The clinical investigation of Citrullus colocynthis (L.) schrad fruit in treatment of type II diabetic patients: A randomized, double blind, placebo-controlled clinical trial

Phytotherapy Research

Volumn 23, Issue 8, 2009, Pages 1186-1189

  Huseini, H Fallah ^a   Darvishzadeh, F ^b   Heshmat, R ^b   Jafariazar, Z ^c   Raza, Mohsin ^d   Larijani, B ^b  

^a AVICENNA RESEARCH INSTITUTE   (Iran)

^b TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c ISLAMIC AZAD UNIVERSITY   (Iran)

^d BAQIYATALLAH UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Citrullus colocynthis; Diabetes; HbA1c; Herbal medicine

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; COLOCYNTH EXTRACT; GLUCOSE; HEMOGLOBIN A1C; HIGH DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN; PLACEBO; TRIACYLGLYCEROL;

ADULT; ARTICLE; CHOLESTEROL BLOOD LEVEL; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; FEMALE; GASTROINTESTINAL SYMPTOM; GLUCOSE BLOOD LEVEL; HUMAN; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; RANDOMIZED CONTROLLED TRIAL; UREA BLOOD LEVEL;

BLOOD CHEMICAL ANALYSIS; BLOOD GLUCOSE; CITRULLUS; DIABETES MELLITUS, TYPE 2; DOUBLE-BLIND METHOD; FEMALE; FRUIT; HEMOGLOBIN A, GLYCOSYLATED; HERBAL MEDICINE; HUMANS; HYPOGLYCEMIC AGENTS; MALE; MIDDLE AGED; PHYTOTHERAPY;

CITRULLUS COLOCYNTHIS;

EID: 68049110179     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.2754     Document Type: Article

References (27)

1. Abdel-Hassan IA, Abdel-Barry JA, Mohammed TS. 2000. The hypoglycaemic and antihyperglycaemic effect of Citrullus colocynthis fruit aqueous extract in normal and alloxan diabetic rabbits. J Ethnopharmacol 71: 325-330.
2. Afifia MD, Sayed MS, Balbaa SI. 1973. Nitrogenous bases of different organs of Citrullus colocynthis. Planta Med 24: 260-265.
3. Al-Faraj S. 1995. Haemorrhagic colitis induced by Citrullus colocynthis. Ann Tropical Med Parasitol 89: 695-696.
4. Al-Ghaithi F, El-Ridi MR, Adeghate E, Amiri MH. 2004. Biochemical effects of Citrullus colocynthis in normal and diabetic rats. Mol Cell Biochem 261: 143-149. (Pubitemid 39022415)
5. Al-Yahya MA, Al-Farhan AH, Adam SE. 2000. Preliminary toxicity study on the individual and combined effects of Citrullus colocynthis and Nerium oleander in rats. Fitoterapia 71: 385-391.
6. American Diabetes Association. 2003. Screening for type 2 diabetes. Diabetes Care 26(Suppl. 1): S21-S24.
7. Bakhiet AO, Adam SEI. 1995. An estimation of Citrullus colocynthis toxicity for chicks. Vet Hum Toxicol 37: 356-359.
8. Barth A, Muller D, Durrling K. 2002. In vitro investigation of a standardized dried extract of Citrullus colocynthis on liver toxicity in adult rats. Exp Toxicol Pathol 54: 223-230.
9. Boden G. 1997. Role of fatty acids in the pathogenesis of insulin resistance and NIDDM. Diabetes 46: 3-10. (Pubitemid 27009941)
10. Bradley R, Oberg EB, Calabrese C, Standish LJ. 2007. Algorithm for complementary and alternative medicine practice and research in type 2 diabetes. J Altern Complement Med 13: 11-12. (Pubitemid 46319005)
11. Darwish SM, Balba ST, Afifi MS. 1974. The glycosidal content of the different organs of Citrullus colocynthis. Planta Med 26: 293-298.
12. Diwan FH, Abdel-Hassan IA, Mohammed ST. 2000. Effect of saponin on mortality and histopathological changes in mice. East Mediterr Health J 6: 345-351.
13. Elawad AA, Abdel Bari EM, Mahmoud OM, Adam SE. 1984. The effect of Citrullus colocynthis on sheep. Vet Hum Toxicol 26: 481-485.
14. Gebhardt R. 2003. Antioxidative, antiproliferative and biochemical effects in HepG2 cells of a homeopathic remedy and its constituent plant tinctures tested separately or in combination. Arzneimittelforschung 53: 823-830. (Pubitemid 38021431)
15. Goldfain D, Lavergne A, Galian A, Chauveinc L, Prudhomme F. 1989. Peculiar acute toxic colitis after ingestion of colocynth: a clinic and pathological study of three cases. Gut J 30: 1412-1418. (Pubitemid 19270152)
16. Haji Sharifi A. 2003. Citrullus colocynthis. In Secretes in Medicinal Plants, 3rd edn. Hafez-e-Novin Press: Tehran, 408-411.
17. Huseini HF, Larijani B, Fakhrzadeh H, Radjabipour B, Toliat T, Reza M. 2006. The efficacy of Silybum marianum (L.) Gaertn. (silymarin) in the treatment of type II diabetes: a randomized, double-blind, placebo-controlled, clinical trial. Phytother Res 20: 1036-1039.
18. McGarry JD. 2002. Banting Lecture 2001: Dysregulation of fatty acid metabolism in the etiology of type 2 diabetes. Diabetes 51: 7-18.
19. Nmila R, Gross R, Rchid H et al. 2000. Insulinotropic effect of Citrullus colocynthis fruit extracts. Planta Med 66: 418-423. (Pubitemid 30413501)
20. Paolisso G, Giugliano D. 1996. Oxidative stress and insulin action. Is there a relationship? Diabetologia 39: 357-363.
21. Ramachandran B, Ravi K, Narayanan V, Kandaswamy M, Subramanian S. 2004. Protective effect of macrocyclic binuclear oxovanadium complex on oxidative stress in pancreas of streptozotocin induced diabetic rats. Chem Biol Interact 149: 9-21. (Pubitemid 39066214)
22. Rosen P, Nawroth PP, King G, Moller W, Tritschler HJ, Packer L. 2001. The role of oxidative stress in the onset and progression of diabetes and its complications: a summary of a Congress Series sponsored by UNESCO-MCBN, the American Diabetes Association, and the German Diabetes Society. Diabetes Metab Res Rev 17: 189-212. (Pubitemid 32624602)
23. Soto CP, Perez BL, Favari LP, Reyes JL. 1998. Prevention of alloxan-induced diabetes mellitus in the rat by silymarin. Comp Biochem Physiol C Pharmacol Toxicol Endocrinol 119: 125-129. (Pubitemid 28221648)
24. Triggiani V, Resta F, Guastamacchia E et al. 2006. Role of antioxidants, essential fatty acids, carnitine, vitamins, phytochemicals and trace elements in the treatment of diabetes mellitus and its chronic complications. Endocr Metab Immune Disorders Drug Targets 6: 77-93. (Pubitemid 43796714)
25. Wasfi IA. 1994. Some pharmacological studies on C. colocynthis. J Herbs Spices Med Plants 2: 65-79.
26. Zaree AB, Fallah Hossini H, Sharifabady R, Norooz-zadeh A, Emani H, Ghoshooni H. 2007. The effect of Citrullus colocynthis extract on prevention/reducing streptozotocin-induced diabetes in rat. Kowsar Med J 12: 8-13.
27. Ziyyat A, Legssyer A, Mckhfi H, Dassouli A, Serhrouchni M, Benjelloum W. 1997. Phytotherapy of hypertension and diabetes in Oriental Morocco. J Ethnopharmacol 58: 45-54. (Pubitemid 27406186)