메뉴 건너뛰기




Volumn 39, Issue 9, 2011, Pages 2113-2120

Relative contribution of three main virulence factors in Pseudomonas aeruginosa pneumonia

Author keywords

lipopolysaccharide; Pseudomonas aeruginosa; quorum sensing; type III secretion system; ventilator associated pneumonia; virulence factors

Indexed keywords

ELASTASE; EXOTOXIN; EXOTOXIN S; EXOTOXIN T; EXOTOXIN U; LIPOPOLYSACCHARIDE; PYOCYANINE; UNCLASSIFIED DRUG;

EID: 80051936857     PISSN: 00903493     EISSN: 15300293     Source Type: Journal    
DOI: 10.1097/CCM.0b013e31821e899f     Document Type: Article
Times cited : (64)

References (53)
  • 1
    • 0027466159 scopus 로고
    • Nosocomial pneumonia in ventilated patients: A cohort study evaluating attributable mortality and hospital stay
    • DOI 10.1016/0002-9343(93)90060-3
    • Fagon JY, Chastre J, Hance AJ, et al: Nosocomial pneumonia in ventilated patients: A cohort study evaluating attributable mortality and hospital stay. Am J Med 1993; 94: 281-288 (Pubitemid 23074802)
    • (1993) American Journal of Medicine , vol.94 , Issue.3 , pp. 281-288
    • Fagon, J.-Y.1    Chastre, J.2    Hance, A.J.3    Montravers, P.4    Novara, A.5    Gibert, C.6
  • 2
    • 0021269853 scopus 로고
    • Bacteremic nosocomial pneumonia. Analysis of 172 episodes from a single metropolitan area
    • Bryan CS, Reynolds KL: Bacteremic nosocomial pneumonia. Analysis of 172 episodes from a single metropolitan area. Am Rev Respir Dis 1984; 129:668-671 (Pubitemid 14104740)
    • (1984) American Review of Respiratory Disease , vol.129 , Issue.5 , pp. 668-671
    • Bryan, C.S.1    Reynolds, K.L.2
  • 3
    • 0029863296 scopus 로고    scopus 로고
    • Ventilator-associated pneumonia due to Pseudomonas aeruginosa
    • Crouch BS, Wunderink RG, Jones CB, et al: Ventilator-associated pneumonia due to Pseudomonas aeruginosa. Chest 1996; 109: 1019-1029 (Pubitemid 26113647)
    • (1996) Chest , vol.109 , Issue.4 , pp. 1019-1029
    • Brewer, S.C.1    Wunderink, R.G.2    Jones, C.B.3    Leeper Jr., K.V.4
  • 5
  • 6
    • 0033598693 scopus 로고    scopus 로고
    • Identification of genes controlled by quorum sensing in Pseudomonas aeruginosa
    • Whiteley M, Lee KM, Greenberg EP: Identification of genes controlled by quorum sensing in Pseudomonas aeruginosa. Proc Nat Acad Sci USA 1999; 96:13904-13909
    • (1999) Proc Nat Acad Sci USA , vol.96 , pp. 13904-13909
    • Whiteley, M.1    Lee, K.M.2    Greenberg, E.P.3
  • 7
    • 0025755803 scopus 로고
    • Cloning and characterization of the Pseudomonas aeruginosa lasR gene, a transcriptional activator of elastase expression
    • Gambello MJ, Iglewski BH: Cloning and characterization of the Pseudomonas aeruginosa lasR gene, a transcriptional activator of elastase expression. J Bacteriol 1991; 173: 3000-3009
    • (1991) J Bacteriol , vol.173 , pp. 3000-3009
    • Gambello, M.J.1    Iglewski, B.H.2
  • 8
    • 0028849833 scopus 로고
    • Synthesis of multiple exoproducts in Pseudomonas aeruginosa is under the control of RhlR-RhlI, another set of regulators in strain PAO1 with homology to the autoinducer-responsive LuxR-LuxI family
    • Brint JM, Ohman DE: Synthesis of multiple exoproducts in Pseudomonas aeruginosa is under the control of RhlR-RhlI, another set of regulators in strain PAO1 with homology to the autoinducer-responsive LuxR-LuxI family. J Bacteriol 1995; 177:7155-7163
    • (1995) J Bacteriol , vol.177 , pp. 7155-7163
    • Brint, J.M.1    Ohman, D.E.2
  • 9
    • 0030188736 scopus 로고    scopus 로고
    • Pseudomonas aeruginosa and Epithelial Permeability: Role of Virulence Factors Elastase and Exotoxin A
    • Azghani AO: Pseudomonas aeruginosa and epithelial permeability: role of virulence factors elastase and exotoxin A. Am J Respir Cell Mol Biol 1996; 15:132-140 (Pubitemid 126439864)
    • (1996) American Journal of Respiratory Cell and Molecular Biology , vol.15 , Issue.1 , pp. 132-140
    • Azghani, A.O.1
  • 11
    • 9644257146 scopus 로고    scopus 로고
    • The role of pyocyanin in Pseudomonas aeruginosa infection
    • DOI 10.1016/j.molmed.2004.10.002, PII S1471491404002606
    • Lau GW, Hassett DJ, Ran H, et al: The role of pyocyanin in Pseudomonas aeruginosa infection. Trends Mol Med 2004; 10:599-606 (Pubitemid 39573151)
    • (2004) Trends in Molecular Medicine , vol.10 , Issue.12 , pp. 599-606
    • Lau, G.W.1    Hassett, D.J.2    Ran, H.3    Kong, F.4
  • 12
    • 0031864184 scopus 로고    scopus 로고
    • Type III protein secretion systems in bacterial pathogens of animals and plants
    • Hueck CJ: Type III protein secretion systems in bacterial pathogens of animals and plants. Microbiol Mol Biol Rev 1998; 62:379-433 (Pubitemid 28270280)
    • (1998) Microbiology and Molecular Biology Reviews , vol.62 , Issue.2 , pp. 379-433
    • Hueck, C.J.1
  • 14
    • 33846688692 scopus 로고    scopus 로고
    • 2 enzymes: Better living through phospholipolysis
    • DOI 10.1016/j.tim.2006.12.003, PII S0966842X06002770
    • Sitkiewicz I, Stockbauer KE, Musser JM: Secreted bacterial phospholipase A2 enzymes: Better living through phospholipolysis. Trends Microbiol 2007; 15:63-69 (Pubitemid 46199188)
    • (2007) Trends in Microbiology , vol.15 , Issue.2 , pp. 63-69
    • Sitkiewicz, I.1    Stockbauer, K.E.2    Musser, J.M.3
  • 15
    • 59849110833 scopus 로고    scopus 로고
    • Role of Pseudomonas aeruginosa type III effectors in disease
    • Engel J, Balachandran P: Role of Pseudomonas aeruginosa type III effectors in disease. Curr Opin Microbiol 2009; 12:61-66
    • (2009) Curr Opin Microbiol , vol.12 , pp. 61-66
    • Engel, J.1    Balachandran, P.2
  • 18
    • 0033919437 scopus 로고    scopus 로고
    • Pseudomonas aeruginosa cell-to-cell signaling is required for virulence in a model of acute pulmonary infection
    • DOI 10.1128/IAI.68.7.4331-4334.2000
    • Pearson JP, Feldman M, Iglewski BH, et al: Pseudomonas aeruginosa cell-to-cell signaling is required for virulence in a model of acute pulmonary infection. Infect Immun 2000; 68:4331-4334 (Pubitemid 30434592)
    • (2000) Infection and Immunity , vol.68 , Issue.7 , pp. 4331-4334
    • Pearson, J.P.1    Feldman, M.2    Iglewski, B.H.3    Prince, A.4
  • 20
    • 3042550379 scopus 로고    scopus 로고
    • Pseudomonas aeruginosa pyocyanin is critical for lung infection in mice
    • DOI 10.1128/IAI.72.7.4275-4278.2004
    • Lau GW, Ran H, Kong F, et al: Pseudomonas aeruginosa pyocyanin is critical for lung infection in mice. Infect Immun 2004; 72: 4275-4278 (Pubitemid 38821943)
    • (2004) Infection and Immunity , vol.72 , Issue.7 , pp. 4275-4278
    • Lau, G.W.1    Ran, H.2    Kong, F.3    Hassett, D.J.4    Mavrodi, D.5
  • 21
    • 0019126522 scopus 로고
    • Isolation and characterization of a Pseudomonas aeruginosa PAO mutant that produces altered elastase
    • Ohman DE, Cryz SJ, Iglewski BH: Isolation and characterization of Pseudomonas aeruginosa PAO mutant that produces altered elastase. J Bacteriol 1980; 142: 836-842 (Pubitemid 11230333)
    • (1980) Journal of Bacteriology , vol.142 , Issue.3 , pp. 836-842
    • Ohman, D.E.1    Cryz, S.J.2    Iglewski, B.H.3
  • 23
    • 15544389065 scopus 로고    scopus 로고
    • Role of the type III secreted exoenzymes S, T, and Y in systemic spread of Pseudomonas aeruginosa PAO1 in vivo
    • DOI 10.1128/IAI.73.3.1706-1713.2005
    • Vance RE, Rietsch A, Mekalanos JJ: Role of the type III secreted exoenzymes S, T, and Y in systemic spread of Pseudomonas aeruginosa PAO1 in vivo. Infect Immun 2005; 73: 1706-1713 (Pubitemid 40470759)
    • (2005) Infection and Immunity , vol.73 , Issue.3 , pp. 1706-1713
    • Vance, R.E.1    Rietsch, A.2    Mekalanos, J.J.3
  • 28
    • 0021339146 scopus 로고
    • Role of lipopolysaccharide in virulence of Pseudomonas aeruginosa
    • Cryz SJ Jr, Pitt TL, Furer E, et al: Role of lipopolysaccharide in virulence of Pseudomonas aeruginosa. Infect Immun 1984; 44:508-513 (Pubitemid 14139022)
    • (1984) Infection and Immunity , vol.44 , Issue.2 , pp. 508-513
    • Cryz Jr., S.J.1    Pitt, T.L.2    Furer, E.3    Germanier, R.4
  • 29
    • 12944297142 scopus 로고    scopus 로고
    • Can laboratory reference strains mirror 'real-world' pathogenesis?
    • DOI 10.1016/j.tim.2004.11.001, PII S0966842X04002550
    • Fux CA, Shirtliff M, Stoodley P, et al: Can laboratory reference strains mirror 'realworld' pathogenesis? Trends Microbiol 2005; 13:58-63 (Pubitemid 40174864)
    • (2005) Trends in Microbiology , vol.13 , Issue.2 , pp. 58-63
    • Fux, C.A.1    Shirtliff, M.2    Stoodley, P.3    Costerton, J.W.4
  • 31
    • 0036191393 scopus 로고    scopus 로고
    • Type III protein secretion is associated with poor clinical outcomes in patients with ventilator-associated pneumonia caused by Pseudomonas aeruginosa
    • Hauser AR, Cobb E, Bodi M, et al: Type III protein secretion is associated with poor clinical outcomes in patients with ventilatorassociated pneumonia caused by. Pseudomonas aeruginosa. Crit Care Med 2002; 30: 521-528 (Pubitemid 34214611)
    • (2002) Critical Care Medicine , vol.30 , Issue.3 , pp. 521-528
    • Hauser, A.R.1    Cobb, E.2    Bodi, M.3    Mariscal, D.4    Valles, J.5    Engel, J.N.6    Rello, J.7
  • 32
    • 0346256754 scopus 로고    scopus 로고
    • Secretion of the Toxin ExoU Is a Marker for Highly Virulent Pseudomonas aeruginosa Isolates Obtained from Patients with Hospital-Acquired Pneumonia
    • DOI 10.1086/379372
    • Schulert GS, Feltman H, Rabin SD, et al: Secretion of the toxin ExoU is a marker for highly virulent Pseudomonas aeruginosa isolates obtained from patients with hospitalacquired pneumonia. J Infect Dis 2003; 188: 1695-1706 (Pubitemid 38010681)
    • (2003) Journal of Infectious Diseases , vol.188 , Issue.11 , pp. 1695-1706
    • Schulert, G.S.1    Feltman, H.2    Rabin, S.D.P.3    Martin, C.G.4    Battle, S.E.5    Rello, J.6    Hauser, A.R.7
  • 33
    • 0031865630 scopus 로고    scopus 로고
    • Pseudomonas aeruginosa lasR transcription correlates with the transcription of lasA, lasB, and toxA in chronic lung infections associated with cystic fibrosis
    • Storey DG, Ujack EE, Rabin HR, et al: Pseudomonas aeruginosa lasR transcription correlates with the transcription of lasA, lasB, and toxA in chronic lung infections associated with cystic fibrosis. Infect Immun 1998; 66:2521-2528 (Pubitemid 28261747)
    • (1998) Infection and Immunity , vol.66 , Issue.6 , pp. 2521-2528
    • Storey, D.G.1    Ujack, E.E.2    Rabin, H.R.3    Mitchell, I.4
  • 35
    • 0028944578 scopus 로고
    • Transcriptional analysis of the Pseudomonas aeruginosa exoenzyme S structural gene
    • Yahr TL, Hovey AK, Kulich SM, et al: Transcriptional analysis of the Pseudomonas aeruginosa exoenzyme S structural gene. J Bacteriol 1995; 177:1169-1178
    • (1995) J Bacteriol , vol.177 , pp. 1169-1178
    • Yahr, T.L.1    Hovey, A.K.2    Kulich, S.M.3
  • 36
    • 0029914812 scopus 로고    scopus 로고
    • Genetic relationship between the 53- and 49-kilodalton forms of exoenzyme S from Pseudomonas aeruginosa
    • Yahr TL, Barbieri JT, Frank DW: Genetic relationship between the 53-and 49-kilodalton forms of exoenzyme S from Pseudomonas aeruginosa. J Bacteriol 1996; 178: 1412-1419 (Pubitemid 26073399)
    • (1996) Journal of Bacteriology , vol.178 , Issue.5 , pp. 1412-1419
    • Yahr, T.L.1    Barbieri, J.T.2    Frank, D.W.3
  • 37
    • 0031917203 scopus 로고    scopus 로고
    • PepA, a secreted protein of Pseudomonas aeruginosa, is necessary for cytotoxicity and virulence
    • DOI 10.1046/j.1365-2958.1998.00727.x
    • Hauser AR, Kang PJ, Engel JN: PepA, a secreted protein of Pseudomonas aeruginosa, is necessary for cytotoxicity and virulence. Mol Microbiol 1998; 27:807-818 (Pubitemid 28081989)
    • (1998) Molecular Microbiology , vol.27 , Issue.4 , pp. 807-818
    • Hauser, A.R.1    Kang, P.J.2    Engel, J.N.3
  • 38
    • 0032709096 scopus 로고    scopus 로고
    • Cell death of human polymorphonuclear neutrophils induced by a Pseudomonas aeruginosa cystic fibrosis isolate requires a functional type III secretion system
    • Dacheux D, Attree I, Schneider C, et al: Cell death of human polymorphonuclear neutrophils induced by a Pseudomonas aeruginosa cystic fibrosis isolate requires a functional type III secretion system. Infect Immun 1999; 67:6164-6167 (Pubitemid 29508152)
    • (1999) Infection and Immunity , vol.67 , Issue.11 , pp. 6164-6167
    • Dacheux, D.1    Attree, I.2    Schneider, C.3    Toussaint, B.4
  • 40
    • 0025988234 scopus 로고
    • Differential responses of the endothelial and epithelial barriers of the lung in sheep to Escherichia coli endotoxin
    • Wiener-Kronish JP, Albertine KH, Matthay MA: Differential responses of the endothelial and epithelial barriers of the lung in sheep to Escherichia coli endotoxin. J Clin Invest 1991; 88:864-875
    • (1991) J Clin Invest , vol.88 , pp. 864-875
    • Wiener-Kronish, J.P.1    Albertine, K.H.2    Matthay, M.A.3
  • 42
    • 18944375457 scopus 로고    scopus 로고
    • Quorum sensing negatively controls type III secretion regulon expression in Pseudomonas aeruginosa PAO1
    • DOI 10.1128/JB.187.11.3898-3902.2005
    • Bleves S, Soscia C, Nogueira-Orlandi P, et al: Quorum sensing negatively controls type III secretion regulon expression in Pseudomonas aeruginosa PAO1. J Bacteriol 2005; 187: 3898-3902 (Pubitemid 40705600)
    • (2005) Journal of Bacteriology , vol.187 , Issue.11 , pp. 3898-3902
    • Bleves, S.1    Soscia, C.2    Nogueira-Orlandi, P.3    Lazdunski, A.4    Filloux, A.5
  • 44
    • 67650446165 scopus 로고    scopus 로고
    • Pseudomonas aeruginosa virulence and therapy: Evolving translational strategies
    • Veesenmeyer JL, Hauser AR, Lisboa T, et al: Pseudomonas aeruginosa virulence and therapy: Evolving translational strategies. Crit Care Med 2009; 37:1777-1786
    • (2009) Crit Care Med , vol.37 , pp. 1777-1786
    • Veesenmeyer, J.L.1    Hauser, A.R.2    Lisboa, T.3
  • 45
    • 0020658362 scopus 로고
    • Evaluation of Pseudomonas aeruginosa exotoxin A and elastase as virulence factors in acute lung infection
    • Blackwood LL, Stone RM, Iglewski BH, et al: Evaluation of Pseudomonas aeruginosa exotoxin A and elastase as virulence factors in acute lung infection. Infect Immun 1983; 39:198-201 (Pubitemid 13212515)
    • (1983) Infection and Immunity , vol.39 , Issue.1 , pp. 198-201
    • Blackwood, L.L.1    Stone, R.M.2    Iglewski, B.H.3    Pennington, J.E.4
  • 47
    • 0023063274 scopus 로고
    • Biological effects of Pseudomonas aeruginosa phenazine pigments
    • Sorensen RU, Klinger JD: Biological effects of Pseudomonas aeruginosa phenazine pigments. Antibiot Chemother 1987; 39: 113-124
    • (1987) Antibiot Chemother , vol.39 , pp. 113-124
    • Sorensen, R.U.1    Klinger, J.D.2
  • 48
    • 0034769748 scopus 로고    scopus 로고
    • Prevalence of type III secretion genes in clinical and environmental isolates of Pseudomonas aeruginosa
    • Feltman H, Schulert G, Khan S, et al: Prevalence of type III secretion genes in clinical and environmental isolates of Pseudomonas aeruginosa. Microbiology 2001; 147: 2659-2669 (Pubitemid 32976307)
    • (2001) Microbiology , vol.147 , Issue.10 , pp. 2659-2669
    • Feltman, H.1    Schulert, G.2    Khan, S.3    Jain, M.4    Peterson, L.5    Hauser, A.R.6
  • 49
    • 0033916705 scopus 로고    scopus 로고
    • Acquisition of expression of the Pseudomonas aeruginosa ExoU cytotoxin leads to increased bacterial virulence in a murine model of acute pneumonia and systemic spread
    • DOI 10.1128/IAI.68.7.3998-4004.2000
    • Allewelt M, Coleman FT, Grout M, et al: Acquisition of expression of the Pseudomonas aeruginosa ExoU cytotoxin leads to increased bacterial virulence in a murine model of acute pneumonia and systemic spread. Infect Immun 2000; 68:3998-4004 (Pubitemid 30434552)
    • (2000) Infection and Immunity , vol.68 , Issue.7 , pp. 3998-4004
    • Allewelt, M.1    Coleman, F.T.2    Grout, M.3    Priebe, G.P.4    Pier, G.B.5
  • 51
    • 9244236027 scopus 로고    scopus 로고
    • Relative contributions of Pseudomonas aeruginosa ExoU, ExoS, and ExoT to virulence in the lung
    • DOI 10.1128/IAI.72.12.6969-6977.2004
    • Shaver CM, Hauser AR: Relative contributions of Pseudomonas aeruginosa ExoU, ExoS, and ExoT to virulence in the lung. Infect Immun 2004; 72:6969-6977 (Pubitemid 39552365)
    • (2004) Infection and Immunity , vol.72 , Issue.12 , pp. 6969-6977
    • Shaver, C.M.1    Hauser, A.R.2
  • 52
    • 51349133753 scopus 로고    scopus 로고
    • Persistent infection with Pseudomonas aeruginosa in ventilator-associated pneumonia
    • El Solh AA, Akinnusi ME, Wiener-Kronish JP, et al: Persistent infection with Pseudomonas aeruginosa in ventilator-associated pneumonia. Am J Respir Crit Care Med 2008; 178:513-519
    • (2008) Am J Respir Crit Care Med , vol.178 , pp. 513-519
    • El Solh, A.A.1    Akinnusi, M.E.2    Wiener-Kronish, J.P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.