Hematopoietic gene therapy restores thymidine phosphorylase activity in a cell culture and a murine model of MNGIE

Gene Therapy

Volumn 18, Issue 8, 2011, Pages 795-806

  Torres Torronteras, J ^a,b   Gomez A ^a   Eixarch, H ^a   Palenzuela, L ^a,b   Pizzorno, G ^c   Hirano, M ^d   Andreu, A L ^a,b   Barquinero, J ^a   Marti R ^a,b  

^a HOSPITAL UNIVERSITARI VALL D HEBRON   (Spain)

^b CENTRO DE INVESTIGACIÓN BIOMÉDICA EN RED DE ENFERMEDADES RARAS CIBERER   (Spain)

^c NEVADA CANCER INSTITUTE   (United States)

^d Department of Medicine   (United States)

Author keywords

lentiviral vector; mitochondria; MNGIE; thymidine phosphorylase; TYMP

Indexed keywords

DEOXYURIDINE; LENTIVIRUS VECTOR; NUCLEOSIDE; RNA; THYMIDINE; THYMIDINE PHOSPHORYLASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL CULTURE; CONTROLLED STUDY; CYTOTOXICITY; DAUDI CELL; DRUG STABILITY; ENZYME ACTIVITY; FEASIBILITY STUDY; GENE EXPRESSION; GENE THERAPY; IN VITRO STUDY; IN VIVO GENE TRANSFER; IN VIVO STUDY; MNGIE SYNDROME; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; VIRAL GENE DELIVERY SYSTEM;

ANIMALS; B-LYMPHOCYTES; CELL CULTURE TECHNIQUES; CELL LINE; FEASIBILITY STUDIES; GENE THERAPY; GENETIC VECTORS; HUMANS; LENTIVIRUS; MICE; MICE, KNOCKOUT; MITOCHONDRIAL ENCEPHALOMYOPATHIES; THYMIDINE PHOSPHORYLASE; TRANSDUCTION, GENETIC;

MURINAE; MUS;

EID: 80051787360     PISSN: 09697128     EISSN: 14765462     Source Type: Journal    
DOI: 10.1038/gt.2011.24     Document Type: Article

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