A CXCL8 receptor antagonist based on the structure of N-acetyl-proline- glycine-proline

European Journal of Pharmacology

Volumn 668, Issue 3, 2011, Pages 435-442

  Jackson, Patricia L ^a   Noerager, Brett D ^b   Jablonsky, Michael J ^c   Hardison, Matthew T ^a   Cox, Bryan D ^c   Patterson, James C ^c   Dhanapal, Boopathy ^d   Blalock, J Edwin ^a   Muccio, Donald D ^c  

^a University of Alabama at Birmingham   (United States)

^b UNIVERSITY OF MONTEVALLO   (United States)

^c UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^d Lipal Biochemicals AG Gundetswil   (Switzerland)

Author keywords

CXCL8; CXCR1; CXCR2; d peptide; Inflammation; NAc PGP

Indexed keywords

CHEMOKINE RECEPTOR CXCR1; CHEMOKINE RECEPTOR CXCR2; N ACETYLPROLYLGLYCYLPROLINE; RECOMBINANT INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; RECOMBINANT INTERLEUKIN 8; RECOMBINANT INTERLEUKIN 8 RECEPTOR BLOCKING AGENT; TRIPEPTIDE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BINDING COMPETITION; CHEMOTAXIS; CHIRALITY; CHRONIC OBSTRUCTIVE LUNG DISEASE; CIRCULAR DICHROISM; CONTROLLED STUDY; CYSTIC FIBROSIS; DRUG ACTIVITY; HUMAN; HUMAN CELL; ISOMER; LEUKOCYTE ACTIVATION; MOLECULAR DYNAMICS; MOLECULAR MODEL; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN MOTIF; RADIORECEPTOR ASSAY; RECEPTOR BINDING;

BINDING, COMPETITIVE; CHEMOTAXIS, LEUKOCYTE; CIRCULAR DICHROISM; DRUG DESIGN; DRUG STABILITY; HL-60 CELLS; HUMANS; INTERLEUKIN-8; ISOMERISM; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR DYNAMICS SIMULATION; NEUTROPHILS; OLIGOPEPTIDES; PROTEIN CONFORMATION; RECEPTORS, INTERLEUKIN-8; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 80052026417     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2011.02.045     Document Type: Article

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