Enhancement of wound healing by topical application of Scorzonera species: Determination of the constituents by HPLC with new validated reverse phase method

Journal of Ethnopharmacology

Volumn 137, Issue 2, 2011, Pages 1018-1027

  Küpeli Akkol, Esra ^a   Acikara, Ozlem Bahadir ^b   Süntar, Ipek ^a   Citolu, Gülin Saltan ^b   Kele, Hikmet ^c   Ergene, Burin ^b  

^a GAZI UNIVERSITY   (Turkey)

^b ANKARA UNIVERSITY   (Turkey)

^c AFYON KOCATEPE UNIVERSITY   (Turkey)

Author keywords

Anti inflammatory; Excision; Incision; Medicinal plant; Scorzonera; Wound healing

Indexed keywords

ANTIINFLAMMATORY AGENT; APIGENIN; CAFFEIC ACID; CHLOROGENIC ACID; FERULIC ACID; HESPERIDIN; HYDROXYPROLINE; HYPERIN; INDOMETACIN; KAEMPFEROL; LUTEOLIN; LUTEOLIN 7 GLUCOSIDE; PARA COUMARIC ACID; PLANT EXTRACT; QUERCETIN; ROSMARINIC ACID; RUTOSIDE; SCORZONERA CINEREA EXTRACT; SCORZONERA INCISA EXTRACT; SCORZONERA LATIFOLIA EXTRACT; SCORZONERA PARVIFLORA EXTRACT; SCORZONERA SZOWITSII EXTRACT; SCORZONERA TOMENTOSA EXTRACT; UNCLASSIFIED DRUG; WOUND HEALING PROMOTING AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CAPILLARY PERMEABILITY; CONTROLLED STUDY; DRUG DETERMINATION; DRUG POTENCY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HISTOPATHOLOGY; IN VIVO STUDY; MALE; NONHUMAN; PLANT ROOT; RAT; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SCORZONERA; SCORZONERA CINEREA; SCORZONERA INCISA; SCORZONERA LATIFOLIA; SCORZONERA PARVIFLORA; SCORZONERA SZOWITSII; SCORZONERA TOMENTOSA; SKIN INJURY; WOUND HEALING;

ADMINISTRATION, TOPICAL; ANIMALS; CALIBRATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DATA INTERPRETATION, STATISTICAL; DISEASE MODELS, ANIMAL; LIMIT OF DETECTION; MALE; PLANT COMPONENTS, AERIAL; PLANT EXTRACTS; PLANT ROOTS; RATS; RATS, SPRAGUE-DAWLEY; REFERENCE STANDARDS; REPRODUCIBILITY OF RESULTS; SCORZONERA; SKIN; WOUND HEALING; WOUNDS, PENETRATING;

SCORZONERA; SCORZONERA MOLLIS;

EID: 80052031555     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2011.07.029     Document Type: Article

References (37)

1. Z. Akdemir, C. Kahraman, I.I. Tatli, E. Küpeli Akkol, I. Süntar, and H. Keles Bioassay-guided isolation of anti-inflammatory, antinociceptive and wound healer glycosides from the flowers of Verbascum mucronatum Lam Journal of Ethnopharmacology 136 2011 436 443
2. Bahadir, Ö., Saltan itolu, G., Özbek, H., Antinociceptive activity of some Scorzonera L. species. Turkish Journal of Medical Sciences, accepted.
3. Ö. Bahadir, G. Saltan itolu, K. Šmejkal, S. Dall'Acqua, H. Özbek, J. Cvacka, and M. Zemlicka Analgesic compounds from Scorzonera latifolia (Fisch. and Mey.) DC. Journal of Ethnopharmacology 131 2010 83 87
4. T. Baytop Türkiye'de Bitkiler ile Tedavi 1999 Nobel Ankara pp. 236-237
5. B.A. Bohm, and T.F. Stuessy Flavonoids of the Sunflower Family (Asteraceae) 2007 Springer Wien New York p. 336
6. G.S. itolu, Ö. Bahadir, and S. Dall'Acqua Dihydroisocoumarin derivatives isolated from the roots of Scorzonera latifolia Turkish Journal of Pharmaceutical Sciences 7 2010 205 212
7. Douglas, J., 2001. Scorzonera hispanica - a European vegetable. Crop and Food Research 28. Available from: http://www.crop.cri.nz/home/products-services/ publications/broadsheets/028scorzonera.pdf.
8. A. Duran, and E. Hamzaolu A new species of Scorzonera L. (Asteraceae) from South Anatolia, Turkey Biologia Bratislava 59 2004 47 50 (Pubitemid 38362445)
9. N. Erdemoglu, E. Küpeli Akkol, E. Yesilada, and I. Calis Bioassay-guided isolation of anti-inflammatory and antinociceptive principles from a folk remedy, Rhododendron ponticum L. leaves Journal of Ethnopharmacology 119 2008 172 178
10. E. Hamzaolu, A. Aksoy, E. Martin, N.M. Pinar, and H. ölgeen A new record for the flora of Turkey: Scorzonera ketzkhovelii Grossh (Asteraceae) Turkish Journal of Botany 34 2010 57 61
11. V.B. Khobrakova, S.M. Nikolaev, V.V. Tolstikhina, and A.A. Semenov Immunomodulating properties of lignan glucoside from cultivated cells of Scorzonera hispanica Pharmaceutical Chemistry Journal 37 2003 10 11
12. T. Kondo Timing of skin wounds Legal Medicine 9 2007 109 114 (Pubitemid 46274468)
13. S. Lodhi, R.S. Pawar, A.P. Jain, and A.K. Singhai Wound healing potential of Tephrosia purpurea (Linn.) Pers. in rats Journal of Ethnopharmacology 108 2006 204 210 (Pubitemid 44635026)
14. F. Menichini, and G. Statti Flavonoid glycosides from Scorzonera columnae Fitoterapia 65 1994 555 556
15. S.B. Nayak, S. Sandiford, and A. Maxwell Evaluation of the wound-healing activity of ethanolic extract of Morinda citrifolia L. leaf Evidence Based Complementary and Alternative Medicine 6 2009 351 356
16. T. Okuda Systematics and health effects of chemically distinct tannins in medicinal plants Phytochemistry 66 2005 2012 2031 (Pubitemid 41261913)
17. S. Öksüz, N. Gören, and A. Ulubelen Terpenoids from Scorzonera tomentosa Fitoterapia 61 1990 92 93 (Pubitemid 20167123)
18. S. Paraschos, P. Magiatis, E. Kalpoutzakis, C. Harvala, and A.L. Skaltsounis Tree new dihydroisocoumarins from the Greek endemic species Scorzonera cretica Journal of Natural Products 64 2001 1585 1587 (Pubitemid 34055754)
19. I. Pesin, U. Koca, H. Keles, and E. Küpeli Akkol Wound healing activity of Rubus sanctus Schreber (Rosaceae): preclinical study in animal models Evidence Based Complementary and Alternative Medicine 2009 10.1093/ecam/nep137
20. I. Pesin Süntar, E. Küpeli Akkol, D. Yilmazer, T. Baykal, H. Kirmizibekmez, M. Alper, and E. Yesilada Investigations on the in vivo wound healing potential of Hypericum perforatum L Journal of Ethnopharmacology 127 2010 468 477
21. A.M. Rasik, R. Raghubir, A. Gupta, A. Shukla, M.P. Dubey, S. Srivastava, H.K. Jain, and D.K. Kulshrestha Healing potential of Calotropis procera on dermal wounds in Guinea pigs Journal of Ethnopharmacology 68 1999 261 266 (Pubitemid 29502483)
22. F. Sadaf, R. Saleem, M. Ahmed, S.I. Ahmad, and Z. Navaid-ul Healing potential of cream containing extract of Sphaeranthus indicius on dermal wounds in guinea pigs Journal of Ethnopharmacology 107 2006 161 163 (Pubitemid 44247437)
23. E. Sezik, E. Yeilada, M. Tabata, G. Honda, Y. Takaishi, T. Fujita, T. Tanaka, and Y. Takeda Traditional medicine in Turkey VIII. Folk medicine in East Anatolia; Erzurum, Erzincan, Ari, Kars, Idir Provinces Economic Botany 51 1997 195 211 (Pubitemid 27416031)
24. L. Suguna, S. Singh, P. Sivakumar, P. Sampath, and G. Chandrakasan Influence of Terminalia chebula on dermal wound healing in rats Phytotherapy Research 16 2002 227 231 (Pubitemid 34534947)
25. I. Süntar, E. Küpeli Akkol, F.S. Senol, H. Keles, and I. Erdogan Orhan Investigating wound healing, tyrosinase inhibitory and antioxidant activities of the ethanol extracts of Salvia cryptantha and Salvia cyanescens using in vivo and in vitro experimental models Journal of Ethnopharmacology 135 2011 71 77
26. N. Tsevegsuren, R.A. Edrada, W. Lin, R. Ebel, C. Torre, S. Ortlepp, V. Wray, and P. Proksch Four new natural products from Mongolian medicinal plants Scorzonera divaricata and Scorzonera pseudodivaricata (Asteraceae) Planta Medica 72 2007 962 967 (Pubitemid 47056110)
27. H. Tsuchiya, M. Sato, T. Miyazaki, S. Fujiwara, S. Tanigaki, M. Ohyama, T. Tanaka, and M. Linuma Comparative study on the antibacterial activity of phytochemical flavanones against methicillin-resistant Staphylococcus aureus Journal of Ethnopharmacology 50 1996 27 34 (Pubitemid 26028892)
28. M. Turan, S. Kordali, H. Zengin, A. Dursun, and Y. Sezen Macro and micro mineral content of some edible leaves consumed in Eastern Anatolia Acta Agriculturae Scandinavica B: Soil and Plant Science 53 2003 129 137 (Pubitemid 44109142)
29. V.A. Tramontina, M.A. Machado, R. Nogueira Filho Gda, S.H. Kim, M.R. Vizzioli, and S. Toledo Effect of bismuth subgallate (local hemostatic agent) on wound healing in rats. Histological and histometric findings Brazilian Dental Journal 13 2002 11 16
30. O. Ünal, and R.S. Göktürk A new species of Scorzonera L. (Asteraceae) from South Anatolia, Turkey Botanical Journal of Linnean Society 142 2003 465 468
31. Y. Wang, R.A. Edrada-Ebel, N. Tsevegsuren, J. Sendker, M. Braun, V. Wray, W. Lin, and P. Proksch Dihydrostilbene derivatives from the Mongolian medicinal plant Scorzonera radiata Journal of Natural Products 72 2009 671 675
32. B.A. Whittle The use of changes in capillary permeability in mice to distinguish between narcotic and non-narcotic analgesics British Journal of Pharmacology 22 1964 246 253
33. J.F. Woessner The determination of hydroxyproline in tissue and protein sample containing small portions of this imino acid Archives of Biochemistry and Biophysics 193 1961 440 447
34. E. Yesilada, and E. Küpeli Clematis vitalba L. aerial part exhibits potent anti-inflammatory, antinociceptive and antipyretic effects Journal of Ethnopharmacology 110 2007 504 515 (Pubitemid 46386365)
35. C. Zidorn, E.P. Ellmerer-Müller, and H. Stuppner Tyrolobibenzyls - novel secondary metabolites from Scorzonera humilis L. Helvetica Chimica Acta 83 2000 2920 2925 (Pubitemid 32178884)
36. C. Zidorn, R. Spitaler, E.P. Ellmerer-Müller, N.B. Perry, C. Gerhauser, and H. Stuppner Structure of tyrolobibenzyl D and biological activity of tyrolobibenzyls from Scorzonera humilis L Zeitschrift fur Naturforschung 57 2002 614 619 (Pubitemid 35008519)
37. C. Zidorn, E.P. Ellmerer, S. Sturm, and H. Stuppner Tyrolobibenzyls E and F from Scorzonera humilis and distribution of caffeic acid derivatives, lignans and tyrolobibenzyls in European taxa of the subtribe Scorzonerinae (Lactuceae, Asteraceae) Phytochemistry 63 2003 61 67 (Pubitemid 36427441)