Propylthiouracil, independent of its antithyroid effect, promotes vascular smooth muscle cells differentiation via PTEN induction

Basic Research in Cardiology

Volumn 105, Issue 1, 2010, Pages 19-28

  Chen, Wei Jan ^a   Pang, Jong Hwei S ^b   Lin, Kwang Huei ^c   Lee, Dany Young ^a   Hsu, Lung An ^a   Kuo, Chi Tai ^a  

^a CHANG GUNG UNIVERSITY COLLEGE OF MEDICINE   (Taiwan)

^b Graduate Institute of Medical Biotechnology   (Taiwan)

^c CHANG GUNG UNIVERSITY   (Taiwan)

Author keywords

Atherosclerosis; Differentiation; Neointimal formation; Propylthiouracil; PTEN; Vascular smooth muscle cells

Indexed keywords

ALPHA ACTIN; CALPONIN; MYOSIN HEAVY CHAIN; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROPYLTHIOURACIL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATHEROGENESIS; CELL DIFFERENTIATION; CONTROLLED STUDY; DOWN REGULATION; DRUG ACTIVITY; ENZYME ACTIVATION; GENE INDUCTION; IMMUNOCYTOCHEMISTRY; IN VITRO STUDY; INTIMA; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; PROTEIN EXPRESSION; RAT; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; UPREGULATION; VASCULAR SMOOTH MUSCLE;

ANIMALS; ANTITHYROID AGENTS; CAROTID ARTERY INJURIES; CAROTID ARTERY, EXTERNAL; CELL DIFFERENTIATION; CELLS, CULTURED; CONTRACTILE PROTEINS; IMMUNOHISTOCHEMISTRY; MALE; MYOCYTES, SMOOTH MUSCLE; PROPYLTHIOURACIL; PTEN PHOSPHOHYDROLASE; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; TRANSCRIPTION, GENETIC;

EID: 72449207514     PISSN: 03008428     EISSN: 14351803     Source Type: Journal    
DOI: 10.1007/s00395-009-0045-z     Document Type: Article

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