Effects of epidural opioid analgesics on heart rate, arterial blood pressure, respiratory rate, body temperature, and behavior in horses

Veterinary Therapeutics

Volumn 4, Issue 4, 2003, Pages

  Natalini, Claudio ^a   Robinson, Elaine ^a   Donovan, Liz ^a  

^a Brazilian Federal Government Postgraduate Agency (CAPES)   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

EQUIDAE;

EID: 79251471136     PISSN: 15283593     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (43)

1. Pape J, Pitzschk C: Versuche uber extradurale Anasthesie beim pferde. Arch Wiss Prakt Tierheilkd 52:558-571, 1925.
2. McLeod WM, Frank ER: A preliminary report regarding epidural anesthesia in equines and bovines. JAVMA 72:327-335, 1927.
3. Valverde A, Little CB, Dyson DH: Use of epidural morphine to relieve pain in a horse. Can Vet J 31:211-212, 1990.
4. Skarda RT: Local and regional anesthetic and analgesic techniques, in Thurmon JC, William JT, Ben-son GJ (eds): Lumb & Jones' Veterinary Anesthesia, ed 3. Baltimore, Williams & Wilkins, 1996, pp 448-478.
5. Gãmez de Segura IA, De Rossi R, Santos M, et al: Epidural injection of ketamine for perineal analgesia in the horse. Vet Surg 27:384-391, 1998.
6. Cousins MJ, Mather LE: Intrathecal and epidural administration of opioids. Anesthesiology 61:276-310, 1984.
7. Skarda RT, Muir WW: Comparison of antinociceptive, cardiovascular, and respiratory effects, head ptosis, and position of pelvic limbs in mares after caudal epidural administration of xylazine and detomidine hydrochloride solution. Am J Vet Res 57:1338-1345, 1996.
8. Cheng JK, Pan MH, Wu KH, et al: Epidural phenylephrine attenuates hypotension induced by alkalinized lidocaine epidural anesthesia. Anesth Analg 88:1322-1326, 1999.
9. LeBlanc PH, Caron JP: Clinical use of epidural xylazine in the horse. Equine Vet J 22:180-181, 1990.
10. LeBlanc PH, Eberhart SW: Cardiopulmonary effects of epidurally administered xylazine in the horse. Equine Vet J 22:389-391, 1990.
11. Grubb TL, Riebold TW, Huber MJ: Comparison of lidocaine, xylazine, and xylazine/lidocaine for caudal epidural analgesia in horses. JAVMA 201:1187-1190, 1992.
12. Skarda RT, Muir WW: Caudal analgesia induced by epidural or subarachnoid administration of detomidine hydrochloride solution in mares. Am J Vet Res 55:670-680, 1994.
13. Wittern C, Hendrickson DA, Trumble T, et al: Complications associated with administration of detomidine into the caudal epidural space in a horse. JAVMA 213:516-518, 1998.
14. Aimone LD: Neurchemistry and modulation of pain, in Sinatra RS, Hord AH, Ginsberg B, Peeble LM (eds): Acute Pain: Mechanisms and Management. St Louis, Mosby, 1992, pp 102-111.
15. Stoelting RK: Pharmacology and Physiology in Anesthetic Practice, ed 3. Philadelphia, Lippincott-Raven Publishers, 1999, pp 77-112.
16. Chung JH, Harris SN: Common side effects associated with spinal opioids and their treatment, in Sinatra RS, Hord AH, Ginsberg B, et al (eds): Acute Pain: Mechanisms and Management. St Louis, Mosby, 1992, pp 279-292.
17. Robinson EP, Moncada-Suarez JR, Felice L: Epidural morphine analgesia in horses [Abstract]. Vet Surf 23:78, 1994.
18. Paddleford RR: Manual of Small Animal Anesthesia, ed 2. Philadelphia, WB Saunders, 1999, pp 227-246.
19. Skarda, RT. Local and regional anesthetic and analgesic techniques, in Thurmon JC, William JT, Benson GJ (eds): Lumb & Jones' Veterinary Anesthesia, ed 3. Baltimore, Williams & Wilkins, 1996, pp 183-209.
20. Pablo LS: Epidural morphine in goats after hindlimb orthopedic surgery. Vet Surg 22:141-147, 1993.
21. Tobin T, Miller JR: The pharmacology of narcotic analgesics in the horse. I. The detection, pharmacokinetics and urinary clearance times of pentazocine. J Equine Med Surg 3:191-198, 1979.
22. Tobin T: Narcotic analgesics and the opiate receptor in the horse. J Equine Med Surg 2:397-399, 1978.
23. Combie J, Dougherty J, Nugent CE, et al: The pharmacology of narcotic analgesics in the horse. IV. Dose and time response relationships for behavioral responses to morphine, meperidine, pentazocine, anileridine, methadone, and hydromorphone. J Equine Med Surg 3:377-385, 1979.
24. Tobin T: Drugs and the Performance Horse. Springfield, IL, Charles C. Thomas, 1981, pp 199-215.
25. Karmerling S, DeQuick D, Weckman T, et al: Dose-related effects of fentanyl on autonomic and behavioral responses in performance horses. Gen Pharmacol 16:253-258, 1985.
26. Tobin T, Combie J, Shults T: II. Pharmacology review: Actions of central stimulant drugs in the horse. J Equine Med Surg 3:102-109, 1979.
27. Tobin T, Combie J, Shults T, et al: The pharmacology of narcotic analgesics in the horse. III. Characteristics of the locomotor effects of fentanyl and apomorphine. J Equine Med Surg 3:284-288, 1979.
28. Combie J, Shults T, Nugent EC, et al: Pharmacology of narcotic analgesics in the horse: Selective blockade of narcotic-induced locomotor activity. Am J Vet Res 42:716-721, 1981.
29. Natalini CC, Robinson EP: Comparative evaluation of the analgesic effects of epidural morphine, alfentanil, butorphanol, tramadol, and U50488H in horses. Am J Vet Res 60:1569-1576, 2000.
30. Mama KR, Pascoe PJ, Steffey EP: Evaluation of the interaction of Mu and Kappa opioid agonists on locomotor behavior in the horse. Can J Vet Res 57:106-109, 1992.
31. Chaney MA: Side effects of intrathecal and epidural opioids. Can J Anesth 42:891-903, 1995.
32. Raffa RB, Friderichs E, Reimann W, et al: Opioid and nonopioid components independently contribute to the mechanism of action of tramadol, an "atypical" opioid analgesic. J Pharmacol Exp Ther 260:275-285, 1992.
33. Eggers KA, Power I: Tramadol. Brit J Anaesth 74:247-249, 1995.
34. Etches RC, Sandler AN, Lawson SL: A comparison of the analgesic and respiratory effects of epidural nalbuphine or morphine in postthoracotomy patients. Anesthesiology 75:9-14, 1991.
35. White MJ, Berghausen EJ, Dumont SW, et al: Side effects during continuous epidural infusion of morphine and fentanyl. Can J Anaesth 39:576-582, 1992.
36. Goetz AM, Rogers PL, Schlichtig R, et al: Adult respiratory distress syndrome associated with epidural fentanyl infusion. Crit Care Med 22:1579-1583
37. Muir WW, Skarda RT, Sheehan RN: Cardiopulmonary effects of narcotic agonists and a partial agonist in horses. Am J Vet Res 39:1632-1635, 1978.
38. Hubbell JAE: Monitoring, in Muir WW, Hubbell JAE (eds): Equine Anesthesia. St. Louis, Mosby, 1991, pp 157-158.
39. Balaban M, Slinger P: Severe hypotension from epidural meperidine in a high-risk patient after thoracotomy. Can J Anesth 36:450-453, 1989.
40. Masoud PJ, Green CD: Effects of massive overdose of epidural morphine sulphate. Can Anesth Soc 29:377-380, 1982.
41. Sysel AM, Pleasant SR, Jacobson JD: Efficacy of an epidural combination of morphine and detomidine in alleviating experimentally induced hindlimb lameness in horses. Vet Surg 25:511-518, 1996.
42. Karmeling S, Weckman T, Donahoe J, et al: Dose related effects of the kappa agonist U-50488H on the behaviour, nociception and autonomic response in the horse. Equine Vet J 20:114-118, 1988.
43. Morgan M: The rational use of intrathecal and extradural opioids. Br J Anaesth 63:165-188, 1989.