The impact of MRI on the clinical management of inflammatory arthritides

Skeletal Radiology

Volumn 40, Issue 9, 2011, Pages 1153-1173

  Weber, Ulrich ^a,b   Ovstergaard, Mikkel ^c   Lambert, Robert G W ^a   Maksymowych, Walter P ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

^b BALGRIST UNIVERSITY HOSPITAL   (Switzerland)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Ankylosing spondylitis; Clinical management; Inflammatory back pain; Magnetic resonance imaging; Osteoarthritis; Rheumatoid arthritis; Spondyloarthritis

Indexed keywords

ADALIMUMAB; CORTICOSTEROID; GADOLINIUM; INFLIXIMAB; METHOTREXATE; NONSTEROID ANTIINFLAMMATORY AGENT; PARACETAMOL; TUMOR NECROSIS FACTOR ALPHA ANTIBODY; TUMOR NECROSIS FACTOR ALPHA INHIBITOR;

ANKYLOSING SPONDYLITIS; ARTHRITIS; BONE DESTRUCTION; BONE EROSION; BONE MARROW EDEMA; BONE RADIOGRAPHY; CLINICAL DECISION MAKING; COMPUTER ASSISTED TOMOGRAPHY; DIAGNOSTIC ACCURACY; DIAGNOSTIC VALUE; DISEASE SURVEILLANCE; DRUG EFFICACY; HISTOPATHOLOGY; HUMAN; IMAGE ANALYSIS; IMAGE PROCESSING; IMAGE QUALITY; IMMUNOREACTIVITY; JOINT FUNCTION; LOW BACK PAIN; NUCLEAR MAGNETIC RESONANCE IMAGING; OSSIFICATION; OSTEOARTHRITIS; OUTCOME ASSESSMENT; PATIENT CARE; PREDICTIVE VALUE; PRIORITY JOURNAL; PROGNOSIS; PSORIATIC ARTHRITIS; REVIEW; RHEUMATOID ARTHRITIS; SACROILIAC JOINT; SACROILIITIS; SENSITIVITY AND SPECIFICITY; SPONDYLOARTHRITIS; SYNOVITIS; SYNOVIUM;

ARTHRITIS; ARTHRITIS, RHEUMATOID; HUMANS; MAGNETIC RESONANCE IMAGING; OSTEOARTHRITIS; PREDICTIVE VALUE OF TESTS; SPONDYLARTHRITIS; SPONDYLITIS, ANKYLOSING;

EID: 80052058356     PISSN: 03642348     EISSN: 14322161     Source Type: Journal    
DOI: 10.1007/s00256-011-1204-5     Document Type: Review

References (175)

1. PC Lauterbur 1973 Image formation by induced local interactions: examples employing nuclear magnetic resonance Nature 242 190 1 1:CAS:528: DyaE3sXhs1Kqu74%3D
2. R Damadian 1971 Tumor detection by nuclear magnetic resonance Science 171 1151 3 5544870 1:STN:280:DyaE3M7hsFyitg%3D%3D
3. FM McQueen A Gao M Vstergaard A King G Shalley E Robinson, et al. 2007 High grade MRI bone oedema is common within the surgical field in rheumatoid arthritis patients undergoing joint replacement and is associated with osteitis in subchondral bone Ann Rheum Dis 66 1581 7 17491098 1:STN:280: DC%2BD2snmvValtw%3D%3D (Pubitemid 350205444)
4. E Jimenez-Boj I Noebauer-Huhmann B Hanslik-Schnabel R Dorotka AH Wanivenhaus F Kainberger, et al. 2007 Bone erosions and bone marrow edema as defined by magnetic resonance imaging reflect true bone marrow inflammation in rheumatoid arthritis Arthritis Rheum 56 1118 24 17393390 (Pubitemid 46608636)
5. H Appel C Loddenkemper Z Grozdanovic H Ebhardt M Dreimann A Hempfing, et al. 2006 Correlation of histopathological findings and magnetic resonance imaging in the spine of patients with ankylosing spondylitis Arthritis Res Ther 8 R143 16925803
6. M Bollow T Fischer A Reisshauer M Backhaus J Sieper B Hamm, et al. 2000 Quantitative analyses of sacroiliac biopsies in spondyloarthropathies: T cells and macrophages predominate in early and active sacroiliitis - cellularity correlates with the degree of enhancement detected by magnetic resonance imaging Ann Rheum Dis 59 135 40 10666170 1:STN:280:DC%2BD3c7ivFCgsQ%3D%3D (Pubitemid 30305612)
7. AG Bergman HK Willen AL Lindstrand HT Pettersson 1994 Osteoarthritis of the knee: correlation of subchondral MR signal abnormalities with histopathologic and radiographic features Skeletal Radiol 23 445 8 7992110 1:STN:280:DyaK2M%2FosVahtA%3D%3D (Pubitemid 24253953)
8. M Zanetti E Bruder J Romero J Hodler 2000 Bone marrow edema pattern in osteoarthritic knees: correlation between MR imaging and histologic findings Radiology 215 835 40 10831707 1:STN:280:DC%2BD3c3ptlCmtg%3D%3D (Pubitemid 30346026)
9. E Saadat B Jobke B Chu Y Lu J Cheng X Li, et al. 2008 Diagnostic performance of in vivo 3-T MRI for articular cartilage abnormalities in human osteoarthritic knees using histology as standard of reference Eur Radiol 18 2292 302 18491096
10. MS Taljanovic AR Graham JB Benjamin AF Gmitro EA Krupinski SA Schwartz, et al. 2008 Bone marrow edema pattern in advanced hip osteoarthritis: quantitative assessment with magnetic resonance imaging and correlation with clinical examination, radiographic findings, and histopathology Skeletal Radiol 37 423 31 18274742
11. M Rudwaleit D van der Heijde R Landewé J Listing N Akkoc J Brandt, et al. 2009 The development of Assessment of SpondyloArthritis International Society classification criteria for axial spondyloarthritis (part II): validation and final selection Ann Rheum Dis 68 777 83 19297344 1:STN:280:DC%2BD1MzjvVygug%3D%3D
12. D Aletaha T Neogi AJ Silman J Funovits DT Felson CO Bingham 3rd, et al. 2010 2010 Rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative Ann Rheum Dis 69 1580 8 20699241
13. Østergaard M. Clarification of the role of ultrasonography, magnetic resonance imaging and conventional radiography in the ACR/EULAR 2010 rheumatoid arthritis classification criteria-comment to the article by Aletaha et al. Ann Rheum Dis. 2010;e-letter published online December 2.
14. Aletaha D, Hawker G, Neogi T, Silman A. Re: Clarification of the role of ultrasonography, magnetic resonance imaging and conventional radiography in the ACR/EULAR 2010 rheumatoid arthritis classification criteria-comment to the article by Aletaha et al. Ann Rheum Dis. 2011;e-letter published online January 11.
15. DJ Hunter T Neogi MC Hochberg 2011 Quality of osteoarthritis management and the need for reform in the US Arthritis Care Res 63 31 8
16. JH Jang MM Ward AN Rucker JD Reveille JC Davis Jr MH Weisman, et al. 2011 Ankylosing spondylitis: patterns of radiographic involvement-a re-examination of accepted principles in a cohort of 769 patients Radiology 258 192 8 20971774
17. Maksymowych WP, Weber U. Diagnostic utility of MRI in early spondyloarthritis. Curr Rheum Rep. 2011;in press.
18. S Van der Linden HA Valkenburg A Cats 1984 Evaluation of diagnostic criteria for ankylosing spondylitis. A proposal for modification of the New York criteria Arthritis Rheum 27 361 8 6231933 (Pubitemid 14134775)
19. W Mau H Zeidler R Mau A Majewski J Freyschmidt W Stangel, et al. 1988 Clinical features and prognosis of patients with possible ankylosing spondylitis. Results of a 10-year followup J Rheumatol 15 1109 14 3262757 1:STN:280:DyaL1M%2FhtFOltw%3D%3D
20. M Rudwaleit H Haibel X Baraliakos J Listing E Maerker-Hermann H Zeidler, et al. 2009 The early disease stage in axial spondylarthritis. Results from the German spondyloarthritis inception cohort Arthritis Rheum 60 717 27 19248087 1:CAS:528:DC%2BD1MXktVGmsLo%3D
21. N Barkham HI Keen LC Coates P O'Connor E Hensor AD Fraser, et al. 2009 Clinical and imaging efficacy of infliximab in HLA-B27-positive patients with magnetic resonance imaging-determined early sacroiliitis Arthritis Rheum 60 946 54 19333933 1:CAS:528:DC%2BD1MXltFenu70%3D
22. H Haibel M Rudwaleit J Listing F Heldmann RL Wong H Kupper, et al. 2008 Efficacy of adalimumab in the treatment of axial spondylarthritis without radiographically defined sacroiliitis Arthritis Rheum 58 1981 91 18576337 1:CAS:528:DC%2BD1cXpt1Wku74%3D
23. AN Bennett D McGonagle P O'Connor EMA Hensor F Sivera LC Coates, et al. 2008 Severity of baseline magnetic resonance imaging-evident sacroiliitis and HLA-B27 status in early inflammatory back pain predict radiographically evident ankylosing spondylitis at eight years Arthritis Rheum 58 3413 8 18975311 1:STN:280:DC%2BD1cjis1ehsA%3D%3D
24. M Rudwaleit AG Jurik KGA Hermann R Landewé D van der Heijde X Baraliakos, et al. 2009 Defining active sacroiliitis on magnetic resonance imaging (MRI) for classification of axial spondyloarthritis: a consensual approach by the ASAS/OMERACT MRI group Ann Rheum Dis 68 1520 7 19454404 1:STN:280:DC%2BD1Mnhs1yltg%3D%3D
25. M Bollow KG Hermann T Biedermann J Sieper M Schontube J Braun 2005 Very early spondyloarthritis: where the inflammation in the sacroiliac joints starts Ann Rheum Dis 64 1644 6 16227415 1:STN:280:DC%2BD2MrkvFektA%3D%3D (Pubitemid 41532051)
26. U Weber CWA Pfirrmann RO Kissling CR MacKenzie MA Khan 2008 Early spondyloarthritis in an HLA B27-positive monozygotic twin pair: a highly concordant onset, sites of involvement, and disease course J Rheumatol 35 1464 7 18609724 (Pubitemid 352000806)
27. RGW Lambert D Salonen P Rahman RD Inman RL Wong SG Einstein, et al. 2007 Adalimumab significantly reduces both spinal and sacroiliac joint inflammation in patients with ankylosing spondylitis Arthritis Rheum 56 4005 14 18050198 1:CAS:528:DC%2BD1cXnt1Oluw%3D%3D
28. W Maksymowych SS Dhillon P Chiowchanwisawakit SJ Pedersen B Martinez M Vstergaard, et al. 2009 Development and validation of web-based training modules for systematic evaluation of active inflammatory lesions in the spine and sacroiliac joints in spondyloarthritis J Rheumatol 36 Suppl 84 48 57
29. CE Althoff E Feist E Burova I Eshed M Bollow B Hamm, et al. 2009 Magnetic resonance imaging of active sacroiliitis: do we really need gadolinium? Eur J Radiol 71 232 6 19446974
30. KB Madsen N Egund AG Jurik 2010 Grading of inflammatory disease activity in the sacroiliac joints with magnetic resonance imaging: comparison between short tau inversion recovery and gadolinium contrast-enhanced sequences J Rheumatol 37 393 400 20032094
31. X Baraliakos KG Hermann R Landewe J Listing W Golder J Brandt, et al. 2005 Assessment of acute spinal inflammation in patients with ankylosing spondylitis by magnetic resonance imaging: a comparison between contrast enhanced T1 and short tau inversion recovery (STIR) sequences Ann Rheum Dis 64 1141 4 15650011 1:STN:280:DC%2BD2MzmtVehsg%3D%3D (Pubitemid 41113347)
32. KB Madsen AG Jurik 2010 Magnetic resonance imaging grading system for active and chronic spondylarthritis changes in the sacroiliac joint Arthritis Care Res 62 11 8
33. O Algin G Gokalp G Ocakoglu 2010 Evaluation of bone cortex and cartilage of spondyloarthropathic sacroiliac joint: efficiency of different fat-saturated MRI sequences (T1-weighted, 3D-FLASH, and 3D-DESS) Acad Radiol 17 1292 8 20621525
34. Weber U, Pedersen SJ, Hodler J, Vstergaard M, Lambert RGW, Maksymowych WP. Does fat infiltration in the sacroiliac joint contribute to the diagnostic utility of MRI in ankylosing spondylitis? Arthritis Rheum. 2009;60(suppl 10):54 [abstract].
35. J Braun M Bollow U Eggens H Koenig A Distler J Sieper 1994 Use of dynamic magnetic resonance imaging with fast imaging in the detection of early and advanced sacroiliitis in spondylarthropathy patients Arthritis Rheum 37 1039 45 8024613 1:STN:280:DyaK2c3ps1CmsA%3D%3D (Pubitemid 24222095)
36. JG Hanly MJ Mitchell DC Barnes L MacMillan 1994 Early recognition of sacroiliitis by magnetic resonance imaging and single photon emission computed tomography J Rheumatol 21 2088 95 7869315 1:STN:280:DyaK2M7ntl2jtg%3D%3D (Pubitemid 24352357)
37. M Bollow J Braun B Hamm U Eggens A Schilling H Koenig, et al. 1995 Early sacroiliitis in patients with spondyloarthropathy: evaluation with dynamic gadolinium-enhanced MR imaging Radiology 194 529 36 7824736 1:STN:280: DyaK2M7isFagsQ%3D%3D
38. U Blum C Buitrago-Tellez A Mundinger T Krause J Laubenberger P Vaith, et al. 1996 Magnetic resonance imaging (MRI) for detection of active sacroiliitis-a prospective study comparing conventional radiography, scintigraphy, and contrast enhanced MRI J Rheumatol 23 2107 15 8970049 1:STN:280: DyaK2s7isV2ntw%3D%3D (Pubitemid 27006759)
39. KB Puhakka AG Jurik N Egund B Schiottz-Christensen K Stengaard-Pedersen G van Overeem Hansen, et al. 2003 Imaging of sacroiliitis in early seronegative spondylarthropathy. Assessment of abnormalities by MRI in comparison with radiography and CT Acta Radiol 44 218 29 12694111
40. M Rudwaleit D van der Heijde MA Khan J Braun J Sieper 2004 How to diagnose axial spondyloarthritis early Ann Rheum Dis 63 535 43 15082484 1:STN:280:DC%2BD2c7osFSjtQ%3D%3D (Pubitemid 38530197)
41. U Weber RGW Lambert M Vstergaard J Hodler SJ Pedersen WP Maksymowych 2010 The diagnostic utility of magnetic resonance imaging in spondylarthritis. An international multicenter evaluation of one hundred eighty-seven subjects Arthritis Rheum 62 3048 58 20496416
42. U Weber RGW Lambert SJ Pedersen J Hodler M Vstergaard WP Maksymowych 2010 Assessment of structural lesions in sacroiliac joints enhances diagnostic utility of magnetic resonance imaging in early spondylarthritis Arthritis Care Res (Hoboken) 62 1763 71
43. WP Maksymowych RD Inman D Salonen SS Dhillon M Williams M Stone, et al. 2005 Spondyloarthritis Research Consortium of Canada magnetic resonance imaging index for assessment of sacroiliac joint inflammation in ankylosing spondylitis Arthritis Rheum (Arthritis Care Res) 53 703 9 (Pubitemid 41463835)
44. WP Maksymowych SS Dhillon P Chiowchanwisawakit SJ Pedersen B Martinez M Vstergaard, et al. 2009 Development and validation of web-based training modules for systematic evaluation of active inflammatory lesions in the spine and sacroiliac joints in spondyloarthritis J Rheumatol 36 suppl 84 48 57
45. RGW Lambert SJ Pedersen WP Maksymowych P Chiowchanwisawakit M Vstergaard 2009 Active inflammatory lesions detected by magnetic resonance imaging in the spine of patients with spondyloarthritis-definitions, assessment system, and reference image set J Rheumatol 36 suppl 84 3 17
46. M Vstergaard WP Maksymowych SJ Pedersen P Chiowchanwisawakit RGW Lambert 2009 Structural lesions detected by magnetic resonance imaging in the spine of patients with spondyloarthritis-definitions, assessment system, and reference image set J Rheumatol 36 suppl 84 18 34
47. SJ Pedersen M Vstergaard P Chiowchanwisawakit RGW Lambert WP Maksymowych 2009 Validation of definitions for active inflammatory lesions detected by magnetic resonance imaging in the spine of patients with spondyloarthritis J Rheumatol 36 suppl 84 35 8
48. P Chiowchanwisawakit M Vstergaard SJ Pedersen RGW Lambert B Conner-Spady WP Maksymowych 2009 Validation of definitions for structural lesions detected by magnetic resonance imaging in the spine of patients with spondyloarthritis J Rheumatol 36 suppl 84 39 47
49. U Weber J Hodler RA Kubik K Rufibach RGW Lambert RO Kissling, et al. 2009 Sensitivity and specificity of spinal inflammatory lesions assessed by whole-body magnetic resonance imaging in patients with ankylosing spondylitis or recent-onset inflammatory back pain Arthritis Rheum (Arthritis Care Res) 61 900 8
50. AN Bennett A Rehman EMA Hensor H Marzo-Ortega P Emery D McGonagle 2009 Evaluation of the diagnostic utility of spinal magnetic resonance imaging in axial spondylarthritis Arthritis Rheum 60 1331 41 19404934 1:STN:280: DC%2BD1MzkvFalsg%3D%3D
51. AN Bennett A Rehman EMA Hensor H Marzo-Ortega P Emery D McGonagle 2010 The fatty Romanus lesion: a non-inflammatory spinal MRI lesion specific for axial spondyloarthropathy Ann Rheum Dis 69 891 4 19666937 1:STN:280: DC%2BC3c3otFSiug%3D%3D
52. WJ Rennie SS Dhillon B Conner-Spady WP Maksymowych RGW Lambert 2009 MRI assessment of spinal inflammation in ankylosing spondylitis: standard clinical protocols may omit inflammatory lesions in thoracic vertebrae Arthritis Rheum 61 1187 93 19714609
53. WP Maksymowych SM Crowther SS Dhillon B Conner-Spady RGW Lambert 2010 Systematic assessment of inflammation by magnetic resonance imaging in the posterior elements of the spine in ankylosing spondylitis Arthritis Care Res (Hoboken) 62 4 10
54. U Weber WP Maksymowych AG Jurik CWA Pfirrmann K Rufibach RO Kissling, et al. 2009 Validation of whole-body against conventional magnetic resonance imaging for scoring acute inflammatory lesions in the sacroiliac joints of patients with spondylarthritis Arthritis Rheum (Arthritis Care Res) 61 893 9
55. U Weber J Hodler AG Jurik CWA Pfirrmann K Rufibach RO Kissling, et al. 2010 Assessment of active spinal inflammatory changes in patients with axial spondyloarthritis: validation of whole body MRI against conventional MRI Ann Rheum Dis 69 648 53 19416801
56. M Rudwaleit S Schwarzlose ES Hilgert J Listing J Braun J Sieper 2008 MRI in predicting a major clinical response to anti-tumour necrosis factor treatment in ankylosing spondylitis Ann Rheum Dis 67 1276 81 18006539 1:STN:280:DC%2BD1crhtlWjtA%3D%3D
57. YF Wang MMH Teng CY Chang HT Wu ST Wang 2005 Imaging manifestations of spinal fractures in ankylosing spondylitis Am J Neuroradiol 26 2067 76 16155161
58. MP Koivikko MJ Kiuru SK Koskinen 2004 Multidetector computed tomography of cervical spine fractures in ankylosing spondylitis Acta Radiol 7 751 9 (Pubitemid 44112714)
59. LA Westerveld JJ Verlaan FC Oner 2009 Spinal fractures in patients with ankylosing spinal disorders: a systematic review of the literature on treatment, neurological status and complications Eur Spine J 18 145 56 18791749 1:STN:280:DC%2BD1M7ht1Gguw%3D%3D
60. X Baraliakos J Listing M Rudwaleit J Sieper J Braun 2008 The relationship between inflammation and new bone formation in patients with ankylosing spondylitis Arthritis Res Ther 10 R104 18761747
61. D Van der Heijde R Landewé X Baraliakos K Hermann H Houben B Hsu, et al. 2008 MRI-inflammation of the vertebral unit (vu) only marginally contributes to new syndesmophyte formation in that unit: a multi-level analysis Ann Rheum Dis 67 Suppl II 130 [abstract]
62. WP Maksymowych P Chiowchanwisawakit T Clare SJ Pedersen M Vstergaard RGW Lambert 2009 Inflammatory lesions of the spine on magnetic resonance imaging predict the development of new syndesmophytes in ankylosing spondylitis: evidence of a relationship between inflammation and new bone formation Arthritis Rheum 60 93 102 19116919
63. L Heuft-Dorenbosch R Landewé R Weijers A Wanders H Houben S van der Linden, et al. 2006 Combining information obtained from magnetic resonance imaging and conventional radiographs to detect sacroiliitis in patients with recent-onset inflammatory back pain Ann Rheum Dis 65 804 8 16219703 1:STN:280:DC%2BD283mslCgug%3D%3D (Pubitemid 43799182)
64. H König J Sieper KJ Wolf 1990 Rheumatoid arthritis: evaluation of hypervascular and fibrous pannus with dynamic MR imaging enhanced with Gd-DTPA Radiology 176 473 7 2367663 (Pubitemid 20225139)
65. M Vstergaard M Stoltenberg P Løvgreen-Nielsen B Volck CH Jensen I Lorenzen 1997 Magnetic resonance imaging-determined synovial membrane and joint effusion volumes in rheumatoid arthritis and osteoarthritis: comparison with the macroscopic and microscopic appearance of the synovium Arthritis Rheum 40 1856 67 9336422 (Pubitemid 27452538)
66. M Vstergaard M Stoltenberg P Løvgreen-Nielsen B Volck S Sonne-Holm I Lorenzen 1998 Quantification of synovitis by MRI: correlation between dynamic and static gadolinium-enhanced magnetic resonance imaging and microscopic and macroscopic signs of synovial inflammation Magn Reson Imaging 16 743 54 9811140 (Pubitemid 28496571)
67. B Ostendorf R Peters P Dann A Becker A Scherer F Wedekind, et al. 2001 Magnetic resonance imaging and miniarthroscopy of metacarpophalangeal joints: sensitive detection of morphologic changes in rheumatoid arthritis Arthritis Rheum 44 2492 502 11710705 1:STN:280:DC%2BD3MnmsFekug%3D%3D (Pubitemid 33049327)
68. D Perry N Stewart N Benton E Robinson S Yeoman J Crabbe, et al. 2005 Detection of erosions in the rheumatoid hand; a comparative study of multidetector computerized tomography versus magnetic resonance scanning J Rheumatol 32 256 67 15693085 (Pubitemid 40209123)
69. U Døhn BJ Ejbjerg M Court-Payen M Hasselquist E Narvestad M Szkudlarek, et al. 2006 Are bone erosions detected by magnetic resonance imaging and ultrasonography true erosions? A comparison with computed tomography in rheumatoid arthritis metacarpophalangeal joints Arthritis Res Ther 8 R110 16848914
70. U Døhn BJ Ejbjerg M Hasselquist E Narvestad J Møller HS Thomsen, et al. 2008 Detection of bone erosions in rheumatoid arthritis wrist joints with magnetic resonance imaging, computed tomography and radiography Arthritis Res Ther 10 R25 18307764
71. UM Døhn B Ejbjerg A Boonen ML Hetland MS Hansen LS Knudsen, et al. 2011 No overall progression and occasional repair of erosions despite persistent inflammation in adalimumab-treated rheumatoid arthritis patients: results from a longitudinal comparative MRI, ultrasonography, CT and radiography study Ann Rheum Dis 70 252 8 20980282
72. A Savnik H Malmskov HS Thomsen T Bretlau LB Graff H Nielsen, et al. 2001 MRI of the arthritic small joints: comparison of extremity MRI (0.2 T) vs high-field MRI (1.5 T) Eur Radiol 11 1030 8 11419149 1:STN:280: DC%2BD38%2FhsVentA%3D%3D (Pubitemid 32755570)
73. H Lindegaard J Vallø K Hørslev-Petersen P Junker M Vstergaard 2001 Low field dedicated magnetic resonance imaging in untreated rheumatoid arthritis of recent onset Ann Rheum Dis 60 770 6 11454641 1:STN:280:DC%2BD3Mvgt1yjtQ%3D%3D (Pubitemid 32685878)
74. JV Crues FG Shellock S Dardashti TW James OM Troum 2004 Identification of wrist and metacarpophalangeal joint erosions using a portable magnetic resonance imaging system compared to conventional radiographs J Rheumatol 31 676 85 15088291 (Pubitemid 38451252)
75. B Taouli S Zaim CG Peterfy JA Lynch A Stork A Guermazi, et al. 2004 Rheumatoid arthritis of the hand and wrist: comparison of three imaging techniques AJR Am J Roentgenol 182 937 43 15039167 (Pubitemid 38391654)
76. BJ Ejbjerg E Narvestad S Jacobsen HS Thomsen M Vstergaard 2005 Optimised, low cost, low field dedicated extremity MRI is highly specific and sensitive for synovitis and bone erosions in rheumatoid arthritis wrist and finger joints: comparison with conventional high field MRI and radiography Ann Rheum Dis 64 1280 7 15650012 1:STN:280:DC%2BD2MvjtFKitA%3D%3D (Pubitemid 41206243)
77. TS Chen JV Crues III M Ali OM Troum 2006 Magnetic resonance imaging is more sensitive than radiographs in detecting change in size of erosions in rheumatoid arthritis J Rheumatol 33 1957 67 16881098 (Pubitemid 44571867)
78. C Schirmer AK Scheel CE Althoff T Schink I Eshed A Lembcke, et al. 2007 Diagnostic quality and scoring of synovitis, tenosynovitis and erosions in low-field MRI of patients with rheumatoid arthritis: A comparison with conventional MRI Ann Rheum Dis 66 522 9 17068069 (Pubitemid 46580475)
79. JE Freeston PG Conaghan S Dass E Vital EM Hensor SP Stewart, et al. 2007 Does extremity-MRI improve erosion detection in severely damaged joints? A study of long-standing rheumatoid arthritis using three imaging modalities Ann Rheum Dis 66 1538 40 17666445 1:STN:280:DC%2BD2sngvFahuw%3D%3D (Pubitemid 350032667)
80. A Duer-Jensen A Vestergaard UM Døhn B Ejbjerg ML Hetland E Albrecht-Beste, et al. 2008 Detection of rheumatoid arthritis bone erosions by two different dedicated extremity MRI units and conventional radiography Ann Rheum Dis 67 998 1003 17984195 1:STN:280:DC%2BD1czot1Gqug%3D%3D (Pubitemid 351958418)
81. A Duer-Jensen B Ejbjerg E Albrecht-Beste A Vestergaard UM Døhn ML Hetland, et al. 2009 Does low-field dedicated extremity MRI (E-MRI) reliably detect bone erosions in rheumatoid arthritis? A comparison of two different E-MRI units and conventional radiography with high-resolution CT scanning Ann Rheum Dis 68 1296 302 18718987 1:STN:280:DC%2BD1MvosF2ltQ%3D%3D
82. M Vstergaard PG Conaghan P O'Connor M Szkudlarek M Klarlund P Emery, et al. 2009 Reducing invasiveness, duration, and cost of magnetic resonance imaging in rheumatoid arthritis by omitting intravenous contrast injection-does it change the assessment of inflammatory and destructive joint changes by the OMERACT RAMRIS? J Rheumatol 36 1806 10 19671817
83. M Vstergaard C Peterfy P Conaghan F McQueen P Bird B Ejbjerg, et al. 2003 OMERACT rheumatoid arthritis magnetic resonance imaging studies. Core set of MRI acquisitions, joint pathology definitions, and the OMERACT RA-MRI scoring system J Rheumatol 30 1385 6 12784422 (Pubitemid 36666373)
84. M Boers P Brooks CV Strand P Tugwell 1998 The OMERACT filter for outcome measures in rheumatology J Rheumatol 25 198 9 9489805 1:STN:280: DyaK1c7kvFCnuw%3D%3D
85. M Vstergaard M Klarlund M Lassere P Conaghan C Peterfy F McQueen, et al. 2001 Interreader agreement in the assessment of magnetic resonance images of rheumatoid arthritis wrist and finger joints-an international multicenter study J Rheumatol 28 1143 50 11361204 (Pubitemid 32422605)
86. P Conaghan M Lassere M Vstergaard C Peterfy F McQueen P O'Connor, et al. 2003 OMERACT rheumatoid arthritis magnetic resonance imaging studies. Exercise 4: an international multicenter longitudinal study using the RA-MRI Score J Rheumatol 30 1376 9 12784420 (Pubitemid 36666371)
87. M Lassere F McQueen M Vstergaard P Conaghan R Shnier C Peterfy, et al. 2003 OMERACT rheumatoid arthritis magnetic resonance imaging studies. Exercise 3: an international multicenter reliability study using the RA-MRI Score J Rheumatol 30 1366 75 12784419 (Pubitemid 36666370)
88. M Vstergaard P Conaghan P O'Connor BJ Ejbjerg M Szkudlarek C Peterfy, et al. 2003 Reducing costs, duration and invasiveness of magnetic resonance imaging in rheumatoid arthritis by omitting intravenous gadolinium injection-does it affect assessments of synovitis, bone erosions and bone edema? Ann Rheum Dis 62 suppl I 67 [abstract]
89. EA Haavardsholm M Vstergaard BJ Ejbjerg NP Kvan TA Uhlig FG Lilleas, et al. 2005 Reliability and sensitivity to change of the OMERACT rheumatoid arthritis magnetic resonance imaging score in a multireader, longitudinal setting Arthritis Rheum 52 3860 7 16320333 (Pubitemid 41798224)
90. P Bird F Joshua M Lassere R Shnier J Edmonds 2005 Training and calibration improve inter-reader reliability of joint damage assessment using magnetic resonance image scoring and computerized erosion volume measurement J Rheumatol 32 1452 8 16078319 (Pubitemid 41113964)
91. M Vstergaard J Edmonds F McQueen C Peterfy M Lassere B Ejbjerg, et al. 2005 The EULAR-OMERACT rheumatoid arthritis MRI reference image atlas Ann Rheum Dis 64 suppl 1 i2 55
92. EA Haavardsholm M Vstergaard BJ Ejbjerg NP Kvan T Kvien 2007 Introduction of a novel magnetic resonance imaging tenosynovitis score for rheumatoid arthritis: reliability in a multireader longitudinal study Ann Rheum Dis 66 1216 20 17392347 (Pubitemid 47309740)
93. Vstergaard M, Bøyesen P, Eshed I, Gandjbakhch F, Lillegraven S, Bird P, et al. Development and preliminary validation of an MRI joint space narrowing score for use in rheumatoid arthritis: a potential adjunct to the OMERACT RA MRI scoring system. J Rheumatol. 2011;in press.
94. MA Quinn PG Conaghan PJ O'Connor Z Karim A Greenstein A Brown, et al. 2005 Very early treatment with infliximab in addition to methotrexate in early, poor-prognosis rheumatoid arthritis reduces magnetic resonance imaging evidence of synovitis and damage, with sustained benefit after infliximab withdrawal: results from a twelve-month randomized, double-blind, placebo-controlled trial Arthritis Rheum 52 27 35 15641102 1:CAS:528:DC%2BD2MXht1KisLY%3D (Pubitemid 40129229)
95. AK Zikou MI Argyropoulou PV Voulgari VG Xydis SN Nikas SC Efremidis, et al. 2006 Magnetic resonance imaging quantification of hand synovitis in patients with rheumatoid arthritis treated with adalimumab J Rheumatol 33 219 23 16465650 1:CAS:528:DC%2BD28XhvFOntrk%3D (Pubitemid 43209294)
96. MI Argyropoulou A Glatzouni PV Voulgari VG Xydis SN Nikas SC Efremidis, et al. 2005 Magnetic resonance imaging quantification of hand synovitis in patients with rheumatoid arthritis treated with infliximab Joint Bone Spine 72 557 61 16376805 (Pubitemid 41821416)
97. UM Døhn H Skjødt ML Hetland A Vestergaard JM Møller LS Knudsen, et al. 2007 No erosive progression revealed by MRI in rheumatoid arthritis patients treated with etanercept, even in patients with persistent MRI and clinical signs of joint inflammation Clin Rheumatol 26 1857 61 17332974 (Pubitemid 47520446)
98. M Vstergaard A Duer H Nielsen JS Johansen E Narvestad BJ Ejbjerg, et al. 2005 Magnetic resonance imaging for accelerated assessment of drug effect and prediction of subsequent radiographic progression in rheumatoid arthritis: a study of patients receiving combined anakinra and methotrexate treatment Ann Rheum Dis 64 1503 6 15778238 (Pubitemid 41623866)
99. MP Lisbona J Maymo J Perich M Almirall C Perez-Garcia J Carbonell 2008 Etanercept reduces synovitis as measured by magnetic resonance imaging in patients with active rheumatoid arthritis after only 6 weeks J Rheumatol 35 394 7 18203329 1:CAS:528:DC%2BD1cXksFKjsbc%3D (Pubitemid 351374410)
100. UM Døhn M Vstergaard P Bird A Boonen SJ Johansen JM Møller, et al. 2009 Tendency towards erosive regression on magnetic resonance imaging at 12 months in rheumatoid arthritis patients treated with rituximab Ann Rheum Dis 68 1072 3 19435723
101. EA Haavardsholm M Vstergaard HB Hammer P Bøyesen A Boonen D van der Heijde, et al. 2009 Monitoring anti-TNFalpha treatment in rheumatoid arthritis: responsiveness of magnetic resonance imaging and ultrasonography of the dominant wrist joint compared with conventional measures of disease activity and structural damage Ann Rheum Dis 68 1572 9 19019893 1:CAS:528: DC%2BD1MXhtlKqtbnL
102. M Vstergaard M Stoltenberg O Henriksen I Lorenzen 1996 Quantitative assessment of synovial inflammation by dynamic gadolinium-enhanced magnetic resonance imaging. A study of the effect of intra-articular methylprednisolone on the rate of early synovial enhancement Br J Rheumatol 35 50 9 8624624
103. O Kubassova 2007 Automatic segmentation of blood vessels from dynamic MRI datasets Med Image Comput Comput Assist Interv 10 593 600 18051107
104. OA Kubassova RD Boyle A Radjenovic 2007 Quantitative analysis of dynamic contrast-enhanced MRI datasets of the metacarpophalangeal joints Acad Radiol 14 1189 200 17889336 (Pubitemid 47418695)
105. RJ Hodgson S Connolly T Barnes B Eyes RS Campbell R Moots 2007 Pharmacokinetic modeling of dynamic contrast-enhanced MRI of the hand and wrist in rheumatoid arthritis and the response to anti-tumor necrosis factor-alpha therapy Magn Reson Med 58 482 9 17763341 1:CAS:528:DC%2BD2sXhtFaku7rE (Pubitemid 350154958)
106. RJ Hodgson T Barnes S Connolly B Eyes RS Campbell R Moots 2008 Changes underlying the dynamic contrast-enhanced MRI response to treatment in rheumatoid arthritis Skeletal Radiol 37 201 7 18058095
107. EE Tripoliti DI Fotiadis M Argyropoulou 2007 Automated segmentation and quantification of inflammatory tissue of the hand in rheumatoid arthritis patients using magnetic resonance imaging data Artif Intell Med 40 65 85 17399962 (Pubitemid 46783423)
108. FM McQueen N Stewart J Crabbe E Robinson S Yeoman PL Tan, et al. 1999 Magnetic resonance imaging of the wrist in early rheumatoid arthritis reveals progression of erosions despite clinical improvement Ann Rheum Dis 58 156 63 10364913 1:STN:280:DyaK1M3ptlantQ%3D%3D (Pubitemid 29172571)
109. M Vstergaard 1999 Magnetic resonance imaging in rheumatoid arthritis. Quantitative methods for assessment of the inflammatory process in peripheral joints Dan Med Bull 46 313 44 10514940
110. M Klarlund M Vstergaard KE Jensen JL Madsen H Skjødt I Lorenzen 2000 Magnetic resonance imaging, radiography, and scintigraphy of the finger joints: one year follow up of patients with early arthritis Ann Rheum Dis 59 521 8 10873961 1:STN:280:DC%2BD3cvgtVejuw%3D%3D (Pubitemid 30445830)
111. M Backhaus GR Burmester D Sandrock D Loreck D Hess A Scholz, et al. 2002 Prospective two year follow up study comparing novel and conventional imaging procedures in patients with arthritic finger joints Ann Rheum Dis 61 895 904 12228160 1:STN:280:DC%2BD38vmvVentA%3D%3D
112. BJ Ejbjerg A Vestergaard S Jacobsen HS Thomsen M Vstergaard 2005 The smallest detectable difference and sensitivity to change of magnetic resonance imaging and radiographic scoring of structural joint damage in rheumatoid arthritis finger, wrist, and toe joints: a comparison of the OMERACT rheumatoid arthritis magnetic resonance imaging score applied to different joint combinations and the Sharp/van der Heijde radiographic score Arthritis Rheum 52 2300 6 16052593 (Pubitemid 41117413)
113. SJ Jarrett PG Conaghan VS Sloan P Papanastasiou CE Ortmann PJ O'Conner, et al. 2006 Preliminary evidence for a structural benefit of the new bisphosphonate zoledronic acid in early rheumatoid arthritis Arthritis Rheum 54 1410 4 16645968 1:CAS:528:DC%2BD28XlsFSqurg%3D
114. P Durez J Malghem TA Nzeusseu G Depresseux BR Lauwerys R Westhovens, et
115. SB Cohen RK Dore NE Lane PA Ory CG Peterfy JT Sharp, et al. 2008 Denosumab treatment effects on structural damage, bone mineral density, and bone turnover in rheumatoid arthritis: a twelve-month, multicenter, randomized, double-blind, placebo-controlled, phase II clinical trial Arthritis Rheum 58 1299 309 18438830 1:CAS:528:DC%2BD1cXms1ehu70%3D (Pubitemid 351705919)
116. M Vstergaard P Emery PG Conaghan RM Fleischmann W Xu EC Hsia, et al. 2010 Golimumab and methotrexate combination therapy significantly improves synovitis, osteitis and bone erosion compared to methotrexate alone-a magnetic resonance imaging study of methotrexate-naïve rheumatoid arthritis patients Arthritis Rheum 62 suppl S952 [abstract]
117. H Sugimoto A Takeda K Hyodoh 2000 Early stage rheumatoid arthritis: prospective study of the effectiveness of MR imaging for diagnosis Radiology 216 569 75 10924587 1:STN:280:DC%2BD3cvgslWitA%3D%3D (Pubitemid 30599883)
118. N Boutry E Hachulla RM Flipo B Cortet A Cotten 2005 MR imaging involvement of the hands in early rheumatoid arthritis: comparison with systemic lupus erythematosus and primary Sjogren syndrome Eur Radiol 15 suppl 1 262 (B-561) [abstract]
119. E Solau-Gervais JL Legrand B Cortet B Duquesnoy RM Flipo 2006 Magnetic resonance imaging of the hand for the diagnosis of rheumatoid arthritis in the absence of anti-cyclic citrullinated peptide antibodies: a prospective study J Rheumatol 33 1760 5 16832852 1:CAS:528:DC%2BD28XhtVGisrzJ (Pubitemid 44373207)
120. M Tamai A Kawakami M Uetani S Takao H Rashid F Tanaka, et al. 2006 Early prediction of rheumatoid arthritis by serological variables and magnetic resonance imaging of the wrists and finger joints: results from prospective clinical examination Ann Rheum Dis 65 134 5 16344501 1:STN:280: DC%2BD2MnmtFCmtA%3D%3D (Pubitemid 41815658)
121. A Duer M Vstergaard K Hørslev-Petersen J Vallø 2008 Magnetic resonance imaging and bone scintigraphy in the differential diagnosis of unclassified arthritis Ann Rheum Dis 67 48 51 17289759 1:STN:280: DC%2BD2sjjslKhsg%3D%3D
122. M Tamai A Kawakami M Uetani S Takao K Arima N Iwamoto, et al. 2009 A prediction rule for disease outcome in patients with undifferentiated arthritis using magnetic resonance imaging of the wrists and finger joints and serologic autoantibodies Arthritis Rheum 61 772 8 19479686 1:CAS:528:DC%2BD1MXot12rs7Y%3D
123. Duer-Jensen A, Hørslev-Petersen K, Hetland ML, Bak L, Ejbjerg B, Hansen MS, et al. MRI bone edema is an independent predictor of development of rheumatoid arthritis in patients with early undifferentiated arthritis. Arthritis Rheum. 2011;63:in press.
124. Suter LG, Fraenkel L, Braithwaite RS. The role of magnetic resonance imaging in the diagnosis and prognosis of rheumatoid arthritis. Arthritis Care Res (Hoboken). 2011;doi: 10.1002/acr.20409.
125. PM Machado R Koevoets C Bombardier D van der Heijde 2010 The value of magnetic resonance imaging and ultrasound in undifferentiated arthritis: a systematic review J Rheumatol 38 suppl 87 31 7
126. A Savnik H Malmskov HS Thomsen LB Graff H Nielsen B Danneskiold- Samsøe, et al. 2002 MRI of the wrist and finger joints in inflammatory joint diseases at 1-year interval: MRI features to predict bone erosions Eur Radiol 12 1203 10 11976868 (Pubitemid 36940192)
127. FM McQueen N Benton D Perry J Crabbe E Robinson S Yeoman, et al. 2003 Bone edema scored on magnetic resonance imaging scans of the dominant carpus at presentation predicts radiographic joint damage of the hands and feet six years later in patients with rheumatoid arthritis Arthritis Rheum 48 1814 27 12847674 (Pubitemid 36828675)
128. K Palosaari J Vuotila R Takalo A Jartti RK Niemelae A Karjalainen, et al. 2006 Bone oedema predicts erosive progression on wrist MRI in early RA-a 2-yr observational MRI and NC scintigraphy study Rheumatol (Oxford) 45 1542 8 (Pubitemid 44822018)
129. N Tanaka H Sakahashi S Ishii E Sato K Hirose T Ishima 2005 Synovial membrane enhancement and bone erosion by magnetic resonance imaging for prediction of radiologic progression in patients with early rheumatoid arthritis Rheumatol Int 25 103 7 14648111 (Pubitemid 40468929)
130. HM Lindegaard J Vallø K Hørslev-Petersen P Junker M Vstergaard 2006 Low-cost, low-field dedicated extremity magnetic resonance imaging in early rheumatoid arthritis: a 1-year follow-up study Ann Rheum Dis 65 1208 12 16540550 1:STN:280:DC%2BD28vnvFKqtA%3D%3D (Pubitemid 44277398)
131. EA Haavardsholm P Bøyesen M Vstergaard A Schildvold TK Kvien 2008 Magnetic resonance imaging findings in 84 patients with early rheumatoid arthritis: bone marrow oedema predicts erosive progression Ann Rheum Dis 67 794 800 17981915 1:STN:280:DC%2BD1czgvFSqtw%3D%3D (Pubitemid 351843277)
132. ML Hetland B Ejbjerg K Hørslev-Petersen S Jacobsen A Vestergaard AG Jurik, et al. 2009 MRI bone oedema is the strongest predictor of subsequent radiographic progression in early rheumatoid arthritis. Results from a 2-year randomised controlled trial (CIMESTRA) Ann Rheum Dis 68 384 90 18388160 1:CAS:528:DC%2BD1MXjs1WitLY%3D
133. ML Hetland K Stengaard-Pedersen P Junker M Vstergaard BJ Ejbjerg S Jacobsen, et al. 2010 Radiographic progression and remission rates in early rheumatoid arthritis-MRI bone oedema and anti-CCP predicted radiographic progression in the 5-year extension of the double-blind randomised CIMESTRA trial Ann Rheum Dis 69 1789 95 20444751 1:CAS:528:DC%2BC3cXhtlems7vJ
134. P Bøyesen EA Haavardsholm M Vstergaard D van der Heijde S Sesseng TK Kvien 2011 MRI in early rheumatoid arthritis: synovitis and bone marrow oedema are independent predictors of subsequent radiographic progression Ann Rheum Dis 70 428 33 20810395
135. P Bøyesen EA Haavardsholm D van der Heijde M Vstergaard HB Hammer S Sesseng, et al. 2011 Prediction of MRI erosive progression: a comparison of modern imaging modalities in early rheumatoid arthritis patients Ann Rheum Dis 70 176 9 21068093
136. N Benton N Stewart J Crabbe E Robinson S Yeoman FM McQueen 2004 MRI of the wrist in early rheumatoid arthritis can be used to predict functional outcome at 6 years Ann Rheum Dis 63 555 61 15082487 1:STN:280: DC%2BD2c7osFSjuw%3D%3D (Pubitemid 38530200)
137. S Zheng E Robinson S Yeoman N Stewart J Crabbe J Rouse, et al. 2006 MRI bone oedema predicts eight year tendon function at the wrist but not the requirement for orthopaedic surgery in rheumatoid arthritis Ann Rheum Dis 65 607 11 16219706 1:STN:280:DC%2BD283gsVOhsg%3D%3D
138. F McQueen V Beckley J Crabbe E Robinson S Yeoman N Stewart 2005 Magnetic resonance imaging evidence of tendinopathy in early rheumatoid arthritis predicts tendon rupture at six years Arthritis Rheum 52 744 51 15751075 (Pubitemid 40365095)
139. AK Brown MA Quinn Z Karim PG Conaghan CG Peterfy E Hensor, et al. 2006 Presence of significant synovitis in rheumatoid arthritis patients with disease-modifying antirheumatic drug-induced clinical remission: evidence from an imaging study may explain structural progression Arthritis Rheum 54 3761 73 17133543 1:CAS:528:DC%2BD2sXktlantA%3D%3D (Pubitemid 44955876)
140. MU Martinez-Martinez E Cuevas-Orta G Reyes-Vaca L Baranda R Gonzalez-Amaro C Abud-Mendoza 2007 Magnetic resonance imaging in patients with rheumatoid arthritis with complete remission treated with disease-modifying antirheumatic drugs or anti-tumour necrosis factor alpha agents Ann Rheum Dis 66 134 5 17178761 1:STN:280:DC%2BD28jjvFCkug%3D%3D (Pubitemid 46049689)
141. AK Brown PG Conaghan Z Karim MA Quinn K Ikeda CG Peterfy, et al. 2008 An explanation for the apparent dissociation between clinical remission and continued structural deterioration in rheumatoid arthritis Arthritis Rheum 58 2958 67 18821687 1:STN:280:DC%2BD1cnkvFeltg%3D%3D
142. FW Roemer F Eckstein A Guermazi 2009 Magnetic resonance imaging-based semiquantitative and quantitative assessment in osteoarthritis Rheum Dis Clin N Am 35 521 55
143. CG Peterfy A Guermazi S Zaim PFJ Tirman Y Miaux D White, et al. 2004 Whole-organ magnetic resonance imaging score (WORMS) of the knee in osteoarthritis Osteoarthritis Cartilage 12 177 90 14972335 1:STN:280: DC%2BD2c%2Fotl2isQ%3D%3D (Pubitemid 38248067)
144. PR Kornaat RYT Ceulemans HM Kroon N Riyazi M Kloppenburg WO Carter, et al. 2005 MRI assessment of knee osteoarthritis: Knee Osteoarthritis Scoring System (KOSS)-inter-observer and intra-observer reproducibility of a compartment-based scoring system Skeletal Radiol 34 95 102 15480649 (Pubitemid 40174014)
145. DJ Hunter GH Lo D Gale AJ Grainger A Guermazi PG Conaghan 2008 The reliability of a new scoring system for knee osteoarthritis MRI and the validity of bone marrow lesion assessment: BLOKS (Boston-Leeds Osteoarthritis Knee Score) Ann Rheum Dis 67 206 11 17472995 1:STN:280:DC%2BD1c%2FisVOntA%3D%3D (Pubitemid 351183309)
146. S Biswal T Hastie TP Andracchi GA Bergman MF Dillingham P Lang 2002 Risk factors for progressive cartilage loss in the knee: a longitudinal magnetic resonance imaging study in forty-three patients Arthritis Rheum 46 2884 92 12428228 (Pubitemid 35315879)
147. JA Lynch FW Roemer MC Nevitt DT Felson J Niu CB Eaton, et al. 2010 Comparison of BLOKS and WORMS scoring systems. Part I. Cross-sectional comparison of methods to assess cartilage morphology, meniscal damage and bone marrow lesions on knee MRI: data from the Osteoarthritis Initiative Osteoarthritis Cartilage 18 1393 401 20816979 1:STN:280:DC%2BC3cblt1Wrtw%3D%3D
148. FW Roemer JA Lynch J Niu Y Zhang MD Crema I Tolstykh, et al. 2010 A comparison of dedicated 1.0 T extremity MRI versus large-bore 1.5 T MRI for semiquantitative whole organ assessment of osteoarthritis: the MOST study Osteoarthritis Cartilage 18 168 74 19766580 1:STN:280:DC%2BC3c%2FpvFyhsQ%3D%3D
149. Wildi LM, Raynauld JP, Martel-Pelletier J, Beaulieu A, Bessette L, Morin F, et al. Chondroitin sulphate reduces both cartilage volume loss and bone marrow lesions in knee osteoarthritis patients starting as early as 6 months after initiation of therapy: a randomised, double-blind, placebo-controlled pilot study using MRI. Ann Rheum Dis. 2011; doi: 10.1136/ard.2010.140848.
150. P Garnero C Peterfy S Zaim M Schoenharting 2005 Bone marrow abnormalities on magnetic resonance imaging are associated with type II collagen degradation in knee osteoarthritis. A three-month longitudinal study Arthritis Rheum 52 2822 9 16145678 1:CAS:528:DC%2BD2MXhtFeltrnK (Pubitemid 41369112)
151. DJ Hunter Y Zhang J Niu J Goggins S Amin MP LaValley, et al. 2006 Increase in bone marrow lesions associated with cartilage loss: a longitudinal magnetic resonance imaging study of knee osteoarthritis Arthritis Rheum 54 1529 35 16646037
152. PR Kornaat M Kloppenburg R Sharma SA Botha-Scheepers MPH Le Graverand LNJ Coene, et al. 2007 Bone marrow edema-like lesions change in volume in the majority of patients with osteoarthritis; associations with clinical features Eur Radiol 17 3073 8 17823802 (Pubitemid 350142331)
153. ML Davies-Tuck AE Wluka Y Wang DR English GG Gilles F Cicuttini 2009 The natural history of bone marrow lesions in community-based adults with no clinical knee osteoarthritis Ann Rheum Dis 68 904 8 18677011 1:STN:280:DC%2BD1MzjvVCitg%3D%3D
154. FW Roemer A Guermazi MK Javaid JA Lynch J Niu Y Zhang, et al. 2009 Change in MRI-detected subchondral bone marrow lesions is associated with cartilage loss: the MOST study. A longitudinal multicentre study of knee osteoarthritis Ann Rheum Dis 68 1461 5 18829615 1:STN:280:DC%2BD1MrltVSjsw%3D%3D
155. LM Wildi JP Raynauld J Martel-Pelletier F Abram M Dorais JP Pelletier 2010 Relationship between bone marrow lesions, cartilage loss and pain in knee osteoarthritis: Results from a randomised controlled clinical trial using MRI Ann Rheum Dis 69 2118 24 20610445
156. DT Felson CE Chaisson CL Hill SMS Totterman ME Gale KM Skinner, et al. 2001 The association of bone marrow lesions with pain in knee osteoarthritis Ann Intern Med 134 541 9 11281736 1:STN:280:DC%2BD3M3gslOqtg%3D%3D (Pubitemid 32245315)
157. DT Felson J Niu A Guermazi F Roemer P Aliabadi M Clancy, et al. 2007 Correlation of the development of knee pain with enlarging bone marrow lesions on magnetic resonance imaging Arthritis Rheum 56 2986 92 17763427 (Pubitemid 47502745)
158. Y Zhang M Nevitt J Niu C Lewis J Torner A Guermazi, et al. 2011 Fluctuation of knee pain and changes in bone marrow lesions, effusions, and synovitis on magnetic resonance imaging Arthritis Rheum 63 691 9 21360498
159. E Yusuf MC Kortekaas I Watt T Huizinga M Kloppenburg 2011 Do knee abnormalities visualized on MRI explain knee pain in knee osteoarthritis? A systematic review Ann Rheum Dis 70 60 7 20829200
160. DT Felson S McLaughlin J Goggins MP LaValley ME Gale S Totterman, et al. 2003 Bone marrow edema and its relation to progression of knee osteoarthritis Ann Intern Med 139 330 6 12965941
161. JP Raynauld J Martel-Pelletier MJ Berthiaume G Beaudoin D Choquette B Haraoui, et al. 2006 Long term evaluation of disease progression through the quantitative magnetic resonance imaging of symptomatic knee osteoarthritis patients: correlation with clinical symptoms and radiographic changes Arthritis Res Ther 8 R21 16507119
162. JP Pelletier JP Raynauld MJ Berthiaume F Abram D Choquette B Haraoui, et al. 2007 Risk factors associated with the loss of cartilage volume on weight-bearing areas in knee osteoarthritis patients assessed by quantitative magnetic resonance imaging: a longitudinal study Arthritis Res Ther 9 R74 17672891
163. A Kothari A Guermazi JS Chmiel D Dunlop J Song O Almagor, et al. 2010 Within-subregion relationship between bone marrow lesions and subsequent cartilage loss in knee osteoarthritis Arthritis Care Res 62 198 203
164. FW Roemer Y Zhang J Niu JA Lynch MD Crema MD Marra, et al. 2009 Tibiofemoral joint osteoarthritis: risk factors for MR-depicted fast cartilage loss over a 30-month period in the Multicenter Osteoarthritis Study Radiology 252 772 80 19635831
165. M Englund A Guermazi FW Roemer M Yang Y Zhang MC Nevitt, et al. 2010 Meniscal pathology on MRI increases the risk for both incident and enlarging subchondral bone marrow lesions of the knee: the MOST study Ann Rheum Dis 69 1796 802 20421344
166. AE Wluka F Hanna M Davies-Tuck Y Wang RJ Bell SR Davis, et al. 2009 Bone marrow lesions predict increase in knee cartilage defects and loss of cartilage volume in middle-aged women without knee pain over 2 years Ann Rheum Dis 68 850 5 18625617 1:STN:280:DC%2BD1MzjvVekuw%3D%3D
167. FW Roemer MK Javaid A Guermazi M Thomas A Kiran R Keen, et al. 2010 Anatomical distribution of synovitis in knee osteoarthritis and its association with joint effusion assessed on non-enhanced and contrast-enhanced MRI Osteoarthritis Cartilage 18 1269 74 20691796 1:STN:280:DC%2BC3cfjsFKqsg%3D%3D
168. D Loeuille AC Rat JC Goebel J Champigneulle A Blum P Netter, et al. 2009 Magnetic resonance imaging in osteoarthritis: which method best reflects synovial membrane inflammation? Correlations with clinical, macroscopic and microscopic features Osteoarthritis Cartilage 17 1186 92 19332177 1:STN:280:DC%2BD1MrmvF2ksA%3D%3D
169. K Baker A Grainger J Niu M Clancy A Guermazi M Crema, et al. 2010 Relation of synovitis to knee pain using contrast-enhanced MRI Ann Rheum Dis 69 1779 83 20472593 1:STN:280:DC%2BC3cfjvVKrtg%3D%3D
170. Guermazi A, Roemer FW, Hayashi D, Crema MD, Niu J, Zhang Y, et al. Assessment of synovitis with contrast-enhanced MRI using a whole-joint semiquantitative scoring system in people with, or at high risk of, knee osteoarthritis: the MOST study. Ann Rheum Dis. 2011; doi: 10.1136/ard.2010. 139618.
171. M Vstergaard M Stoltenberg P Gideon K Sorensen O Henriksen I Lorenzen 1996 Changes in synovial membrane and joint effusion volumes after intraarticular methylprednisolone. Quantitative assessment of inflammatory and destructive changes in arthritis by MRI J Rheumatol 23 1151 61 8823685
172. KD Brandt SA Mazzuca KA Buckwalter 2006 Acetaminophen, like conventional NSAIDs, may reduce synovitis in osteoarthritic knees Rheumatol (Oxford) 45 1389 94 1:CAS:528:DC%2BD28XhtFeisb3P (Pubitemid 44605475)
173. LA Rhodes AJ Grainger AM Keenan C Thomas P Emery PG Conaghan 2005 The validation of simple scoring methods for evaluating compartment-specific synovitis detected by MR in knee osteoarthritis Rheumatology 44 1569 73 16188949 1:STN:280:DC%2BD2MnitlWmug%3D%3D (Pubitemid 41742478)
174. D Loeuille I Chary-Valckenaere J Champigneulle AC Rat F Toussaint A Pinzano-Watrin, et al. 2005 Macroscopic and microscopic features of synovial membrane inflammation in the osteoarthritic knee: correlating magnetic resonance imaging findings with disease severity Arthritis Rheum 52 3492 501 16255041 (Pubitemid 41612215)
175. AK Fotinos-Hoyer A Guermazi H Jara F Eckstein A Ozonoff H Khard, et al. 2010 Assessment of synovitis in the osteoarthritic knee: comparison between manual segmentation, semiautomated segmentation, and semiquantitative assessment using contrast-enhanced fat-suppressed T1-weighted MRI Magn Res Med 64 604 9