Facile and convenient syntheses of fluorine-containing pyrido[2,3- h ]-quinazolines and 1,7-phenanthrolines by condensation reactions of 6,8-bis(trifluoroacetyl)quinolin-5-amine with carbonyl compounds

Synthesis

Volumn , Issue 17, 2011, Pages 2754-2760

  Hinoshita, Mamoru ^a   Shibata, Dai ^a   Hatakenaka, Mizuki ^a   Okada, Etsuji ^a  

^a KOBE UNIVERSITY   (Japan)

Author keywords

1,7 phenanthrolines; condensation reaction; fluorine; pyrido 2,3 h quinazolines; quinolin 5 amines

Indexed keywords

1,7-PHENANTHROLINES; AQUEOUS AMMONIA; CYCLOHEXANONES; QUINAZOLINES; QUINOLIN-5-AMINES;

ALDEHYDES; CARBONYLATION; CONDENSATION; FLUORINE; KETONES; ORGANIC COMPOUNDS;

CONDENSATION REACTIONS;

1 (2 ETHYL 3 METHYL 4 TRIFLUOROMETHYL 1,7 PHENANTHROLIN 6 YL) 2,2,2 TRIFLUOROETHANE 1,1 DIOL; 1 (2 ETHYL 4 TRIFLUOROMETHYL 1,2 DIHYDROPYRIDO[2,3 H]QUINAZOLIN 6 YL) 2,2,2 TRIFLUOROETHANE 1,1 DIOL; 1 (2 ETHYL 4 TRIFLUOROMETHYLPYRIDO[2,3 H]QUINAZOLIN 6 YL)2,2,2 TRIFLUOROETHANE 1,1 DIOL; 1 [2 (4 CHLOROPHENYL) 4 TRIFLUOROMETHYL 1,2 DIHYDROPYRIDO[2,3 H]QUINAZOLIN 6 YL] 2,2,2 TRIFLUOROETHANE 1,1 DIOL; 1 [2 (4 CHLOROPHENYL) 4 TRIFLUOROMETHYLPYRIDO[2,3 H]QUINAZOLIN 6 YL] 2,2,2 TRIFLUOROETHANE 1,1 DIOL; 1,7 PHENANTHROLINE DERIVATIVE; 2,2,2 TRIFLUORO 1 (2 ISOPROPYL 4 TRIFLUOROMETHYL 1,2 DIHYDROPYRIDO[2,3 H]QUINAZOLIN 6 YL)ETHANE 1,1 DIOL; 2,2,2 TRIFLUORO 1 (2 ISOPROPYL 4 TRIFLUOROMETHYL 1,7 PHENANTHROLIN 6 YL)ETHANE 1,1 DIOL; 2,2,2 TRIFLUORO 1 (2 ISOPROPYL 4 TRIFLUOROMETHYLPYRIDO[2,3 H]QUINAZOLIN 6 YL)ETHANE 1,1 DIOL; 2,2,2 TRIFLUORO 1 (2 METHYL 4 TRIFLUOROMETHYL 1,2 DIHYDROPYRIDO[2,3 H]QUINAZOLIN 6 YL)ETHANE 1,1 DIOL; 2,2,2 TRIFLUORO 1 (2 METHYL 4 TRIFLUOROMETHYL 1,7 PHENANTHROLIN 6 YL)ETHANE 1,1 DIOL; 2,2,2 TRIFLUORO 1 (2 METHYL 4 TRIFLUOROMETHYLPYRIDO[2,3 H]QUINAZOLIN 6 YL)ETHANE 1,1 DIOL; 2,2,2 TRIFLUORO 1 (2 PARA TOLYL 4 TRIFLUOROMETHYL 1,2 DIHYDROPYRIDO[2,3 H]QUINAZOLIN 6 YL)ETHANE 1,1 DIOL; 2,2,2 TRIFLUORO 1 (2 PARA TOLYL 4 TRIFLUOROMETHYLPYRIDO[2,3 H]QUINAZOLIN 6 YL)ETHANE 1,1 DIOL; 2,2,2 TRIFLUORO 1 (2 PHENYL 4 TRIFLUOROMETHYL 1,2 DIHYDROPYRIDO[2,3 H]QUINAZOLIN 6 YL)ETHANE 1,1 DIOL; 2,2,2 TRIFLUORO 1 (2 PHENYL 4 TRIFLUOROMETHYLPYRIDO[2,3 H]QUINAZOLIN 6 YL)ETHANE 1,1 DIOL; 2,2,2 TRIFLUORO 1 (3 METHYL 4 TRIFLUOROMETHYL 1,7 PHENANTHROLIN 6 YL)ETHANE 1,1 DIOL; 2,2,2 TRIFLUORO 1 (4 TRIFLUOROMETHYL 1,7 PHENANTHROLIN 6 YL)ETHANE 1,1 DIOL; 2,2,2 TRIFLUORO 1 [2 (4 METHOXYMETHYL) 4 TRIFLUOROMETHYL 1,2 DIHYDROPYRIDO[2,3 H]QUINAZOLIN 6 YL]ETHANE 1,1 DIOL; 2,2,2 TRIFLUORO 1 [2 (4 METHOXYPHENYL) 4 TRIFLUOROMETHYLPYRIDO[2,3 H]QUINAZOLIN 6 YL]ETHANE 1,1 DIOL; 6,8 BIS(TRIFLUOROACETYL)QUINOLIN 5 AMINE; AMMONIA; CARBONYL DERIVATIVE; CYCLOHEXANONE; FLUORINE; KETONE; PHENANTHROLINE DERIVATIVE; PYRIDO[2,3 H]QUINAZOLINE DERIVATIVE; QUINAZOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL ANALYSIS; CHEMICAL STRUCTURE; CYCLIZATION; DEHYDROGENATION; METHYLATION; NONHUMAN; POLYMERIZATION;

EID: 80052047741     PISSN: 00397881     EISSN: 1437210X     Source Type: Journal    
DOI: 10.1055/s-0030-1260133     Document Type: Article

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