Protective effects of diosmetin extracted from Galium verum L. on the thymus of U14-bearing mice

Canadian Journal of Physiology and Pharmacology

Volumn 89, Issue 9, 2011, Pages 665-673

  Zhao, Rui ^a   Chen, Zhibao ^a   Jia, Guiyan ^a   Li, Jian ^b   Cai, Yaping ^a   Shao, Xingyue ^c  

^a HEILONGJIANG AUGUST FIRST LAND RECLAMATION UNIVERSITY   (China)

^b YANSHAN UNIVERSITY   (China)

^c DAQING OILFIELD CO LTD   (China)

Author keywords

CD4 +; CD8 +; Diosmetin; Fas FasL; Galium verum L.

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; DIOSMETIN; FAS ANTIGEN; FAS LIGAND; INTERLEUKIN 10; INTERLEUKIN 2; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER INHIBITION; CELL PROLIFERATION; CONTROLLED STUDY; DRUG EFFECT; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; GALIUM VERUM L.; HELPER CELL; HUMAN; HUMAN CELL; IMMUNOBLOTTING; MEDICINAL PLANT; NONHUMAN; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL; SUPPRESSOR CELL; THYMUS; THYMUS CANCER; WESTERN BLOTTING;

ANIMALS; ANTIGENS, CD95; APOPTOSIS; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELL LINE, TUMOR; CELL PROLIFERATION; DRUGS, CHINESE HERBAL; FAS LIGAND PROTEIN; FEMALE; FLAVONOIDS; GALIUM; IN SITU NICK-END LABELING; INTERLEUKIN-10; INTERLEUKIN-2; KIDNEY; LIVER; MICE; THYMUS GLAND; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR-ALPHA; UTERINE CERVICAL NEOPLASMS;

EID: 80051976219     PISSN: 00084212     EISSN: 12057541     Source Type: Journal    
DOI: 10.1139/y11-058     Document Type: Article

References (28)

1. Aquino Esperanza, J.A., Aguirre, M.V., Aispuru, G.R., Lettieri, C.N., Juaristi, J.A., Alvarez, M.A., and Brandan, N.C. 2008. In vivo 5-fluorouracil-induced apoptosis on murine thymocytes: involvement of FAS, Bax and Caspase3. Cell Biol. Toxicol. 24(5): 411-422. doi:10.1007/s10565-008-9056-z. PMID:18266059.
2. Chouaib, S., Asselin-Paturel, C., Mami-Chouaib, F., Caignard, A., and Blay, J.Y. 1997. The host-tumor immune conflict: from immunosuppression to resistance and destruction. Immunol. Today, 18(10): 493-497. doi:10.1016/S0167-5699(97)01115-8. PMID:9357142.
3. Eichhorst, S.T., Müerköster, S., Weigand, M.A., and Krammer, P.H. 2001. The chemotherapeutic drug 5-fluorouracil induces apoptosis in mouse thymocytes in vivo via activation of the CD95 (APO-1/ Fas) system. Cancer Res. 61(1): 243-248. PMID:11196169.
4. El Hilaly, J., and Lyoussi, B. 2002. Hypoglycaemic effect of the lyophilised aqueous extract of Ajuga iva in normal and streptozocin diabetic rats. J. Ethnopharmacol. 80(2-3): 109-113. doi:10.1016/S0378-8741(01)00407-X. PMID:12007699.
5. Finke, J., Ferrone, S., Frey, A., Mufson, A., and Ochoa, A. 1999. Where have all the T cells gone? Mechanisms of immune evasion by tumors. Immunol. Today, 20(4): 158-160. doi:10.1016/S0167-5699(98)01435-2. PMID:10203710.
6. Gopalakrishnan, A., Xu, C.J., Nair, S.S., Chen, C., Hebbar, V., and Kong, A.N. 2006. Modulation of activator protein-1 (AP-1) and MAPK pathway by flavonoids in human prostate cancer PC3 cells. Arch. Pharm. Res. 29(8): 633-644. doi:10.1007/BF02968247. PMID:16964758.
7. Guest, L., and Uetrecht, J. 2000. Drugs toxic to the bone marrow that target the stromal cells. Immunopharmacology, 46(2): 103-112. doi:10.1016/S0162-3109(99)00168-X.
8. Il'ina, T.V., Kovaleva, A.M., Goryachaya, O.V., and Aleksandrov, A. N. 2009. Essential oil from Galium verum flowers. Chem. Nat. Compd. 45(4): 587-588. doi:10.1007/s10600-009-9375-1.
9. Institute of Laboratory Animal Research. 1996. Guide for the care and use of laboratory animals. National Academy Press, Washington, D.C.
10. Kahn, S.R. 1998. The clinical diagnosis of deep venous thrombosis: integrating incidence, risk factors and symptoms and signs. Arch. Intern. Med. 158(21): 2315-2323. doi:10.1001/archinte.158.21. 2315. PMID:9827782.
11. Krammer, P.H. 2000. CD95's deadly mission in the immune system. Nature (Lond.), 407(6805): 789-795. doi:10.1038/35037728. PMID:11048730.
12. Manosroi, A., Saraphanchotiwitthaya, A., and Manosroi, J. 2005. In vivo immunodulating activity of wood extracts from Clausena excavata Burm. f. J. Ethnopharmacol. 102(1): 5-9. doi:10.1016/j. jep.2005.04.033. PMID:16023813.
13. Mandal, D., Lahiry, L., Bhattacharyya, A., Bhattacharyya, S., Sa, G., and Das, T. 2006. Tumor-induced thymic involution via inhibition of IL-7Ra and its JAK-STAT signaling pathway: protection by black tea. Int. Immunopharmacol. 6(3): 433-444. doi:10.1016/j. intimp.2005.09.005. PMID:16428079.
14. Muñoz, N., Bosch, F.X., de Sanjosé, S., Herrero, R., Castellsagué, X., Shah, K.V., et al. International Agency for Research on Cancer Multicenter Cervical Cancer Study Group. 2003. Epidemiologic classification of human papillomavirus types associated with cervical cancer. N. Engl. J. Med. 348(6): 518-527. doi:10.1056/ NEJMoa021641. PMID:12571259.
15. Nagata, S. 1997. Apoptosis by death factor. Cell, 88(3): 355-365. doi:10.1016/S0092-8674(00)81874-7. PMID:9039262.
16. Nguyen, H.H., Broker, T.R., Chow, L.T., Alvarez, R.D., Vu, H.L., Andrasi, J., et al. 2005. Immune responses to human papillomavirus in genital tract of women with cervical cancer. Gynecol. Oncol. 96(2): 452-461. doi:10.1016/j.ygyno.2004.10.019. PMID: 15661235.
17. Oh, H., Kim, D.H., Cho, J.H., and Kim, Y.C. 2004. Hepatoprotective and free radical scavenging activities of phenolic petrosins and flavonoids isolated from Equisetum arvense. J. Ethnopharmacol. 95(2-3): 421-424. PMID:15507369.
18. Parker, W.B., and Cheng, Y.C. 1990. Metabolism and mechanism of action of 5-fluorouracil. Pharmacol. Ther. 48(3): 381-395. doi:10. 1016/0163-7258(90)90056-8. PMID:1707544.
19. + T cells in peripheral blood of colorectal cancer patients and involvement in cancer establishment and progression. Cancer Immunol. Immunother. 42(1): 1-8. doi:10.1007/s002620050244. PMID:8625361.
20. Peter, M.E., and Krammer, P.H. 2003. The CD95(APO-1/Fas) DISC and beyond. Cell Death Differ. 10(1): 26-35. doi:10.1038/sj.cdd. 4401186. PMID:12655293.
21. Poch, B., Lotspeich, E., Ramadani, M., Gansauge, S., Beger, H.G., and Gansauge, F. 2007. Systemic immune dysfunction in pancreatic cancer patients. Langenbecks Arch. Surg. 392(3): 353-358. doi:10.1007/s00423-006-0140-7. PMID:17235586.
22. Pritchard, D.M., Watson, A.J.M., Potten, C.S., Jackman, A.L., and Hickmann, J.A. 1997. Inhibition by uridine but not thymidine of p53-dependent intestinal apoptosis initiated by 5-fluorouracil: evidence for the involvement of RNA perturbation. Proc. Natl. Acad. Sci. U.S.A. 94(5): 1795-1799. doi:10.1073/pnas.94.5.1795. PMID:9050858.
23. Schmitz-Winnenthal, F.H., Volk, C., Z'graggen, K., Galindo, L., Nummer, D., Ziouta, Y., et al. 2005. High frequencies of functional tumorreactive T cells in bone marrow and blood of pancreatic cancer patients. Cancer Res. 65(21): 10079-10087. doi:10.1158/0008-5472.CAN-05-1098. PMID:16267034.
24. Schwartsmann, G., Ratain, M.J., Cragg, G.M., Wong, J.E., Saijo, N., Parkinson, D.R., et al. 2002. Anticancer drug discovery and development throughout the world. J. Clin. Oncol. 20(18S): 47S-59S. PMID:12235225.
25. Ye, C.L., Liu, Y., and Wei, D.Z. 2007. Antioxidant and anticancer activity of 3'-formyl-4',6'-dihydroxy-2'-methoxy-5'-methylchalcone and (2S)-8-formyl-5-hydroxy-7-methoxy-6-methylflavanone. J. Pharm. Pharmacol. 59(4): 553-559. doi:10.1211/jpp.59.4.0010. PMID:17430639.
26. Zhang, X.L., Komada, Y., Chipeta, J., Li, Q.S., Inaba, H., Azuma, E., et al. 2000. Intracellular cytokine profile of T cells from children with acute lymphoblastic leukemia. Cancer Immunol. Immunother. 49(3): 165-172. doi:10.1007/s002620050616. PMID: 10881696.
27. Zhao, C.C. 2007. Studies on the chemical constituents and biological activities of fruits of Ailanthus altissima Swingle and Galium verum L. Ph.D. thesis, Shenyang Pharmaceutical University, Shenyang, China.
28. Zhao, C.C., Shao, J.H., and Li, X. 2006. A new bioflavonoid from Calium verum L. Chin. J. Med. Chem. 16(6): 386-390.