Hepatic oval cell lines generate hepatocellular carcinoma following transfection with HBx gene and treatment with aflatoxin B1 in vivo

Cancer Letters

Volumn 311, Issue 1, 2011, Pages 1-10

  Li, Chang Hai ^a   Wang, Yan Jun ^a   Dong, Wei ^a   Xiang, Shuai ^a   Liang, Hui Fang ^a   Wang, Heng Yi ^a   Dong, Han Hua ^a   Chen, Lin ^a   Chen, Xiao Ping ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

AFB1; Hepatic oval cell; Hepatitis B virus X gene; Hepatocellular carcinoma

Indexed keywords

AFLATOXIN B1; ALBUMIN; BIOLOGICAL MARKER; CYTOKERATIN 7; CYTOKERATIN 8; HEPATITIS B VIRUS X PROTEIN; HEPATOCYTE PARAFFIN 1; SMOOTH MUSCLE ANTIBODY; UNCLASSIFIED DRUG; VIMENTIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; GENETIC TRANSFECTION; HBX ONCOGENE; HEPATIC OVAL CELL; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; LIVER CELL CARCINOMA; LIVER TUMOR; MALE; MALIGNANT TRANSFORMATION; MESENCHYME CELL; MESENCHYMOMA; MOUSE; NONHUMAN; ONCOGENE; PRIORITY JOURNAL; RAT; STEM CELL; SUBCUTANEOUS TISSUE TUMOR;

AFLATOXIN B1; ANIMALS; CELL LINE, TUMOR; HEPATOCYTES; LIVER; LIVER NEOPLASMS, EXPERIMENTAL; MICE; MICE, INBRED BALB C; MICE, NUDE; RATS; TRANS-ACTIVATORS; TRANSFECTION;

ANIMALIA; HEPATITIS B VIRUS; MUS MUSCULUS; RATTUS;

EID: 80052175702     PISSN: 03043835     EISSN: 18727980     Source Type: Journal    
DOI: 10.1016/j.canlet.2011.05.035     Document Type: Article

References (40)

1. Shupe T., Petersen B.E. Evidence regarding a stem cell origin of hepatocellular carcinoma. Stem Cell Rev. 2005, 1:261-264.
2. Roskams T. Liver stem cells and their implication in hepatocellular and cholangiocarcinoma. Oncogene 2006, 25:3818-3822.
3. Roskams T.A., Theise N.D., Balabaud C., Bhagat G., Bhathal P.S., Bioulac-Sage P., Brunt E.M., Crawford J.M., Crosby H.A., Desmet V., Finegold M.J., Geller S.A., Gouw A.S., Hytiroglou P., Knisely A.S., Kojiro M., Lefkowitch J.H., Nakanuma Y., Olynyk J.K., Park Y.N., Portmann B., Saxena R., Scheuer P.J., Strain A.J., Thung S.N., Wanless I.R., West A.B. Nomenclature of the finer branches of the biliary tree: canals. Ductules, and ductular reactions in human livers. Hepatology 2004, 39:1739-1745.
4. Zhang F., Chen X.P., Zhang W., Dong H.H., Xiang S., Zhang W.G., Zhang B.X. Combined hepatocellular cholangiocarcinoma originating from hepatic progenitor cells: immunohistochemical and double-fluorescence immunostaining evidence. Histopathology 2008, 52:224-232.
5. Petersen B.E. Hepatic stem cells: coming full circle. Blood Cells Mol. Dis. 2001, 27:590-600.
6. Sell S., Dunsford H.A. Evidence for the stem cell origin of hepatocellular carcinoma and cholangiocarcinoma. Am. J. Pathol. 1989, 134:1347-1363.
7. Steinberg P., Steinbrecher R., Radaeva S., Schirmacher P., Dienes H.P., Oesch F., Bannasch P. Oval cell lines OC/CDE 6 and OC/CDE 22 give rise to cholangio-cellular and undifferentiated carcinomas after transformation. Lab Invest. 1994, 71:700-709.
8. Hsia C.C., Evarts R.P., Nakatsukasa H., Marsden E.R., Thorgeirsson S.S. Occurrence of oval-type cells in hepatitis B virus-associated human hepatocarcinogenesis. Hepatology 1992, 16:1327-1333.
9. Sell S. The role of determined stem-cells in the cellular lineage of hepatocellular carcinoma. Int. J. Dev. Biol. 1993, 37:189-201.
10. He X.Y., Smith G.J., Enno A., Nicholson R.C. Short-term diethylnitrosamine-induced oval cell responses in three strains of mice. Pathology 1994, 26:154-160.
11. Alison M.R. Liver stem cells: implications for hepatocarcinogenesis. Stem Cell Rev. 2005, 1:253-260.
12. Braun L., Goyette M., Yaswen P., Thompson N.L., Fausto N. Growth in culture and tumorigenicity after transfection with the ras oncogene of liver epithelial cells from carcinogen-treated rats. Cancer Res. 1987, 47:4116-4124.
13. Dumble M.L., Croager E.J., Yeoh G.C., Quail E.A. Generation and characterization of p53 null transformed hepatic progenitor cells: oval cells give rise to hepatocellular carcinoma. Carcinogenesis 2002, 23:435-445.
14. Sun Z., Lu P., Gail M.H., Pee D., Zhang Q., Ming L., Wang J., Wu Y., Liu G., Zhu Y. Increased risk of hepatocellular carcinoma in male hepatitis B surface antigen carriers with chronic hepatitis who have detectable urinary aflatoxin metabolite M1. Hepatology 1999, 30:379-383.
15. Lian M., Liu Y., Yu S.Z., Qian G.S., Wan S.G., Dixon K.R., Hepatitis B. Hepatitis B virus x gene and cyanobacterial toxins promote aflatoxin B1-induced hepatotumorigenesis in mice. World J Gastroenterol 2006, 12:3065-3072.
16. Na T.Y., Shin Y.K., Roh K.J., Kang S.A., Hong I., Oh S.J., Seong J.K., Park C.K., Choi Y.L., Lee M.O. Liver X receptor mediates hepatitis B virus X protein-induced lipogenesis in hepatitis B virus-associated hepatocellular carcinoma. Hepatology 2009, 49:1122-1131.
17. Brechot C., Gozuacik D., Murakami Y., Paterlini-Brechot P. Molecular bases for the development of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC). Semin. Cancer Biol. 2000, 10:211-231.
18. Peng Z., Zhang Y., Gu W., Wang Z., Li D., Zhang F., Qiu G., Xie K. Integration of the hepatitis B virus X fragment in hepatocellular carcinoma and its effects on the expression of multiple molecules: a key to the cell cycle and apoptosis. Int. J. Oncol. 2005, 26:467-473.
19. Kew M.C. Synergistic interaction between aflatoxin B1 and hepatitis B virus in hepatocarcinogenesis. Liver Int. 2003, 23:405-409.
20. Yaswen P., Hayner N.T., Fausto N. Isolation of oval cells by centrifugal elutriation and comparison with other cell types purified from normal and preneoplastic livers. Cancer Res. 1984, 44:324-331.
21. Lazaro C.A., Rhim J.A., Yamada Y., Fausto N. Generation of hepatocytes from oval cell precursors in culture. Cancer Res. 1998, 58:5514-5522.
22. Dong H.H., Xiang S., Chen X.P., Liang H.F., Zhang W., Jing K., Zhang W.G., Chen L. The epithelial-mesenchymal transition promotes transdifferentiation of subcutaneously implanted hepatic oval cells into mesenchymal tumor tissue. Stem Cells Dev. 2009, 18:1293-1298.
23. Nguyen L.N., Furuya M.H., Wolfraim L.A., Nguyen A.P., Holdren M.S., Campbell J.S., Knight B., Yeoh G.C., Fausto N., Parks W.T. Transforming growth factor-beta differentially regulates oval cell and hepatocyte proliferation. Hepatology 2007, 45:31-41.
24. Oh B.K., Lee C.H., Park C., Park Y.N. Telomerase regulation and progressive telomere shortening of rat hepatic stem-like epithelial cells during in vitro aging. Exp. Cell Res. 2004, 298:445-454.
25. Li C.H., Chen X.P., Liang H.F., Wang H.Y., Wang Y.J., Dong W. Construction of pEGFP-HBx gene recombinant plasmid and establishment of stable transfected HBx gene liver oval cell strain. Zhonghua Wai Ke Za Zhi 2008, 46:1919-1922.
26. Su J.J., Li Y., Ban K.C., Qin L.L., Wang H.Y., Yang C., Ou C., Duan X.X., Lee Yl Y., Yan R.Q. Alteration of the p53 gene during tree shrews' hepatocarcinogenesis. Hepatobiliary Pancreat. Dis. Int. 2003, 2:612-616.
27. Qin L.L., Su J.J., Li Y., Yang C., Ban K.C., Yian R.Q. Expression of IGF- II, p53, p21 and HBxAg in precancerous events of hepatocarcinogenesis induced by AFB1 and/or HBV in tree shrews. World J. Gastroenterol 2000, 6:138-139.
28. Wang Y.J., Liang H.F., Chen X.P., Dong W., Li C.H., Chen L., Liu L.P. The studies of hepatitis B virus X gene induces oval cell malignant transformation. Zhonghua Wai Ke Za Zhi 2009, 47:1410-1414.
29. Yang L., Li S., Hatch H., Ahrens K., Cornelius J.G., Petersen B.E., Peck A.B. In vitro trans-differentiation of adult hepatic stem cells into pancreatic endocrine hormone-producing cells. Proc. Natl. Acad. Sci. USA 2002, 99:8078-8083.
30. Rietze R.L., Valcanis H., Brooker G.F., Thomas T., Voss A.K., Bartlett P.F. Purification of a pluripotent neural stem cell from the adult mouse brain. Nature 2001, 412:736-739.
31. Kim J.H., Rho H.M. Activation of the human transforming growth factor alpha (TGF-alpha) gene by the hepatitis B viral X protein (HBx) through AP-2 sites. Mol. Cell Biochem. 2002, 231:155-161.
32. Calvisi D.F., Ladu S., Factor V.M., Thorgeirsson S.S. Activation of beta-catenin provides proliferative and invasive advantages in c-myc/TGF-alpha hepatocarcinogenesis promoted by phenobarbital. Carcinogenesis 2004, 25:901-908.
33. Chu P.G., Ishizawa S., Wu E.B.S., Weiss L. Hepatocyte antigen as a marker of hepatocellular carcinoma: an immunohistochemical comparison to carcinoembryonic antigen, CD10, and alphafetoprotein. Am. J. Surg. Pathol. 2002, 26:978-988.
34. Sohn S., Jaitovitch-Groisman I., Benlimame N., Galipeau J., Batist G., Alaoui-Jamali M.A. Retroviral expression of the hepatitis B virus x gene promotes liver cell susceptibility to carcinogen-induced site specific mutagenesis. Mutat. Res. 2000, 460:17-28.
35. Mykkanen H., Zhu H., Salminen E., Juvonen R.O., Ling W., Ma J., Polychronaki N., Kemilainen H., Mykkanen O., Salminen S., El-Nezami H. Fecal and urinary excretion of aflatoxin B1 metabolites (AFQ1, AFM1 and AFB-N7-guanine) in young Chinese males. Int. J. Cancer 2005, 115:879-884.
36. Martin-Lluesma S., Schaeffer C., Robert E.I., Van Breugel P.C., Leupin O., Hantz O., Strubin M. Hepatitis B virus X protein affects S phase progression leading to chromosome segregation defects by binding to damaged DNA binding protein 1. Hepatology 2008, 48:1467-1476.
37. Reifenberg K., Lohler J., Pudollek H.P., Schmitteckert E., Spindler G., Kock J., Schlicht H.J. Long-term expression of the hepatitis B virus core-e- and X-proteins does not cause pathologic changes in transgenic mice. J. Hepatol. 1997, 26:119-130.
38. Onyemelukwe G.C., Ogbadu G.H., Salifu A. Aflatoxins, B1, B2, G1, G2 in primary liver cell carcinoma. Toxicol. Lett. 1982, 10:309-312.
39. Aguilar F., Hussain S.P., Cerutti P. Aflatoxin B1 induces the transversion of G→T in codon 249 of the p53 tumor suppressor gene in human hepatocytes. Proc. Natl. Acad. Sci. USA 1993, 90:8586-8590.
40. Van Vleet T.R., Watterson T.L., Klein P.J., Coulombe R.A. Aflatoxin B1 alters the expression of p53 in cytochrome P450-expressing human lung cells. Toxicol. Sci. 2006, 89:399-407.