Association of increased prenatal estrogen with risk factors for schizophrenia

Schizophrenia Bulletin

Volumn 37, Issue 5, 2011, Pages 946-949

  Brown Jr , James S ^a,b  

^a Crossroads Community Services Board   (United States)

^b VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

Author keywords

autoimmune; endocrine disruption; psychosis; urban stress; viruses

Indexed keywords

AROMATASE; CORTISONE; DIENESTROL; DIETHYLSTILBESTROL; ESTRADIOL; ESTROGEN; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; PROGESTERONE; REELIN; TESTOSTERONE;

AUTOIMMUNE DISEASE; AVIAN INFECTIOUS BRONCHITIS VIRUS; BRAIN CELL; BRAIN GROWTH; CORONAVIRUS; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTION; DENDRITIC CELL; DISEASE ASSOCIATION; DISEASE PREDISPOSITION; ENZYME ACTIVATION; ESTROGEN BLOOD LEVEL; HERPES SIMPLEX; HERPES SIMPLEX VIRUS 2; HUMAN; HYDROCORTISONE BLOOD LEVEL; IMMUNE DEFICIENCY; INFECTION RISK; INFLUENZA VIRUS; INTESTINE INFECTION; LIMBIC SYSTEM; MATERNAL MORTALITY; NONHUMAN; PREGNANCY DISORDER; PRENATAL EXPOSURE; PRENATAL PERIOD; PRIORITY JOURNAL; PROGESTERONE BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTOPLASMATIC ASTROCYTE; REMISSION; REVIEW; RHEUMATOID ARTHRITIS; RNA VIRUS INFECTION; SCHIZOPHRENIA; SJOEGREN SYNDROME; SMOKING; STRESS; T CELL DEPLETION; TESTOSTERONE BLOOD LEVEL; TOXOPLASMOSIS; URBAN AREA; UROGENITAL TRACT INFECTION; VIRUS ETIOLOGY; VIRUS INFECTION; VIRUS REACTIVATION;

ESTROGENS; FEMALE; HUMANS; PREGNANCY; PREGNANCY COMPLICATIONS; PRENATAL EXPOSURE DELAYED EFFECTS; SCHIZOPHRENIA;

EID: 80052232973     PISSN: 05867614     EISSN: 17451701     Source Type: Journal    
DOI: 10.1093/schbul/sbp161     Document Type: Review

References (38)

1. Brown JS, Jr. Effects of bisphenol-A and other endocrine disruptors compared with abnormalities of schizophrenia: an endocrine-disruption theory of schizophrenia. Schizophr Bull. 2009;35:256-278.
2. Kulkarni J. Oestrogen-a new treatment approach for schizophrenia? Med J Aust. 2009;190(Suppl):S37-S38.
3. Canuso CM, Pandina G. Gender and schizophrenia. Psychopharmacol Bull. 2007;40:178-190.
4. Sonnex C. Influence of ovarian hormones on urogenital infection. Sex Transm Infect. 1998;74:11-19. (Pubitemid 28201975)
5. Escribese MM, Kraus T, Rhee E, Fernandez-Sesma A, Lopez CB, Moran TM. Estrogen inhibits dendritic cell maturation to RNA viruses. Blood. 2008;112:4574-4584.
6. Nunes SO, Itano EN, Amarante MK, et al. RNA from Borna disease virus in patients with schizophrenia, schizoaffective patients, and in their biological relatives. J Clin Lab Anal. 2008;22:314-320.
7. Dalman C, Allebeck P, Gunnell D, et al. Infections in the CNS during childhood and the risk of subsequent psychotic illness: a cohort study of more than one million Swedish subjects. Am J Psychiatry. 2008;165:59-65. (Pubitemid 351704553)
8. Brown AS, Vinogradov S, Kremen WS, et al. Prenatal exposure to maternal infection and executive dysfunction in adult schizophrenia. Am J Psychiatry. 2009;166:683-690.
9. Severance EG, Dickerson FB, Viscidi RP, et al. Coronavirus immunoreactivity in individuals with a recent onset of psychotic symptoms [published online ahead of print June 2, 2009]. Schizophr Bull. doi: 10.1093/schbul/sbp052.
10. Nakano K, Matsushita S, Saito K, Yamaoka K, Tanaka Y. [Dopamine as an immune-modulator between dendritic cells and T cells and the role of dopamine in the pathogenesis of rheumatoid arthritis]. Nihon Rinsho Meneki Gakkai Kaishi. 2009;32:1-6.
11. Torrey EF, Yolken RH. The schizophrenia-rheumatoid arthritis connection: infectious, immune, or both? Brain Behav Immun. 2001;15:401-410.
12. Lawrence D, Mitrou F, Zubrick SR. Smoking and mental illness: results from population surveys in Australia and the United States. BMC Public Health. 2009;9:285.
13. Zhang XY, Cao LY, Song C, et al. Lower serum cytokine levels in smokers than nonsmokers with chronic schizophrenia on long-term treatment with antipsychotics. Psychopharmacology (Berl). 2008;201:383-389.
14. Cutolo M, Capellino S, Sulli A, et al. Estrogens and autoimmune diseases. Ann N Y Acad Sci. 2006;1089:538-547. (Pubitemid 47092097)
15. Kim YK, Myint AM, Verkerk R, Scharpe S, Steinbusch H, Leonard B. Cytokine changes and tryptophan metabolites in medication-naive and medication-free schizophrenic patients. Neuropsychobiology. 2009;59:123-129.
16. Mortimer AM. Relationship between estrogen and schizophrenia. Expert Rev Neurother. 2007;7:45-55. (Pubitemid 46105295)
17. Yde CW, Clausen MP, Bennetzen MV, Lykkesfeldt AE, Mouritsen OG, Guerra B. The antipsychotic drug chlorpromazine enhances the cytotoxic effect of tamoxifen in tamoxifensensitive and tamoxifen-resistant human breast cancer cells. Anticancer Drugs. 2009;20:723-735.
18. Ostensen M. Sex hormones and pregnancy in rheumatoid arthritis and systemic lupus erythematosus. Ann N Y Acad Sci. 1999;876:131-143.
19. Elenkov IJ, Wilder RL, Bakalov VK, et al. IL-12, TNF-alpha, and hormonal changes during late pregnancy and early postpartum: implications for autoimmune disease activity during these times. J Clin Endocrinol Metab. 2001;86:4933-4938. (Pubitemid 33020544)
20. Eaton WW, Byrne M, Ewald H, et al. Association of schizophrenia and autoimmune diseases: linkage of Danish national registers. Am J Psychiatry. 2006;163:521-528. (Pubitemid 44469397)
21. Yolken RH, Dickerson FB, Fuller TE. Toxoplasma and schizophrenia. Parasite Immunol. 2009;31:706-715.
22. Kittas C, Henry L. Effect of sex hormones on the immune system of guinea-pigs and on the development of toxoplasmic lesions in non-lymphoid organs. Clin Exp Immunol. 1979;36: 16-23. (Pubitemid 9147652)
23. Kittas C, Henry L. Effect of sex hormones on the response of mice to infection with Toxoplasma gondii. Br J Exp Pathol. 1980;61:590-600. (Pubitemid 11155104)
24. Pung OJ, Luster MI. Toxoplasma gondii: decreased resistance to infection in mice due to estrogen. Exp Parasitol. 1986;61:48-56. (Pubitemid 16166833)
25. Liesenfeld O, Nguyen TA, Pharke C, Suzuki Y. Importance of gender and sex hormones in regulation of susceptibility of the small intestine to peroral infection with Toxoplasma gondii tissue cysts. J Parasitol. 2001;87: 1491-1493. (Pubitemid 34013843)
26. Buka SL, Cannon TD, Torrey EF, Yolken RH. Maternal exposure to herpes simplex virus and risk of psychosis among adult offspring. Biol Psychiatry. 2008;63:809-815. (Pubitemid 351400765)
27. MacDonald EM, Savoy A, Gillgrass A, et al. Susceptibility of human female primary genital epithelial cells to herpes simplex virus, type-2 and the effect of TLR3 ligand and sex hormones on infection. Biol Reprod. 2007;77: 1049-1059. (Pubitemid 350197982)
28. Gillgrass AE, Fernandez SA, Rosenthal KL, Kaushic C. Estradiol regulates susceptibility following primary exposure to genital herpes simplex virus type 2, while progesterone induces inflammation. J Virol. 2005;79:3107-3116. (Pubitemid 40270589)
29. Kleinman D, Sarov I, Insler V. Reactivation of cytomegalovirus in endometrial cells by estradiol. Gynecol Obstet Invest. 1986;21:136-143. (Pubitemid 16129960)
30. Koment RW. Lytic cytomegalovirus replication and the hormones of human pregnancy. J Med Virol. 1985;15: 149-156. (Pubitemid 15161381)
31. Ambali AG, Jones RC. The effects of three reproductive hormones and cortisone on the replication of avian infectious bronchitis virus in vitro. Rev Roum Virol. 1990;41: 151-156.
32. Torrey EF, Bowler A. Geographical distribution of insanity in America: evidence for an urban factor. Schizophr Bull. 1990;16:591-604.
33. Oliver PL, Davies KE. Interaction between environmental and genetic factors modulates schizophrenic endophenotypes in the Snap-25 mouse mutant blind-drunk. Hum Mol Genet. 2009;18:4576-4589.
34. Ter Horst GJ, Wichmann R, Gerrits M, Westenbroek C, Lin Y. Sex differences in stress responses: focus on ovarian hormones. Physiol Behav. 2009;97:239-249.
35. Macho L, Rovensky J, Kvetnansky R, Radikova Z, Fickova M, Zorad S. Hormone response to stress in rat strains of different susceptibility to immunologic challenge. Endocr Regul. 2008;42:23-28.
36. Gonzalez M, Cabrera-Socorro A, Perez-Garcia CG, et al. Distribution patterns of estrogen receptor alpha and beta in the human cortex and hippocampus during development and adulthood. J Comp Neurol. 2007;503:790-802. (Pubitemid 47290563)
37. Kalus P, Senitz D, Beckmann H. Cortical layer I changes in schizophrenia: a marker for impaired brain development? J Neural Transm. 1997;104:549-559. (Pubitemid 27379909)
38. Fatemi SH, Emamian ES, Kist D, et al. Defective corticogenesis and reduction in Reelin immunoreactivity in cortex and hippocampus of prenatally infected neonatal mice. Mol Psychiatry. 1999;4:145-154. (Pubitemid 29163977)