Computationally designed adeno-associated virus (AAV) Rep 78 is efficiently maintained within an adenovirus vector

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 34, 2011, Pages 14294-14299

  Sitaraman, Varsha ^a   Hearing, Patrick ^a   Ward, Charles B ^b   Gnatenko, Dmitri V ^a   Wimmer, Eckard ^a   Mueller, Steffen ^a   Skiena, Steven ^b   Bahou, Wadie F ^a  

^a STONY BROOK UNIVERSITY   (United States)

^b Stony Brook University   (United States)

Author keywords

Codon pair bias; Gene therapy; Hybrid virus; Systems biology

Indexed keywords

ADENOVIRUS VECTOR; CIS ACTING ELEMENT; ENDONUCLEASE; HELICASE; MUTANT PROTEIN; POLYPEPTIDE; REP 78 POLYPEPTIDE; UNCLASSIFIED DRUG;

ADENO ASSOCIATED VIRUS; AMINO ACID SEQUENCE; ARTICLE; CODON; COMPUTER AIDED DESIGN; CONTROLLED STUDY; GENE EXPRESSION; GENETIC ALGORITHM; GENETIC ENGINEERING; LONG TERMINAL REPEAT; MOLECULAR PHYLOGENY; NONHUMAN; PHENOTYPIC VARIATION; PRIORITY JOURNAL; PROTEIN ENGINEERING; TITRIMETRY; VIRAL GENE DELIVERY SYSTEM; VIRUS GENE; VIRUS REPLICATION; WILD TYPE;

BASE SEQUENCE; CODON; COMPUTATIONAL BIOLOGY; DEPENDOVIRUS; ENDONUCLEASES; GENES, VIRAL; GENETIC VECTORS; HEK293 CELLS; HELA CELLS; HUMANS; MUTATION; VIRAL PROTEINS; VIRUS REPLICATION;

ADENO-ASSOCIATED VIRUS; ADENOVIRIDAE; PARVOVIRUS;

EID: 80052172355     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1102883108     Document Type: Article

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