Activation of β 3 -adrenoceptor promotes rapid pacing-induced atrial electrical remodeling in rabbits

Cellular Physiology and Biochemistry

Volumn 28, Issue 1, 2011, Pages 87-96

  Yu, Jiahui ^a   Li, Weimin ^a   Li, Yue ^a   Zhao, Jing ^a   Wang, Lanfeng ^a   Dong, Deli ^a   Pan, Zhenwei ^a   Yang, Baofeng ^a  

^a HARBIN MEDICAL UNIVERSITY   (China)

Author keywords

Atrial electrical remodeling; Inward rectifier potassium current; L type calcium current; Transient outward potassium current

Indexed keywords

1 (2 ETHYLPHENOXY) 3 (1,2,3,4 TETRAHYDRO 1 NAPHTHYLAMINO) 2 PROPANOL OXALATE; 4 [2 [[2 (3 CHLOROPHENYL) 2 HYDROXYETHYL]AMINO]PROPYL]PHENOXYACETIC ACID; BETA 3 ADRENERGIC RECEPTOR; CALCIUM CHANNEL L TYPE; INWARDLY RECTIFYING POTASSIUM CHANNEL;

ACTION POTENTIAL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ELECTROCARDIOGRAM; EXPERIMENTAL RABBIT; HEART ATRIUM FIBRILLATION; HEART ATRIUM PACING; HEART ELECTROPHYSIOLOGY; HEART MUSCLE CELL; HEART MUSCLE REFRACTORY PERIOD; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; UPREGULATION; WESTERN BLOTTING;

ORYCTOLAGUS CUNICULUS;

EID: 80051965858     PISSN: 10158987     EISSN: 14219778     Source Type: Journal    
DOI: 10.1159/000331717     Document Type: Article

References (39)

1. Nattel S: Atrial electrophysiological remodeling caused by rapid atrial activation: underlying mechanisms and clinical relevance to atrial fibrillation. Cardiovasc Res 1999;42:298-308. (Pubitemid 29243158)
2. Wijffels MC, Kirchhof CJ, Dorland R, Allessie MA: Atrial fibrillation begets atrial fibrillation. A study in awake chronically instrumented goats. Circulation 1995;92:1954-1968.
3. Morillo CA, Klein GJ, Jones DL, Guiraudon CM: Chronic rapid atrial pacing. Structural, functional, and electrophysiological characteristics of a new model of sustained atrial fibrillation. Circulation 1995;91:1588-1595.
4. Gaspo R, Bosch RF, Talajic M, Nattel S: Functional mechanisms underlying tachycardia-induced sustained atrial fibrillation in a chronic dog model. Circulation 1997;96:4027-4035.
5. Boutjdir M, Le Heuzey JY, Lavergne T, Chauvaud S, Guize L, Carpentier A, Peronneau P: Inhomogeneity of cellular refractoriness in human atrium: factor of arrhythmia? Pacing Clin Electrophysiol 1986;9:1095-1100. (Pubitemid 17206781)
6. Nattel S, Maguy A, Le Bouter S, Yeh YH: Arrhythmogenic ion-channel remodeling in the heart: heart failure, myocardial infarction, and atrial fibrillation. Physiol Rev 2007;87:425-456. (Pubitemid 47084677)
7. Billman GE: Cardiac autonomic neural remodeling and susceptibility to sudden cardiac death. effect of endurance exercise training. Am J Physiol Heart Circ Physiol 2009;297:H1171-1193.
8. Gauthier C, Tavernier G, Charpentier F, Langin D, Le Marec H: Functional 3-adrenoceptor in the human heart. J Clin Invest 1996;98:556-562.
9. Sartiani L, De Paoli P, Stillitano F, Aimond F, Vassort G, Mugelli A, Cerbai E: Functional remodeling in postmyocardial infarcted rats: focus on betaadrenoceptor subtypes. J Mol Cell Cardiol 2006;40:258-266. (Pubitemid 43152381)
10. Pott C, Steinritz D, Napp A, Bloch W, Schwinger RH, Brixius K: On the function of beta3-adrenoceptors in the human heart: signal transduction, inotropic effect and therapeutic prospects. Wien Med Wochenschr 2006;156:451-458. (Pubitemid 44448601)
11. Rozec B, Gauthier C: 3-Adrenoceptors in the cardiovascular system: putative roles in human pathologies. Pharmacol 2006;111:652-673. (Pubitemid 44137382)
12. Bosch RF, Schneck AC, Kiehn J, Zhang W: 3-adrenergic regulation of an ion channel in the heart-inhibition of the slow delayed rectifier potassium current IKS in guinea pig ventricular myocytes. Cardiovasc Res 2002;56:393-403. (Pubitemid 35351561)
13. Scherer D, Kiesecker C, Kulzer M, Günth M, Scholz EP, Kathöfer S, Thomas D, Maurer M, Kreuzer J, Bauer A, Katus HA, Karle CA, Zitron E: Activation of inwardly rectifying Kir2.x potassium channels by 3-adrenoceptors is mediated via different signaling pathways with a predominant role of PKC for Kir2.1 and of PKA for Kir2.2. Naunyn Schmiedebergs Arch Pharmacol 2007;375:311-322. (Pubitemid 46945337)
14. Skeberdis VA, Gendviliene V, Zablockaite D, Treinys R, Macianskiene R, Bogdelis A, Jurevicius J, Fischmeister R: 3-adrenergic receptor activation increases human atrial tissue contractility and stimulates the L-type Ca2+ current. J Clin Invest 2008;118:3219-3227.
15. Zhou S, Tan AY, Paz O, Ogawa M, Chou CC, Hayashi H, Nihei M, Fishbein MC, Chen LS, Lin SF, Chen PS: Antiarrhythmic effects of 3-adrenergic receptor stimulation in a canine model of ventricular tachycardia. Heart Rhythm 2008;5:289-297. (Pubitemid 351168550)
16. Zhang Z, Cheng H, Onishi K, Wannenburg T, Cheng CP: Enhanced inhibition of Ltype Ca2+ current by beta3-adrenergic stimulation in failing rat heart. J Pharmacol Exp Ther 2005;315:1203-1211. (Pubitemid 41635409)
17. Li Y, Li WM, Gong YT, Li BX, Liu W, Han W, Dong D, Sheng L, Xue JY, Zhang L, Chu S, Yang BF: The effects of cilizapril and valsartan on the mRNA and protein expression of atrial calpains and atrialmyolysis in atrial fibrillation dogs. Basic Res Cardiol 2007;102:245-256. (Pubitemid 46566279)
18. Bosch RF, Scherer CR, Rüb N, Wöhrl S, Steinmeyer K, Haase H, Busch AE, Seipel L, Kühlkamp V: Molecular mechanisms of early electrical remodeling: transcriptional downregulation of ion channel subunits reduces ICa, L and Ito in rapid atrial pacing in rabbits. J Am Coll Cardiol 2003;41:858-869. (Pubitemid 36308398)
19. Pott C, Brixius K, Bundkirchen A, Bölck B, Bloch W, Steinritz D, Mehlhorn U, Schwinger RH: The preferential beta3-adrenoceptor agonist BRL37344 increases force via beta1-/beta2-adrenoceptors and induces endothelial nitric oxide synthase via beta3-adrenoceptors in human atrial myocardium. Br J Pharmacol 2003;138:521-529. (Pubitemid 36269492)
20. Pelat M, Verwaerde P, Galitzky J, Lafontan M, Berlan M, Senard JM, Montastruc JL: High isoproterenol doses are required to activate beta3-adrenoceptor-mediated functions in dogs. J Pharmacol Exp Ther 2003;304:246-253. (Pubitemid 36008935)
21. Li Y, Li WM, Xue JY, Han W, Yang SS, Gu HY: Effects of Losartan on acute atrial electrical remodeling. Chin Med J (Engl) 2004;117:643-646. (Pubitemid 38735814)
22. Gaspo R, Sun H, Fareh S, Levi M, Yue L, Allen BG, Hebert TE, Nattel S: Dihydropyridine and beta adrenergic receptor binding in dogs with tachycardia-induced atrial fibrillation. Cardiovasc Res 1999;42:434-442. (Pubitemid 29243169)
23. Audigane L, Kerfant BG, Harchi AE, Schmidt IL, Toumaniantz G, Cantereaus A, Potreau D, Charpentier F, Noireaud J, Gauthier C Rabbit, a relevant model for the study of cardiac beta3-adrenoceptors. Exp Physiol 2009;94:400-411.
24. Wang Z, Feng J, Shi H, Pond A, Nerbonne JM, Nattel S: The potential molecular basis of different physiological properties of transient outward K+ current in rabbit and human hearts. Circ Res 1999;84:551-561. (Pubitemid 29138592)
25. Zhang Y, Xiao J, Lin H, Luo X, Wang H, Bai Y, Wang J, Zhang H, Yang B, Wang Z: Ionic mechanisms underlying abnormal QT prolongation and the associated arrhythmias in diabetic rabbits: a role of rapid delayed rectifier K+ current. Cell Physiol Biochem 2007;19:225-238. (Pubitemid 46701498)
26. Imbrogno S, Angelone T, Adamo C, Pulerà E, Tota B, Cerra MC: Beta3-adrenoceptor in the eel (Anguilla anguilla) heart: negative inotropy and NO-cGMP-dependent mechanism. J Exp Biol 2006;209:4966-4973. (Pubitemid 46166724)
27. Chang CM, Wu TJ, Zhou S, Doshi RN, Lee MH, Ohara T, Fishbein MC, Karagueuzian HS, Chen PS, Chen LS: Nerve sprouting and sympathetic hyperinnervation in a canine model of atrial fibrillation produced by prolonged right atrial pacing. Circulation 2001;103:22-25 (Pubitemid 32050864)
28. Jayachandran JV, Sih HJ, Winkle W, Zipes DP, Hutchins GD, Olgin JE: Atrial fibrillation by prolonged rapid atrial pacing is associated with heterogeneous changes in atrial sympathetic innervation. Circulation 2000;101:1185-1191. (Pubitemid 30146622)
29. Summers RJ, Kompa A, Roberts SJ: Betaadrenoceptor subtypes and their desensitization mechanisms. J Auton Pharmacol 1997;17:331-343. (Pubitemid 28177411)
30. Gauthier C, Leblais V, Moniotte S, Langin D, Balligand JL: The negative inotropic action of catecholamines: role of beta3-adrenoceptors. Can J Physiol Pharmacol 2000;78:681-690.
31. Chamberlain PD, Jennings KH, Paul F, Cordell J, Berry A, Holmes SD, Park J, Chambers J, Sennitt MV, Stock MJ, Cawthorne MA, Young PW, Murphy GJ: The tissue distribution of the human 3-adrenoceptor studied using a monoclonal antibody: direct evidence of the beta3-adrenoceptor in human adipose tissue, atrium and skeletal muscle. Int J Obes Relat Metab Disord 1999;23:1057-1065. (Pubitemid 29476208)
32. Allessie M, Ausma J, Schotten U: Electrical, contractile and structural remodeling during atrial fibrillation. Cardiovasc Res 2002;54:230-246. (Pubitemid 34327903)
33. Nattel S, Burstein B, Dobrev D: Atrial remodeling and atrial fibrillation: mechanisms and implications. Circ Arrhythm Electrophysiol 2008;1:62-73.
34. Yue L, Feng J, Gaspo R, Li GR, Wang Z, Nattel S: Ionic remodeling underlying action potential changes in a canine model of atrial fibrillation. Circ Res 1997;81:512-525. (Pubitemid 27432738)
35. Cheng HJ, Zhang ZS, Onishi K, Ukai T, Sane DC, Cheng CP: Upregulation of functional 3-adrenergic receptor in the failing canine myocardium. Circ Res 2001;89:599-606. (Pubitemid 32924214)
36. Ehrlich JR: Inward rectifier potassium currents as a target for atrial fibrillation therapy. J Cardiovasc Pharmacol 2008;52:129-135.
37. Gauthier C, Tavernier G, Trochu JN, Leblais V, Laurent K, Langin D, Escande D, Le Marec H: Interspecies differences in the cardiac negative inotropic effects of beta(3)-adrenoceptor agonists. J Pharmacol Exp Ther 1999;290:687-693. (Pubitemid 29344563)
38. Torsten C, Peter M, Paul MK, Ursula R, Alberto JK. Human atrial 1L-adrenoceptor but not 3-adrenoceptor activation increases force and Ca2+ current at physiological temperature. Brit J Pharmacol 2011;162:823-839.
39. Martin CM, Sian EH, Richard AB. Are there functional 3-adrenoceptors in the human heart? Brit J Pharmacol 2011;162:817-822.