Insights from epidemiology into dichloromethane and cancer risk

International Journal of Environmental Research and Public Health

Volumn 8, Issue 8, 2011, Pages 3380-3398

  Cooper, Glinda S ^a   Scott, Cheryl Siegel ^a   Bale, Ambuja S ^a  

^a U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

Author keywords

Cancer; Dichloromethane; Epidemiology; Methylene chloride; Solvents

Indexed keywords

DICHLOROMETHANE;

BILE DUCT CANCER; BRAIN CANCER; BREAST CANCER; CANCER EPIDEMIOLOGY; CANCER INCIDENCE; CANCER LOCALIZATION; CANCER MORTALITY; CANCER RISK; COHORT ANALYSIS; ENVIRONMENTAL EXPOSURE; EPIDEMIOLOGICAL DATA; EUROPE; HEMATOLOGIC MALIGNANCY; HIGH RISK POPULATION; HUMAN; LIVER CANCER; MALIGNANT NEOPLASTIC DISEASE; NONHODGKIN LYMPHOMA; OCCUPATIONAL CANCER; OCCUPATIONAL EXPOSURE; POPULATION BASED CASE CONTROL STUDY; POPULATION RESEARCH; POPULATION SIZE; REVIEW; RISK ASSESSMENT; SYSTEMATIC REVIEW; UNITED STATES;

EID: 80052167227     PISSN: None     EISSN: 16604601     Source Type: Journal    
DOI: 10.3390/ijerph8083380     Document Type: Review

References (67)

1. Chemical Marketing Reporter (CMR). Chemical Profile on Methylene Chloride; CMR: New York, NY, USA, 6 August 1979.
2. National Toxicology Program (NTP). Report on Carcinogens, eleventh edition; NTP: Research Triangle Park, NC, USA, 2005 Available online: http://ntp.niehs.nih.gov/INDEXA5E1.HTM? objectid=32BA9724-F1F6-975E-7FCE50709CB4C932 (accessed on 6 July 2011).
3. National Toxicology Program (NTP). Toxicology and Carcinogenesis Studies of Dichloromethane (methylene chloride) (CAS No. 75-09-2) in F344/N Rats and B6C3F1 Mice (Inhalation Studies); NTP: Research Triangle Park, NC, USA, 1986 Available online: http://ntp.niehs.nih.gov/ntp/htdocs/LT_rpts/tr306.pdf (accessed on 6 July 2011).
4. Mennear, J.H.; McConnell, E.E.; Huff, J.E.; Renne, R.A.; Giddens, E. Inhalation toxicity and carcinogenesis studies of methylene chloride (dichloromethane) in F344/N rats and B6C3F1 mice. Ann. NY Acad. Sci. 1988, 534, 343-351.
5. Guengerich, F.P.; Kim, M.S.; Muller, M.; Lowe, L.G. Chemical mechanisms of formation of DNA-carcinogen adducts, elucidation of potential of adducts for mutagenicity, and mechanisms of polymerase fidelity and mutation in the presence of adducts. Recent Results Canc. Res. 1997, 143, 49-63.
6. 13C nuclear magnetic resonance spectroscopic studies. Chem. Res. Toxicol. 1994, 7, 291-296.
7. Gargas, M.L.; Clewell, H.J., 3rd; Andersen, M.E. Metabolism of inhaled dihalomethanes in vivo: Differentiation of kinetic constants for two independent pathways. Toxicol. Appl. Pharmacol. 1986, 82, 211-223.
8. Olvera-Bello, A.E.; Estrada-Muniz, E.; Elizondo, G.; Vega, L. Susceptibility to the cytogenetic effects of dichloromethane is related to the glutathione S-transferase theta phenotype. Toxicol. Lett. 2010, 199, 218-224.
9. DeMarini, D.M.; Shelton, M.L.; Warren, S.H.; Ross, T.M.; Shim, J.Y.; Richard, A.M.; Pegram, R.A. Glutathione S-transferase-mediated induction of GC-->AT transitions by halomethanes in Salmonella. Environ. Mol. Mutagen. 1997, 30, 440-447.
10. Graves, R.J.; Green, T. Mouse liver glutathione S-transferase mediated metabolism of methylene chloride to a mutagen in the CHO/HPRT assay. Mutat. Res. 1996, 367, 143-150.
11. Graves, R.J.; Trueman, P.; Jones, S.; Green, T. DNA sequence analysis of methylene chloride-induced HPRT mutations in Chinese hamster ovary cells: Comparison with the mutation spectrum obtained for 1,2-dibromoethane and formaldehyde. Mutagenesis 1996, 11, 229-233.
12. Graves, R.J.; Coutts, C.; Green, T. Methylene chloride-induced DNA damage: An interspecies comparison. Carcinogenesis 1995, 16, 1919-1926.
13. Graves, R.J.; Callander, R.D.; Green, T. The role of formaldehyde and S-chloromethylglutathione in the bacterial mutagenicity of methylene chloride. Mutat. Res. 1994, 320, 235-243.
14. Graves, R.J.; Coutts, C.; Eyton-Jones, H.; Green, T. Relationship between hepatic DNA damage and methylene chloride-induced hepatocarcinogenicity in B6C3F1 mice. Carcinogenesis 1994, 15, 991-996.
15. Their, R.; Taylor, J.B.; Pemble, S.E.; Humphreys, W.G.; Persmark, M.; Ketterer, B.; Guengerich, F.P. Expression of mammalian glutathione S-transferase 5-5 in Salmonella typhimurium TA1535 leads to base-pair mutations upon exposure to dihalomethanes. Proc. Natl. Acad. Sci. USA 1993, 90, 8576-8580.
16. Costantini, A.S.; Benvenuti, A.; Vineis, P.; Kriebel, D.; Tumino, R.; Ramazzotti, V.; Rodella, S.; Stagnaro, E.; Crosignani, P.; Amadori, D.; et al. Risk of leukemia and multiple myeloma associated with exposure to benzene and other organic solvents: Evidence from the Italian Multicenter Case-control study. Am. J. Ind. Med. 2008, 51, 803-811.
17. Miligi, L.; Costantini, A.S.; Benvenuti, A.; Kriebel, D.; Bolejack, V.; Tumino, R.; Ramazzotti, V.; Rodella, S.; Stagnaro, E.; Crosignani, P.; et al. Occupational exposure to solvents and the risk of lymphomas. Epidemiology 2006, 17, 552-561.
18. Seidler, A.; Mohner, M.; Berger, J.; Mester, B.; Deeg, E.; Elsner, G.; Nieters, A.; Becker, N. Solvent exposure and malignant lymphoma: A population-based case-control study in Germany. J. Occup. Med. Toxicol. 2007, 2, 2.
19. Barry, K.H.; Zhang, Y.; Lan, Q.; Zahm, S.H.; Holford, T.R.; Leaderer, B.; Boyle, P.; Dean Hosgood, H.; Chanock, S.; Yeager, M. et al. Genetic variation in metabolic genes, occupational solvent exposure, and risk of non-hodgkin lymphoma. Am. J. Epidem/i>, 404-413.
20. Wang, R.; Zhang, Y.; Lan, Q.; Holford, T.R.; Leaderer, B.; Zahm, S.H.; Boyle, P.; Dosemeci, M.; Rothman, N.; Zhu, Y. et al. Occupational exposure to solvents and risk of non-Hodgkin lymphoma in Connecticut women. Am. J. Epidemiol. 2009, 169, 176-185.
21. Infante-Rivard, C.; Siemiatycki, J.; Lakhani, R.; Nadon, L. Maternal exposure to occupational solvents and childhood leukemia. Environ. Health Perspect. 2005, 113, 787-792.
22. Gold, L.S.; Stewart, P.A.; Milliken, K.; Purdue, M.; Severson, R.; Seixas, N.; Blair, A.; Hartge, P.; Davis, S.; De Roos, A.J. The relationship between multiple myeloma and occupational exposure to six chlorinated solvents. Occup. Environ. Med. 2011, 68, 391-399.
23. Friedlander, B.R.; Hearne, T.; Hall, S. Epidemiologic investigation of employees chronically exposed to methylene chloride: Mortality analysis. J. Occup. Med. 1978, 20, 657-666.
24. Hearne, F.T.; Grose, F.; Pifer, J.W.; Friedlander, B.R.; Raleigh, R.L. Methylene chloride mortality study: Dose-response characterization and animal model comparison. J. Occup. Med. 1987, 29, 217-228.
25. Hearne, F.T.; Pifer, J.W.; Grose, F. Absence of adverse mortality effects in workers exposed to methylene chloride: An update. J. Occup. Med. 1990, 32, 234-240.
26. Spirtas, R.; Stewart, P.A.; Lee, J.S.; Marano, D.E.; Forbes, C.D.; Grauman, D.J.; Pettigrew, H.M.; Blair, A.; Hoover, R.N.; Cohen, J.L. Retrospective cohort mortality study of workers at an aircraft maintenance facility. I. Epidemiological results. Br. J. Ind. Med. 1991, 48, 515-530.
27. Blair, A.; Hartge, P.; Stewart, P.A.; McAdams, M.; Lubin, J. Mortality and cancer incidence of aircraft maintenance workers exposed to trichloroethylene and other organic solvents and chemicals: Extended follow up. Occup. Environ. Med. 1998, 55, 161-171.
28. Lanes, S.F.; Cohen, A.; Rothman, K.J.; Dreyer, N.A.; Soden, K.J. Mortality of cellulose fiber production workers. Scand. J. Work. Environ. Health 1990, 16, 247-251.
29. Hearne, F.T.; Pifer, J.W. Mortality study of two overlapping cohorts of photographic film base manufacturing employees exposed to methylene chloride. J. Occup. Environ. Med. 1999, 41, 1154-1169.
30. Tomenson, J.A.; Bonner, S.M.; Heijne, C.G.; Farrar, D.G.; Cummings, T.F. Mortality of workers exposed to methylene chloride employed at a plant producing cellulose triacetate film base. Occup. Environ. Med. 1997, 54, 470-476.
31. Lanes, S.F.; Rothman, K.J.; Dreyer, N.A.; Soden, K.J. Mortality update of cellulose fiber production workers. Scand. J. Work. Environ. Health 1993, 19, 426-428.
32. Gibbs, G.W.; Amsel, J.; Soden, K. A cohort mortality study of cellulose triacetate-fiber workers exposed to methylene chloride. J. Occup. Environ. Med. 1996, 38, 693-697.
33. Radican, L.; Blair, A.; Stewart, P.; Wartenberg, D. Mortality of aircraft maintenance workers exposed to trichloroethylene and other hydrocarbons and chemicals: Extended follow-up. J. Occup. Environ. Med. 2008, 50, 1306-1319.
34. Stewart, P.A.; Lee, J.S.; Marano, D.E.; Spirtas, R.; Forbes, C.D.; Blair, A. Retrospective cohort mortality study of workers at an aircraft maintenance facility. II. Exposures and their assessment. Br. J. Ind. Med. 1991, 48, 531-537.
35. Gibbs, G.W. The Mortality of Workers Employed at a Cellulose Acetate and Triacetate Fibers Plant in Cumberland, Maryland: A "1970" Cohort Followed 1970-1989 [Final Report]; Safety Health Environment International Consultants Corporation: Devon, Alberta, Canada, 1992.
36. Cantor, K.P.; Stewart, P.A.; Brinton, L.A.; Dosemeci, M. Occupational exposures and female breast cancer mortality in the United States. J. Occup. Environ. Med. 1995, 37, 336-348.
37. Kernan, G.J.; Ji, B.T.; Dosemeci, M.; Silverman, D.T.; Balbus, J.; Zahm, S.H. Occupational risk factors for pancreatic cancer: A case-control study based on death certificates from 24 U.S. states. Am. J. Ind. Med. 1999, 36, 260-270.
38. Dosemeci, M.; Cocco, P.; Chow, W.H. Gender differences in risk of renal cell carcinoma and occupational exposures to chlorinated aliphatic hydrocarbons. Am. J. Ind. Med. 1999, 36, 54-59.
39. Dumas, S.; Parent, M.E.; Siemiatycki, J.; Brisson, J. Rectal cancer and occupational risk factors: A hypothesis-generating, exposure-based case-control study. Int. J. Cancer 2000, 87, 874-879.
40. Cocco, P.; Heineman, E.F.; Dosemeci, M. Occupational risk factors for cancer of the central nervous system (CNS) among US women. Am. J. Ind. Med. 1999, 36, 70-74.
41. Heineman, E.F.; Cocco, P.; Gomez, M.R.; Dosemeci, M.; Stewart, P.A.; Hayes, R.B.; Zahm, S.H.; Thomas, T.L.; Blair, A. Occupational exposure to chlorinated aliphatic hydrocarbons and risk of astrocytic brain cancer. Am. J. Ind. Med. 1994, 26, 155-169.
42. Gomez, M.R.; Cocco, P.; Dosemeci, M.; Stewart, P.A. Occupational exposure to chlorinated aliphatic hydrocarbons: job exposure matrix. Am. J. Ind. Med. 1994, 26, 171-183.
43. Dosemeci, M.; Cocco, P.; Gomez, M.; Stewart, P.A.; Heineman, E.F. Effects of three features of a job-exposure matrix on risk estimates. Epidemiology 1994, 5, 124-127.
44. Dell, L.D.; Mundt, K.A.; McDonald, M.; Tritschler, J. P, 2nd; Mundt, D.J. Critical review of the epidemiology literature on the potential cancer risks of methylene chloride. Int. Arch. Occup. Environ. Health 1999, 72, 429-442.
45. Hazleton Laboratories. 24-Month Oncogenicity Study of Methylene Chloride in Mice [final report]; Hazlelton Laboratories America, Inc.: Vienna, VA, USA, 1983.
46. Serota, D.G.; Thakur, A.K.; Ulland, B.M.; Kirschman, J.C.; Brown, N.M.; Coots, R.H.; Morgareidge, K. A two-year drinking-water study of dichloromethane in rodents. II. Mice. Food Chem. Toxicol. 1986, 24, 959-963.
47. Serota, D.G.; Thakur, A.K.; Ulland, B.M.; Kirschman, J.C.; Brown, N.M.; Coots, R.H.; Morgareidge, K. A two-year drinking-water study of dichloromethane in rodents. I. Rats. Food Chem. Toxicol. 1986, 24, 951-958.
48. Burek, J.D.; Nitschke, K.D.; Bell, T.J.; Wackerle, D.L.; Childs, R.C.; Beyer, J.E.; Dittenber, D.A.; Rampy, L.W.; McKenna, M.J. Methylene chloride: A two-year inhalation toxicity and oncogenicity study in rats and hamsters. Fundam. Appl. Toxicol. 1984, 4, 30-47.
49. Nitschke, K.D.; Burek, J.D.; Bell, T.J.; Kociba, R.J.; Rampy, L.W.; McKenna, M.J. Methylene chloride: A 2-year inhalation toxicity and oncogenicity study in rats. Fundam Appl. Toxicol. 1988, 11, 48-59.
50. Green, T. Methylene chloride induced mouse liver and lung tumours: An overview of the role of mechanistic studies in human safety assessment. Hum. Exp. Toxicol. 1997, 16, 3-13.
51. Their, R.; Wiebel, F.A.; Hinkel, A.; Burger, A.; Bruning, T.; Morgenroth, K.; Senge, T.; Wilhelm, M.; Schulz, T.G. Species differences in the glutathione transferase GSTT1-1 activity towards the model substrates methyl chloride and dichloromethane in liver and kidney. Arch. Toxicol. 1998, 72, 622-629.
52. Sherratt, P.J.; Williams, S.; Foster, J.; Kernohan, N.; Green, T.; Hayes, J.D. Direct comparison of the nature of mouse and human GST T1-1 and the implications on dichloromethane carcinogenicity. Toxicol. Appl. Pharmacol. 2002, 179, 89-97.
53. Mainwaring, G.W.; Williams, S.M.; Foster, J.R.; Tugwood, J.; Green, T. The distribution of theta-class glutathione S-transferases in the liver and lung of mouse, rat and human. Biochem. J. 1996, 318, 297-303.
54. Moore, L.E.; Boffetta, P.; Karami, S.; Brennan, P.; Stewart, P.S.; Hung, R.; Zaridze, D.; Matveev, V.; Janout, V.; Kollarova, H.; et al. Occupational trichloroethylene exposure and renal carcinoma risk: Evidence of genetic susceptibility by reductive metabolism gene variants. Cancer Res. 2010, 70, 6527-6536.
55. Lehmann, L.; Wagner, J. Gene expression of 17-beta-estradiol-metabolizing isozymes: Comparison of normal human mammary gland to normal human liver and to cultured human breast adenocarcinoma cells. Adv. Exp. Med. Biol. 2008, 617, 617-624.
56. Juronen, E.; Tasa, G.; Uuskula, M.; Pooga, M.; Mikelsaar, A.V. Purification, characterization and tissue distribution of human class theta glutathione S-transferase T1-1. Biochem. Mol. Biol. Int. 1996, 39, 21-29.
57. Savolainen, H.; Kurppa, K.; Pfaffli, P.; Kivisto, H. Dose-related effects of dichloromethane on rat brain in short-term inhalation exposure. Chem. Biol. Interact. 1981, 34, 315-322.
58. Sills, R.C.; Hailey, J.R.; Neal, J.; Boorman, G.A.; Haseman, J.K.; Melnick, R.L. Examination of low-incidence brain tumor responses in F344 rats following chemical exposures in National Toxicology Program carcinogenicity studies. Toxicol. Pathol. 1999, 27, 589-599.
59. Kim, A.S.; Eastmond, D.A.; Preston, R.J. Childhood acute lymphocytic leukemia and perspectives on risk assessment of early-life stage exposures. Mutat. Res. 2006, 613, 138-160.
60. Colt, J.S.; Blair, A. Parental occupational exposures and risk of childhood cancer. Environ. Health Perspect. 1998, 106(Suppl 3), 909-925.
61. Scott, C.S.; Chiu, W.A. Trichloroethylene cancer epidemiology: A consideration of select issues. Environ. Health Perspect. 2006, 114, 1471-1478.
62. Morton, L.M.; Turner, J.J.; Cerhan, J.R.; Linet, M.S.; Treseler, P.A.; Clarke, C.A.; Jack, A.; Cozen, W.; Maynadie M.; Spinelli, J.J.; et al. Proposed classification of lymphoid neoplasms for epidemiologic research from the Pathology Working Group of the International Lymphoma Epidemiology Consortium (InterLymph). Blood 2007, 110, 695-708.
63. Bakke, B.; Stewart, P.A.; Waters, M.A. Uses of and exposure to trichloroethylene in U.S. industry: A systematic literature review. J. Occup. Environ. Hyg. 2007, 4, 375-390.
64. Gold, L.S.; De Roos, A.J.; Waters, M.; Stewart, P. Systematic literature review of uses and levels of occupational exposure to tetrachloroethylene. J. Occup. Environ. Hyg. 2008, 5, 807-839.
65. Teschke, K.; Olshan, A.F.; Daniels, J.L.; De Roos, A.J.; Parks, C.G.; Schulz, M.; Vaughan, T.L. Occupational exposure assessment in case-control studies: Opportunities for improvement. Occup. Environ. Med. 2002, 59, 575-593; discussion 94.
66. Parks, C.G.; Cooper, G.S.; Nylander-French, L.A.; Hoppin, J.A.; Sanderson, W.T.; Dement, J.M. Comparing questionnaire-based methods to assess occupational silica exposure. Epidemiology 2004, 15, 433-441.
67. Weinberg, C.R.; Shore, D.L.; Umbach, D.M.; Sandler, D.P. Using risk-based sampling to enrich cohorts for endpoints, genes, and exposures. Am. J. Epidemiol. 2007, 166, 447-455.