Early administration of sivelestat, the neutrophil elastase inhibitor, in adults for acute lung injury following gastric aspiration

Shock

Volumn 36, Issue 3, 2011, Pages 223-227

  Hayashida, Kei ^a   Fujishima, Seitaro ^a   Sasao, Kenichiro ^b   Orita, Tomohiko ^b   Toyoda, Yukitoshi ^b   Kitano, Mitsuhide ^b   Hori, Shingo ^a  

^a KEIO UNIVERSITY   (Japan)

^b SAISEIKAI YOKOHAMASHI TOBU HOSPITAL   (Japan)

Author keywords

acute respiratory distress syndrome; Aspiration pneumonia; critically ill patients; lung injury scores; systemic inflammatory response syndrome

Indexed keywords

SIVELESTAT;

ACUTE LUNG INJURY; ADULT; AGED; ARTIFICIAL VENTILATION; COHORT ANALYSIS; CONFIDENCE INTERVAL; CONTROLLED STUDY; FEMALE; GASTRIC SUCTION; HOSPITAL ADMISSION; HUMAN; INDEPENDENT VARIABLE; INTENSIVE CARE UNIT; LOGISTIC REGRESSION ANALYSIS; MAJOR CLINICAL STUDY; MALE; PREDICTOR VARIABLE; PROSPECTIVE STUDY; REVIEW; RISK;

ACUTE LUNG INJURY; AGED; AGED, 80 AND OVER; FEMALE; GLYCINE; HUMANS; LARYNGOPHARYNGEAL REFLUX; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; PROTEINASE INHIBITORY PROTEINS, SECRETORY; SULFONAMIDES; TIME FACTORS; TREATMENT OUTCOME;

EID: 80052029225     PISSN: 10732322     EISSN: 15400514     Source Type: Journal    
DOI: 10.1097/SHK.0b013e318225acc3     Document Type: Review

References (30)

1. Kikawada M, Iwamoto T, Takasaki M: Aspiration and infection in the elderly: epidemiology, diagnosis and management. Drugs Aging 22:115-130, 2005. (Pubitemid 40445322)
2. Bynum LJ, Pierce AK: Pulmonary aspiration of gastric contents. Am Rev Respir Dis 114:1129-1136, 1976.
3. Pepe PE, Potkin RT, Reus DH, Hudson LD, Carrico CJ: Clinical predictors of the adult respiratory distress syndrome. Am J Surg 144:124-130, 1982. (Pubitemid 12093173)
4. Fowler AA, Hamman RF, Good JT, Benson KN, Baird M, Eberle DJ, Petty TL, Hyers TM: Adult respiratory distress syndrome: risk with common predispositions. Ann Intern Med 98:593-597, 1983. (Pubitemid 13091168)
5. Rubenfeld GD, Caldwell E, Peabody E, Weaver J, Martin DP, Neff M, Stern EJ, Hudson LD: Incidence and outcomes of acute lung injury. N Engl J Med 353:1685-1693, 2005. (Pubitemid 41464707)
6. Sukumaran M, Granada MJ, Berger HW, Lee M, Reilly TA: Evaluation of corticosteroid treatment in aspiration of gastric contents: a controlled clinical trial. Mt Sinai J Med 47:335-340, 1980. (Pubitemid 10019727)
7. St John RC, Mizer LA, Kindt GC, Weisbrode SE, Moore SA, Dorinsky PM: Acid aspirationYinduced acute lung injury causes leukocyte-dependent systemic organ injury. J Appl Physiol 74:1994-2003, 1993. (Pubitemid 23133505)
8. Folkesson HG, Matthay MA, Hebert CA, Broaddus VC: Acid aspirationY induced lung injury in rabbits is mediated by interleukin-8-dependent mechanisms. J Clin Invest 96:107-116, 1995.
9. Goldman G, Welbourn R, Kobzik L, Valeri CR, Shepro D, Hechtman HB: Reactive oxygen species and elastase mediate lung permeability after acid aspiration. J Appl Physiol 73:571-575, 1992.
10. Kaneko K, Kudoh I, Hattori S, Yamada H, Ohara M, Wiener-Kronish J, Okumura F: Neutrophil elastase inhibitor, ONO-5046, modulates acid-induced lung and systemic injury in rabbits. Anesthesiology 87:635-641, 1997. (Pubitemid 27433014)
11. Smedly LA, Tonnesen MG, Sandhaus RA, Haslett C, Guthrie LA, Johnston RB Jr, Henson PM, Worthen GS: Neutrophil-mediated injury to endothelial cells. Enhancement by endotoxin and essential role of neutrophil elastase. J Clin Invest 77:1233-1243, 1986. (Pubitemid 16047145)
12. Carden D, Xiao F, Moak C, Willis BH, Robinson-Jackson S, Alexander S: Neutrophil elastase promotes lung microvascular injury and proteolysis of endothelial cadherins. Am J Physiol 275:H385-H392, 1998. (Pubitemid 128734405)
13. Moraes TJ, Chow CW, Downey GP: Proteases and lung injury. Crit Care Med 31:S189-S194, 2003. (Pubitemid 36458166)
14. Hagio T, Nakao S, Matsuoka H, Matsumoto S, Kawabata K, Ohno H: Inhibition of neutrophil elastase activity attenuates complement-mediated lung injury in the hamster. Eur J Pharmacol 426:131-138, 2001. (Pubitemid 32781798)
15. Hagio T, Matsumoto S, Nakao S, Abiru T, Ohno H, Kawabata K: Elastase inhibition reduced death associated with acid aspirationYinduced lung injury in hamsters. Eur J Pharmacol 488:173-180, 2004. (Pubitemid 38388537)
16. Hagio T, Matsumoto S, Nakao S, Matsuoka S, Kawabata K: Sivelestat, a specific neutrophil elastase inhibitor, prevented phorbol myristate acetate-induced acute lung injury in conscious rabbits. Pulm Pharmacol Ther 18:285-290, 2005. (Pubitemid 40379751)
17. Tamakuma S, Ogawa M, Aikawa N, Kubota T, Hirasawa H, Ishizaka A, Taenaka N, Hamada C, Matsuoka S, Abiru T: Relationship between neutrophil elastase and acute lung injury in humans. Pulm Pharmacol Ther 17:271-279, 2004. (Pubitemid 39345408)
18. Bernard GR, Artigas A, Brigham KL, Carlet J, Falke K, Hudson L, Lamy M, Legall JR, Morris A, Spragg R: The American-European Consensus Conference on ARDS. Definitions, mechanisms, relevant outcomes, and clinical trial coordination. Am J Respir Crit Care Med 149:818-824, 1994.
19. American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference: definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Crit Care Med 20:864-874, 1992.
20. Murray JF, Matthay MA, Luce JM, Flick MR: An expanded definition of the adult respiratory distress syndrome. Am Rev Respir Dis 138:720-723, 1988.
21. Gando S, Kameue T, Matsuda N, Sawamura A, Hayakawa M, Kato H: Systemic inflammation and disseminated intravascular coagulation in early stage of ALI and ARDS: role of neutrophil and endothelial activation. Inflammation 28:237-244, 2004. (Pubitemid 41449424)
22. Kawabata K, Hagio T, Matsumoto S, Nakao S, Orita S, Aze Y, Ohno H: Delayed neutrophil elastase inhibition prevents subsequent progression of acute lung injury induced by endotoxin inhalation in hamsters. Am J Respir Crit Care Med 161:2013-2018, 2000. (Pubitemid 30418145)
23. Hagio T, Kishikawa K, Kawabata K, Tasaka S, Hashimoto S, Hasegawa N, Ishizaka A: Inhibition of neutrophil elastase reduces lung injury and bacterial count in hamsters. Pulm Pharmacol Ther 21:884-891, 2008.
24. Leroy O, Vandenbussche C, Coffinier C, Bosquet C, Georges H, Guery B, Thevenin D, Beaucaire G: Community-acquired aspiration pneumonia in intensive care units. Epidemiological and prognosis data. Am J Respir Crit Care Med 156:1922-1929, 1997. (Pubitemid 28011803)
25. Hickling KG, Howard R: A retrospective survey of treatment and mortality in aspiration pneumonia. Intensive Care Med 14:617-622, 1988.
26. Zilberberg MD, Epstein SK: Acute lung injury in the medical ICU: comorbid conditions, age, etiology, and hospital outcome. Am J Respir Crit Care Med 157:1159-1164, 1998.
27. Eichacker PQ, Parent C, Kalil A, Esposito C, Cui X, Banks SM, Gerstenberger EP, Fitz Y, Danner RL, Natanson C: Risk and the efficacy of antiinflammatory agents: retrospective and confirmatory studies of sepsis. Am J Respir Crit Care Med 166:1197-1205, 2002. (Pubitemid 35222596)
28. Kawabata K, Suzuki M, Sugitani M, Imaki K, Toda M, Miyamoto T: ONO-5046, a novel inhibitor of human neutrophil elastase. Biochem Biophys Res Commun 177:814-820, 1991.
29. Zeiher BG, Artigas A, Vincent JL, Dmitrienko A, Jackson K, Thompson BT, Bernard G: Neutrophil elastase inhibition in acute lung injury: results of the STRIVE study. Crit Care Med 32:1695-1702, 2004. (Pubitemid 39050520)
30. Hashimoto S, Okayama Y, Shime N, Kimura A, Funakoshi Y, Kawabata K, Ishizaka A, Amaya F: Neutrophil elastase activity in acute lung injury and respiratory distress syndrome. Respirology 13:581-584, 2008. (Pubitemid 351725279)