y, Tao XY, Shan XQ, Sheng Y, Wu F. Preparation of hemoglobin-loaded nano-sized particles with porous structure as oxygen carriers. Biomaterials 2007; 28: 1414-22.
61. Takahashi D, Azuma H, Sakai H, et al. Phagocytosis of liposome particles by rat splenic immature monocytes makes them transiently and highly immunosuppressive in ex vivo culture conditions. J Pharmacol Exp Ther. 2011; 337:42-9.