Cilostazol promotes vascular smooth muscles cell differentiation through the cAMP response element-binding protein-dependent pathway

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 31, Issue 9, 2011, Pages 2106-2113

  Chen, Wei Jan ^a   Chen, Ying Hwa ^b   Lin, Kwang Huei ^c   Ting, Chiao Hsuan ^a   Yeh, Yung Hsin ^a  

^a CHANG GUNG UNIVERSITY COLLEGE OF MEDICINE   (Taiwan)

^b TAIPEI VETERANS GENERAL HOSPITAL   (Taiwan)

^c CHANG GUNG UNIVERSITY   (Taiwan)

Author keywords

cilostazol; CREB; differentiation; neointimal formation; vascular smooth muscle cells

Indexed keywords

CILOSTAZOL; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP DEPENDENT PROTEIN KINASE INHIBITOR; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; SERINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CAROTID ARTERY INJURY; CELL DIFFERENTIATION; CELL STRUCTURE; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DRUG MECHANISM; IN VIVO STUDY; MALE; MUTATIONAL ANALYSIS; NEOINTIMA; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; SMOOTH MUSCLE FIBER; UPREGULATION; VASCULAR SMOOTH MUSCLE;

ANIMALS; CAROTID ARTERIES; CELL DIFFERENTIATION; CELLS, CULTURED; CONTRACTILE PROTEINS; CYCLIC AMP; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; CYCLIC AMP-DEPENDENT PROTEIN KINASES; MALE; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; NEOINTIMA; PHOSPHODIESTERASE 3 INHIBITORS; RATS; RATS, SPRAGUE-DAWLEY; RATS, WISTAR; TETRAZOLES;

EID: 80052161485     PISSN: 10795642     EISSN: 15244636     Source Type: Journal    
DOI: 10.1161/ATVBAHA.111.230987     Document Type: Article

References (38)

1. Owens GK. Molecular regulation of vascular smooth muscle cell differentiation in development and disease. Physiol Rev. 2004;84:767-801. (Pubitemid 38823766)
2. Ross R. Atherosclerosis-an inflammatory disease. N Engl J Med. 1999; 340:115-126.
3. Regan CP, Adam PJ, Madsen CS, Owens GK. Molecular mechanisms of decreased smooth muscle differentiation marker expression after balloon injury. J Clin Invest. 2000;106:1139-1147.
4. Li S, Sims S, Jiao Y, Chow LH, Pickering JG. Evidence from a novel human cell clone that adult vascular smooth muscle cells can convert reversibly between noncontractile and contractile phenotypes. Circ Res. 1999;85:338-348. (Pubitemid 29398866)
5. Christen T, Bochaton-Piallat ML, Neuville P, Rensen S, Redard M, Eys G, Gabbiani G. Cultured porcine coronary artery smooth muscle cells: a new model with advanced differentiation. Circ Res. 1999;85:99-107. (Pubitemid 29321046)
6. Han M, Wen JK, Zheng B, Cheng Y, Zhang C. Serum deprivation results in redifferentiation of human umbilical vascular smooth muscle cells. Am J Physiol Cell Physiol. 2006;291:C50-C58.
7. Chen WJ, Pang JHS, Lin KH, Lee DY, Hsu LA, Kuo CT. Propylthiouracil, independent of its antithyroid effect, promotes VSMC differentiation via PTEN induction. Basic Res Cardiol. 2010;105:19-28.
8. Dawson DL, Cutler BS, Meissner MH, Strandness DE Jr. Cilostazol has beneficial effects in treatment of intermittent claudication: results from a multicenter, randomized, prospective, double-blind trial. Circulation. 1998;98:678-686. (Pubitemid 28387495)
9. Tjon JA, Riemann LE. Treatment of intermittent claudication with pentoxyifylline and cilostazol. Am J Health Syst Pharm. 2001;58:485-496.
10. Ishizaka N, Taguchi J, Kimura Y, Ikari Y, Aizawa T, Togo M, Miki K, Kurokawa K, Ohno M. Effects of a single local administration of cilostazol on neointimal formation in balloon-injured rat carotid artery. Atherosclerosis. 1999;142:41-46. (Pubitemid 28551808)
11. Kim MJ, Park KG, Lee KM, Kim HS, Kim SY, Kim CS, Lee SL, Chang YC, Park JY, Lee KU, Lee IK. Cilostazol inhibits vascular smooth muscle cell growth by downregulation of the transcription factor E2F. Hypertension. 2005;45:552-556.
12. Tuschikane E, Fukuhara A, Kobayashi T, Kirino M, Yamasaki K, Kobayashi T, Izumi M, Otsuji S, Tateyama H, Sakurai M, Awata N. Impact of cilostazol on restenosis after percutaneous coronary balloon angioplasty. Circulation. 1999;100:21-26. (Pubitemid 29297935)
13. Douglas JS, Holmes DR, Kereiakes DJ, Grines CL, Block E, Ghazzal ZMB, Morris DC, Liberman H, Parker K, Jurkovitz C, Murrah N, Foster J, Hyde P, Mancini GBJ, Weintraub WS. Coronary stent restenosis in patients treated with cilostazol. Circulation. 2005;112:2826-2832. (Pubitemid 41641677)
14. Dandre F, Owens GK. Platelet-derived growth factor-BB and Ets-1 transcription factor negatively regulate transcription of multiple smooth muscle cell differentiation marker genes. Am J Physiol. 2004;286: H2042-H2051. (Pubitemid 38685215)
15. Chen WJ, Yeh YH, Lin KH, Chang GJ, Kuo CT. Molecular characterization of thyroid hormone-inhibited atrial L-type calcium channel expression: implication for atrial fibrillation in hyperthyroidism. Basic Res Cardiol. 2011;106:163-174.
16. Shaywitz AJ, Greenberg ME. CREB: a stimulus-induced transcription factor activated by a diverse array of extracellular signals. Annu Rev Biochem. 1999;68:821-861. (Pubitemid 29449210)
17. Johannessen M, Delghandi MP, Moens U. What turns CREB on? Cell Signal. 2004;16:1211-1227. (Pubitemid 39165450)
18. Tokunou T, Shibata R, Kai H, Ichiki T, Morisaki T, Fukuyama K, Ono H, Iino N, Masuda S, Shimokawa H, Egashira K, Imaizumi T, Takeshita A. Apotosis induced by inhibition of cyclic AMP response element-binding protein in vascular smooth muscle cells. Circulation. 2003;108: 1246-1252. (Pubitemid 37099995)
19. Durchdewald M, Angel P, Hess J. The transcription factor Fos: a Janus-type regulator in health and disease. Histol Histopathol. 2009;24: 1451-1461.
20. Assender JW, Southgate KM, Hallett MB, Newby AC. Inhibition of proliferation, but not of Ca2 mobilization, by cyclic AMP and GMP in rabbit aortic smooth-muscle cells. Biochem J. 1992;288:527-532.
21. Cornwell TL, Arnold E, Boerth NJ, Lincoln TM. Inhibition of smooth muscle cell growth by nitric oxide and activation of cAMP-dependent protein kinase by cGMP. Am J Physiol. 1994;267:C1405-1413.
22. Indolfi C, Avvedimento EV, Lorenzo ED, Esposito G, Rapacciuolo A, Giuliano P, Grieco D, Cavuto L, Stingone AM, Ciullo I, Condorelli G, Chiariello M. Activation of cAMP-PKA signaling in vivo inhibits smooth muscle cell proliferation induced by vascular injury. Nat Med. 1997;3:775-779.
23. Wu YJ, Bond M, Sala-Newby GB, Newby AC. Altered S-phase kinaseassociated protein-2 levels are a major mediator of cyclic nucleotideinduced inhibition of vascular smooth muscle cell proliferation. Circ Res. 2006;98:1141-1150. (Pubitemid 43948100)
24. Sassi Y, Lipskaia L, Vandecasteele G, Nikolaev VO, Hatem SN, Aubart FC, Russel FG, Mougenot N, Vrignaud C, Lechat P, Lompre AM, Hulot JS. Multidrug resistance-associated protein 4 regulates cAMP-dependent signaling pathways and controls human and rat SMC proliferation. J Clin Invest. 2008;118:2747-2757.
25. Southgate K, Newby AC. Serum-induced proliferation of rabbit aortic smooth muscle cells from the contractile state is inhibited by 8-Br-cAMP but not 8-Br-cGMP. Atherosclerosis. 1990;82:113-123. (Pubitemid 20170548)
26. Sinnaeve P, Chiche JD, Gillijns H, Polt NV, Wirthlin D, Werf FV, Collen D, Bloch KD, Janssens S. Overexpression of a constitutively active protein kinase G mutant reduces neointima formation and in-stent restenosis. Circulation. 2002;105:2911-2916. (Pubitemid 34666107)
27. Aizawa T, Wei H, Miano JM, Abe J, Berk BC, Yan C. Role of phosphodiesterase 3 in NO/cGMP-mediated antiinflamatory effects in vascular smooth muscle cells. Circ Res. 2003;93:406-413. (Pubitemid 37100005)
28. Klemm DJ, Watson PA, Frid MG, Dempsey EC, Schaack J, Colton LA, Nesterova A, Stenmark KR, Reusch JEB. cAMP response elementbinding protein content is a molecular determinant of smooth muscle cell proliferation and migration. J Biol Chem. 2001;276:46132-46141.
29. Watson PA, Nesterova A, Burant CF, Klemm DJ, Reusch JE. Diabetesrelated changes in cAMP response element-binding protein content enhance smooth cell proliferation and migration. J Biol Chem. 2001;276: 46142-46150.
30. Pulver RA, Rose-Curtis P, Roe MW, Wellma GC, Lounsbury KM. Store-operated Ca2 entry activates the CREB transcription factor in vascular smooth muscle. Circ Res. 2004;94:1351-1358. (Pubitemid 38724481)
31. Kamiya K, Sakakibara K, Reyer EJ, Hom RP, Leof EB, Kent KC, Liu B. Phosphorylation of the cyclic AMP response element binding protein mediates transforming growth factor-induced downregulation of cycle A in vascular smooth muscle cells. Mol Cell Biol. 2007;27:3489-3498. (Pubitemid 46685223)
32. Schauer IE, Knaub LA, Lloyd M, Watson PA, Gliwa C, Lewis KE, Chait A, Klemm DJ, Gunter JM, Bouchard R, McDonald TO, O'Brien KD, Reusch JE. CREB dowregulation in vascular disease: a common response to cardiovascular risk. Arterioscler Thromb Vasc Biol. 2010;30:733-741.
33. Reusch JEB, Klemm DJ. Cyclic AMP response element-binding protein in the vessel wall: good or bad? Circulation. 2003;108:1164-1166. (Pubitemid 37099981)
34. Chava KR, Karpurapu M, Wang D, Bhanoori M, Kundumani-Sridharan V, Zhang Q, Ichiki T, Glasgow WC, Rao G. CREB-mediated IL-6 expression is required for 15(S)-hydroxyeicosatetraenoic acid-induced vascular smooth muscle cell migration. Arterioscler Thromb Vasc Biol. 2009;29:809-815.
35. Hayashi K, Takahashi M, Kimura K, Nishida W, Sega H, Sobue K. Changes in the balance of phosphatidylinositol 3-kinase/protein kinase B (Akt) and the mitogen-activated protein kinases (ERK/p38MARK) determine a phenotype of visceral and vascular smooth muscle cells. J Cell Biol. 1999;145:727-740. (Pubitemid 29240851)
36. Reusch HP, Zimmermann S, Schaefer M, Paul M, Moelling K. Regulation of Raf by Akt controls growth and differentiation in vascular smooth muscle cells. J Biol Chem. 2001;276:33630-33637.
37. Soderling SH, Beavo JA. Regulation of cAMP and cGMP signaling: new phosphodiesterases and new functions. Curr Opin Cell Biol. 2000;12:174-179. (Pubitemid 30142563)
38. Dunkerley HA, Tilley DG, Palmer D, Liu H, Jimmo SL, Maurice DH. Reduced phosphodiesterase 3 activity and phosphodiesterase 3 level in synthetic vascular smooth muscle cells: implications for use of phosphodiesterase 3 inhibitors in cardiovascular tissues. Mol Pharmacol. 2002; 61:1033-1040. (Pubitemid 34441768)