Altered expression of matrix metalloproteinases and their tissue inhibitors as possible contributors to corneal droplet formation in climatic droplet keratopathy

Acta Ophthalmologica

Volumn 89, Issue 6, 2011, Pages 569-574

  Holopainen, Juha M ^a   Serra, Horacio M ^b   Sánchez, María C ^b   Sorsa, Timo ^c   Zalentein, Waldir N ^a   Barcelona, Pablo F ^b   Moilanen, Jukka A O ^a   Tervahartiala, Taina ^c   Tervo, Timo M T ^a   Cafaro, Thamara A ^b   Virtanen, Ismo ^d   Urrets Zavalia, Enrique A ^e   Bhattacharya, Sanjoy K ^f   Urrets Zavalia, Julio A ^e  

^a UNIVERSITY OF HELSINKI   (Finland)

^b UNIVERSIDAD NACIONAL DE CÓRDOBA   (Argentina)

^c HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^d UNIVERSITY OF HELSINKI   (Finland)

^e UNIVERSIDAD CATÓLICA DE CÓRDOBA   (Argentina)

^f UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

climatic droplet keratopathy; cornea; matrix metalloproteinases; tissue inhibitors

Indexed keywords

COLLAGENASE 3; GELATINASE A; GELATINASE B; MATRIX METALLOPROTEINASE; TISSUE INHIBITOR OF METALLOPROTEINASE; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TISSUE INHIBITOR OF METALLOPROTEINASE 2;

ADULT; AGED; ARTICLE; CLIMATIC DROPLET KERATOPATHY; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; FEMALE; FLUOROIMMUNOASSAY; FLUOROMETRY; HUMAN; KERATOPATHY; LACRIMAL FLUID; MALE; MOLECULAR PATHOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; QUANTITATIVE ANALYSIS; WESTERN BLOTTING; ZYMOGRAPHY;

AGED; AGED, 80 AND OVER; BLOTTING, WESTERN; CORNEAL DISEASES; FEMALE; FLUOROIMMUNOASSAY; HUMANS; MALE; MATRIX METALLOPROTEINASES; MIDDLE AGED; TEARS; TISSUE INHIBITOR OF METALLOPROTEINASE-1; TISSUE INHIBITOR OF METALLOPROTEINASE-2;

EID: 80052099884     PISSN: 1755375X     EISSN: 17553768     Source Type: Journal    
DOI: 10.1111/j.1755-3768.2009.01764.x     Document Type: Article

References (48)

1. Afonso AA, Sobrin L, Monroy DC, Selzer M, Lokeshwar B, &, Pflugfelder SC, (1999): Tear fluid gelatinase B activity correlates with IL-1alpha concentration and fluorescein clearance in ocular rosacea. Invest Ophthalmol Vis Sci 40: 2506-2512. (Pubitemid 29455477)
2. Azar DT, Hahn TW, Jain S, Yeh YC, &, Stetler-Stevensen WG, (1996): Matrix metalloproteinases are expressed during wound healing after excimer laser keratectomy. Cornea 15: 18-24. (Pubitemid 26004904)
3. Bradford MM, (1976): A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72: 248-254.
4. Brew K, Dinakarpandian D, &, Nagase H, (2000): Tissue inhibitors of metalloproteinases: evolution, structure and function. Biochim Biophys Acta 1477: 267-283. (Pubitemid 30119906)
5. Chen HY, Cox SW, Eley BM, Mantyla P, Ronka H, &, Sorsa T, (2000): Matrix metalloproteinase-8 levels and elastase activities in gingival crevicular fluid from chronic adult periodontitis patients. J Clin Periodontol 27: 366-369.
6. Duhaiman AS, Gorban AM, Shoukrey N, &, Tabbara KF, (1988): Biochemical analysis of climatic droplet keratopathy. Saudi Bull Ophthalmol 2: 147-149.
7. Dursun D, Kim MC, Solomon A, &, Pflugfelder SC, (2001): Treatment of recalcitrant recurrent corneal erosions with inhibitors of matrix metalloproteinase-9, doxycycline and corticosteroids. Am J Ophthalmol 132: 8-13. (Pubitemid 32600883)
8. Fini ME, Parks WC, Rinehart WB, et al., (1996): Role of matrix metalloproteinases in failure to re-epithelialize after corneal injury. Am J Pathol 149: 1287-1302. (Pubitemid 26337246)
9. Garner A, Morgan G, &, Tripathi RC, (1973): Climate dropley keratopathy. II. Pathologic findings. Arch Ophthalmol 89: 198-204.
10. Girard MT, Matsubara M, Kublin C, Tessier MJ, Cintron C, &, Fini ME, (1993): Stromal fibroblasts synthesize collagenase and stromelysin during long-term tissue remodeling. J Cell Sci 104 (Pt 4): 1001-1011. (Pubitemid 23154307)
11. Golub LM, Lee HM, Ryan ME, Giannobile WV, Payne J, &, Sorsa T, (1998): Tetracyclines inhibit connective tissue breakdown by multiple non-antimicrobial mechanisms. Adv Dent Res 12: 12-26.
12. Gray RH, Johnson GJ, &, Freedman A, (1992): Climatic droplet keratopathy. Surv Ophthalmol 36: 241-253.
13. Gueders MM, Balbin M, Rocks N, et al., (2005): Matrix metalloproteinase-8 deficiency promotes granulocytic allergen-induced airway inflammation. J Immunol 175: 2589-2597. (Pubitemid 41113872)
14. Gutierrez-Fernandez A, Inada M, Balbin M, et al., (2007): Increased inflammation delays wound healing in mice deficient in collagenase-2 (MMP-8). FASEB J 21: 2580-2591. (Pubitemid 47230686)
15. Hanemaaijer R, Sorsa T, Konttinen YT, et al., (1997): Matrix metalloproteinase-8 is expressed in rheumatoid synovial fibroblasts and endothelial cells. Regulation by tumor necrosis factor-alpha and doxycycline. J Biol Chem 272: 31504-31509. (Pubitemid 28013291)
16. Heikkila P, Suojanen J, Pirila E, Vaananen A, Koivunen E, Sorsa T, &, Salo T, (2006): Human tongue carcinoma growth is inhibited by selective antigelatinolytic peptides. Int J Cancer 118: 2202-2209.
17. Holopainen JM, Moilanen JA, Sorsa T, Kivela-Rajamaki M, Tervahartiala T, Vesaluoma MH, &, Tervo TM, (2003): Activation of matrix metalloproteinase-8 by membrane type 1-MMP and their expression in human tears after photorefractive keratectomy. Invest Ophthalmol Vis Sci 44: 2550-2556. (Pubitemid 36618414)
18. Johnson GJ, &, Overall M, (1978): Histology of spheroidal degeneration of the cornea in Labrador. Br J Ophthalmol 62: 53-61. (Pubitemid 8292955)
19. Kaji Y, Nagai R, Amano S, Takazawa Y, Fukayama M, &, Oshika T, (2007): Advanced glycation end product deposits in climatic droplet keratopathy. Br J Ophthalmol 91: 85-88. (Pubitemid 46094016)
20. Kenney MC, Chwa M, Alba A, Saghizadeh M, Huang ZS, &, Brown DJ, (1998): Localization of TIMP-1, TIMP-2, TIMP-3, gelatinase A and gelatinase B in pathological human corneas. Curr Eye Res 17: 238-246. (Pubitemid 28138270)
21. Kervick GN, Pflugfelder SC, Haimovici R, Brown H, Tozman E, &, Yee R, (1992): Paracentral rheumatoid corneal ulceration. Clinical features and cyclosporine therapy. Ophthalmology 99: 80-88.
22. Koivunen E, Arap W, Valtanen H, et al., (1999): Tumor targeting with a selective gelatinase inhibitor. Nat Biotechnol 17: 768-774. (Pubitemid 29365104)
23. Kumagai N, Yamamoto K, Fukuda K, Nakamura Y, Fujitsu Y, Nuno Y, &, Nishida T, (2002): Active matrix metalloproteinases in the tear fluid of individuals with vernal keratoconjunctivitis. J Allergy Clin Immunol 110: 489-491.
24. Labermeier U, &, Kenney MC, (1983): The presence of EC collagen and type IV collagen in bovine Descemet's membranes. Biochem Biophys Res Commun 116: 619-625. (Pubitemid 14242782)
25. Matsubara M, Girard MT, Kublin CL, Cintron C, &, Fini ME, (1991): Differential roles for two gelatinolytic enzymes of the matrix metalloproteinase family in the remodelling cornea. Dev Biol 147: 425-439. (Pubitemid 121003872)
26. McMillan SJ, Kearley J, Campbell JD, et al., (2004): Matrix metalloproteinase-9 deficiency results in enhanced allergen-induced airway inflammation. J Immunol 172: 2586-2594. (Pubitemid 38182410)
27. Menegay M, Lee D, Tabbara KF, Cafaro TA, Urrets-Zavalia JA, Serra HM, &, Bhattacharya SK, (2008): Proteomic analysis of climatic keratopathy droplets. Invest Ophthalmol Vis Sci 49: 2829-2837.
28. Millin JA, Golub BM, &, Foster CS, (1986): Human basement membrane components of keratoconus and normal corneas. Invest Ophthalmol Vis Sci 27: 604-607. (Pubitemid 16116309)
29. Owen CA, Hu Z, Lopez-Otin C, &, Shapiro SD, (2004): Membrane-bound matrix metalloproteinase-8 on activated polymorphonuclear cells is a potent, tissue inhibitor of metalloproteinase-resistant collagenase and serpinase. J Immunol 172: 7791-7803. (Pubitemid 38747647)
30. Pflugfelder SC, Farley W, Luo L, Chen LZ, de Paiva CS, Olmos LC, Li DQ, &, Fini ME, (2005): Matrix metalloproteinase-9 knockout confers resistance to corneal epithelial barrier disruption in experimental dry eye. Am J Pathol 166: 61-71. (Pubitemid 40051660)
31. Prikk K, Maisi P, Pirila E, Sepper R, Salo T, Wahlgren J, &, Sorsa T, (2001): In vivo collagenase-2 (MMP-8) expression by human bronchial epithelial cells and monocytes/macrophages in bronchiectasis. J Pathol 194: 232-238.
32. Ren H, &, Wilson G, (1994): The effect of ultraviolet-B irradiation on the cell shedding rate of the corneal epithelium. Acta Ophthalmol (Copenh) 72: 447-452. (Pubitemid 24302812)
33. Rodger FC, Cuthill JA, Fydelor PJ, &, Lenham AP, (1974): Ultra-violet radiation as a possible cause of corneal degenerative changes under certain physiographic conditions. Acta Ophthalmol (Copenh) 52: 777-785.
34. Saari H, Suomalainen K, Lindy O, Konttinen YT, &, Sorsa T, (1990): Activation of latent human neutrophil collagenase by reactive oxygen species and serine proteases. Biochem Biophys Res Commun 171: 979-987. (Pubitemid 20318046)
35. Saika S, Kawashima Y, Okada Y, Tanaka SI, Yamanaka O, Ohnishi Y, &, Ooshima A, (1998): Recombinant TIMP-1 and -2 enhance the proliferation of rabbit corneal epithelial cells in vitro and the spreading of rabbit corneal epithelium in situ. Curr Eye Res 17: 47-52. (Pubitemid 28039667)
36. Sakimoto T, Shoji J, &, Sawa M, (2003): Active form of gelatinases in tear fluidin patients with corneal ulcer or ocular burn. Jpn J Ophthalmol 47: 423-426. (Pubitemid 37102819)
37. Sakimoto T, Shoji J, Kanno H, &, Sawa M, (2004): Gelatinase expression in ocular surface disorders. Jpn J Ophthalmol 48: 17-22. (Pubitemid 38181925)
38. Sivak JM, &, Fini ME, (2002): MMPs in the eye: emerging roles for matrix metalloproteinases in ocular physiology. Prog Retin Eye Res 21: 1-14. (Pubitemid 34242704)
39. Smith VA, Hoh HB, &, Easty DL, (1999): Role of ocular matrix metalloproteinases in peripheral ulcerative keratitis. Br J Ophthalmol 83: 1376-1383.
40. Smith VA, Rishmawi H, Hussein H, &, Easty DL, (2001): Tear film MMP accumulation and corneal disease. Br J Ophthalmol 85: 147-153. (Pubitemid 32146751)
41. Sobrin L, Liu Z, Monroy DC, Solomon A, Selzer MG, Lokeshwar BL, &, Pflugfelder SC, (2000): Regulation of MMP-9 activity in human tear fluid and corneal epithelial culture supernatant. Invest Ophthalmol Vis Sci 41: 1703-1709. (Pubitemid 30354340)
42. Solomon A, Li DQ, Lee SB, &, Tseng SC, (2000): Regulation of collagenase, stromelysin, and urokinase-type plasminogen activator in primary pterygium body fibroblasts by inflammatory cytokines. Invest Ophthalmol Vis Sci 41: 2154-2163. (Pubitemid 30450987)
43. Sorsa T, &, Golub LM, (2005): Is the excessive inhibition of matrix metalloproteinases (MMPs) by potent synthetic MMP inhibitors (MMPIs) desirable in periodontitis and other inflammatory diseases? That is: 'Leaky' MMPIs vs excessively efficient drugs. Oral Dis 11: 408-409. (Pubitemid 41727242)
44. Taylor HR, West SK, Rosenthal FS, Munoz B, Newland HS, &, Emmett EA, (1989): Corneal changes associated with chronic UV irradiation. Arch Ophthalmol 107: 1481-1484. (Pubitemid 19247253)
45. Urrets-Zavalia JA, Knoll EG, Maccio JP, Urrets-Zavalia EA, Saad JA, &, Serra HM, (2006): Climatic droplet keratopathy in the Argentine Patagonia. Am J Ophthalmol 141: 744-746.
46. Urrets-Zavalia JA, Maccio JP, Knoll EG, Cafaro T, Urrets-Zavalia EA, &, Serra HM, (2007): Surface alterations, corneal hypoesthesia, and iris atrophy in patients with climatic droplet keratopathy. Cornea 26: 800-804. (Pubitemid 47220550)
47. Wilson SE, Mohan RR, Ambrosio R Jr, Hong J, &, Lee J, (2001): The corneal wound healing response: cytokine-mediated interaction of the epithelium, stroma, and inflammatory cells. Prog Retin Eye Res 20: 625-637. (Pubitemid 32695343)
48. Ye HQ, Maeda M, Yu FS, &, Azar DT, (2000): Differential expression of MT1-MMP (MMP-14) and collagenase III (MMP-13) genes in normal and wounded rat corneas. Invest Ophthalmol Vis Sci 41: 2894-2899.