Assessment of cellular toxicity of TiO 2 nanoparticles for cardiac tissue engineering applications

Nanotoxicology

Volumn 5, Issue 3, 2011, Pages 372-380

  Jawad, Hedeer ^a,b   Boccaccini, Aldo R ^a   Ali, Nadire N ^a   Harding, Sian E ^a  

^a NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Cardiomyocytes; Nanoparticles; Titanium dioxide; Toxicity and tissue engineering

Indexed keywords

NANOPARTICLE; TITANIUM DIOXIDE;

ANIMAL CELL; ARTICLE; CARDIOVASCULAR SYSTEM; CELL CULTURE; CELL DEATH; CELL PROLIFERATION; CELL SURVIVAL; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; EMBRYONIC STEM CELL; FIBROBLAST; HEART ARRHYTHMIA; HEART MUSCLE CELL; HEART MUSCLE CONTRACTILITY; HUMAN; HUMAN CELL; NONHUMAN; PARTICLE SIZE; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; SPRAGUE DAWLEY RAT; TISSUE ENGINEERING;

ANIMALS; CELL LINE; CELL PROLIFERATION; CELLS, CULTURED; ELECTROPHYSIOLOGICAL PHENOMENA; L-LACTATE DEHYDROGENASE; METAL NANOPARTICLES; MYOCARDIUM; MYOCYTES, CARDIAC; PARTICLE SIZE; RATS; RATS, SPRAGUE-DAWLEY; TISSUE ENGINEERING; TITANIUM;

RATTUS;

EID: 80052057857     PISSN: 17435390     EISSN: 17435404     Source Type: Journal    
DOI: 10.3109/17435390.2010.516844     Document Type: Article

References (27)

1. Bacakova L, Grausova L, Vacik J, Fraczek A, Blazewicz S, Kromka A. 2007. Improved adhesion and growth of human osteoblast-like MG 63 cells on biomaterials modified with carbon nanoparticles. Diamond Related Mater 16: 2133-2140. (Pubitemid 350117426)
2. Brito-Martins M, Harding SE, Ali NN. 2008. beta(1)-and beta(2)-adrenoceptor responses in cardiomyocytes derived from human embryonic stem cells: Comparison with failing and non-failing adult human heart. Br J Pharmacol 153:751-759. (Pubitemid 351271760)
3. 2 nanocomposites by in situ polycondensation. Materials Lett 59:2300-2304. (Pubitemid 40751777)
4. 2) nanoparticles filled poly(D,L lactid acid) (PDLLA) matrix composites for bone tissue engineering. J Mater Sci Mater Med 2007;18:1287-1298. (Pubitemid 47007597)
5. Harding SE, Ali NN, Brito-Martins M, Ali NN. 2007. The human embryonic stem cell-derived cardiomyocyte as a pharmacological model. Pharmacol Therapeut 113:341-353. (Pubitemid 46149048)
6. Helfenstein M, Miragoli M, Rohr S, Muller L, Wick P, Mohr M. 2008. Effects of combustion-derived ultrafine particles and manufactured nanoparticles on heart cells in vitro. Toxicology 253:70-78.
7. Hussain SM, Hess KL, Gearhart JM, Geiss KT, Schlager JJ. 2005. In vitro toxicity of nanoparticles in BRL 3A rat liver cells. Toxicol in Vitro 19:975-983. (Pubitemid 41563236)
8. Jawad H, Harding SE, Piegat A, El-Fray M, Boccaccini AR, Ali NN. 2008a. Myocardial tissue engineering using ES cell-derived cardiomyocytes and elastomeric polymers. Tissue Eng A 14:759-759.
9. Jawad H, Lyon AR, Harding SE, Ali NN, Boccaccini AR. 2008b. Myocardial tissue engineering. Br Med Bull 87:31-47.
10. Jin C, Zhu B, Wang X, Lu Q. 2008. Cytotoxicity of titanium dioxide nanoparticles in mouse fibroblast cells. Chem Res Toxicol 21:1871-1877.
11. Jog JP. 2006. Crystallization in polymer nanocomposites. Mater Sci Tech 22:797-806.
12. Jones SM, Hunt NA, Del Monte F, Harding SE. 1990. Contraction of cardiac myocytes from noradrenaline-treated rats in response to isoprenaline, forskolin and dibutyryl cAMP. Eur J Pharmacol 191:129-140.
13. Liu A, Hong Z, Zhuang X, Chen X, Cui Y, Liu Y, et al. 2008. Surface modification of bioactive glass nanoparticles and the mechanical and biological properties of poly(L-lactide) composites. Acta Biomater 4:1005-1015.
14. Long TC, Saleh N, Tilton RD, Lowery GV, Veronesi B. 2006. Titanium dioxide (P25) produces reactive oxygen species in immortalized brain microglia (BV2): Implications for nanopar-ticle neurotoxicity. Environ Sci Technology 40:4346-4352. (Pubitemid 44092366)
15. Mei F, Zhong JS, Yang XP, Ouyang XY, Zhang S, Hu XY. 2007. Improved biological characteristics of poly(L-lactic acid) elec-trospun membrane by incorporation of multiwalled carbon nanotubes/hydroxyapatite nanoparticles. Biomacromolecules 8:3729-3735.
16. Miragoli M, Salvarani N, Rohr S. 2007. Myofibroblasts induce ectopic activity in cardiac tissue. Circ Res 101:755-758. (Pubitemid 350287189)
17. Oudit GY, Trivieri MG, Khaper N, Husain T, Wilson GJ, Liu P, Sole MJ, Backx PH. 2004. Taurine supplementation reduces oxidative stress and improves cardiovascular function in an iron-overload murine model. Circulation 109:1877-1885. (Pubitemid 38509123)
18. Ramkumar V, Hallam DM, Nie Z. 2001. Adenosine, oxidative stress and cytoprotection. Jpn J Pharmacol 86:265-274.
19. Sartiani L, Bettiol E, Stillitano F, Mugelli A, Cerbai E, Jaconi ME. 2007. Developmental changes in cardiomyocytes differentiated from human embryonic stem cells: A molecular and electrophysiological approach. Stem Cells 25: 1136-1144. (Pubitemid 46684873)
20. Stuckey DJ, Ishii H, Chen QZ, Boccaccini AR, Hansen U, Carr CA, Roether JA, Jawad H, Tyler DJ, Ali NN, Clarke K, Harding SE. 2010. Magnetic resonance imaging evaluation of remodeling by cardiac elastomeric tissue scaffold biomaterials in a rat model of myocardial infarction. Tissue Eng Part A, 2010, Jul 20. [Epub ahead of print].
21. 2 nano-particles in the anatase and rutile crystal phases. Toxicol Lett 183:72-80.
22. 2 nanoparticles. Toxicology 254:82-90.
23. Wang JX, Zhou GQ, Chen CY, Yu HW, Wang TC, Ma YM. 2007. Acute toxicity and biodistribution of different sized titanium dioxide particles in mice after oral administration. Toxicol Lett 168(2):176-185.
24. Webster TJ, Ergun, C, Doremus RH, Lanford WA. 2003. Increased osteoblast adhesion on titanium-coated hydro-xylapatite that forms CaTiO3. J Biomed Mater Res 67A: 975-980. (Pubitemid 37521573)
25. Webster TJ, Smith TA. 2005. Increase osteoblast function on PLGA composites containing nanophase titania. J Biomed Mater Res 74A:677-686. (Pubitemid 41216270)
26. Xu C, Police S, Rao N, Carpenter MK. 2002. Characterization and enrichment of cardiomyocytes derived from human embryonic stem cells. Circ Res 91:501-508.
27. Zhao L, Chang J, Zhai WY. 2009. Preparation and HL-7702 cell functionality of titania/chitosan composite scaffolds. J Mater Sci Mater Med 20:949-957.