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Volumn 25, Issue 7, 2011, Pages 607-610

Fragment-based lead discovery: Challenges and opportunities

Author keywords

Biologics; Fragment based drug design; Off shoring; Outsourcing

Indexed keywords

BIOLOGIC; DRUG DESIGN; FRAGMENT-BASED DRUG DESIGN; OFF-SHORING; PHARMACEUTICAL INDUSTRY;

EID: 80051798254     PISSN: 0920654X     EISSN: 15734951     Source Type: Journal    
DOI: 10.1007/s10822-011-9451-z     Document Type: Article
Times cited : (22)

References (25)
  • 1
    • 0029836953 scopus 로고    scopus 로고
    • Discovering high-affinity ligands for proteins: SAR by NMR
    • DOI 10.1126/science.274.5292.1531
    • SB Shuker PJ Hajduk RP Meadows SW Fesik 1996 Science 274 1531 1534 10.1126/science.274.5292.1531 1:CAS:528:DyaK28Xnt1ansLs%3D (Pubitemid 26403929)
    • (1996) Science , vol.274 , Issue.5292 , pp. 1531-1534
    • Shuker, S.B.1    Hajduk, P.J.2    Meadows, R.P.3    Fesik, S.W.4
  • 4
    • 36549033318 scopus 로고    scopus 로고
    • Integration of fragment screening and library design
    • DOI 10.1016/j.drudis.2007.08.005, PII S1359644607003108
    • G Siegal E Ab J Schultz 2007 Drug Discov Today 12 1032 1039 10.1016/j.drudis.2007.08.005 1:CAS:528:DC%2BD2sXhsVSmurnI (Pubitemid 350180558)
    • (2007) Drug Discovery Today , vol.12 , Issue.23-24 , pp. 1032-1039
    • Siegal, G.1    Ab, E.2    Schultz, J.3
  • 6
    • 33751204422 scopus 로고    scopus 로고
    • Fragment-based lead discovery: A chemical update
    • DOI 10.1016/j.copbio.2006.10.007, PII S0958166906001510
    • DA Erlanson 2006 Curr Opin Biotechnol 17 643 652 10.1016/j.copbio.2006. 10.007 1:CAS:528:DC%2BD28Xht1eqs7zF (Pubitemid 44791912)
    • (2006) Current Opinion in Biotechnology , vol.17 , Issue.6 , pp. 643-652
    • Erlanson, D.A.1
  • 7
    • 33751112979 scopus 로고    scopus 로고
    • Puzzling through fragment-based drug design
    • DOI 10.1038/nchembio1206-658, PII NCHEMBIO1206658
    • PJ Hajduk 2006 Nat Chem Biol 2 658 659 10.1038/nchembio1206-658 1:CAS:528:DC%2BD28Xht1SrtLbI (Pubitemid 44764204)
    • (2006) Nature Chemical Biology , vol.2 , Issue.12 , pp. 658-659
    • Hajduk, P.J.1
  • 8
    • 33845364148 scopus 로고    scopus 로고
    • Fragment-based drug design: How big is too big?
    • DOI 10.1021/jm060511h
    • PJ Hajduk 2006 J Med Chem 49 6972 6976 10.1021/jm060511h 1:CAS:528:DC%2BD28XhtFOmtLbJ (Pubitemid 44885985)
    • (2006) Journal of Medicinal Chemistry , vol.49 , Issue.24 , pp. 6972-6976
    • Hajduk, P.J.1
  • 10
    • 33847381100 scopus 로고    scopus 로고
    • A decade of fragment-based drug design: Strategic advances and lessons learned
    • DOI 10.1038/nrd2220, PII NRD2220
    • PJ Hajduk J Greer 2007 Nat Rev Drug Discov 6 211 219 10.1038/nrd2220 1:CAS:528:DC%2BD2sXit12rtr4%3D (Pubitemid 46344625)
    • (2007) Nature Reviews Drug Discovery , vol.6 , Issue.3 , pp. 211-219
    • Hajduk, P.J.1    Greer, J.2
  • 11
    • 67649341990 scopus 로고    scopus 로고
    • 10.1016/j.drudis.2009.04.007 1:CAS:528:DC%2BD1MXotFyktLo%3D
    • G Chessari AJ Woodhead 2009 Drug Discov Today 14 668 675 10.1016/j.drudis.2009.04.007 1:CAS:528:DC%2BD1MXotFyktLo%3D
    • (2009) Drug Discov Today , vol.14 , pp. 668-675
    • Chessari, G.1    Woodhead, A.J.2
  • 13
    • 0242291985 scopus 로고    scopus 로고
    • Why is big Pharma getting out of antibacterial drug discovery?
    • DOI 10.1016/j.mib.2003.08.003
    • SJ Projan 2003 Curr Opin Microbiol 6 427 430 10.1016/j.mib.2003.08.003 (Pubitemid 37345405)
    • (2003) Current Opinion in Microbiology , vol.6 , Issue.5 , pp. 427-430
    • Projan, S.J.1
  • 14
    • 23044491214 scopus 로고    scopus 로고
    • Optimizing the discovery organization for innovation
    • DOI 10.1016/S1359-6446(05)03539-7, PII S1359644605035397
    • F Sams-Dodd 2005 Drug Discov Today 10 1049 1056 10.1016/S1359-6446(05) 03539-7 (Pubitemid 41074143)
    • (2005) Drug Discovery Today , vol.10 , Issue.15 , pp. 1049-1056
    • Sams-Dodd, F.1
  • 15
    • 13844276627 scopus 로고    scopus 로고
    • Target-based drug discovery: Is something wrong?
    • DOI 10.1016/S1359-6446(04)03316-1, PII S1359644604033161
    • F Sams-Dodd 2005 Drug Discov Today 10 139 147 10.1016/S1359-6446(04) 03316-1 1:CAS:528:DC%2BD2MXhsFarsbk%3D (Pubitemid 40247812)
    • (2005) Drug Discovery Today , vol.10 , Issue.2 , pp. 139-147
    • Sams-Dodd, F.1
  • 16
    • 33646504430 scopus 로고    scopus 로고
    • 10.1016/j.drudis.2006.04.014 1:CAS:528:DC%2BD28XkvVGjt7g%3D
    • SE Hall 2006 Drug Discov Today 11 495 502 10.1016/j.drudis.2006.04.014 1:CAS:528:DC%2BD28XkvVGjt7g%3D
    • (2006) Drug Discov Today , vol.11 , pp. 495-502
    • Hall, S.E.1
  • 19
    • 77949370572 scopus 로고    scopus 로고
    • 10.1111/j.1476-5381.2009.00476.x 1:CAS:528:DC%2BC3cXjs1ektro%3D
    • M Congreve F Marshall 2010 Br J Pharmacol 159 986 996 10.1111/j.1476-5381.2009.00476.x 1:CAS:528:DC%2BC3cXjs1ektro%3D
    • (2010) Br J Pharmacol , vol.159 , pp. 986-996
    • Congreve, M.1    Marshall, F.2
  • 20
    • 78149501220 scopus 로고    scopus 로고
    • 10.1016/j.neuropharm.2010.07.016
    • RE Hubbard 2010 Neuropharmacology 60 7 23 10.1016/j.neuropharm.2010.07. 016
    • (2010) Neuropharmacology , vol.60 , pp. 7-23
    • Hubbard, R.E.1
  • 22
    • 70449726880 scopus 로고    scopus 로고
    • 10.1038/nrd3040 1:CAS:528:DC%2BD1MXhtlCjtr3F
    • M Goodman 2009 Nat Rev Drug Discov 8 837 10.1038/nrd3040 1:CAS:528:DC%2BD1MXhtlCjtr3F
    • (2009) Nat Rev Drug Discov , vol.8 , pp. 837
    • Goodman, M.1
  • 23
    • 34447336944 scopus 로고    scopus 로고
    • 10.1002/biot.200790064 1:CAS:528:DC%2BD2sXnsVGjtrs%3D
    • NS Wong HP Kocher MG Yap 2007 Biotechnol J 2 657 658 10.1002/biot. 200790064 1:CAS:528:DC%2BD2sXnsVGjtrs%3D
    • (2007) Biotechnol J , vol.2 , pp. 657-658
    • Wong, N.S.1    Kocher, H.P.2    Yap, M.G.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.