Bioassay-guided isolation of anti-inflammatory and antinociceptive principles from a folk remedy, Rhododendron ponticum L. leaves

Journal of Ethnopharmacology

Volumn 119, Issue 1, 2008, Pages 172-178

  Erdemoglu, Nurgun ^a   Akkol, Esra Küpeli ^a   Yesilada, Erdem ^b   Caliş, Ihsan ^c  

^a GAZI UNIVERSITY   (Turkey)

^b YEDITEPE UNIVERSITY   (Turkey)

^c HACETTEPE UNIVERSITY   (Turkey)

Author keywords

12 O tetradecanoyl 13 acetate (TPA); Anti inflammatory activity; Antinociceptive activity; Ericaceae; Flavonoids; Rhododendron ponticum L.

Indexed keywords

1,4 BENZOQUINONE; 6 C GLUCOSYLNARINGENIN; ACETIC ACID ETHYL ESTER; ACETYLSALICYLIC ACID; CARRAGEENAN; FLAVONOID GLYCOSIDE; HYPERIN; INDOMETACIN; ISOQUERCITRIN; PHORBOL 13 ACETATE 12 MYRISTATE; PLANT EXTRACT; QUERCITRIN; RHODODENDRON PONTICUM EXTRACT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ANTINOCICEPTION; ARTICLE; BIOASSAY; CONTROLLED STUDY; DRUG EFFECT; DRUG ISOLATION; DRUG SCREENING; DRUG STRUCTURE; ETHNOPHARMACOLOGY; MALE; MOUSE; NONHUMAN; PAW EDEMA; PLANT LEAF; RHODODENDRIN; RHODODENDRON;

ANALGESICS; ANIMALS; ANTI-INFLAMMATORY AGENTS; BIOLOGICAL ASSAY; DISEASE MODELS, ANIMAL; EDEMA; FLAVONES; INFLAMMATION; MALE; MEDICINE, TRADITIONAL; MICE; PAIN; PAIN MEASUREMENT; PLANT EXTRACTS; PLANT LEAVES; RHODODENDRON; TURKEY;

ERICACEAE; RHODODENDRON PONTICUM;

EID: 49149116347     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jep.2008.06.021     Document Type: Article

References (40)

1. Abdel-Kader M.S. Two new norphenylpropanoid glucosides and hemipholin from the flowers of Ononis vaginalis. Journal of the Brazilian Chemical Society 8 (1997) 637-639
2. Baytop T. Therapy with Medicinal Plants in Turkey: Past and Present. Second edition (1999), Nobel Ti{dotless}p Kitabevleri, Istanbul
3. Bernabas C.G.G., and Nagarajan S. Chemical and pharmacological studies on the leaves of Solanum melongena. Fitoterapia 60 (1989) 77-78
4. Budzianowski J., and Skrzypczakowa L. 6-C-Glucosylnaringenin from Tulipa gesneriana. Phytochemistry 17 (1978) 2044
5. Cechinel Filho V., Da Silva K.L., De Souza M.M., Oliveira A.E., Yunes R.A., Guimaraes C.L., Verdi L.G., Simionatto E.L., and Delle Monache F. I3-naringenin-II8-4′-OMe-eriodictyol: a new potential analgesic agent isolated from Rheedia gardneriana leaves. Zeitschrift für Naturforschung C: Journal of Biosciences 55 (2000) 820-823
6. Chang Q., Zuo Z., Chow M.S.S., and Ho W.K.K. Difference in absorption of the two structurally similar flavonoid glycosides, hyperoside and isoquercitrin, in rats. European Journal of Pharmaceutics and Biopharmaceutics 59 (2005) 549-555
7. Choi J.S., Young H.S., Park J.C., Choi J.H., and Woo W.S. Flavonoids from the leaves of Rhododendron brachycarpum. Archives of Pharmacal Research (1986) 233-236
8. Chosson E., Chaboud A., Chulia A.J., and Raynoud J. Dihydroflavonol glycosides from Rhododendron ferrugineum. Phytochemistry 49 (1998) 1431-1433
9. Deng F.X., Lin G.T., Gui X.M., and Zhou B.N. Studies on the chemical-constituents of Man-Shan-Bai (Rhododendron-Seniavinii-maxim). Acta Chimica Sinica 40 2 (1982) 178-180
10. De Young L.M., Kheifets J.B., Ballaron S.J., and Young J.M. Edema and cell infiltration in the phorbol ester treated mouse ear are temporally separate and can be differently modulated by pharmacologic agents. Agents Activity 26 (1989) 335-341
11. Di Carlo G., Mascolo N., Izzo A.A., and Capasso F. Flavonoids: old and new aspects of a class of natural therapeutic drugs. Life Sciences 65 (1999) 337-353
12. Durmishidze, S.V., Shalasvilee, A.G., Mzhavanadze, V.V., Tsiklauree, G.C., 1981. In flavonoids on oxycinnamic acids in some species of Georgia wild flora Tblisi. Metnireba. Chapter 1. Flavonoids in Rhododendron caucasian and Rhododendron pontific.
13. Erdemoglu N., Kupeli E., and Yesilada E. Anti-inflammatory and antinociceptive activity assessment of plants used as remedy in Turkish folk medicine. Journal of Ethnopharmacology 89 (2003) 123-129
14. Gadotti V.M., Schmeling L.O., Machado C., Liz F.H., Cechinel Filho V., Meyre-Silva C., and Santos A.R.S. Antinociceptive action of the extract and the flavonoid quercitrin isolated from Bauhinia microstachya leaves. Journal of Pharmacy and Pharmacology 57 (2005) 1345-1351
15. Grieve M. "A Modern Herbal", Leyel (1994), Tiger Books International, London
16. Ho L.K., and Lin W.N. Quercetin 5. 4'-dimethyl ether from Rhododendron ellipticum. Phytochemistry 39 (1995) 463-464
17. Kim H.K., Namgoong S.Y., and Kim H.P. Antiinflammatory activity of flavonoids: mouse ear edema inhibition. Archives of Pharmacological Research 16 (1993) 18-24
18. Kurihara T., Kikuchi M., Suzuki S., and Toyoda E. Studies on the constituents of leaves of Rhododendron degronianum Carr. Yakugaku Zasshi 96 12 (1976) 1407-1411
19. Lavault M., and Richomme P. Constituents of Helichrysum stoechas variety olonnense. Chemistry of Natural Compounds 40 (2004) 118-121
20. Lee S.J., Son K.H., Chang H.W., Do J.C., Jung K.Y., Kang S.S., and Kim H.P. Anti-inflammatory activity of naturally occuring flavone and flavonol glycosides. Archives of Pharmacological Research 16 (1993) 25-28
21. Lee S., Shin D.-S., Oh K.-B., and Shin K.H. Antibacterial compounds from the leaves of Acanthopanax senticosus. Archives of Pharmacological Research 26 (2003) 40-42
22. Li C.-J., Wang L.-Q., Chen S.-N., and Qin G.-W. Diterpenoids from the fruits of Rhododendron molle. Journal of Natural Products 63 (2000) 1214-1217
23. Manga H.M., Brkic D., Marie D.E.P., and Quetin-Leclercq J. In vivo anti-inflammatory activity of Alchornea cordifolia (Schumach. & Thonn.) Mull. Arg. (Euphorbiaceae). Journal of Ethnopharmacology 92 (2004) 209-214
24. Manjeet K.R., and Ghosh B. Quercetin inhibits LPS-induced nitric oxide and tumor necrosis factor-α production in murine macrophage. International Journal of Immunopharmacology 21 (1999) 435-443
25. Melzig M.F., Pertz H.H., and Krenn L. Anti-inflammatory and spasmolytic activity of extracts from Droserae Herba. Phytomedicine 8 (2001) 225-229
26. Okun R., Liddon S.C., and Lasagnal L. The effect of aggregation, electric shock and adrenergic bloking drugs on inhibition of the "writhing syndrome". Journal of Pharmacology and Experimental Therapeutics 139 (1963) 107-114
27. Pyo M.K., Koo Y.K., and Yun-Choi H.S. Anti-platelet effect of the phenolic constituents isolated from the leaves of Magnolia obovata. Natural Product Sciences 8 (2002) 147-151
28. Recio M.C., Giner R.M., manez S., Talens A., Cubells L., Gueho J., Julien H.R., Hostettmann K., and Rios J.L. Anti-inflammatory activity of flavonol glycosides from Erythrospermum monticolum depending on single or repeated local TPA administration. Planta Medica 61 (1995) 502-504
29. Sales F., and Milne R. Rhododendron L. In: Güner A., Özhatay N., Ekim T., and Başer K.H.C. (Eds). Flora of Turkey and the East Aegean Islands vol. 11 (2000), University Press, Edinburgh 181-183
30. Sanchez de Medina F., Galvez J., Romero J.A., and Zarzuelo A. Effect of quercitrin on acute and chronic experimental colitis in the rat. Journal of Pharmacology and Experimental Therapeutics 278 (1996) 771-779
31. Sanchez de Medina F., Vera B., Galvez J., and Zarzuelo A. Effect of quercitrin on the early stages of hapten induced colonic inflammation in the rat. Life Sciences 70 (2002) 3097-3108
32. Samuelsson G. Drugs of Natural Origin. 4th revised edition (1999), Swedish Pharmaceutical Press, Kristiandstad, Sweden
33. Stevens P.F. Rhododendron L. In: Davis P.H. (Ed). Flora of Turkey and the East Aegean Islands vol. 6 (1978), Edinburgh University Press, Edinburgh 90-94
34. Tordera M., Ferrandiz M.L., and Alcaraz M.J. Influence of anti-inflammatory flavonoids on degranulation and arachidonic acid release in rat neutrophils. Zeitschrift fur Naturforschung, C: Journal of Biosciences 49 (1994) 235-240
35. Ullah F., Hussain H., Hussain J., Bukhari A., Tareq M., Khan H., Choudhary M.I., Gilani A.H., and Ahmad V.U. Tyrosine inhibitory pentacyclic triterpenes and analgesic and spasmolytic activities of methanol extracts of Rhododendron collettianum. Phytotherapy Research 21 (2008) 1076-1081
36. Xia C., Du A., Wang H., Zhou Z., and Wang X. Chemical studies on the active constituents of Rhododendron micranthum Turcz. Zhongguo Yaoke Daxue Xuebao 30 (1999) 314-315
37. Yesilada E., and Küpeli E. Clematis vitalba L. aerial part exhibits potent anti-inflammatory, antinociceptive and antipyretic effects. Journal of Ethnopharmacology 110 (2007) 504-515
38. Yesilada E., Sezik E., Honda G., Takasihi Y., Takeda Y., and Tanaka T. Traditional medicine in Turkey IX. Folk medicine in Noth-West Anatolia. Journal of Ethnopharmacology 64 (1999) 195-210
39. Zapesochnaya G.G., and Ban'kovskii A.I. Study of the chemical composition of the leaves of Rhododendron aureum Georgi. Khimiya Prirodnykh Soedinenii 1 4 (1965) 289-292
40. Zhang X.F., Hung T.M., Phuong P.T., Ngoc T.M., Min B.-S., Song K.-S., Seong Y.H., and Bae K. Anti-inflammatory activity of flavonoids from Populus davidiana. Archives of Pharmacological Research 29 (2006) 1102-1108