Serum iga against type 3 muscarinic acetylcholine receptor is a novel marker in diagnosis of Sjögren's syndrome

Chinese Medical Journal

Volumn 124, Issue 16, 2011, Pages 2490-2495

  Li, Ying Ni ^a   Guo, Jian Ping ^a   He, Jing ^a   Liu, Xia ^b   Yin, Fang Rui ^c   Ding, Yan ^a   Yao, Hai Hong ^a   Kang, Ai Jun ^d   Li, Zhan Guo ^a  

^a PEKING UNIVERSITY PEOPLE S HOSPITAL   (China)

^b CHINA JAPAN FRIENDSHIP HOSPITAL   (China)

^c BAOTOU MEDICAL COLLEGE   (China)

^d PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

Author keywords

Autoantibodies; Enzyme linked immunosorbent assay; Sj gren's syndrome; Type 3 muscarinic acetylcholine receptor

Indexed keywords

IMMUNOGLOBULIN A ANTIBODY; LA ANTIBODY; MUSCARINIC M3 RECEPTOR; RO ANTIBODY;

ADULT; AGED; ANTIBODY DETECTION; ARTICLE; CONTROLLED STUDY; DIAGNOSTIC VALUE; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; IMMUNOGLOBULIN BLOOD LEVEL; LABORATORY DIAGNOSIS; MALE; SENSITIVITY AND SPECIFICITY; SERODIAGNOSIS; SJOEGREN SYNDROME;

ADULT; AGED; AGED, 80 AND OVER; ANIMALS; AUTOANTIBODIES; BIOLOGICAL MARKERS; CATTLE; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMANS; IMMUNOGLOBULIN A; MALE; MIDDLE AGED; RECEPTORS, MUSCARINIC; SJOGREN'S SYNDROME; YOUNG ADULT;

EID: 80051981533     PISSN: 03666999     EISSN: None     Source Type: Journal    
DOI: 10.3760/cma.j.issn.0366-6999.2011.16.017     Document Type: Article

References (22)

1. Fox RI. Sjögren's syndrome. Lancet 2005; 366: 321-331.
2. Nikolov NP, Illei GG. Pathogenesis of Sjögren's syndrome. Curr Opin Rheumatol 2009; 21: 465-470.
3. Koo NY, Li J, Hwang SM, Choi SY, Lee SJ, Oh SB, et al. Functional epitope of muscarinic type 3 receptor which interacts with autoantibodies from Sjögren's syndrome patients. Rheumatology (Oxford) 2008; 47: 828-833.
4. Cavill D, Waterman SA, Gordon TP. Antibodies raised against the second extracellular loop of the human muscarinic M3 receptor mimic functional autoantibodies in Sjögren's syndrome. Scand J Immunol 2004; 59: 261-266.
5. Dawson LJ, Stanbury J, Venn N, Hasdimir B, Rogers SN, Smith PM. Antimuscarinic antibodies in primary Sjögren's syndrome reversibly inhibit the mechanism of fluid secretion by human submandibular salivary acinar cells. Arthritis Rheum 2006; 54: 1165-1173.
6. Li J, Ha YM, Kü NY, Choi SY, Lee SJ, Oh SB, et al. Inhibitory effects of autoantibodies on the muscarinic receptors in Sjögren's syndrome. Lab Invest 2004; 84: 1430-1438.
7. Waterman SA, Gordon TP, Rischmueller M. Inhibitory effects of muscarinic receptor autoantibodies on parasympathetic neurotransmission in Sjögren's syndrome. Arthritis Rheum 2000; 43: 1647-1654.
8. Proctor GB, Carpenter GH. Regulation of salivary gland function by autonomic nerves. Auton Neurosci 2007; 133: 3-18.
9. Enriquez-de-Salamanca A, Calonge M. Muscarinic receptors in the ocular surface. Curr Opin Allergy Clin Immunol 2006; 6: 379-382.
10. Nakamura T, Matsui M, Uchida K, Futatsugi A, Kusakawa S, Matsumoto N, et al. M (3) muscarinic acetylcholine receptor plays a critical role in parasympathetic control of salivation in mice. J Physiol 2004; 558 (Pt2): 561-575.
11. Mandl T, Granberg V, Apelqvist J, Wollmer P, Manthorpe R, Jacobsson LT. Autonomic nervous symptoms in primary Sjögren's syndrome. Rheumatology (Oxford) 2008; 47: 914-919.
12. Kovacs L, Marczinovits I, György A, Tóth GK, Dorgai L, Pál J, et al. Clinical associations of autoantibodies to human muscarinic acetylcholine receptor 3(213-228) in primary Sjögren's syndrome. Rheumatology (Oxford) 2005; 44: 1021-1025.
13. Zigon P, Bozic B, Cucnik S, Rozman B, Tomsic M, Kveder T. Are autoantibodies against a 25-mer synthetic peptide of M3 muscarinic acetylcholine receptor a new diagnostic marker for Sjögren's syndrome? Ann Rheum Dis 2005; 64: 1247.
14. Roescher N, Kingman A, Shirota Y, Chiorini JA, Illei GG. Peptide-based ELISAs are not sensitive and specific enough to detect muscarinic receptor type 3 autoantibodies in serum from patients with Sjögren's syndrome. Ann Rheum Dis 2011; 70: 235-236.
15. He J, Guo JP, Ding Y, Li YN, Pan SS, Li ZG. Diagnostic significance of measuring antibodies to cyclic type 3 muscarinic acetylcholine receptor peptides in primary Sjögren's syndrome. Rheumatology (Oxford) 2011; 50: 879-884.
16. Vitali C, Bombardieri S, Jonsson R, Moutsopoulos HM, Alexander EL, Carsons SE, et al. Classification criteria for Sjögren's syndrome: a revised version of the European criteria proposed by the American-European Consensus Group. Ann Rheum Dis 2002; 61: 554-558.
17. Tan EM, Cohen AS, Fries JF, Masi AT, McShane DJ, Rothfield NF, et al. The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 1982; 25: 1271-1277.
18. Arnett FC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, Cooper NS, et al. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 1988; 31: 315-324.
19. Mera K, Nagai M, Brock JW, Fujiwara Y, Murata T, Maruyama T, et al. Glutaraldehyde is an effective cross-linker for production of antibodies against advanced glycation end-products. J Immunol Methods 2008; 334: 82-90.
20. Berra A, Sterin-Borda L, Bacman S, Borda E. Role of salivary IgA in the pathogenesis of Sjögren syndrome. Clin Immunol 2002; 104: 49-57.
21. Bacman S, Berra A, Sterin-Borda L, Borda E. Muscarinic acetylcholine receptor antibodies as a new marker of dry eye Sjögren syndrome. Invest Ophthalmol Vis Sci 2001; 42: 321-327.
22. Gao J, Cha S, Jonsson R, Opalko J, Peck AB. Detection of anti-type 3 muscarinic acetylcholine receptor autoantibodies in the sera of Sjögren's syndrome patients by use of a transfected cell line assay. Arthritis Rheum 2004; 50: 2615-2621.