Recombinant protein purification using gradient assisted simulated moving bed hydrophobic interaction chromatography. Part II: Process design and experimental validation

Journal of Chromatography A

Volumn 1218, Issue 37, 2011, Pages 6402-6411

  Gueorguieva, Ludmila ^a   Palani, Sivakumar ^b,c   Rinas, Ursula ^d,e   Jayaraman, Guhan ^b   Seidel Morgenstern, Andreas ^a,c  

^a OTTO VON GUERICKE UNIVERSITY   (Germany)

^b INDIAN INSTITUTE OF TECHNOLOGY MADRAS   (India)

^c MAX PLANCK INSTITUTE FOR DYNAMICS OF COMPLEX TECHNICAL SYSTEMS   (Germany)

^d HELMHOLTZ CENTRE FOR INFECTION RESEARCH   (Germany)

^e LEIBNIZ UNIVERSITY HANNOVER   (Germany)

Author keywords

Hydrophobic interaction chromatography; Streptokinase; Two step gradient open loop simulated moving bed chromatography

Indexed keywords

CHROMATOGRAPHIC PROCESS; CONTINUOUS SEPARATION; DESIGN APPROACHES; EQUILIBRIUM STAGE MODEL; EQUILIBRIUM THEORY; ESCHERICHIA COLI CELLS; EXPERIMENTAL VALIDATIONS; HYDROPHOBIC INTERACTION CHROMATOGRAPHY; OPEN LOOPS; RECOMBINANT PROTEIN PURIFICATION; SALT CONCENTRATION; SALT GRADIENT; SIMULATED MOVING BED; SIMULATED MOVING BEDS; STREPTOKINASE; TWO-STEP GRADIENT OPEN-LOOP SIMULATED MOVING BED CHROMATOGRAPHY;

ADSORPTION; COLUMN CHROMATOGRAPHY; COMPUTER SIMULATION; DESIGN; ESCHERICHIA COLI; GEL PERMEATION CHROMATOGRAPHY; HYDROPHOBICITY;

HYDROPHOBIC CHROMATOGRAPHY;

SODIUM CHLORIDE; STREPTOKINASE;

ADSORPTION; ARTICLE; CELL LYSATE; ESCHERICHIA COLI; HYDROPHOBIC INTERACTION CHROMATOGRAPHY; ISOTHERM; MATHEMATICAL ANALYSIS; MOVING BED HYDROPHOBIC INTERACTION CHROMATOGRAPHY; PRIORITY JOURNAL; PROTEIN PURIFICATION; SEPARATION TECHNIQUE; SIMULATION;

CHROMATOGRAPHY, LIQUID; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ESCHERICHIA COLI; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; MODELS, CHEMICAL; RECOMBINANT PROTEINS; REPRODUCIBILITY OF RESULTS; SEPHAROSE; STREPTOKINASE;

ESCHERICHIA COLI;

EID: 80051870442     PISSN: 00219673     EISSN: 18733778     Source Type: Journal    
DOI: 10.1016/j.chroma.2011.07.008     Document Type: Article

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