Herbs and herbal preparations for glycemic control in diabetes mellitus (a systematic review)

Journal of Medicinal Plants Research

Volumn 5, Issue 16, 2011, Pages 3846-3855

  Shojaii, A ^a   Goushegir, A ^a   Hashem Dabaghian, F ^a   Abdollahi, M ^c   Fallah Huseini, H ^b  

^a TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b AVICENNA RESEARCH INSTITUTE   (Iran)

^c NONE

Author keywords

Andomized controlled trial (RCT); Clinical trial; Diabetes mellitus; Herb; Plant; Review

Indexed keywords

ALMOND OIL; AMORPHOPHALLUS KONJAC EXTRACT; ANTIDIABETIC AGENT; CINNAMON AROMATICUM EXTRACT; COCCINIA CORDIFOLIA EXTRACT; COLOCYNTH EXTRACT; CUMINUM CYMINUM EXTRACT; GANODERMA LUCIDUM EXTRACT; GINKGO BILOBA EXTRACT; GLIBENCLAMIDE; GLUCOSE; GYNOSTEMMA PENTAPHYLLUM EXTRACT; HEMOGLOBIN A1C; HERBACEOUS AGENT; IPOMOEA BATATAS EXTRACT; ISPAGULA; MOMORDICA CHARANTIA EXTRACT; NIGELLA SATIVA EXTRACT; PINUS MARITIMA EXTRACT; PLACEBO; PLANT EXTRACT; SALACIA OBLONGA EXTRACT; SATUREJA KHUZETANICA EXTRACT; SILYBUM MARIANUM EXTRACT; STEVIA REBAUDIANA EXTRACT; SYZYGIUM CUMINI EXTRACT; THEA SINENSIS; TINOSPORA CRISPA EXTRACT; TRIGONELLA FOENUM GRAECUM EXTRACT; UNCLASSIFIED DRUG; UNINDEXED DRUG;

AMORPHOPHALLUS KONJAC; CHINESE MEDICINE; CINNAMON AROMATICUM; COCCINIA CORDIFOLIA; CUMIN; DIET RESTRICTION; DRUG EFFICACY; GLUCOSE BLOOD LEVEL; GLYCEMIC CONTROL; HUMAN; MEDICINAL PLANT; NON INSULIN DEPENDENT DIABETES MELLITUS; PINUS MARITIMA; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; SALACIA OBLONGA; SATUREJA KHUZETANICA; STEVIA; SWEET POTATO; SYSTEMATIC REVIEW; THEA SINENSIS; TINOSPORA CRISPA;

CITRULLUS; IPOMOEA; SCOPUS; SILYBUM MARIANUM;

EID: 80051932573     PISSN: None     EISSN: 19960875     Source Type: Journal    
DOI: None     Document Type: Review

References (66)

1. Abidov M, Ramazanov A, Jimenez DRM, Chkhikvishvili I (2006). Effect of Blueberin on fastimg glucose, C-reactive proten and plasma aminotransferases, in female volunteers with diabetes type 2: doubleblind, placebo controlled clinical study. Georgian Med. News, 141: 66-72.
2. Andallu B, Ramaya V (2007). Anti-hyperglycemic, cholesterol-lowering and HDL-raising effects of cumin (Cuminum cyminum) seeds in type 2 diabetes. J. Nat. Remedies, 7: 142-149.
3. Azimi-Nezhad M, Ghayour-Mobarhan M, Parizadeh MR, Safarian M, Esmaeili H, Parizadeh SMJ, Khodaee G, Hosseini J, Abasalti Z, Hassankhani B, Ferns G (2008). Prevalence of type 2 diabetes mellitus in Iran and its relationship with gender, urbanisation, education, marital status and occupationSingapore Med. J., 49(7): 571-576.
4. Bailey CJ, Day C (1989). Traditional plant medicines as treatments for diabetes. Diabetes Care, 12: 553-546.
5. Baker WL, Gutierrez-Williams G, White CM, Kluger J, Coleman CI (2008). Effect of cinnamon on glucose control and lipid parameters. Diabetes Care, 31(1): 41-43.
6. Bawadi HA, Maghaydah SN, Tayyem RF (2009). The postprandial hypoglycemic activity of fenugreek seed and seeds extract in type 2 diabetics: A plot study. Pharmacogn. Mag., 4(18): 134-138.
7. Berman BM, Swyers JP, Kaczmarczyk J (1999). Complementary and alternative medicine: herbal therapies for diabetes. J. Assoc. Acad. Min. Phys., 10: 10-14.
8. Blevins SM, Leyva MJ, Brown J, Wright J, Scofield RH, Aston CE (2007). Effect of Cinnamon on Glucose and Lipid Levels in Non- Insulin-Dependent Type 2 Diabetes., Diabetes Care, 30(9): 2236-2237.
9. Chao M, Zou D, Zhang Y, Chen Y, Wang M, Wu H, Ning G, Wang W (2009). Improving insulin resistance with traditional Chinese medicine in type 2 diabetic patients. Endocrine, 36(2): 268-274.
10. Chen HL, Sheu WH, Tai TS, Liaw YP, Chen YC (2003). Konjac supplement alleviated hypercholesterolemia and hyperglycemia in type 2 diabetic subject: a randomized double-blind trial. J. Am. Coll. Nutr., 22(1): 36-42.
11. Chitwood M (1999). Botanical therapies for diabetes: on the cutting edge. Diabetes Care Educ., 20: 3-20.
12. Dans AM, Villarruz MV, Jimeno CA (2007). The effect of Momordica charantia capsule preparation on glycemic control in type 2 diabetes mellitus needs further studies. J. Clin. Eidemiol., 60(6): 554-559.
13. Dham S, Shah V, Hirsch S, Banerji MA (2006). The role of complementary and alternative medicine in diabetes, Curr. Diab. Rep., 6(3): 251-258.
14. Dugoua JJ, Seely D, Perri D, Cooley K, Forelli T, Mills E, Koren G (2007). From type 2 diabetes to antioxidant activity: a systematic review of the safety and efficacy of common and Cassia cinnamon bark. Can. J. Physiol. Pharmacol., 85: 837-847.
15. Elder C, Aickin M, Bauer V, Cairns J, Vuckovic N (2006). Randomized trial of whole-system Ayurvedic protocol for type 2 diabetes. Altern. Ther. Health Med., 12(5): 24-30.
16. Ernst E (1996). Hypoglycemic plant medicines. Perfusion, 9: 416-418.
17. Ernst E (1997). Plants with hypoglycemic activity in humans. Phytomedicine, 4: 73-78.
18. Fakhoury WKH, LeReun C, Wright D (2010). A Meta-Analysis of Placebo-Controlled Clinical Trials Assessing the Efficacy and Safety of Incretin-Based Medications in Patients with Type 2 Diabetes. Pharmacology, 86: 44-57.
19. Fallah HH, Heshmat R, Larijani B (2006). The clinical investigation of Citrullus Colocynthus (L) Schrad Fruit in treatment of type II diabetic patients: A randomized double-blind, placebo -controlled study. J. Med. Plant., (5): 31-35
20. Fallah HH, Zarei BA, Heshmat R (2006). The effect of Citrullus Colocynthus (L) Schrad fruit on oxidative stress parameters in type II diabetic patients. J. Med. Plant, 5: 55-60.
21. Fallah HH, Darvishzadeh F, Heshmat R, Jafariazar Z, Raza M, Larijani B (2009). The clinical investigation of Citrullus colocynthus (L.) schrad fruit in treatment of Type II diabetic patients: a randomized, double blind, placebo-controlled clinical trial. Phytother. Res., 23(8): 1186-1189.
22. Fallah HH, Larijani B, Fakhrzadeh H (2004). The clinical trial of Silybum Marianum seed extract (Silymarin) on type II diabetic patients with hyperlipidemia. Iran. J. Diabetes Lipid Disord., 2: 201-206.
23. Fallah HH, Larijani B, Heshmat R, Fakhrzadeh H, Radjabipour B, Toliat T, Raza M (2006). The efficacy of Silybum marianum (L.) Gaertn. (Silymarin) in the treatment of type II diabetes: a randomized, doubleblind, placebo-controlled, clinical trial. Phytother. Res., 20(12): 1036-1039.
24. Fallah HH, Hooseini P, Heshmat R, Yazdani D, Hemati MHR, Rahmani M, Larijani B, Alavi SHR (2006). The clinical investigation of Securigera securidaca (L.)(Degen and Doerfler) seeds in type II diabetic patients; a randomized, double-blind, placebo-controlled study. J. Med. Plants, 5(20): 75-79.
25. Fukino Y, Ikeda A, Maruyama K, Aoki N, Okubo T, Iso H (2008). Randomized controlled trial for an effect of green tea-extract powder supplementation on glucose abnormalities. Eur. J. Clin. Nutr. 62(8): 953-960.
26. Gori M, Campbell R (1998). Natural products and diabetes treatment. Diabetes Educ., 24: 201-208.
27. Gregersen S, Jeppesen PB, Holst JJ, Hermansen K (2004). Antihypoglycemic effects of stevioside in type 2 diabetic subjects. Metabolism: Clin. Exp., 53(1): 73-76.
28. Hsia SH, Bazargan M, Davidson MB (2004). Effect of Pancrease Tonic (an Ayurvedic herbal supplement) in type 2 diabetes mellitus. Metabolism, 53(9): 1166-1173.
29. Hsu CH, Liao YL, Lin SC, Hwang KC, Chou P (2007). The mushroom Agaricus Blazei murill in combination with Metformin and gliclazide improves insulin resistance in type 2 diabetes: a randomized, double-blind, and placebo-controlled clinical trial. J. Altern. Complement. Med., 13(1): 97-102.
30. Huyen VT, Phan DV, Thang P, Hoa NK, Ostenson CG (2010). Antidiabetic effect of Gynostemma pentaphyllum tea in randomly assigned type 2 diabetic patients.Horm. metab. Res., 42(5): 353-357.
31. Jayawardena MHS, De ANMW, Hettigoda V, Fernando DJS (2005). A double blind randomized placebo controlled cross over study of a herbal preparation containing Salacia reticulate in the treatment of type 2 diabetes. J. Ethnopharmacol., 97: 215-218.
32. John AJ, Cherian R, Subhash HS, Cherian AM (2003). Evaluation of the efficacy of bitter gourd (Momordica Charantia) as an oral hypoglycemic agent - a randomized controlled clinical trial. Indian J. Physiol. Pharmacol., 47(3): 363-365.
33. Khan A, Safdar M, Ali Khan MM, Khattak KN, Anderson RA (2003). Cinnamon improves glucose and Lipids of people with type 2 diabetes. Diabetes Care, 26: 3215-3218.
34. Kudolo GB, Wang W, Elrod R, Barrientos J, Haase A, Blodgett J (2006). Short-term ingestion of Ginkgo biloba extract does not alter whole body insulin sensitivity in non-diabetic, pre-diabetic or type 2 diabetic subjects- - a randomized double-blind placebo-controlled crossover study. Clin. Nutr., 25(1): 123-134.
35. Kuriyan R, Rajendran R, Bantwal G, Kurpad AV (2008). Effect of supplementation of Coccinia cordifolia Extract on Newly Detected Diabetic Patients. Diabetes Care, 31(2): 216-220.
36. Leng L, Birtwhistle R, Kotecha J, Hannah S, Cuthbertson Sh (2009). Anti-diabetic and hypoglycemic effect of Momordica charantia (bitter melon): a mini review. Br. J. Nutr., 102(12): 1703-1708.
37. Li SC, Liu YH, Liu JF, Chang WH, Chen CM, Chen C-YO (2011). Almond consumption glycemic control and lipid profiles in patients with type 2 diabetes mellitus. Metab. Clin. Exp., 60(4): 474-479
38. Liu X, Wei J, Tan F, Zhou S, Wurthwein G, Rohdewald P (2004). Antidiabetic effect of Pycnogenol French maritime pine bark extract in patients with diabetes type II. Life Sci., 75(21):2505-2513.
39. Lovejoy JC, Most MM, Lefevre M, Greenway FL, Rood JC (2002). Effect of diet enriched in almonds on insulin action and serum lipids in adults with normal glucose tolerance or type 2 diabetes. Am. J. Clin. Nutr., 76: 1000-1006.
40. Ludvik B, Waldhusl W, Prager R, Kautzky-Willer A, Pacini G (2003). Mode of action of Ipomoea batatas (Caiapo) in type 2 diabetic patients. Metabolism, 52(7): 875-880.
41. Ludvik B, Neuffer B, Pacini G (2004). Efficacy of Ipomoea batatas(Caiapo)on diabetes control in type 2 diabetic subject treated with diet. Diabetes Care, 27(2): 436-440.
42. Mang B, Wolters M, Schmitt B, Kelb K, Lichtinghagen R, Stichtenoth DO, Hahn A (2006). Effects of a cinnamon extract on plasma glucose, HbA, and serum lipids in diabetes mellitus type 2. Eur. J. Clin. Invest., 36(5): 340-344.
43. Mooradian AD, Failla M, Hoogwerf B, Maryniuk M, Wylie-Rosett J (1994). Selected vitamins and minerals in diabetes. Diabetes Care, 17: 464-479.
44. Modak M, Dixit P, Londhe J, Ghaskadbi S, Devasagayam TP (2007). Indian Herbs and Herbal Drugs Used for the Treatment of Diabetes. J. Clin. Biochem. Nutr., 40: 163-173.
45. Morelli V, Zoorob RJ (2000). Alternative therapies.I. Depression, diabetes, obesity. Am. Fam. Phys., 62: 1051-1060.
46. O'Connell B (2001). Select vitamins and minerals in the management of diabetes. Diabetes Spectr., 14: 133-148.
47. Ogbera AO, Dada O, Adeyeye F, Jewo PI (2010). Complementary and alternative medicine use in diabetes mellitus, West Afr. J. Med., 29(3): 158-162.
48. Ooi CP, Yassin Z, Hamid TA (2010). Momordica charantia for type 2 diabetes mellitus, Cochrane Database of systematic reviews 17; 2:CD007845.
49. Pandey VN, Rajagopalan SS, Chowdhary DP (1995). An effective Ayurvedic hypoglycemic formulation. J. Res. Ayurvedic siddha, 16: 1-14.
50. Pradhan SC, Girish C (2006). Hepatoprotective herbal drug, silymarin from experimental pharmacology to clinical medicine, Indian J. Med. Res., 124(5): 491-504.
51. Qidwai W, Hamza HB, Qureshi R, Gilani A (2009). Effectiveness, safety, and tolerability of powdered Nigella sativa (Kalonji) seed in capsules on serum lipid levels, blood sugar, blood pressure, and body weight in adults: results of a randomized, double-blind controlled trial. J. Altern. Complement. Med., 15(6): 639-644.
52. Rodbard HW, Blonde L, Braithwaite SS, Brett EM, Cobin RH, Handelsman Y, Hellman R, Jellinger PS, Jovanovic LG, Levy P, Mechanick JI, Zangeneh F (2007). American Association of Clinical Endocrinologists medical guidelines for clinical practice for the management of diabetes mellitus. Endocr. Pract., 13(1): 1-68.
53. Samer S, El-Kamary SS, Shardell MD, Abdel-Hamid M, Ismail S, El-Ateek M, Metwally M (2009). A Randomized Controlled Trial to Assess the Safety and Efficacy of Silymarin on Symptoms, Signs and Biomarkers of Acute Hepatitis. Phyomedicine, 16(5): 391-400.
54. Sangsuwan C, Udompanthurak S, Vannasaeng S, Thamlikitkul V (2004). Randomized controlled trial of Tinospora crispa for additional theray in patients with type 2 diabetes mellitus. J. Med. Assoc. Thai 87(5):543-6
55. Shane-McWhorter L (2001). Biological complementary therapies: a focus on botanical products in diabetes. Diabetes Spectrum 14: 199-208.
56. Suppapitiporn S, Kanapaksi N, Suppapitiporn S (2006). The effect of Cinnamon cassia powder in type 2 diabetes mellitus. J. Med. Assoc. Thai. Sep., 89(3): S200-205.
57. Teixeira CC, Funchs FD, Weinert LS, Esteves J (2006). The efficacy of folk medicines in the management of type 2 diabetes mellitus:Result of a randomized controlled trial of Syzygium cumini (L.)Skeels. J. clin pharm. Ther., 31(1): 1-5.
58. Vosough-Ghanbari S, Rahimi R, Kharabaf S, Zeinali S, Mohammadirad A, Amini S, Yasa N, Salehnia A, Toliat T, Nikfar S, Larijani B, Abdollahi M (2010). Effects of Satureja Khuzestanica on serum glucose, lipids and markers of oxidative stress in patients with Type 2 diabetes mellitus: A double-blind randomized controlled trial., Evidence-based. Complement. Altern. Med., 7(1): 465-470.
59. Vray M, Attalli JR (1995). Randomized study of glibenclamide versus traditional Chinese treatment in type 2 diabetic patients. Diabetes Metab., 21: 433-439.
60. Wang CW, Tschen JSm, Sheu WHH (2008). Gandoderma Lucidum on metabolic control in type 2 diabetes subjects-A double blinded placebo control study. J. Intern. Med. Taiwan, 19(1): 54-60.
61. Wild S, Roglic G, Green A, Sicree R, King H (2004). Global Prevalence of Diabetes. Diabetes Care, 27(5): 1047-1053.
62. Williams JA, Choe YS, Noss MJ, Baumgartner CJ, Mustad VA (2007). Extract of Salacia oblonga lowers acute glycemia in atients with type 2 diabetes. Am. J. Clin. Nutr., 86: 124-130.
63. Yeh GY, Eisenberg DM, Kaptchuk TJ (2003). Philips RS. Systematic Review of Herbs and Dietary Supplements for Glycemic Control in Diabetes. Diabetes Care, 26(4): 1277-1294.
64. Yin YQ, Huang XF, Kong LY, Niwa M (2008). Three New Penta saccharide Resin Glycosides from the Roots of Sweet Potato (Ipomoea batatas), Chem. Pharm. Bull., 56(12): 1670-1674.
65. Ziai SA, Larijani B, Akhoondzadeh S, Fakhrzadeh H, Dastpak A, Bandarian F, Rezai A, Badi HN, Emami T (2005). Psyllium decreased serum glucose and glycosylated hemoglobin significantly in diabetic outpatients. J. Ethnopharmacol., 102(2): 202-207.
66. Ziyyat A, Legssyer A, Mckhfi H, Dassouli A, Serhrouchni M, Benjelloum W (1997). Phytotherapy of hypertension and diabetes in Oriental Morocco. J. Ethnopharmacol., 58: 45-54.