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Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 18, 2011, Pages 5577-5582

Overcoming hERG activity in the discovery of a series of 4-azetidinyl-1-aryl-cyclohexanes as CCR2 antagonists

(12) Zhang, Xuqing a Hufnagel, Heather a Markotan, Thomas a Lanter, James a Cai, Chaozhong a Hou, Cuifen a Singer, Monica a Opas, Evan a McKenney, Sandra a Crysler, Carl a Johnson, Dana a Sui, Zhihua a

a JOHNSON AND JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT (United States)

Author keywords

Azetidine; CCR2; hERG

Indexed keywords

4 AZETIDINYL 1 ARYL CYCLOHEXANE DERIVATIVE; AMPHOLYTE; AZETIDINE DERIVATIVE; CHEMOKINE RECEPTOR CCR2 ANTAGONIST; POTASSIUM CHANNEL HERG; UNCLASSIFIED DRUG;

ARTICLE; DRUG ACTIVITY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; STRUCTURE ACTIVITY RELATION;

AZETIDINES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DISCOVERY; ETHER-A-GO-GO POTASSIUM CHANNELS; HIPPURATES; HUMANS; MOLECULAR STRUCTURE; RECEPTORS, CCR2; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 80051924657 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2011.06.080 Document Type: Article

Times cited : (18)

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