Bothrops jararaca peptide with anti-hypertensive action normalizes endothelium dysfunction involved in physiopathology of Preeclampsia

PLoS ONE

Volumn 6, Issue 8, 2011, Pages

  Benedetti, Gabriel ^a,b   Morais, Katia L P ^a,b   Guerreiro, Juliano R ^c   de Oliveira, Eduardo Fontana ^a,b   Hoshida, Mara Sandra ^c   Oliveira, Leandro ^d   Sass, Nelson ^d   Lebrun, Ivo ^a   Ulrich, Henning ^c   Lameu, Claudiana ^c   de Camargo, Antonio Carlos Martins ^a,c  

^a INSTITUTO BUTANTAN   (Brazil)

^b FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

^c UNIVERSITY OF SÃO PAULO   (Brazil)

^d Hospital Maternidade Vila Nova Cachoeirinha   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIHYPERTENSIVE AGENT; ARGININOSUCCINATE SYNTHASE; CALCIUM ION; CITRULLINE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; NITRIC OXIDE; PEPTIDE PRO 10C; SNAKE VENOM; SUPEROXIDE; UNCLASSIFIED DRUG; ARGININE; CALCIUM; OLIGOPEPTIDE; PRO 10C PROTEIN, BOTHROPS JARARACA; PRO-10C PROTEIN, BOTHROPS JARARACA; VIPER VENOM;

ANTIHYPERTENSIVE ACTIVITY; ARTICLE; BOTHROPS JARARACA; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; DRUG SCREENING; DRUG TARGETING; ENDOTHELIAL DYSFUNCTION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME REGULATION; FEMALE; HUMAN; HUMAN CELL; HYPERTENSION; IN VITRO STUDY; PATHOGENESIS; PREECLAMPSIA; PROTEIN EXPRESSION; SNAKE; UMBILICAL VEIN ENDOTHELIAL CELL; UPREGULATION; AMINO ACID SEQUENCE; ANIMAL; CELL CULTURE; DOSE RESPONSE; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; PREGNANCY; PREGNANCY COMPLICATION; VASCULAR ENDOTHELIUM; WESTERN BLOTTING;

BOTHROPS JARARACA; RATTUS;

AMINO ACID SEQUENCE; ANIMALS; ANTIHYPERTENSIVE AGENTS; ARGININE; ARGININOSUCCINATE SYNTHASE; BLOTTING, WESTERN; BOTHROPS; CALCIUM; CELLS, CULTURED; CITRULLINE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIUM, VASCULAR; FEMALE; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE III; OLIGOPEPTIDES; PRE-ECLAMPSIA; PREGNANCY; PREGNANCY COMPLICATIONS, CARDIOVASCULAR; SUPEROXIDES; VIPER VENOMS;

EID: 80051813760     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0023680     Document Type: Article

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