Tadalafil analgesia in experimental arthritis involves suppression of intra-articular TNF release

British Journal of Pharmacology

Volumn 164, Issue 2 B, 2011, Pages 828-835

  Rocha, F A C ^a   Silva Jr , F S ^a   Leite, A C R M ^a   Leite, A K R M ^a   Girao V C C ^b   Castro, R R ^a   Cunha, F Q ^c  

^a FEDERAL UNIVERSITY OF CEARÁ   (Brazil)

^b STATE UNIVERSITY OF CEARÁ   (Brazil)

^c UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

arthirits; chemokines; cytokines; inflammation; neutrophils; pain; PDE inhibitors; tadalafil

Indexed keywords

1H 1,2,4 OXADIAZOLO[4,3 A]QUINOXALIN 1 ONE; CHEMOKINE; CYTOKINE INDUCED NEUTROPHIL CHEMOATTRACTANT; CYTOKINE INDUCED NEUTROPHIL CHEMOATTRACTANT 1; INTERLEUKIN 1; MORPHINE; NALOXONE; TADALAFIL; TUMOR NECROSIS FACTOR; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; ZYMOSAN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTERIOR CRUCIATE LIGAMENT; ANTIINFLAMMATORY ACTIVITY; ANTINOCICEPTION; ARTHRALGIA; ARTICLE; CELL COUNT; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFICACY; DRUG INHIBITION; ENZYME RELEASE; MALE; NONHUMAN; OSTEOARTHRITIS; PAIN ASSESSMENT; PRIORITY JOURNAL; RAT; TREATMENT RESPONSE;

ANALGESICS; ANIMALS; ANTI-INFLAMMATORY AGENTS; ARTHRALGIA; ARTHRITIS, EXPERIMENTAL; CARBOLINES; CHEMOKINE CXCL1; CHEMOKINES; CYCLIC GMP; GUANYLATE CYCLASE; INJECTIONS, INTRA-ARTICULAR; INTERLEUKIN-1; JOINTS; MALE; NALOXONE; NARCOTIC ANTAGONISTS; NEUTROPHILS; NOCICEPTION; OSTEOARTHRITIS; OXADIAZOLES; QUINOXALINES; RATS; RATS, WISTAR; TUMOR NECROSIS FACTOR-ALPHA; ZYMOSAN;

EID: 80052218941     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2011.01469.x     Document Type: Article

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