X4 tropic multi-drug resistant quasi-species detected at the time of primary HIV-1 infection remain exclusive or at least dominant far from PHI

PLoS ONE

Volumn 6, Issue 8, 2011, Pages

  Ghosn, Jade ^a,b   Galimand, Julie ^a,c   Raymond, Stéphanie ^d   Meyer, Laurence ^e   Deveau, Christiane ^e   Goujard, Cécile ^b,e   Izopet, Jacques ^d   Rouzioux, Christine ^a,c   Chaix, Marie Laure ^a,c  

^a UNIVERSITÉ PARIS DESCARTES   (France)

^b BICÊTRE HOSPITAL   (France)

^c HÔPITAL NECKER ENFANTS MALADES   (France)

^d CHU PURPAN   (France)

^e CENTRE FOR RESEARCH IN EPIDEMIOLOGY AND POPULATION HEALTH   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CCR5; CHEMOKINE RECEPTOR CXCR4; RNA DIRECTED DNA POLYMERASE; VIRUS DNA; VIRUS RNA; REVERSE TRANSCRIPTASE, HUMAN IMMUNODEFICIENCY VIRUS 1;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; ENVELOPE GENE; FEMALE; FOLLOW UP; GENE SEQUENCE; GENETIC VARIABILITY; GENOTYPE; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; MALE; MOLECULAR CLONING; MULTIDRUG RESISTANCE; NONHUMAN; PHENOTYPE; VIRAL TROPISM; VIRUS GENE; VIRUS GENOME; VIRUS MUTATION; VIRUS STRAIN; ADOLESCENT; BLOOD; ENZYMOLOGY; GENETICS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LONGITUDINAL STUDY; MIDDLE AGED; MOLECULAR GENETICS; PHYLOGENY; PHYSIOLOGY; TROPISM; VIROLOGY;

HUMAN IMMUNODEFICIENCY VIRUS 1;

ADOLESCENT; ADULT; AGED; DNA, VIRAL; DRUG RESISTANCE, MULTIPLE, VIRAL; FEMALE; HIV INFECTIONS; HIV REVERSE TRANSCRIPTASE; HIV-1; HUMANS; LONGITUDINAL STUDIES; MALE; MIDDLE AGED; MOLECULAR SEQUENCE DATA; PHYLOGENY; RNA, VIRAL; TROPISM; YOUNG ADULT;

EID: 80052011672     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0023301     Document Type: Article

References (51)

1. Smith DM, Wong JK, Shao H, Hightower GK, Mai SH, et al. (2007) Long-term persistence of transmitted HIV drug resistance in male genital tract secretions: implications for secondary transmission. J Infect Dis 196: 356-360.
2. Chaix ML, Descamps D, Wirden M, Bocket L, Delaugerre C, et al. (2009) Stable frequency of HIV-1 transmitted drug resistance in patients at the time of primary infection over 1996-2006 in France. AIDS 23: 717-724.
3. Yerly S, Junier T, Gayet-Ageron A, Amari EB, von Wyl V, et al. (2009) The impact of transmission clusters on primary drug resistance in newly diagnosed HIV-1 infection. AIDS 23: 1415-1423.
4. Vercauteren J, Wensing AM, van de Vijver DA, Albert J, Balotta C, et al. (2009) Transmission of drug-resistant HIV-1 is stabilizing in Europe. J Infect Dis 200: 1503-1508.
5. Wensing AM, van de Vijver DA, Angarano G, Asjo B, Balotta C, et al. (2005) Prevalence of drug-resistant HIV-1 variants in untreated individuals in Europe: implications for clinical management. J Infect Dis 192: 958-966.
6. Yerly S, Jost S, Telenti A, Flepp M, Kaiser L, et al. (2004) Infrequent transmission of HIV-1 drug-resistant variants. Antivir Ther 9: 375-384.
7. Ghosn J, Pellegrin I, Goujard C, Deveau C, Viard JP, et al. (2006) HIV-1 resistant strains acquired at the time of primary infection massively fuel the cellular reservoir and persist for lengthy periods of time. AIDS 20: 159-170.
8. Delaugerre C, Marcelin AG, Soulie C, Chaix ML, Katlama C, et al. (2007) Transmission of multidrug-resistant HIV-1: 5 years of immunological and virological survey. AIDS 21: 1365-1367.
9. Frange P, Galimand J, Goujard C, Deveau C, Ghosn J, et al. (2009) High frequency of X4/DM-tropic viruses in PBMC samples from patients with primary HIV-1 subtype-B infection in 1996-2007: the French ANRS CO06 PRIMO Cohort Study. J Antimicrob Chemother 64: 135-141.
10. de Mendoza C, Van Baelen K, Poveda E, Rondelez E, Zahonero N, et al. (2008) Performance of a population-based HIV-1 tropism phenotypic assay and correlation with V3 genotypic prediction tools in recent HIV-1 seroconverters. J Acquir Immune Defic Syndr 48: 241-244.
11. de Mendoza C, Rodriguez C, Garcia F, Eiros JM, Ruiz L, et al. (2007) Prevalence of X4 tropic viruses in patients recently infected with HIV-1 and lack of association with transmission of drug resistance. J Antimicrob Chemother 59: 698-704.
12. Raymond S, Delobel P, Mavigner M, Cazabat M, Encinas S, et al. (2010) CXCR4-using viruses in plasma and peripheral blood mononuclear cells during primary HIV-1 infection and impact on disease progression. AIDS 24: 2305-2312.
13. Dalmau J, Puertas MC, Azuara M, Marino A, Frahm N, et al. (2009) Contribution of immunological and virological factors to extremely severe primary HIV type 1 infection. Clin Infect Dis 48: 229-238.
14. Chaix ML, Desquilbet L, Descamps D, Costagliola D, Deveau C, et al. (2007) Response to HAART in French patients with resistant HIV-1 treated at primary infection: ANRS Resistance Network. Antivir Ther 12: 1305-1310.
15. Markowitz M, Mohri H, Mehandru S, Shet A, Berry L, et al. (2005) Infection with multidrug resistant, dual-tropic HIV-1 and rapid progression to AIDS: a case report. Lancet 365: 1031-1038.
16. Bhaskaran K, Pillay D, Walker AS, Fisher M, Hawkins D, et al. (2004) Do patients who are infected with drug-resistant HIV have a different CD4 cell decline after seroconversion? An exploratory analysis in the UK Register of HIV Seroconverters. AIDS 18: 1471-1473.
17. Sucupira M, Sanabani S, Tomiyama H, Sauer M, Sabino E, et al. (2010) Faster HIV-1 disease prgression among Brazilian recently infected individuals harbouring CXCR4-using strains. Antivir Ther 15: A163.
18. Strain MC, Gunthard HF, Havlir DV, Ignacio CC, Smith DM, et al. (2003) Heterogeneous clearance rates of long-lived lymphocytes infected with HIV: intrinsic stability predicts lifelong persistence. Proc Natl Acad Sci U S A 100: 4819-4824.
19. Ghosn J, Wirden M, Ktorza N, Peytavin G, Ait-Mohand H, et al. (2005) No benefit of a structured treatment interruption based on genotypic resistance in heavily pretreated HIV-infected patients. AIDS 19: 1643-1647.
20. Turner D, Brenner B, Routy JP, Moisi D, Rosberger Z, et al. (2004) Diminished representation of HIV-1 variants containing select drug resistance-conferring mutations in primary HIV-1 infection. J Acquir Immune Defic Syndr 37: 1627-1631.
21. Wei X, Liang C, Gotte M, Wainberg MA, (2003) Negative effect of the M184V mutation in HIV-1 reverse transcriptase on initiation of viral DNA synthesis. Virology 311: 202-212.
22. Delaugerre C, Morand-Joubert L, Chaix ML, Picard O, Marcelin AG, et al. (2004) Persistence of multidrug-resistant HIV-1 without antiretroviral treatment 2 years after sexual transmission. Antivir Ther 9: 415-421.
23. Gandhi RT, Wurcel A, Rosenberg ES, Johnston MN, Hellmann N, et al. (2003) Progressive reversion of human immunodeficiency virus type 1 resistance mutations in vivo after transmission of a multiply drug-resistant virus. Clin Infect Dis 37: 1693-1698.
24. Bomsel M, David V, (2002) Mucosal gatekeepers: selecting HIV viruses for early infection. Nat Med 8: 114-116.
25. Moore JP, Kitchen SG, Pugach P, Zack JA, (2004) The CCR5 and CXCR4 coreceptors-central to understanding the transmission and pathogenesis of human immunodeficiency virus type 1 infection. AIDS Res Hum Retroviruses 20: 111-126.
26. Moyle GJ, Wildfire A, Mandalia S, Mayer H, Goodrich J, et al. (2005) Epidemiology and predictive factors for chemokine receptor use in HIV-1 infection. J Infect Dis 191: 866-872.
27. Balandya E, Sheth S, Sanders K, Wieland-Alter W, Lahey T, (2010) Semen protects CD4+ target cells from HIV infection but promotes the preferential transmission of R5 tropic HIV. J Immunol 185: 7596-7604.
28. Raymond S, Delobel P, Mavigner M, Cazabat M, Souyris C, et al. (2009) Genotypic prediction of human immunodeficiency virus type 1 CRF02-AG tropism. J Clin Microbiol 47: 2292-2294.
29. Jordan M, Kearney M, Palmer S, Shao W, Maldarelli F, et al. (2010) Comparison of standard PCR/cloning to single genome sequencing for analysis of HIV-1 populations. J Virol Methods 168: 114-120.
30. Waters L, Mandalia S, Randell P, Wildfire A, Gazzard B, et al. (2008) The impact of HIV tropism on decreases in CD4 cell count, clinical progression, and subsequent response to a first antiretroviral therapy regimen. Clin Infect Dis 46: 1617-1623.
31. Shepherd JC, Jacobson LP, Qiao W, Jamieson BD, Phair JP, et al. (2008) Emergence and persistence of CXCR4-tropic HIV-1 in a population of men from the multicenter AIDS cohort study. J Infect Dis 198: 1104-1112.
32. Weiser B, Philpott S, Klimkait T, Burger H, Kitchen C, et al. (2008) HIV-1 coreceptor usage and CXCR4-specific viral load predict clinical disease progression during combination antiretroviral therapy. AIDS 22: 469-479.
33. Goujard C, Chaix ML, Lambotte O, Deveau C, Sinet M, et al. (2009) Spontaneous control of viral replication during primary HIV infection: when is "HIV controller" status established? Clin Infect Dis 49: 982-986.
34. Soulie C, Marcelin AG, Ghosn J, Amellal B, Assoumou L, et al. (2007) HIV-1 X4/R5 co-receptor in viral reservoir during suppressive HAART. AIDS 21: 2243-2245.
35. Wagner T, McKernan J, Tobin N, Frenkel L, (2010) Emergence of monotypic HIV-1 DNA during ART suggests proliferation of cells with integrated HIV DNA provirus may sustain infection. Antivir Ther 15: A45.
36. Ghosn J, Deveau C, Chaix ML, Goujard C, Galimand J, et al. (2010) Despite being highly diverse, immunovirological status strongly correlates with clinical symptoms during primary HIV-1 infection: a cross-sectional study based on 674 patients enrolled in the ANRS CO 06 PRIMO cohort. J Antimicrob Chemother 65: 741-748.
37. Desquilbet L, Goujard C, Rouzioux C, Sinet M, Deveau C, et al. (2004) Does transient HAART during primary HIV-1 infection lower the virological set-point? AIDS 18: 2361-2369.
38. Schiffer V, Deveau C, Meyer L, Iraqui I, Nguyen-Wartel A, et al. (2004) Recent changes in the management of primary HIV-1 infection: results from the French PRIMO cohort. HIV Med 5: 326-333.
39. Yeni P, (2010) Prise en charge médicale des personnes infectées par le VIH. Editions Médecine Sciences- Flammarion, Paris.
40. Troude P, Chaix ML, Tran L, Deveau C, Seng R, et al. (2009) No evidence of a change in HIV-1 virulence since 1996 in France. AIDS 23: 1261-1267.
41. Avettand-Fenoel V, Chaix ML, Blanche S, Burgard M, Floch C, et al. (2009) LTR real-time PCR for HIV-1 DNA quantitation in blood cells for early diagnosis in infants born to seropositive mothers treated in HAART area (ANRS CO 01). J Med Virol 81: 217-223.
42. Avettand-Fenoel V, Boufassa F, Galimand J, Meyer L, Rouzioux C, (2008) HIV-1 DNA for the measurement of the HIV reservoir is predictive of disease progression in seroconverters whatever the mode of result expression is. J Clin Virol 42: 399-404.
43. Pasquier C, Millot N, Njouom R, Sandres K, Cazabat M, et al. (2001) HIV-1 subtyping using phylogenetic analysis of pol gene sequences. J Virol Methods 94: 45-54.
44. Briggs DR, Tuttle DL, Sleasman JW, Goodenow MM, (2000) Envelope V3 amino acid sequence predicts HIV-1 phenotype (co-receptor usage and tropism for macrophages). AIDS 14: 2937-2939.
45. de Jong JJ, Goudsmit J, Keulen W, Klaver B, Krone W, et al. (1992) Human immunodeficiency virus type 1 clones chimeric for the envelope V3 domain differ in syncytium formation and replication capacity. J Virol 66: 757-765.
46. Fouchier RA, Groenink M, Kootstra NA, Tersmette M, Huisman HG, et al. (1992) Phenotype-associated sequence variation in the third variable domain of the human immunodeficiency virus type 1 gp120 molecule. J Virol 66: 3183-3187.
47. Raymond S, Delobel P, Mavigner M, Cazabat M, Souyris C, et al. (2008) Correlation between genotypic predictions based on V3 sequences and phenotypic determination of HIV-1 tropism. AIDS 22: F11-16.
48. Raymond S, Delobel P, Mavigner M, Ferradini L, Cazabat M, et al. (2010) Prediction of HIV type 1 subtype C tropism by genotypic algorithms built from subtype B viruses. J Acquir Immune Defic Syndr 53: 167-175.
49. Raymond S, Delobel P, Mavigner M, Cazabat M, Souyris C, et al. (2010) Development and performance of a new recombinant virus phenotypic entry assay to determine HIV-1 coreceptor usage. J Clin Virol 47: 126-130.
50. Nischalke H, Nattermann J, Lichterfeld M, Woitas R, Rockstroh J, et al. (2004) Rapid determination of the Delta32 deletion in the human CC-chemokine receptor 5 (CCR5) gene without DNA extraction by lightcycler real-time polymerase chain reaction. AIDS Res Hum Retroviruses 20: 750-754.
51. Felsenstein J, (1997) An alternating least squares approach to inferring phylogenies from pairwise distances. Syst Biol 46: 101-111.