Update of the reference and HBM values derived by the German Human Biomonitoring Commission

International Journal of Hygiene and Environmental Health

Volumn 215, Issue 1, 2011, Pages 26-35

  Schulz, Christine ^a   Wilhelm, Michael ^b   Heudorf, Ursel ^c   Kolossa Gehring, Marike ^a  

^a UMWELTBUNDESAMT   (Germany)

^b RUHR UNIVERSITY BOCHUM   (Germany)

^c Health Office   (Germany)

Author keywords

Blood; Breast milk; Environmental medicine; Germany; HBM values; Human biomonitoring; Reference values; Urine

Indexed keywords

ACRYLAMIDE; AMINE; CHLORINE; FLUOROCARBON; HEAVY METAL; PESTICIDE; PHTHALIC ACID BIS(2 ETHYLHEXYL) ESTER;

ARTICLE; BLOOD; BREAST MILK; ENVIRONMENTAL MONITORING; GERMANY; HUMAN; INFORMATION PROCESSING; MAXIMUM ALLOWABLE CONCENTRATION; METABOLISM; METHODOLOGY; POLLUTANT; REFERENCE VALUE; URINE;

ACRYLAMIDE; AMINES; CHLORINE; DATA COLLECTION; DIETHYLHEXYL PHTHALATE; ENVIRONMENTAL MONITORING; ENVIRONMENTAL POLLUTANTS; FLUOROCARBONS; GERMANY; HUMANS; MAXIMUM ALLOWABLE CONCENTRATION; METALS, HEAVY; MILK, HUMAN; PESTICIDES; REFERENCE VALUES;

EID: 80051795485     PISSN: 14384639     EISSN: 1618131X     Source Type: Journal    
DOI: 10.1016/j.ijheh.2011.06.007     Document Type: Article

References (47)

1. Angerer J., Ewers U., Wilhelm M. Human biomonitoring: state of the art. Int. J. Hyg. Environ. Health 2007, 210:201-228.
2. Angerer, J., Aylward, L.L., Hays, S.M., Heinzow, B. Wilhelm, M., on behalf of the German Human Biomonitoring Commission. Human biomonitoring assessment values: Approaches and data requirements. Int. J. Hyg. Environ. Health, 2011; doi:10.1016/j.ijheh.2011.06.002.
3. Axmon A., Hagmar L., Jönsson B.A. Rapid decline of persistent organochlorine pollutants in serum among young Swedish males. Chemosphere 2008, 70:1620-1628.
4. Becker K., Schulz C., Kaus S., Seiwert M., Seifert B. German Environmental Survey 1998 (GerES III): environmental pollutants in blood of the German population. Int. J. Hyg. Environ. Health 2002, 205:297-308.
5. Becker K., Schulz C., Kaus S., Seiwert M., Seifert B. German Environmental Survey 1998 (GerES III): environmental pollutants in urine of the German population. Int. J. Hyg. Environ. Health 2003, 206:15-24.
6. Centers for Disease Control and Prevention (CDC), 2011. Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, February 2011. http://www.cdc.gov/exposurereport.
7. DFG (Deutsche Forschungsgemeinschaft) Acrylamid. Gesundheitsschädliche Arbeitsstoffe: Toxikologischarbeitsmedizinische Begründungen von MAK-Werten 2006, Wiley-VCH. D. Henschler, H. Greim (Eds.).
8. DFG (Deutsche Forschungsgemeinschaft) MAK- und BAT-Wert-Liste. Senatskommission zur Prüfung gesundheitsschädlicher Arbeitsstoffe. Mitteilung 43 2007, Wiley-VCH Verlag, Weinheim.
9. EFSA (European Food Saftey Authority) Scientific opinion of the panel on contaminants in the food chain on a request from the European commission on cadmium in food. EFSA J. 2009, 980:1-139. http://efsa.europa.eu/EFSA/efsa_locale-1178620753812_1211902396126.htm.
10. EFSA (European Food Saftey Authority), 2009b. Cadmium in Foodstuffs - Follow Up of the EFSA Opinion Rev. 2. Working Document 09.10.2009.
11. Ewers U., Krause C., Schulz C., Wilhelm M. Reference values and human biological biomonitoring values for environmental toxins. Int. Arch. Occup. Environ. Health 1999, 72:255-260.
12. Fromme H., Tittlemier S.A., Völkel W., Wilhelm M., Twardella D. Perfluorinated compounds - exposure assessment for the general population in western countries. Int. J. Hyg. Environ. Health 2009, 212:239-270.
13. Hays S.M., Aylward L.L., LaKind J.S., Bartels M.J., Barton H.A., Boogaard P.J., Brunk C., DiZio S., Dourson M., Goldstein D.A., Kilpatrick M.E., Krewski D., Krishnan K., Lipscomb J., Nordberg M., Okino M., Tan Y.-M., Viau C., Yager J.W. Guidelines for the derivation of biomonitoring equivalents: report from the biomonitoring equivalents expert workshop. Regul. Toxicol. Pharmacol. 2008, 51:S4-S15.
14. HBM (Human Biomonitoring) Commission, 1999a. Referenzwerte für HCB, beta-HCH, DDT und PCB in Frauenmilch. Bundesgesundheitsbl. Gesundheitsforsch. Gesundheitsschutz 42, 533-539.
15. HBM (Human Biomonitoring) Commission, 1999b. Aktualisierung der Referenzwerte für Pentachlorphenol im Serum und im Urin. Bundesgesundheitsbl. Gesundheitsforsch. Gesundheitsschutz 42, 599-600.
16. HBM (Human Biomonitoring) Commission, 2005. Stoffmonographie Di(2-ethylhexyl)phthalat (DEHP) - Referenzwerte für 5oxo-MEHP und 5OH-MEHP im Urin. Bundesgesundheitsbl. Gesundheitsforsch. Gesundheitsschutz 48, 706-722.
17. HBM (Human Biomonitoring) Commission, 2007a. Ableitung von Human-Biomonitoring-(HBM)-Werten auf der Basis tolerabler Aufnahmemengen. Teil II. Grundlagen und Ableitungsweg. Bundesgesundheitsbl. Gesundheitsforsch. Gesundheitsschutz 50, 251-254. English version: Derivation of human biomonitoring (HBM) values based on tolerable intake doses. Part II. Rationale and way of derivation, see: http://www.uba.de/gesundheit-e/publikationen/index.htm%23khb.
18. HBM (Human Biomonitoring) Commission, 2007b. Ableitung von Human-Biomonitoring-(HBM)-Werten auf der Basis tolerabler Aufnahmemengen. Teil III. HBM-Werte für Di(2-ethylhexyl)phthalat (DEHP). Bundesgesundheitsbl. Gesundheitsforsch. Gesundheitsschutz 50(2), 255-259. English version: Derivation of human biomonitoring (HBM) values based on tolerable intake doses. Part III. HBM values for di(2-ethylhexyl)phthalate (DEHP), see: http://www.uba.de/gesundheit-e/publikationen/index.htm%23khb.
19. HBM (Human Biomonitoring) Commission, 2007c. Naphthalin/Naphthole und Human-Biomonitoring. Bundesgesundheitsbl. Gesundheitsforsch. Gesundheitsschutz 50, 1357-1364.
20. HBM (Human Biomonitoring) Commission, 2008a. Acrylamid und Human-Biomonitoring. Bundesgesundheitsbl. Gesundheitsforsch. Gesundheitsschutz 51, 98-108. English version: Acrylamide and Human Biomonitoring, see: http://www.umweltdaten.de/gesundheit-e/monitor/acrylamide_and_hbm.pdf.
21. HBM (Human Biomonitoring) Commission, 2008b. Aktualisierung der Referenzwerte für HCB, ß-HCH, DDT und PCB in Frauenmilch. Bundesgesundheitsbl. Gesundheitsforsch. Gesundheitsschutz 51, 1239-1242.
22. HBM (Human Biomonitoring) Commission, 2009a. Addendum zum Konzept der Referenz- und Human-Biomonitoring-Werte (HBM) in der Umweltmedizin. Bundesgesundheitsbl. Gesundheitsforsch. Gesundheitsschutz 52, 874-877. English version: Addendum to the concept of reference and human biomonitoring values in environmental medicine, see http://www.umweltdaten.de/gesundheit-e/addendum_to_the_concept_of_refere nce_and_hbm_values.pdf.
23. HBM (Human Biomonitoring) Commission, 2009b. Stoffmonografie Chlorphenole - Referenzwerte. Bundesgesundheitsbl. Gesundheitsforsch. Gesundheitsschutz 52, 987-1001.
24. HBM (Human Biomonitoring) Commission, 2009c. Referenzwerte für Perfluoroctansäure (PFOA) und Perfluoroctansulfonsäure (PFOS) im Blutplasma. Bundesgesundheitsbl. Gesundheitsforsch. Gesundheitsschutz 52, 878-875.
25. HBM (Human Biomonitoring) Commission, 2009d. Neue und aktualisierte Referenzwerte für Metabolite von polyzyklischen aromatischen Kohlenwasserstoffen (PAK) im Urin von Kindern in Deutschland. Bundesgesundheitsbl. Gesundheitsforsch. Gesundheitsschutz 52, 969-972.
26. HBM (Human Biomonitoring) Commission, 2009e. Addendum zur " Stoffmonographie Quecksilber - Referenz- und Human-Biomonitoring-Werte" der Kommission Human-Biomonitoring des Umweltbundesamtes. Bundesgesundheitsbl. Gesundheitsforsch. Gesundheitsschutz 52, 1228-1234.
27. HBM (Human Biomonitoring) Commission, 2011a. Stoffmonographie Thallium - Referenz- und Human-Biomonitoring-(HBM)-Werte für Thallium im Urin. Bundesgesundheitsbl. Gesundheitsforsch. Gesundheitsschutz 54, 516-524.
28. HBM (Human Biomonitoring) Commission, 2011b. Stoffmonographie und Referenzwerte für monocyklische Aminoaromaten im Urin. Bundesgesundheitsbl. Gesundheitsforsch. Gesundheitsschutz 54, 650-663.
29. HBM (Human Biomonitoring) Commission, 2011c. Stoffmonographie für Phthalate - Neue und aktualisierte Referenzwerte für Monoester und oxidierte Metabolite im Urin von Kindern und Erwachsenen. Bundesgesundheitsbl. Gesundheitsforsch. Gesundheitsschutz 54, doi:10.1007/s00103-011-1278-1.
30. HBM (Human Biomonitoring) Commission. 2011d. Aktualisierte Stoffmonographie Cadmium - Referenz- und Human-Biomonitoring (HBM)-Werte. Bundesgesundheitsbl. Gesundheitsforsch. Gesundheitsschutz 54, doi:10.1007/s00103-011-1327-9.
31. Heudorf U., Butte W., Schulz C., Angerer J. Reference values for metabolites of pyrethroid and organophosphorous insecticides in urine for human biomonitoring in environmental medicine. Int. J. Hyg. Environ. Health 2006, 209:293-299.
32. IARC (International Agency for Research on Cancer), 1994. Acrylamide. IARC Monogr Eval. Carcinog. Risks Hum. 60, 389-434.
33. IARC (International Agency for Research on Cancer), 2006. Agents reviewed by the IARC monographs (vols. 1-88): IARC Monographs on the evaluation of carcinogenic risks to humans. http://monographs.iarc.fr/.
34. Kasper-Sonnenberg M., Koch H.M., Wittsiepe J., Wilhelm M. Levels of phthalate metabolites in urine among mother-child-pairs - Results from the Duisburg birth cohort study, Germany. Int. J. Hyg. Environ. Health 2012, 10.1016/j.ijheh.2011.09.004.
35. Kütting, B., Schettgen, T., Angerer, J., Drexler, H., 2006. Abschlussbericht des Forschungsvorhabens " Belastung und Beanspruchung der Bevölkerung durch Acrylamid - Quellen und Gesundheitsrisiko" Förderung durch das Bayerische Staatsministerium für Lebensmittelsicherheit und Verbraucherschutz.
36. Kütting B., Schettgen T., Schwegler U., Fromme H., Uter W., Angerer J., Drexler H. Acrylamide as environmental noxious agent: a health risk assessment for the general population based on the internal acrylamide burden. Int. J. Hyg. Environ. Health. 2009, 212:470-480.
37. Lignell S., Aune M., Darnerud P.O., Cnattingius S., Glynn A. Persistent organochlorine and organobromine compounds in mother's milk from Sweden 1996-2006: compound-specific temporal trends. Environ. Res. 2009, 109:760-767.
38. Schulz C., Angerer J., Ewers U., Kolossa-Gehring M. The German human biomonitoring commission. Int. J. Hyg. Environ. Health 2007, 210:373-382.
39. Schulz C., Butte W. Revised reference value for pentachlorophenol in morning urine. Int. J. Hyg. Environ. Health 2007, 210:741-744.
40. Schulz C., Angerer J., Ewers U., Heudorf U., Wilhelm M. Revised and new reference values for environmental pollutants in urine or blood of children in Germany derived from the German Environmental Survey on Children 2003-2006 (GerES IV). Int. J. Hyg. Environ. Health 2009, 212:637-647. on behalf of the Human Biomonitoring Commission of the German Federal Environment Agency.
41. Wilhelm M., Ewers U., Schulz C. Revised and new reference values for some persistent organic pollutants (POPs) in blood for human biomonitoring in environmental medicine. Int. J. Hyg. Environ. Health 2003, 206:223-229.
42. Wilhelm M., Ewers U., Schulz C. Revised and new reference values for some trace elements in blood and urine for human biomonitoring in environmental medicine. Int. J. Hyg. Environ. Health 2004, 207:69-73.
43. Wilhelm M., Schulz C., Schwenk M. Revised and new reference values for arsenic, cadmium, lead and mercury in blood or urine of children. Basis for validation of human biomonitoring data in environmental medicine. Int. J. Hyg. Environ. Health 2006, 209:301-305.
44. Wilhelm M., Ewers U., Wittsiepe J., Fürst P., Hölzer J., Eberwein G., Angerer J., Marczynski B., Ranft U. Human biomonitoring studies in North Rhine Westphalia, Germany. Int. J. Hyg. Environ. Health 2007, 210:307-318.
45. Wilhelm M., Hardt J., Schulz C., Angerer J. New reference values and the background exposure of PAH metabolites 1-hydroxypyrene and 1- and 2-naphthol in urine of the general population in Germany: basis for validation of human biomonitoring data in environmental medicine. Int. J. Hyg. Environ. Health 2008, 211:447-453. on behalf of the Human Biomonitoring Commission of the German Federal Environment Agency.
46. Wilhelm M., Heinzow B., Angerer J., Schulz C. Reassessment of critical lead effects by the German Human Biomonitoring Commission results in suspension of the human biomonitoring values (HBM I and HBM II) for lead in blood of children and adults. Int. J. Hyg. Environ. Health 2010, 213:265-269.
47. Zietz B.P., Hoopmann M., Funcke M., Huppmann R., Suchenwirth R., Gierden E. Long-term biomonitoring of polychlorinated biphenyls and organochlorine pesticides in human milk from mothers living in northern Germany. Int. J. Hyg. Environ Health 2008, 211:624-638.