A role for the cancer-associated miR-106b~25 cluster in neuronal stem cells

Aging

Volumn 3, Issue 4, 2011, Pages 329-331

  Peck, Barrie ^a   Schulze, Almut ^a  

^a IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

FORKHEAD TRANSCRIPTION FACTOR; MICRORNA; MIRN106 MICRORNA, MOUSE;

ANIMAL; CELL DIFFERENTIATION; CELL PROLIFERATION; GENETICS; METABOLISM; MOUSE; MULTIGENE FAMILY; NEURAL STEM CELL; NOTE; PHYSIOLOGY; SIGNAL TRANSDUCTION;

ANIMALS; CELL DIFFERENTIATION; CELL PROLIFERATION; FORKHEAD TRANSCRIPTION FACTORS; MICE; MICRORNAS; MULTIGENE FAMILY; NEURAL STEM CELLS; SIGNAL TRANSDUCTION;

EID: 80052103071     PISSN: 19454589     EISSN: None     Source Type: Journal    
DOI: 10.18632/aging.100302     Document Type: Note

References (17)

1. Brett JO, Renault VM, Rafalski VA, Webb AE, Brunet A. The microRNA cluster miR-106b~25 regulates adult neural stem/progenitor cell proliferation and neuronal differentiation. Aging. 2011; 3: 108-124.
2. Kan T, Sato F, Ito T, Matsumura N, David S, et al. The miR-106b-25 polycistron, activated by genomic amplification, functions as an oncogene by suppressing p21 and Bim. Gastroenterology. 2009; 136: 1689-1700.
3. Petrocca F, Vecchione A, Croce CM. Emerging role of miR-106b-25/miR-17-92 clusters in the control of transforming growth factor beta signaling. Cancer Research. 2008; 68: 8191-8194.
4. Poliseno L, Salmena L, Riccardi L, Fornari A, Song MS, et al. Identification of the miR-106b~25 microRNA cluster as a protooncogenic PTEN-targeting intron that cooperates with its host gene MCM7 in transformation. Sci Signal. 2010; 3: ra29.
5. Gangaraju VK, Lin H. MicroRNAs: key regulators of stem cells. Nat Rev Mol Cell Biol. 2009; 10: 116-125.
6. Kanellopoulou C, Muljo SA, Kung AL, Ganesan S, Drapkin R, et al. Dicer-deficient mouse embryonic stem cells are defective in differentiation and centromeric silencing. Genes Dev. 2005; 19: 489-501.
7. Li X, Jin P. Roles of small regulatory RNAs in determining neuronal identity. Nat Rev Neurosci 2010; 11: 329-338.
8. van der Horst A, Burgering BM. Stressing the role of FoxO proteins in lifespan and disease. Nat Rev Mol Cell Biol. 2007; 8: 440-450.
9. Renault VM, Rafalski VA, Morgan AA, Salih DA, Brett JO, et al. FoxO3 regulates neural stem cell homeostasis. Cell Stem Cell. 2009; 5: 527-539.
10. Paik JH, Ding Z, Narurkar R, Ramkissoon S, Muller F, et al. FoxOs cooperatively regulate diverse pathways governing neural stem cell homeostasis. Cell Stem Cell. 2009; 5: 540-553.
11. Wang K, Li PF (2010) Foxo3a regulates apoptosis by negatively targeting miR-21. J Biol Chem 285: 16958-16966.
12. Kong W, He L, Coppola M, Guo J, Esposito NN, et al. MicroRNA-155 regulates cell survival, growth, and chemosensitivity by targeting FOXO3a in breast cancer. J Biol Chem. 2010; 285: 17869-17879.
13. Shohet JM, Hicks MJ, Plon SE, Burlingame SM, Stuart S, et al. Minichromosome maintenance protein MCM7 is a direct target of the MYCN transcription factor in neuroblastoma. Cancer Research. 2002; 62: 1123-1128.
14. Bouchard C, Marquardt J, Bras A, Medema RH, Eilers M. Myc-induced proliferation and transformation require Aktmediated phosphorylation of FoxO proteins. Embo Journal. 2004; 23: 2830-2840.
15. Delpuech O, Griffiths B, East P, Essafi A, Lam EW, et al. Induction of Mxi1-SR{alpha} by FOXO3a Contributes to Repression of Myc-Dependent Gene Expression. Mol Cell Biol. 2007; 27: 4917-4930.
16. Gan B, Lim C, Chu G, Hua S, Ding Z, et al. FoxOs enforce a progression checkpoint to constrain mTORC1-activated renal tumorigenesis. Cancer Cell. 2010; 18: 472-484.
17. Bishop NA, Lu T, Yankner BA. Neural mechanisms of ageing and cognitive decline. Nature. 2010; 464: 529-535.