Residue mutations in the sweetness loops for the sweet-tasting protein brazzein

Food Chemistry

Volumn 129, Issue 4, 2011, Pages 1327-1330

  Yoon, Sug Young ^a   Kong, Ji Na ^a   Jo, Dong Hyeon ^a   Kong, Kwang Hoon ^a  

^a Chung Ang University   (South Korea)

Author keywords

Brazzein; Loop; Mutagenesis; Sweet protein; Sweetness determinant; Taste

Indexed keywords

BRAZZEIN; LOOP; SWEET PROTEIN; SWEETNESS DETERMINANT; TASTE;

MUTAGENESIS;

PROTEINS;

AMINO ACID; BRAZZEIN PROTEIN; SWEET PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; GENE OVEREXPRESSION; MOLECULAR DOCKING; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PROTEIN ANALYSIS; RECEPTOR BINDING; SITE DIRECTED MUTAGENESIS; SWEETNESS; TASTE ACUITY;

EID: 80051780947     PISSN: 03088146     EISSN: 18737072     Source Type: Journal    
DOI: 10.1016/j.foodchem.2011.06.054     Document Type: Article

References (21)

1. F.M. Assadi-Porter, F. Abildgaard, H. Blad, C.C. Cornilescu, and J.L. Markely Brazzein, a small, sweet protein: Effect of mutation on its structure, dynamics and functional properties Chemical Senses 30 Suppl. 1 2005 i90 i91
2. F.M. Assadi-Porter, F. Abildgaard, H. Blad, and J.L. Markley Correlation of the sweetness of variants of the protein brazzein with patterns of hydrogen bonds detected by NMR spectroscopy Journal of Biological Chemistry 278 2003 31331 31339 (Pubitemid 36994653)
3. F.M. Assadi-Porter, D.J. Aceti, and J.L. Markley Sweetness determinant sites of brazzein, a small, heat-stable, sweet-tasting protein Archives of Biochemistry and Biophysics 376 2000 259 265 (Pubitemid 30210872)
4. F.M. Assadi-Porter, M. Tonelli, E.L. Maillet, J.L. Markely, and M. Max Interactions between the human sweet-sensing T1R2-T1R3 receptor and sweeteners detected by saturation transfer difference NMR spectroscopy Biochimica et Biophyosica Acta 1798 2010 82 86
5. J.E. Caldwell, F. Abildgaard, Z. Dzakula, D. Ming, G. Hellekant, and J.L. Markley Solution structure of the thermostable sweet-tasting protein brazzein Nature Structural and Molecular Biology 5 1998 427 431 (Pubitemid 28265023)
6. V. Esposito, R. Gallucci, D. Picone, G. Saviano, T. Tancredi, and P.A. Temussi The importance of electrostatic potential in the interaction of sweet proteins with the sweet taste receptor Journal of Molecular Biology 360 2006 448 456 (Pubitemid 43927834)
7. G.H. Gao, J.X. Dai, M. Ding, G. Hellekant, J.F. Wang, and D.C. Wang Solution conformation of brazzein by 1H nuclear magnetic resonance: Resonance assignment and secondary structure International Journal of Biological Macromolecules 24 1999 351 359 (Pubitemid 29268121)
8. H. Izawa, M. Ota, M. Kohmura, and Y. Ariyoshi Synthesis and characterization of the sweet protein brazzein Biopolymers 39 1996 95 101
9. P. Jiang, Q. Ji, Z. Liu, L.A. Snyder, L.M. Benard, and R.F. Margolskee The cysteine-rich region of T1R3 determines responses to intensely sweet proteins Journal of Biological Chemistry 279 2004 45068 45075 (Pubitemid 39430921)
10. Z. Jin, V. Danilova, F.M. Assadi-Porter, D.J. Aceti, J.L. Markley, and G. Hellekant Critical regions for the sweetness of brazzein FEBS Letters 544 2003 33 37 (Pubitemid 36628032)
11. R. Kaneko, and N. Kitabatake Sweetness of sweet protein haumatin is more thermoresistant under acid conditions than under neutral or alkaline conditions Bioscience, Biotechnology, and Biochemistry 65 2001 409 413 (Pubitemid 33626254)
12. J.U. Koh, H.Y. Cho, and K.H. Kong Site-directed mutagenesis of arginine 13 residue in human glutathione S-transferase P1-1 Bulletin of the Korean Chemical Society 28 2007 772 776
13. J.J. Lee, J.N. Kong, H.D. Do, D.H. Jo, and K.H. Kong Design and efficient soluble expression of a sweet protein, brazzein and minor-form mutant Bulletin of the Korean Chemical Society 31 2010 3830 3833
14. D. Ming, and G. Hellekant Brazzein, a new high-potency thermostable sweet protein from Pentadiplandra brazzeana B FEBS Letters 355 1994 106 108
15. T. Mizukoshi, M. Kohmura, E.I. Suzuki, and Y. Ariyoshi Structure and dynamic studies by NMR of the potent sweet protein monellin and a non-sweet analog. Evidence on the importance of residue AspB7 for sweet taste FEBS Letters 413 1997 409 416 (Pubitemid 27371474)
16. N. Niccolai, R. Spadaccini, M. Scarselli, A. Bernini, O. Crescenzi, and O. Spiga Probing the surface of a sweet protein; NMR study of MNEI with a paramagnetic probe Protein Science 10 2001 1498 1507 (Pubitemid 32667044)
17. R.K. Scopes Measurement of protein by spectrophotometry at 250 nm Analytical Biochemistry 59 1974 277 282
18. R. Spadaccini, F. Trabucco, G. Saviano, D. Picone, O. Crescenzi, and T. Trancredi The mechanism of interaction of sweet proteins with the T1R2-T1R3 receptor: Evidence from the solution structure of G16A-MNEI Journal of Molecular Biology 328 2003 683 692 (Pubitemid 36438581)
19. P.A. Temussi Why are sweet proteins sweet? Interaction of brazzein, monellin and thaumatin with the T1R2-T1R3 receptor FEBS Letters 526 2002 1 4 (Pubitemid 35245681)
20. P.A. Temussi Natural sweet macromolecules: How sweet proteins work Cellular and Molecular Life Sciences 63 2006 1876 1888
21. D.E. Walters, and G. Helleknt Interactions of the sweet protein brazzein with the sweet taste receptor Journal of Agricultural and Food Chemistry 54 2006 10129 10133 (Pubitemid 46159019)