Use of meropenem by continuous infusion to treat a patient with a bla kpc-2-positive klebsiella pneumoniae blood stream infection

Surgical Infections

Volumn 12, Issue 4, 2011, Pages 325-327

  Ho, Vanessa P ^a   Jenkins, Stephen G ^b   Afaneh, Cheguevara I ^a   Turbendian, Harma K ^a   Nicolau, David P ^d   Barie, Philip S ^a,c  

^a WEILL CORNELL MEDICAL CENTER   (United States)

^b Department of Pathology ^*  (United States)

^c WEILL CORNELL MEDICAL COLLEGE   (United States)

^d HARTFORD HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMIKACIN; BACTERIAL PROTEIN; CREATININE; DAPTOMYCIN; LINEZOLID; MEROPENEM; PIPERACILLIN PLUS TAZOBACTAM; POLYMYXIN B; PROTEIN KPC 2; UNCLASSIFIED DRUG;

ABDOMINAL WALL; ACUTE KIDNEY FAILURE; ADULT; ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ANTIBIOTIC THERAPY; AORTA DISSECTION; ARTICLE; BACTEREMIA; BACTERIAL STRAIN; BLOOD SAMPLING; BLOODSTREAM INFECTION; CASE REPORT; CATHETER INFECTION; CONTINUOUS INFUSION; CREATININE BLOOD LEVEL; CREATININE CLEARANCE; DRUG BLOOD LEVEL; DRUG DOSE REGIMEN; DRUG MEGADOSE; FOLLOW UP; GLOMERULUS FILTRATION RATE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HOSPITAL PATIENT; HUMAN; INTESTINE FISTULA; KLEBSIELLA PNEUMONIAE; KLEBSIELLA PNEUMONIAE INFECTION; MALE; MEDICAL HISTORY; MEDICAL LITERATURE; MINIMUM INHIBITORY CONCENTRATION; MIXED INFECTION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RECURRENT INFECTION; RESPIRATORY FAILURE; TOTAL PARENTERAL NUTRITION; URINARY TRACT INFECTION; VENTILATOR ASSOCIATED PNEUMONIA;

ANTI-BACTERIAL AGENTS; BACTEREMIA; BETA-LACTAM RESISTANCE; BETA-LACTAMASES; HUMANS; INFUSIONS, INTRAVENOUS; KLEBSIELLA INFECTIONS; KLEBSIELLA PNEUMONIAE; MALE; MICROBIAL SENSITIVITY TESTS; MIDDLE AGED; SERUM; THIENAMYCINS; TREATMENT OUTCOME;

EID: 80052003278     PISSN: 10962964     EISSN: 15578674     Source Type: Journal    
DOI: 10.1089/sur.2010.072     Document Type: Article

References (12)

1. Gaynes R, Edwards J, Weinstein R. Overview of nosocomial infections caused by gram-negative bacilli. Clin Infect Dis 2005;41:848-854. (Pubitemid 41266753)
2. Yigit H, Queenan A, Anderson G, et al. Novel carbapenemhydrolyzing beta-lactamase, KPC-1, from a carbapenemresistant strain of Klebsiella pneumoniae. Antimicrob Agents Chemother 2001;45:1151-1161. (Pubitemid 32230996)
3. Borer A, Saidel-Odes L, Riesenberg K, et al. Attributable mortality rate for carbapenem-resistant Klebsiella pneumoniae bacteremia. Infect Control Hosp Epidemiol 2009;30:972-976.
4. Drusano GL. Pharmacodynamics: Critical interactions of 'bug and drug.' Nat Rev Microbiol 2004;2:289-300. (Pubitemid 39490099)
5. Elkhaili H, Niedergang S, Pompei D, et al. High-performance liquid chromatographic assay for meropenem in serum. J Chromatog B: Biomed Sci Applic 1996;686:19-26. (Pubitemid 26382454)
6. Krueger W, Schroeder T, Hutchison M, et al. Pharmacokinetics of meropenem in critically ill patients with acute renal failure treated by continuous hemodiafiltration. Antimicrob Agents Chemother 1998;42:2421-2424. (Pubitemid 28420389)
7. Hermsen E, Maiefski M, Florescu M, et al. Comparison of the Modification of Diet in Renal Disease and Cockcroft-Gault equations for dosing antimicrobials. Pharmacother 2009;29: 649-655.
8. Brun-Buisson C, Legrand P, Philippon A, et al. Transferable enzymatic resistance to third-generation cephalosporins during nosocomial outbreak of multiresistant Klebsiella pneumoniae. Lancet 1987;2:302-306. (Pubitemid 17104206)
9. Nordmann P, Cuzon G, Naas T. The real threat of Klebsiella pneumoniae carbapenemase-producing bacteria. Lancet Infect Dis 2009;9:228-236.
10. Roberts JA, Kirkpatrick CM, Roberts MS, et al. Meropenem dosing in critically ill patients with sepsis and without renal dysfunction: Intermittent bolus versus continuous administration? Monte Carlo dosing simulations and subcutaneous tissue distribution. J Antimicrob Chemother 2009 Jul;64:142-150.
11. Lorente L, Lorenzo L, Martin M, et al. Meropenem by continuous versus intermittent infusion in ventilator-associated pneumonia due to gram-negative bacilli. Ann Pharmacother 2006;40:219-223. (Pubitemid 43269850)
12. Roberts JA, Webb S, Paterson D, et al. A systematic review on clinical benefits of continuous administration of betalactam antibiotics. Crit Care Med 2009;37:2071-2078.