A microbial aetiology of acne: What is the evidence?

British Journal of Dermatology

Volumn 165, Issue 3, 2011, Pages 474-485

  Shaheen, B ^a   Gonzalez, M ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACNE; ACNE VULGARIS; ANTIBIOTIC THERAPY; BACTERIAL COLONIZATION; HUMAN; MICROBIOLOGICAL EXAMINATION; MICROFLORA; NONHUMAN; PAPULE; PATHOGENESIS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROPIONIBACTERIUM ACNES; PUSTULE; REVIEW; SKIN BIOPSY; SKIN FLORA; SKIN INFLAMMATION; SKIN SURFACE;

ACNE VULGARIS; ADOLESCENT; DERMATITIS; GRAM-POSITIVE BACTERIAL INFECTIONS; HUMANS; PROPIONIBACTERIUM ACNES; YOUNG ADULT;

EID: 80052221943     PISSN: 00070963     EISSN: 13652133     Source Type: Journal    
DOI: 10.1111/j.1365-2133.2011.10375.x     Document Type: Review

References (61)

1. Evans C, Smith W, Johnston E, Giblett E,. Bacterial flora of the normal human skin. J Invest Dermatol 1950; 15: 305-24.
2. Leyden JJ, McGinley KJ, Mills OH, Kligman AM,. Age-related changes in the resident bacterial flora of the human face. J Invest Dermatol 1975; 65: 379-81.
3. Puhvel SM, Barfatani M, Warnick M, Sternberg TH,. Study of antibody levels to Corynebacterium acnes in the serum of patients with acne vulgaris, using bacterial agglutination, agar gel immunodiffusion, and immunofluorescence techniques. Arch Dermatol 1964; 90: 421-7.
4. Marples R, Downing D, Kligman AM,. Control of free fatty acids in human surface lipids by Corynebacterium acnes. J Invest Dermatol 1971; 56: 127-31.
5. Kligman AM, Wheatley V, Mills OH,. Comedogenicity of human sebum. Arch Dermatol 1970; 102: 267-75.
6. McGinley KJ, Webster GF, Leyden JJ,. Regional variations of cutaneous propionibacteria. Appl Environ Microbiol 1978; 35: 62-6. (Pubitemid 8275052)
7. Guého E, Boekhout T, Ashbee H, et al. The role of Malassezia species in the ecology of human skin and as pathogens. Med Mycol 1998; 36 (Suppl. 1): 220-9.
8. Leyden JJ, McGinley KJ, Vowels B,. Propionibacterium acnes colonization in acne and nonacne. Dermatology 1998; 196: 55-8. (Pubitemid 28116040)
9. Williamson P, Kligman AM,. A new method for the quantitative investigation of cutaneous bacteria. J Invest Dermatol 1965; 45: 498-503.
10. McGinley KJ, Webster GF, Ruggieri M, Leyden JJ,. Regional variations in density of cutaneous propionibacteria: correlation of Propionibacterium acnes populations with sebaceous secretion. J Clin Microbiol 1980; 12: 672-5. (Pubitemid 10025056)
11. Rebillo T, Hawk JL,. Skin surface glycerol levels in acne vulgaris. J Invest Dermatol 1978; 70: 352-4. (Pubitemid 8369149)
12. Király C, Alén M, Korvola J, Horsmanheimo M,. The effect of testosterone and anabolic steroids on the skin surface lipids and the population of Propionibacteria acnes in young postpubertal men. Acta Derm Venereol (Stockh) 1988; 68: 21-6. (Pubitemid 18032672)
13. Miller J, Wojnarowska F, Dowd P, et al. Anti-androgen treatment in women with acne: a controlled trial. Br J Dermatol 1986; 114: 705-16. (Pubitemid 16079772)
14. Cunliffe WJ, Shuster S,. Pathogenesis of acne. Lancet 1969; i: 685-7.
15. Pochi P, Strauss J,. Endocrinologic control of the development and activity of the human sebaceous gland. J Invest Dermatol 1974; 62: 191-201.
16. Leeming J, Holland K, Cunliffe WJ,. The microbial ecology of pilosebaceous units isolated from human skin. J Gen Microbiol 1984; 130: 803-7. (Pubitemid 14132785)
17. Leeming J, Holland K, Cunliffe WJ,. The pathological and ecological significance of microorganisms colonizing acne vulgaris comedones. J Med Microbiol 1985; 20: 11-16. (Pubitemid 15042284)
18. Till A, Goulden V, Cunliffe WJ, Holland K,. The cutaneous microflora of adolescent, persistent and late-onset acne patients does not differ. Br J Dermatol 2000; 142: 885-92. (Pubitemid 30304597)
19. Shehadeh N, Kligman AM,. The bacteriology of acne. Arch Dermatol 1963; 88: 829-31.
20. Ganor S, Sacks T,. A comparison of the flora of the comedones of acne vulgaris and comedones in elderly people. Dermatologica 1969; 138: 1-9.
21. Marples R, McGinley KJ, Mills OH,. Microbiology of comedones in acne vulgaris. J Invest Dermatol 1973; 60: 80-3.
22. Puhvel S, Amirian D,. Bacterial flora of comedones. Br J Dermatol 1979; 101: 543-8. (Pubitemid 10132179)
23. Lavker RM, Leyden JJ, McGinley KJ,. The relationship between bacteria and the abnormal follicular keratinization in acne vulgaris. J Invest Dermatol 1981; 77: 325-30. (Pubitemid 12233947)
24. Marples R, Izumi A,. Bacteriology of pustular acne. J Invest Dermatol 1970; 54: 252-5.
25. Brook I, Frazier EH, Cox ME, Yeager JK,. The aerobic and anaerobic microbiology of pustular acne lesions. Anaerobe 1995; 1: 305-7.
26. Nishijima S, Kurokawa I, Katoh N, Watanabe K,. The bacteriology of acne vulgaris and antimicrobial susceptibility of Propionibacterium acnes and Staphylococcus epidermidis isolated from acne lesions. J Dermatol 2000; 27: 318-23. (Pubitemid 30431746)
27. Leeming J, Holland K, Cunliffe WJ,. The microbial colonization of inflamed acne vulgaris lesions. Br J Dermatol 1988; 118: 203-8.
28. Saint-Leger D, Bague A, Cohen E, Chivot M,. A possible role for squalene in the pathogenesis of acne I. In vitro study of squalene oxidation. Br J Dermatol 1986; 114: 535-42. (Pubitemid 16115877)
29. Motoyoshi K,. Enhanced comedo formation in rabbit ear skin by squalene and oleic acid peroxides. Br J Dermatol 1983; 109: 191-8. (Pubitemid 13078736)
30. Burkhart CG, Burkhart CN,. Expanding the microcomedone theory and acne therapeutics: Propionibacterium acnes biofilm produces biological glue that holds corneocytes together to form plug. J Am Acad Dermatol 2007; 57: 722-4. (Pubitemid 47384925)
31. Iinuma K, Sato T, Akimoto N, et al. Involvement of Propionibacterium acnes in the augmentation of lipogenesis in hamster sebaceous glands in vivo and in vitro. J Invest Dermatol 2009; 129: 2113-19.
32. Morello A, Downing D, Strauss J,. Octadecadienoic acids in the skin surface lipids of acne patients and normal subjects. J Invest Dermatol 1976; 66: 319-23.
33. Stewart M, Greenwood R, Cunliffe WJ, et al. Effect of cyproterone acetate-ethinyl estradiol treatment on the proportions of linoleic and sebaleic acids in various skin surface lipid classes. Arch Dermatol Res 1986; 278: 481-5. (Pubitemid 16022301)
34. Downing D, Stewart M, Wertz P, Strauss J,. Essential fatty acids and acne. J Am Acad Dermatol 1986; 14: 221-5. (Pubitemid 16068070)
35. Jeremy A, Holland DB, Roberts S, et al. Inflammatory events are involved in acne lesion initiation. J Invest Dermatol 2003; 121: 20-7. (Pubitemid 36900450)
36. Watt F,. Role of integrins in regulating epidermal adhesion, growth and differentiation. EMBO J 2002; 21: 3919-26. (Pubitemid 34857425)
37. Jarrousse V, Castex-Rizzi N, Khammari A, et al. Modulation of integrins and filaggrin expression by Propionibacterium acnes extracts on keratinocytes. Arch Dermatol Res 2007; 299: 441-7. (Pubitemid 47546920)
38. Graham G, Farrar M, Cruse-Sawyer J, et al. Proinflammatory cytokine production by human keratinocytes stimulated with Propionibacterium acnes and P. acnes GroEL. Br J Dermatol 2004; 150: 421-8. (Pubitemid 38446295)
39. Guy R, Green M, Kealey T,. Modeling acne in vitro. J Invest Dermatol 1996; 106: 176-82. (Pubitemid 26052064)
40. Ingham E, Walters C, Eady E, et al. Inflammation in acne vulgaris: failure of skin micro-organisms to modulate keratinocyte interleukin 1 alpha production in vitro. Dermatology 1998; 196: 86-8. (Pubitemid 28116049)
41. Puhvel S, Reisner R,. The production of hyaluronidase (hyaluronate lyase) by Corynebacterium acnes. J Invest Dermatol 1972; 58: 66-70.
42. Hoffler U, Kohler HC, Adam R, Mauff G,. Neuraminidase production of Propionibacterium acnes and related bacteria. FEMS Microbiol Lett 1978; 4: 177-9. (Pubitemid 9003025)
43. Ingham E, Gowland G, Ward R, et al. Antibodies to P. acnes and P. acnes exocellular enzymes in the normal population at various ages and in patients with acne vulgaris. Br J Dermatol 1987; 116: 805-12. (Pubitemid 17075400)
44. Holland K, Holland DB, Cunliffe WJ, Cutcliffe A,. Detection of Propionibacterium acnes polypeptides which have stimulated an immune response in acne patients but not in normal individuals. Exp Dermatol 1993; 2: 12-16. (Pubitemid 23244482)
45. Russell R, McInroy R, Wilkinson P, White R,. A lipid chemotactic factor from anaerobic coryneform bacteria including Corynebacterium parvum with activity for macrophages and monocytes. Immunology 1976; 30: 935-49.
46. Webster GF, Leyden JJ,. Characterization of serum-independent polymorphonuclear leukocyte chemotactic factors produced by Propionibacterium acnes. Inflammation 1980; 4: 261-9. (Pubitemid 11244438)
47. Webster GF, Leyden JJ, Nilsson UR,. Complement activation in acne vulgaris: consumption of complement by comedones. Infect Immun 1979; 26: 183-6. (Pubitemid 10248649)
48. Webster GF, Leyden JJ, Norman ME, Nilsson UR,. Complement activation in acne vulgaris: in vitro studies with Propionibacterium acnes and Propionibacterium granulosum. Infect Immun 1978; 22: 523-9. (Pubitemid 9052629)
49. Vowels B, Yang S, Leyden JJ,. Induction of proinflammatory cytokines by a soluble factor of Propionibacterium acnes: implications for chronic inflammatory acne. Infect Immun 1995; 63: 3158-65.
50. Jugeau S, Tenaud I, Knol A, et al. Induction of toll-like receptors by Propionibacterium acnes. Br J Dermatol 2005; 153: 1105-13. (Pubitemid 41779563)
51. Nagy I, Pivarcsi A, Koreck A, et al. Distinct strains of Propionibacterium acnes induce selective human beta-defensin-2 and interleukin-8 expression in human keratinocytes through toll-like receptors. J Invest Dermatol 2005; 124: 931-8. (Pubitemid 40629093)
52. Holland K, Cunliffe WJ, Roberts C,. The role of bacteria in acne vulgaris: a new approach. Clin Exp Dermatol 1978; 3: 253-7. (Pubitemid 9036431)
53. Greenman J, Holland K, Cunliffe WJ,. Effects of pH on biomass, maximum specific growth rate and extracellular enzyme production by three species of cutaneous propionibacteria grown in continuous culture. J Gen Microbiol 1983; 129: 1301-7. (Pubitemid 13094092)
54. Aldana OL, Holland DB, Cunliffe WJ,. Variation in pilosebaceous duct keratinocyte proliferation in acne patients. Dermatology 1998; 196: 98-9. (Pubitemid 28116053)
55. Cunliffe WJ, Holland DB, Clark S, Stables G,. Comedogenesis: some new aetiological, clinical and therapeutic strategies. Br J Dermatol 2000; 142: 1084-91. (Pubitemid 30418292)
56. Sims J, Smith D,. The IL-1 family: regulators of immunity. Nat Rev Immunol 2010; 10: 89-102.
57. Webster GF, Graber E,. Antibiotic treatment for acne vulgaris. Semin Cutan Med Surg 2008; 27: 183-7.
58. Leyden JJ, McGinley KJ, Mills OH, Kligman AM,. Propionibacterium levels in patients with and without acne vulgaris. J Invest Dermatol 1975; 65: 382-4.
59. Cove J, Cunliffe WJ, Holland K,. Acne vulgaris: is the bacterial population size significant? Br J Dermatol 1980; 102: 277-80. (Pubitemid 10138646)
60. Holland K, Cunliffe WJ, Roberts C,. Acne vulgaris: an investigation into the number of anaerobic diphtheroids and members of the Micrococcaceae in normal and acne skin. Br J Dermatol 1977; 96: 623-6. (Pubitemid 8129264)
61. Gowland G, Ward R, Holland K, Cunliffe WJ,. Cellular immunity to P. acnes in the normal population and patients with acne vulgaris. Br J Dermatol 1978; 99: 43-7. (Pubitemid 8396030)