Engineered lentiviral vectors pseudotyped with a CD4 receptor and a fusogenic protein can target cells expressing HIV-1 envelope proteins

Virus Research

Volumn 160, Issue 1-2, 2011, Pages 340-350

  Lee, Chi Lin ^a   Dang, Jason ^a   Joo, Kye Il ^a   Wang, Pin ^a,b  

^a University of Southern California   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

Human immunodeficiency virus; Lentivirus; Retrovirus; Targeted gene delivery

Indexed keywords

CD4 ANTIGEN; CELL SURFACE MARKER; CHEMOKINE RECEPTOR CCR5; CHEMOKINE RECEPTOR CXCR4; CHLORPROMAZINE; CLATHRIN; COMPLEMENTARY DNA; DYNAMIN II; ENVELOPE PROTEIN; GANCICLOVIR; GENISTEIN; GLYCOPROTEIN E1; GLYCOPROTEIN E2; HUMAN IMMUNODEFICIENCY VIRUS PROTEIN; LENTIVIRUS VECTOR; LOW AFFINITY NERVE GROWTH FACTOR RECEPTOR; NERVE GROWTH FACTOR RECEPTOR; NYSTATIN; PLASMID DNA; RAB PROTEIN; RETROVIRUS VECTOR; THYMIDINE KINASE; UNCLASSIFIED DRUG; VIRUS GLYCOPROTEIN; VIRUS RECEPTOR;

ARTICLE; CELL CULTURE; CONTROLLED STUDY; ENDOSOME; GENE CONSTRUCT; GENE TARGETING; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; NONHUMAN; PH; PLASMID; PRIORITY JOURNAL; PROTEIN EXPRESSION; PSEUDOTYPING; SINDBIS VIRUS; STABLE EXPRESSION; SUICIDE GENE; SUICIDE GENE THERAPY; THYMIDINE KINASE GENE; TRANSIENT TRANSFECTION; VIRAL GENE DELIVERY SYSTEM; VIRAL TROPISM; VIRUS ATTACHMENT; VIRUS GENE; VIRUS RECOMBINANT; VIRUS TITRATION;

ANTIGENS, CD4; CELL LINE; ENV GENE PRODUCTS, HUMAN IMMUNODEFICIENCY VIRUS; GENE EXPRESSION; GENE THERAPY; GENE TRANSFER TECHNIQUES; GENETIC ENGINEERING; GENETIC VECTORS; HIV-1; HUMANS; RECEPTORS, HIV; SINDBIS VIRUS; TRANSDUCTION, GENETIC; VIRAL FUSION PROTEINS; VIRUS ATTACHMENT;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; LENTIVIRUS; SINDBIS VIRUS;

EID: 80052157712     PISSN: 01681702     EISSN: 18727492     Source Type: Journal    
DOI: 10.1016/j.virusres.2011.07.010     Document Type: Article

References (48)

1. Alkhatib G., Broder C.C., Berger E.A. Cell type-specific fusion cofactors determine human immunodeficiency virus type 1 tropism for T-cell lines versus primary macrophages. J. Virol. 1996, 70(8):5487-5494.
2. Bittner A., Mitnacht-Kraus R., Schnierle B.S. Specific transduction of HIV-1 envelope expressing cells by retroviral vectors pseudotyped with hybrid CD4/CXCR4 receptors. J. Virol. Methods 2002, 104(1):83-92.
3. Black M.E., Kokoris M.S., Sabo P. Herpes simplex virus-1 thymidine kinase mutants created by semi-random sequence mutagenesis improve prodrug-mediated tumor cell killing. Cancer Res. 2001, 61(7):3022-3026.
4. Blanchard E., Belouzard S., Goueslain L., Wakita T., Dubuisson J., Wychowski C., Rouille Y. Hepatitis C virus entry depends on clathrin-mediated endocytosis. J. Virol. 2006, 80(14):6964-6972.
5. Blumenthal M., Skelton D., Pepper K.A., Jahn T., Methangkool E., Kohn D.B. Effective suicide gene therapy for leukemia in a model of insertional oncogenesis in mice. Mol. Ther. 2007, 15(1):183-192.
6. Blumenthal R., Gallo S.A., Viard M., Raviv Y., Puri A. Fluorescent lipid probes in the study of viral membrane fusion. Chem. Phys. Lipids 2002, 116(1-2):39-55.
7. Cronin J., Zhang X.Y., Reiser J. Altering the tropism of lentiviral vectors through pseudotyping. Curr. Gene Ther. 2005, 5(4):387-398.
8. DeTulleo L., Kirchhausen T. The clathrin endocytic pathway in viral infection. EMBO J. 1998, 17(16):4585-4593.
9. Dimitrov D.S. How do viruses enter cells? The HIV coreceptors teach us a lesson of complexity. Cell 1997, 91(6):721-730.
10. Doxsey S.J., Brodsky F.M., Blank G.S., Helenius A. Inhibition of endocytosis by anti-clathrin antibodies. Cell 1987, 50(3):453-463.
11. Endres M.J., Jaffer S., Haggarty B., Turner J.D., Doranz B.J., O'Brien P.J., Kolson D.L., Hoxie J.A. Targeting of HIV- and SIV-infected cells by CD4-chemokine receptor pseudotypes. Science 1997, 278(5342):1462-1464.
12. Gao F., Li Y., Decker J.M., Peyerl F.W., Bibollet-Ruche F., Rodenburg C.M., Chen Y., Shaw D.R., Allen S., Musonda R., Shaw G.M., Zajac A.J., Letvin N., Hahn B.H. Codon usage optimization of HIV type 1 subtype C gag, pol, env, and nef genes: in vitro expression and immune responses in DNA-vaccinated mice. AIDS Res. Hum. Retroviruses 2003, 19(9):817-823.
13. Glomb-Reinmund S., Kielian M. The role of low pH and disulfide shuffling in the entry and fusion of Semliki Forest virus and Sindbis virus. Virology 1998, 248(2):372-381.
14. Hoffman T.L., Labranche C.C., Zhang W., Canziani G., Robinson J., Chaiken I., Hoxie J.A., Doms R.W. Stable exposure of the coreceptor-binding site in a CD4-independent HIV-1 envelope protein. Proc. Natl. Acad. Sci. U.S.A. 1999, 96(11):6359-6364.
15. Joo K.I., Lei Y., Lee C.L., Lo J., Xie J., Hamm-Alvarez S.F., Wang P. Site-specific labeling of enveloped viruses with quantum dots for single virus tracking. ACS Nano 2008, 2(8):1553-1562.
16. Joo K.I., Wang P. Visualization of targeted transduction by engineered lentiviral vectors. Gene Ther. 2008, 15(20):1384-1396.
17. Kirchhausen T. Clathrin. Annu. Rev. Biochem. 2000, 69:699-727.
18. Kohn D.B. Lentiviral vectors ready for prime-time. Nat. Biotechnol. 2007, 25(1):65-66.
19. Lei Y., Joo K.-I., Wang P. Engineering fusogenic molecules to achieve targeted transduction of enveloped lentiviral vectors. J. Biol. Eng. 2009, 3:8.
20. Lei Y., Joo K.I., Zarzar J., Wong C., Wang P. Targeting lentiviral vector to specific cell types through surface displayed single chain antibody and fusogenic molecule. Virol. J. 2010, 7:35.
21. Lois C., Hong E.J., Pease S., Brown E.J., Baltimore D. Germline transmission and tissue-specific expression of transgenes delivered by lentiviral vectors. Science 2002, 295(5556):868-872.
22. Lu Y.E., Cassese T., Kielian M. The cholesterol requirement for sindbis virus entry and exit and characterization of a spike protein region involved in cholesterol dependence. J. Virol. 1999, 73(5):4272-4278.
23. Mebatsion T., Finke S., Weiland F., Conzelmann K.K. A CXCR4/CD4 pseudotype rhabdovirus that selectively infects HIV-1 envelope protein-expressing cells. Cell 1997, 90(5):841-847.
24. Mellman I., Fuchs R., Helenius A. Acidification of the endocytic and exocytic pathways. Annu. Rev. Biochem. 1986, 55:663-700.
25. Moore J.P. Coreceptors: implications for HIV pathogenesis and therapy. Science 1997, 276(5309):51-52.
26. Nabi I.R., Le P.U. Caveolae/raft-dependent endocytosis. J. Cell Biol. 2003, 161(4):673-677.
27. Naldini L., Blomer U., Gallay P., Ory D., Mulligan R., Gage F.H., Verma I.M., Trono D. In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector. Science 1996, 272(5259):263-267.
28. Nichols B.J., Lippincott-Schwartz J. Endocytosis without clathrin coats. Trends Cell Biol. 2001, 11(10):406-412.
29. Peretti S., Schiavoni I., Pugliese K., Federico M. Selective elimination of HIV-1-infected cells by Env-directed, HIV-1-based virus-like particles. Virology 2006, 345(1):115-126.
30. Pleskoff O., Treboute C., Alizon M. The cytomegalovirus-encoded chemokine receptor US28 can enhance cell-cell fusion mediated by different viral proteins. J. Virol. 1998, 72(8):6389-6397.
31. Press B., Feng Y., Hoflack B., Wandinger-Ness A. Mutant Rab7 causes the accumulation of cathepsin D and cation-independent mannose 6-phosphate receptor in an early endocytic compartment. J. Cell Biol. 1998, 140(5):1075-1089.
32. Rothberg K.G., Heuser J.E., Donzell W.C., Ying Y.S., Glenney J.R., Anderson R.G. Caveolin, a protein component of caveolae membrane coats. Cell 1992, 68(4):673-682.
33. Rust M.J., Lakadamyali M., Zhang F., Zhuang X. Assembly of endocytic machinery around individual influenza viruses during viral entry. Nat. Struct. Mol. Biol. 2004, 11(6):567-573.
34. Schnell M.J., Johnson J.E., Buonocore L., Rose J.K. Construction of a novel virus that targets HIV-1-infected cells and controls HIV-1 infection. Cell 1997, 90(5):849-857.
35. Somia N., Verma I.M. Gene therapy: trials and tribulations. Nat. Rev. Genet. 2000, 1(2):91-99.
36. Somia N.V., Miyoshi H., Schmitt M.J., Verma I.M. Retroviral vector targeting to human immunodeficiency virus type 1-infected cells by receptor pseudotyping. J. Virol. 2000, 74(9):4420-4424.
37. Stenmark H., Parton R.G., Steele-Mortimer O., Lutcke A., Gruenberg J., Zerial M. Inhibition of rab5 GTPase activity stimulates membrane fusion in endocytosis. EMBO J. 1994, 13(6):1287-1296.
38. Tiscornia G., Singer O., Verma I.M. Production and purification of lentiviral vectors. Nat. Protoc. 2006, 1(1):241-245.
39. Verma I.M., Somia N. Gene therapy-promises, problems and prospects. Nature 1997, 389(6648):239-242.
40. Verma I.M., Weitzman M.D. Gene therapy: twenty-first century medicine. Annu. Rev. Biochem. 2005, 74:711-738.
41. Vidricaire G., Tremblay M.J. A clathrin, caveolae, and dynamin-independent endocytic pathway requiring free membrane cholesterol drives HIV-1 internalization and infection in polarized trophoblastic cells. J. Mol. Biol. 2007, 368(5):1267-1283.
42. Waehler R., Russell S.J., Curiel D.T. Engineering targeted viral vectors for gene therapy. Nat. Rev. 2007, 8(8):573-587.
43. Wang L.H., Rothberg K.G., Anderson R.G. Mis-assembly of clathrin lattices on endosomes reveals a regulatory switch for coated pit formation. J. Cell Biol. 1993, 123(5):1107-1117.
44. Yang H., Ziegler L., Joo K.I., Cho T., Lei Y., Wang P. Gamma-retroviral vectors enveloped with an antibody and an engineered fusogenic protein achieved antigen-specific targeting. Biotechnol. Bioeng. 2008, 101(2):357-368.
45. Yang L., Bailey L., Baltimore D., Wang P. Targeting lentiviral vectors to specific cell types in vivo. Proc. Natl. Acad. Sci. U.S.A. 2006, 103(31):11479-11484.
46. Yang L., Baltimore D. Long-term in vivo provision of antigen-specific T cell immunity by programming hematopoietic stem cells. Proc. Natl. Acad. Sci. U.S.A. 2005, 102(12):4518-4523.
47. Ye Z., Harmison G.G., Ragheb J.A., Schubert M. Targeted infection of HIV-1 Env expressing cells by HIV(CD4/CXCR4) vectors reveals a potential new rationale for HIV-1 mediated down-modulation of CD4. Retrovirology 2005, 2:80.
48. Ziegler L., Yang L., Joo K., Yang H., Baltimore D., Wang P. Targeting lentiviral vectors to antigen-specific immunoglobulins. Hum. Gene Ther. 2008, 19(9):861-872.