Gimeracil, an inhibitor of dihydropyrimidine dehydrogenase, inhibits the early step in homologous recombination

Cancer Science

Volumn 102, Issue 9, 2011, Pages 1712-1716

  Sakata, Koh Ichi ^a   Someya, Masanori ^a   Matsumoto, Yoshihisa ^a   Tauchi, Hiroshi ^b   Kai, Masahiro ^c   Toyota, Minoru ^c   Takagi, Masaru ^a   Hareyama, Masato ^a   Fukushima, Masakazu ^d  

^a SAPPORO MEDICAL UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b TOKYO INSTITUTE OF TECHNOLOGY   (Japan)

^c IBARAKI UNIVERSITY   (Japan)

^d TAIHO PHARMACEUTICAL CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

DIHYDROPYRIMIDINE DEHYDROGENASE; FANCONI ANEMIA GROUP D2 PROTEIN; GIMERACIL; MRE11 PROTEIN; NIBRIN; RAD50 PROTEIN; RAD51 PROTEIN; REPLICATION FACTOR A; SMALL INTERFERING RNA;

ARTICLE; CONTROLLED STUDY; DNA REPAIR; DOUBLE STRANDED DNA BREAK; DRUG MECHANISM; ENZYME INHIBITION; HELA CELL; HOMOLOGOUS RECOMBINATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DEPLETION; RADIOSENSITIZATION;

CELL LINE, TUMOR; DIHYDROURACIL DEHYDROGENASE (NADP); DNA REPAIR; ENZYME INHIBITORS; HELA CELLS; HUMANS; PYRIDINES; RADIATION-SENSITIZING AGENTS; RECOMBINATION, GENETIC; RNA, SMALL INTERFERING; TRANSFECTION;

EID: 80051824097     PISSN: 13479032     EISSN: 13497006     Source Type: Journal    
DOI: 10.1111/j.1349-7006.2011.02004.x     Document Type: Article

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