Measurement of glycidol hemoglobin adducts in humans who ingest edible oil containing small amounts of glycidol fatty acid esters

Food and Chemical Toxicology

Volumn 49, Issue 10, 2011, Pages 2536-2540

  Honda, Hiroshi ^a   Onishi, Masayuki ^b   Fujii, Kenkichi ^a   Ikeda, Naohiro ^a   Yamaguchi, Tohru ^a   Fujimori, Taketoshi ^a   Nishiyama, Naohiro ^a   Kasamatsu, Toshio ^a  

^a KAO CORPORATION   (Japan)

^b Sumika Chemicals Analysis Service Ltd   (Japan)

Author keywords

DAG oil; Edible oil; Glycidol; Glycidol fatty acid ester; Hemoglobin adducts

Indexed keywords

DIACYLGLYCEROL; FATTY ACID ESTER; GLYCIDOL; GLYCIDOL FATTY ACID ESTER; HEMOGLOBIN; N (2,3 DIHYDROXYPROPYL)VALINE; UNCLASSIFIED DRUG; VALINE;

ADULT; ARTICLE; BLOOD ANALYSIS; CONTROLLED STUDY; FEMALE; FOOD SAFETY; GAS CHROMATOGRAPHY; HUMAN; MALE; TANDEM MASS SPECTROMETRY;

ADULT; DIETARY FATS, UNSATURATED; EPOXY COMPOUNDS; FEMALE; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HEMOGLOBINS; HUMANS; MALE; MIDDLE AGED; PROPANOLS; TANDEM MASS SPECTROMETRY; VALINE;

ANIMALIA;

EID: 80051903571     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2011.06.057     Document Type: Article

References (34)

1. Bakhiya N., Abraham K., Gurtler R., Appel K.E., Lampen A. Toxicological assessment of 3-chloropropane-1,2-diol and glycidol fatty acid esters in food. Mol. Nutr. Food Res. 2011, 55:1-13.
2. Bergmark E. Hemoglobin adducts of acrylamide and acrylonitrile in laboratory workers, smokers, and nonsmokers. Chem. Res. Toxicol. 1997, 10:78-84.
3. BfR, 2009a. Initial evaluation of the assessment of levels of glycidol fatty acid esters detected in refined vegetable fats. BfR Opinion No. 007/2009.
4. BfR, 2009b. Erste Einschätzung zur Bewertung der in raffinierten pflanzlichen Fetten nach-gewiesenen Gehalte von Glycidol-Fettsäureestern Stellungnahme Nr. 007/2009 des BfR vom 10. März 2009.
5. Boogaard P.J. Use of haemoglobin adducts in exposure monitoring and risk assessment. J. Chromatogr. B: Anal. Technol. Biomed. Life Sci. 2002, 778:309-322.
6. EU, 2002. European Union Risk Assessment Report, Acrylamide. 1st Priority List, 24.
7. Fennell T.R., Sumner S.C., Snyder R.W., Burgess J., Spicer R., Bridson W.E., Friedman M.A. Metabolism and hemoglobin adduct formation of acrylamide in humans. Toxicol. Sci. 2005, 85:447-459.
8. Flickinger B.D., Matsuo N. Nutritional characteristics of DAG oil. Lipids 2003, 38:129-132.
9. Hagmar L., Törnqvist M., Nordander C., Rosén I., Bruze M., Kautiainen A., Magnusson A.L., Malmberg B., Aprea P., Granath F., Axmon A. Health effects of occupational exposure to acrylamide using hemoglobin adducts as biomarkers of internal dose. Scand. J. Environ. Health 2001, 27:219-226.
10. Hamlet C.G. Analytical methods for the determination of 3-chloro-1,2-propandiol and 2-chloro-1,3-propandiol in hydrolysed vegetable protein, seasonings and food products using gas chromatography/ion trap tandem mass spectrometry. Food Addit. Contam. 1998, 15(4):451-465.
11. Hauschild, R., Petit, J., 1956. Contribution à l' étude la déshydratation thermique du glycérol pur. Bulletin de la Société Chimique de France, Mémoires, pp. 878-881.
12. JECFA 64th, 2004. Safety evaluation of certain contaminants in food. Prepared by the Sixty-fourth meeting of the Joint FAO/WHO Expert Committee on Food Additives (JECFA). FAO Food Nutr. Pap. 82, WHO food additives series 55, pp. 1-156.
13. JECFA 72nd, 2010. Summary report of the seventy-second meeting of JECFA.
14. Jones A.R. The metabolism of 3-chloro-, 3-bromo- and 3-iodoprpan-1,2-diol in rats and mice. Xenobiotica 1975, 5(3):155-165.
15. Landin H.H., Osterman-Golkar S., Zorcec V., Törnqvist M. Biomonitoring of epichlorohydrin by hemoglobin adducts. Anal. Biochem. 1996, 240:1-6.
16. Landin H.H., Grummt T., Laurent C., Tates A. Monitoring of occupational exposure to epichlorohydrin by genetic effects and hemoglobin adducts. Mutat. Res. 1997, 381:217-226.
17. Landin H.H., Tareke E., Rydberg P., Olsson U., Törnqvist M. Heating of food and haemoglobin adducts from carcinogens: possible precursor role of glycidol. Food Chem. Toxicol. 2000, 38:963-969.
18. Masukawa Y., Shiro H., Nakamura S., Kondo N., Jin N., Suzuki N., Ooi N., Kudo N. A new analytical method for the quantification of glycidol fatty acid esters in edible oils. J. Oleo. Sci. 2010, 59:81-88.
19. Mowrer J., Törnqvist M., Jensen S., Ehrenberg L. Modified Edman degradation applied to hemoglobin for monitoring occupational exposure to alkylating agents. Toxicol. Environ. Chem. 1986, 11:215-231.
20. Nagao T., Watanabe H., Goto N., Onizawa K., Taguchi H., Matsuo N., Yasukawa T., Tsushima R., Shimasaki H., Itakura H. Dietary diacylglycerol suppresses accumulation of body fat compared to triacylglycerol in men in a double-blind controlled trial. J. Nutr. 2000, 130:792-797.
21. Nishide T., Shimizu M., Tiffany T.R., Ogawa H. Cooking oil: cooking properties and sensory evaluation. Diacylglycerol Oil 2004, AOCS Press, (Chapter 19, pp. 197-207).
22. Nomeir A.A., Silveira D.M., Ferrala N.F., Markham P.M., McComish M.F., Ghanayem B.I., Chadwick M. Comparative disposition of 2,3-epoxy-1-propanol (glycidol) in rats following oral and intravenous administration. J. Toxicol. Environ. Health 1995, 44(2):203-217.
23. Ogawa M., Oyama T., Isse T., Yamaguchi T., Murakami T., Endo Y., Kawamoto T. Hemoglobin adducts as a marker of exposure to chemical substances, especially PRTR class I designated chemical substances. J. Occup. Health 2006, 48:314-328.
24. Osterman-Golkar S., Ehrenberg L., Segerback D., Hallstrom I. Evaluation of genetic risks of alkylating agents. II. Haemoglobin as a dose monitor. Mutat. Res. 1976, 34:1-10.
25. Patel J.M., Wood J.C., Leibman K.C. The biotransformation of allyl alcohol and acrolein in rat liver and lung preparations. Drug Metab Dispos. 1980, 8(5):305-308.
26. Piasecki A., Ruge A., Marquardt H. Malignant transformation of mouse M2-fibroblasts by glycerol chlorohydrines contained in protein hydrolysates and commercial food. Arzneimittelforschung 1990, 40(9):1054-1055.
27. Rosén J., Hellenäs K.E. Analysis of acrylamide in cooked foods by liquid chromatography tandem mass spectrometry. Analyst 2002, 127:880-882.
28. Sasaki, S., 2004. Development and evaluation of dietary assessment methods using biomarkers and diet history questionnaires for individuals (in Japanese). In: Tanaka, H. (Ed.). Research for Evaluation Methods of Nutrition and Dietary Lifestyle Programs Held on Healthy Japan 21. Summary Report. Ministry of Health, Welfare, and Labour, Tokyo, pp. 10-44.
29. Shemin D., Rittenberg D. The life span of the human red blood cell. J. Biol. Chem. 1946, 166:627-636.
30. Tareke E., Rydberg P., Karlsson P., Eriksson S., Törnqvist M. Analysis of acrylamide, a carcinogen formed in heated foodstuffs. J. Agric. Food. Chem. 2002, 50:4998-5006.
31. Törnqvist M., Landin H.H. Hemoglobin adducts for in vivo dose monitoring and cancer risk estimation. J. Occup. Environ. Med. 1995, 37:1077-1085.
32. Törnqvist M., Magnusson A.-L., Farmer P.B., Tang Y.-S., Jeffrey A.M., Wazneh L., Beulink G.D.T., van der Waal H., van Sittert N.J. Ring test for low levels of N-(2-hydroxyethyl)valine in human hemoglobin. Anal. Biochem. 1992, 203:357-360.
33. US EPA, 2010. Toxicological review of acrylamide. In: Support of Summary Information on the Integrated Risk Information System (IRIS).
34. Yasunaga K., Glinsmann W.H., Seo Y., Katsuragi Y., Kobayashi S., Flickinger B., Kennepohl E., Yasukawa T., Borzelleca J.F. Safety aspects regarding the consumption of high-dose dietary diacylglycerol oil in men and women in a double-blind controlled trial in comparison with consumption of a triacylglycerol control oil. Food Chem. Toxicol. 2004, 42:1419-1429.