Low-dose mifepristone increases uterine natural killer cell cytotoxicity and perforin expression during the receptive phase

Fertility and Sterility

Volumn 96, Issue 3, 2011, Pages 649-653

  Zhou, Feng ^a   Chen, Xiu Ying ^b   Zhuang, Ya Ling ^a   Chen, Yue Zhou ^a   Huang, Li Li ^a  

^a ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

cytotoxicity; endometrium; immune tolerance; implantation window; Mifepristone; uNK cells

Indexed keywords

MIFEPRISTONE; PERFORIN;

ADULT; ARTICLE; CONCENTRATION RESPONSE; CONTRACEPTION; CYTOTOXICITY; DRUG MECHANISM; ENDOMETRIUM; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOMODULATION; LOW DRUG DOSE; NATURAL KILLER CELL; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ADULT; BIOLOGICAL MARKERS; BIOPSY; CONTRACEPTIVES, ORAL, SYNTHETIC; DOSE-RESPONSE RELATIONSHIP, DRUG; EMBRYO IMPLANTATION; ENDOMETRIUM; FEMALE; FERTILITY; HUMANS; KILLER CELLS, NATURAL; MENSTRUAL CYCLE; MIFEPRISTONE; PORE FORMING CYTOTOXIC PROTEINS;

EID: 80052198336     PISSN: 00150282     EISSN: 15565653     Source Type: Journal    
DOI: 10.1016/j.fertnstert.2011.06.074     Document Type: Article

References (39)

1. D. Navot, and P. Bergh Preparation of the human endometrium for implantation Ann N Y Acad Sci 622 1991 209 212
2. C.B. Coulam, C. Goodman, R.G. Roussev, E.J. Thomanson, and K.D. Beaman Systemic CD 56+ cells can predict pregnancy outcome Am J Reprod Immunol 33 1995 40 46
3. A. King, P. Wooding, L. Gardner, and Y.W. Loke Expression of perforin, granzyme A and TIA-1 by human uterine CD56+ NK cells implies they are activated and capable of effector functions Hum Reprod 8 1983 2061 2067
4. D. Kagi, B. Ledermann, K. Bürki, P. Seiler, B. Odermatt, and K.J. Olsen Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice Nature 369 1994 31 37 (Pubitemid 24144352)
5. D.M. Davis Assembly of the immunological synapse for T cells and NK cells Trends Immunol 23 2002 356 363 (Pubitemid 34717913)
6. - natural killer cells: in situ proliferation of residual cells or selective recruitment from circulating peripheral blood? J Reprod Immunol 76 2007 45 53 (Pubitemid 350100877)
7. +) natural killer cells recruitment: association with decidual reaction rather than embryo implantation Am J Reprod Immunol 55 2006 369 377
8. Y.X. Hu, J.P. Dutz, C.D. MacCalman, P. Yong, R. Tan, and P.V. Dadelszen Decidual NK cells alter in vitro first trimester extravillous cytotrophoblast migration: a role for IFN-γ J Immunol 177 2006 8522 8530 (Pubitemid 44893814)
9. D.K. Mahajan, and S.N. London Mifepristone (RU486): a review Fertil Steril 68 1997 967 976 (Pubitemid 28013354)
10. K.G. Danielsson, L. Marions, and M. Bygdeman Effects of mifepristone on endometrial receptivity Steroids 68 2003 1069 1075 (Pubitemid 37532432)
11. H.X. Zhu, W.W. Zhang, Y.L. Zhuang, and L.L. Huang Mifepristone as an anti-implantation contraceptive drug: roles in regulation of uterine natural killer cells during implantation phase Am J Reprod Immunol 61 2009 68 74
12. R.W. Noyes, A.T. Hertig, and J. Rock Dating the endometrial biopsy Fertil Steril 1 1950 3 25
13. D.J. Dudley, H.H. Hatasaka, D.W. Branch, E. Hammond, and M.D. Mitchell A human endometrial explant system: validation and potential applications Am J Obstet Gynecol 167 1992 1774 1780 (Pubitemid 23009323)
14. S. Illouz, L. Boubli, M.N. Lavaut, C. Allasia, and C. Charpin Endometrial response to sexual steroids as assessed by prostaglandin F(2alpha) output in explant culture and hormone receptor expression Gynecol Obstet Invest 50 2000 43 49 (Pubitemid 30445755)
15. B.N. Chabbert, S. Djakoure, M.S. Christin, and P. Bouchard Regulation of the human menstrual cycle Front Neuroendocrinol 19 1998 151 186 (Pubitemid 28347695)
16. A.P. Wilson Cytotoxicity and viability assays in animal cell culture: a practical approach 3rd ed. 2000 Oxford University Press Oxford 175-219
17. R.F. Hussain, A.M.E. Nouri, and R.T.D. Oliver A new approach for measurement of cytotoxicity using colorimetric assay J Immunol Method 160 1993 89 96
18. S.S. Lin, S.W. Ueng, S.S. Lee, E.C. Chan, K.T. Chen, and C.Y. Yang In vitro elution of antibiotic from antibiotic-impregnated biodegradable calcium alginate wound dressing J Trauma 47 1999 136 141 (Pubitemid 29361604)
19. T. Nakayama, K. Kitaya, T. Okubo, H. Kuroboshi, N. Daikoku, and S. Fushiki Fluctuation of 6Ckine expression in human endometrium during the menstrual cycle Fertil Steril 80 2003 1461 1465 (Pubitemid 37532463)
20. J. Sengupta, and D. Ghosh Role of progesterone on peri-implantation stage endometrium-embryo interaction in the primate Steroids 65 2000 753 762
21. D. Ghosh, and J. Sengupta Anti-nidatory effect of a single post-ovulatory administration of mifepristone (RU486) in the rhesus monkey Hum Reprod 8 1993 552 558 (Pubitemid 23116957)
22. H.B. Croxatto, L. Kovács, R. Massai, B.A. Resch, B. Fuentealba, and A.M. Salvatierra Effects of long-term low-dose mifepristone on reproductive function in women Hum Reprod 13 1998 793 798 (Pubitemid 28239176)
23. N.N. Sarkar The potential of mifepristone (RU486) as a female contraceptive drug Int J Clin Pract 56 2002 140 144 (Pubitemid 34232989)
24. A. Fukui, S. Fujii, E. Yamaguchi, H. Kimura, S. Sato, and Y. Saito Natural killer cell subpopulations and cytotoxicity for infertile patients undergoing in vitro fertilization Am J Reprod Immunol 41 1999 413 422 (Pubitemid 29373985)
25. S. Quenby, M. Bates, T. Doig, J. Brewster, D.I. Lewis-Jones, P.M. Johnson, and etal Pre-implantation endometrial leukocytes in women with recurrent miscarriage Hum Reprod 14 1999 2386 2391 (Pubitemid 29425436)
26. K. Clifford, A.M. Flanagan, and L. Regan Endometrial CD56+ natural killer cells in women with recurrent miscarriage: a histomorphometric study Hum Reprod 14 1999 2727 2730 (Pubitemid 29520681)
27. H.N. Ho, K.H. Chao, C.K. Chen, Y.S. Yang, and S.C. Huang Activation status of T and NK cells in the endometrium throughout menstrual cycle and normal and abnormal early pregnancy Hum Immunol 49 1996 130 136
28. K.H. Chao, Y.S. Yang, H.N. Ho, S.U. Chen, H.F. Chen, and H.J. Dai Decidual natural killer cytotoxicity decreased in normal pregnancy but not in anembryonic pregnancy and recurrent spontaneous abortion Am J Reprod Immunol 34 1995 274 280
29. D.J. Oosterlynck, F.J. Cornillie, M. Waer, M. Vandeputte, and P.R. Koninckx Women with endometriosis show a defect in natural killer activity resulting in a decreased cytotoxicity to autologous endometrium Fertil Steril 56 1991 45 51
30. K. Kusakabe, M. Naka, Y. Ito, N. Eid, and Y. Otsuki Regulation of natural-killer cell cytotoxicity and enhancement of complement factors in the spontaneously aborted mouse placenta Supplement 90 2008 1451 1459
31. G. Laskarin, N. Strbo, V. Sotosek, D. Rukavina, Z. Faust, and J. Szekeres-Bartho Progesterone directly and indirectly affects perforin expression in cytolytic cells Am J Reprod Immunol 42 1999 312 320 (Pubitemid 29502164)
32. A. King, L. Gardner, and Y.W. Loke Evaluation of oestrogen and progesterone receptor expression in uterine mucosal lymphocytes Hum Reprod 11 1996 1079 1082 (Pubitemid 26177285)
33. J.A. Stewart, J.N. Bulmer, and A.P. Murdoch Endometrial leucocytes: expression of steroid hormone receptors J Clin Pathol 51 1998 121 126 (Pubitemid 28140725)
34. K. Sorachi, S. Kumagai, M. Sugita, J. Yodoi, and H. Imura Enhancing effect of 17β-estradiol on human NK cell activity Immunol Lett 36 1993 31 35
35. V. Rider, X. Li, G. Peterson, J. Dawson, B.F. Kimler, and N.I. Abdou Differential expression of estrogen receptors in women with systemic lupus erythematosus J Rheumatol 33 2006 1093 1101 (Pubitemid 43825458)
36. J.K. Scariano, A.J. Emery-Cohen, G.G. Pickett, M. Morgan, P.C. Simons, and F. Alba Estrogen receptors alpha (ESR1) and beta (ESR2) are expressed in circulating human lymphocytes J Recept Signal Transduct Res 28 2008 285 293 (Pubitemid 351882219)
37. E.R. Levin Plasma membrane estrogen receptors Trends Endocrinol Metab 20 2009 477 482
38. M. Pierdominici, A. Maselli, T. Colasanti, A.M. Giammarioli, F. Delunardo, and D. Vacirca Estrogen receptor profiles in human peripheral blood lymphocytes Immunol Lett 132 2010 79 85
39. A.F. Glasier, H. Wang, J.E. Davie, R.W. Kelly, and H.O.D. Critchley Administration of an antiprogesterone up-regulates estrogen receptors in the endometrium of women using Norplant™: a pilot study Fertil Steril 77 2002 366 372 (Pubitemid 34086914)