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Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 18, 2011, Pages 5248-5250

Cracking the molecular weight barrier: Fragment screening of an aminotransferase using an NMR-based functional assay

(9) Mendoza, Renaldo a Petros, Andrew M a Liu, Yaya a Thimmapaya, Rama a Surowy, Carol S a Leise, Walter F a Pereda Lopez, Ana a Panchal, Sanjay C a Sun, Chaohong a

a ABBOTT LABORATORIES (United States)

Author keywords

BCATc; Fragment; NMR

Indexed keywords

AMINOTRANSFERASE; AMINOTRANSFERASE INHIBITOR; DIMER; GLUTAMIC ACID; HISTIDINE;

AMINO ACID SYNTHESIS; ARTICLE; DRUG TARGETING; ENZYME ANALYSIS; MOLECULAR WEIGHT; NEUROLOGIC DISEASE; NUCLEAR MAGNETIC RESONANCE; PROTEIN TARGETING; SCREENING;

BIOCATALYSIS; CARBON ISOTOPES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; LIGANDS; MOLECULAR STRUCTURE; MOLECULAR WEIGHT; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; ORGANIC CHEMICALS; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSAMINASES;

EID: 80051953287 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2011.07.039 Document Type: Article

Times cited : (1)

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