Metastasis of tumor cells is enhanced by downregulation of Bit1

PLoS ONE

Volumn 6, Issue 8, 2011, Pages

  Karmali, Priya Prakash ^a   Brunquell, Chris ^a   Tram, Hau ^b   Ireland, Shubha Kale ^b   Ruoslahti, Erkki ^a   Biliran, Hector ^b  

^a BURNHAM INSTITUTE   (United States)

^b XAVIER UNIVERSITY OF LOUISIANA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BCL 2 INHIBITOR OF TRANSCRIPTION 1 PROTEIN; MITOCHONDRIAL PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATASE; SHORT HAIRPIN RNA; UNCLASSIFIED DRUG; BIT1 PROTEIN, MOUSE; CARBOXYLESTERASE;

ADVANCED CANCER; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANOIKIS; ARTICLE; BREAST CANCER; CANCER CELL; CANCER GROWTH; CELL ADHESION; CELL LEVEL; CELL MIGRATION; CELL MOTILITY; CELL TYPE; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; ENZYME ACTIVITY; FEMALE; GENE DISRUPTION; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE REPRESSION; GENE SILENCING; GENE TARGETING; HUMAN; HUMAN CELL; HUMAN TISSUE; LUNG METASTASIS; MOLECULAR CLONING; MOUSE; NONHUMAN; TISSUE MICROARRAY; ANIMAL; BAGG ALBINO MOUSE; BREAST TUMOR; DISEASE COURSE; GENETICS; LUNG TUMOR; METASTASIS; NEOPLASM; PATHOLOGY; PHYSIOLOGY; SIGNAL TRANSDUCTION; TUMOR CELL LINE;

MUS MUSCULUS;

ANIMALS; ANOIKIS; BREAST NEOPLASMS; CARBOXYLIC ESTER HYDROLASES; CELL LINE, TUMOR; DISEASE PROGRESSION; DOWN-REGULATION; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LUNG NEOPLASMS; MAP KINASE SIGNALING SYSTEM; MICE; MICE, INBRED BALB C; NEOPLASM METASTASIS; NEOPLASMS;

EID: 80051997985     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0023840     Document Type: Article

References (27)

1. Ruoslahti E, (1999) Fibronectin and its integrin receptors in cancer. Adv. Cancer Res 76: 1-20.
2. Hanahan D, Weinber RA, (2000) The Hallmarks of Cancer. Cell 100: 57-70.
3. Frish SM, Frances H, (1994) Disruption of epithelial cell-matrix interactions induce apoptosis. J. Cell Biol 124: 619-626.
4. Frisch SM, Ruoslahti E, (1997) Integrins and anoikis. Curr. Opin. Cell Biol 9: 701-706.
5. Jan Y, Matter M, Pai JT, Chen YL, Pilch J, et al. (2004) A mitochondrial protein, Bit1, mediates apoptosis regulated by integrins and Groucho/TLE corepressors. Cell 116: 751-762.
6. Biliran H, Jan Y, Chen R, Pasquale EB, Ruoslahti E, (2008) Protein kinase D is a positive regulator of Bit1 apoptotic function. J. Biol. Chem 283: 28029-28037.
7. Jeffers M, Fiscella M, Webb CP, Anver M, Koochekpour S, (1998) The mutationally activated Met receptor mediates motility and metastasis. Proc. Natl. Acad. Sci. USA 95: 14417-22.
8. Webb CP, Taylor GA, Jeffers M, Fiscella M, Oskarsson M, et al. (1988) Evidence for a role of Met-HGF/SF during Ras-mediated tumorigenesis/metastasis. Oncogene 17: 2019-25.
9. Ward Y, Wang W, Woodhouse E, Linnoila I, Liotta L, et al. (2001) Signal pathways which promote invasion and metastasis: critical and distinct contributions of extracellular signal-regulated kinase and Ral-specific guanine exchange factor pathways. Mol Cell Biol 21: 5958-69.
10. Kairouz-Wahbe R, Biliran H, Luo X, Khor I, Wankell M, et al. (2008) Anoikis effector Bit1 negatively regulates Erk activity. Proc. Natl. Acad. Sci. USA 105: 1528-1532.
11. Shipp MA, Ross KN, Tamayo P, Weng AP, Kutok JL, et al. (2002) Diffuse large B-cell lymphoma outcome prediction by gene-expression profiling and supervised machine learning. Nat. Med 8: 68-74.
12. Allen T, Tuyl van M, Iyengar P, Jothy S, Post M, et al. (2006) Grg1 Acts as a Lung-Specific Oncogene in a Transgenic Mouse Model. Cancer Res 66: 1294-1301.
13. Sonoshita M, Aoki M, Fuwa H, Aoki K, Hosogi H, et al. (2011) Suppression of Colon Cancer Metastasis by Aes through Inhibition of Notch Signaling. Cancer Cell 19: 125-137.
14. Hood JD, Cheresh DA, (2002) A. Role of integrins in cell invasion and migration. Nat. Rev. Cancer 2: 91-100.
15. Westhoff MA, Serrels B, Fincham VJ, Frame MC, Carragher NO, (2004) Src-Mediated Phosphorylation of Focal Adhesion Kinase Couples Actin and Adhesion Dynamics to Survival Signaling. Mol. Cell. Biol 24: 8113-8133.
16. Fidler IJ, (1990) Critical factors in the biology of human cancer metastasis: twenty-eight G.H.A. Clowes memorial award lecture. Cancer Res 50: 6130-6138.
17. Lester BR, McCarthy JB, (1992) Tumor cell adhesion to the extracellular matrix and signal transduction mechanisms implicated in tumor cell motility, iunvasion, and metastasis. Cancer Metastasis Rev 11: 31-44.
18. Li Z, Xi X, Du X, (2001) A Mitogen-activated Protein Kinase-dependent Signaling Pathway in the Activation of Platelet Integrin αIIbβ3. J Biol Chem 276: 42226-42232.
19. Blaschke F, Stawowy P, Goetze S, Hintz O, Grafe M, et al. (2002) Hypoxia activates β1-integrin via ERK 1/2 and p38 MAP kinase in human vascular smooth muscle cells. BBRC 296: 890-896.
20. Thompson EW, Newgreen DF, (2005) Carcinoma invasion and metastasis: A role for Epithelial-Mesenchymal Transition? Cancer Res 65: 5991-5995.
21. Griffiths GS, Grundl M, Leychenko A, Reiter S, Young-Robbins SS, et al. (2011) Bit-1 mediates integrin-dependent cell survival through activation of the NFkappaB pathway. J Biol Chem 286: 14713-14723.
22. De Pereda JM, Waas W, Jan Y, Ruoslahti E, Schimmel P, et al. (2004) Crystal Structure of a Human Peptidyl-tRNA Hydrolase Reveals a New Fold and Suggests Basis for a Bifunctional Activity. J. Biol. Chem 279: 8111-8115.
23. Lipton SA, Bossy-Wetzel E, (2002) Dueling Activities of AIF in Cell Death versus Survival: DNA Binding and Redox Activity. Cell 111: 147-150.
24. Laakko T, Juliano RL, (2003) Adhesion regulation of stromal cell-derived factor-1 activation of ERK in lymphocytes by phosphatases. J. Biol. Chem 278: 31621-31628.
25. Mitsushima M, Ueda K, Kioka N, (2007) Involvement of phosphatases in the anchorage-dependent regulation of ERK2 activation. Exp. Cell Res 313: 1830-1838.
26. Obenauer JC, Cantley LC, Yaffe MB, (2003) Scansite 2.0: proteome-wide prediction of cell signaling interactions using short sequence motifsRK2 activation. Nucleic Acids Res 31: 3635-3641.
27. Luzzi KJ, MacDonald IC, Schmidt EE, Kerkvliet N, Morris VI, (1998) Multistep nature of metastatic inefficiency: dormancy of solitary cells after successful extravasation and limited survival of early micrometastasis. Am. J. Pathol 153: 865-873.