Values of promoter hypermethylation of FHIT, p 16, MGMT and RASSF 1A genes in plasma in the diagnosis of lung cancer

Tumor

Volumn 31, Issue 8, 2011, Pages 729-734

  Kang, Chun Yan ^a   Zhou, Hui Cong ^b   Tang, Shao Peng ^c   Xiao, Hong ^a  

^a ZHENGZHOU UNIVERSITY   (China)

^b XINXIANG MEDICAL UNIVERSITY   (China)

^c Henan Chest Hospital   (China)

Author keywords

Lung neoplasms; Methylation; Molecular diagnostic techniques; Plasma; Tissues

Indexed keywords

FRAGILE HISTIDINE TRIAD PROTEIN; METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE; PROTEIN P16; RAS ASSOCIATION DOMAIN FAMILY PROTEIN 1A;

ARTICLE; CANCER DIAGNOSIS; CANCER SCREENING; CANCER TISSUE; CONTROLLED STUDY; DIAGNOSTIC TEST ACCURACY STUDY; DIAGNOSTIC VALUE; DISEASE ASSOCIATION; DNA METHYLATION; EARLY DIAGNOSIS; HUMAN; HUMAN TISSUE; LUNG CANCER; PLASMA; POLYMERASE CHAIN REACTION; PROMOTER REGION; SENSITIVITY AND SPECIFICITY; SMOKING; TUMOR GENE; TUMOR SUPPRESSOR GENE;

EID: 80052233712     PISSN: 10007431     EISSN: None     Source Type: Journal    
DOI: 10.3781/j.issn.1000-7431.2011.08.010     Document Type: Article

References (11)

1. BELINSKY S A, KLINGE D M, DEKKER J D, et al . Gene promoter methylation in plasma and sputum increases with lung cancer risk[J]. Clin Cancer Res , 2005, 11(15): 6505-6511.
2. HSU H S , CHEN T P , HUNG C H, e t a l . Characterization of a multiple epigenetic marker panel for lung cancer detection and risk assessment in plasma[J]. Cancer , 2007, 110(9): 2019-2026.
3. OTA N, KAWAKAMIK, OKUDA T, et al . Prognostic significance of p16(INK4a) hypermethylation in non-small cell lung cancer is evident by quantitative DNA methylation analysis[J]. Anticancer Res , 2006, 26(5B): 3729-3732.
4. GROTE H J, SCHMIEMANN V, GEDDERT H, et al . Methylation of RAS association domain family protein 1A as a biomarker of lung cancer[J]. Cancer , 2006, 108(2): 129-134.
5. WALI A, SRINIVASAN R, SHABNAM M S, et al . Loss of fragile histidine triad gene expression in advanced lung cancer is consequent to allelic loss at 3p14 locus and promoter methylation[J]. Mol Cancer Res , 2006, 4(2): 93-99.
6. 6- methylguanine-DNA methyltransferase gene: more common in lung adenocarcinomas from never smokers than smokers and associated with tumor progression[J]. Cancer Res , 2003, 63(16): 4842-4848.
7. BELINSKY S A, NIKULA K, PALMISANO W A, et al . Aberrant methylation of p16INK4A is an early event in lung cancer and a potential biomarker for early diagnosis[J]. Proc Natl Acad Sci USA , 1998, 95(20): 11891-11896.
8. HERMAN J G, GRAFF J R, MYOHANEN S, et al . Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands[J]. Proc NatI Acad Sci USA , 1996, 93(18): 9821-9826.