Intravenous lipid emulsion for the treatment of cardiotoxicity due to lipophilic drugs beyond local anesthetics: Antidote or rescue therapy?;Les émulsions lipidiques dans le traitement des effets cardiotoxiques des médicaments lipophiles autres que les anesthésiques locaux:Antidote ou traitement d'exception?

Annales Francaises de Medecine d'Urgence

Volumn 1, Issue 1, 2011, Pages 26-32

  de Roock, S ^a   Hantson, P ^a  

^a UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

Author keywords

Antidote; Cardiotoxicity; Lipid emulsion; Lipophilic drugs; Local anesthetics

Indexed keywords

ANTIDOTE; LIPID EMULSION; LOCAL ANESTHETIC AGENT;

ARTICLE; CARDIOTOXICITY; CLINICAL OBSERVATION; CLINICAL PROTOCOL; DISEASE SEVERITY; DRUG EFFICACY; DRUG MECHANISM; DRUG SAFETY; HUMAN; LIPOPHILICITY; PROSPECTIVE STUDY; RESUSCITATION; TREATMENT DURATION; TREATMENT INDICATION;

EID: 80051778783     PISSN: 21086524     EISSN: 21086591     Source Type: Journal    
DOI: 10.1007/s13341-010-0004-3     Document Type: Article

References (47)

1. Cottrel M, Nguyen BV, Guillouët M, et al (2008) Les émulsions lipidiques dans les intoxications aux stabilisants de membrane. Réanimation 17: 670-675.
2. Aya AGM, Ripart J, Sebbane MA, de La Coussaye JE (2010) Les émulsions lipidiques dans le traitement de la toxicité systémique des anesthésiques locaux: efficacité et limites. Ann Fr Anesth Reanim 29: 464-469.
3. Felice K, Schumann H (2008) Intravenous lipid emulsion for local anesthetic toxicity: a review of the literature. J Med Toxicol 4: 184-191.
4. Weinberg G, VadeBoncouer T, Ramaraju GA, et al (1998) Pretreatment or resuscitation with a lipid infusion shifts the dose-response to bupivacaine-induced asystole in rats. Anesthesiology 88: 1071-1075.
5. Weinberg G, Ripper R, Feinstein DL, Hoffman W (2003) Lipid emulsion infusion rescues dogs from bupivacaine-induced cardiac toxicity. Reg Anesth Pain Med 28: 198-202.
6. Turner-Lawrence D, Kerns W (2008) Intravenous fat emulsion: a potent novel antidote. J Med Toxicol 4: 109-114.
7. Cave G, Harvey M (2009) Intravenous lipid emulsion as antidote beyond local anesthetic toxicity: a systematic review. Acad Emerg Med 16: 815-824.
8. Jamaty C, Bailey B, Larocque A, et al (2010) Lipid emulsion in the treatment of acute poisoning: a systematic review of human and animal studies. Clin Toxicol 48: 1-27.
9. Baud FJ, Borron SW, Bismuth C (1995) Modifying toxicokinetics with antidotes. Toxicol Lett 82-83: 785-793.
10. Weinberg G, Ripper R, Murphy P, et al (2006) Lipid infusion accelerates removal of bupivacaine and recovery from bupivacaine toxicity in the isolated rat heart. Reg Anesth Pain Med 31: 296-303.
11. Krieglstein J, Meffert A, Niemeyer DH (1974) Influence of emulsified fat on chlorpromazine availability in rabbit blood. Experientia 30: 924-926.
12. Straathof DJ, Driessen O, Meijer JW, et al (1984) Influence of Intralipid infusion on the elimination of phenytoin. Arch Int Pharmacodyn Ther 267: 180-186.
13. Litz RJ, Roessel T, Heller AR, Stehr SN (2008) Reversal of central nervous system and cardiac toxicity after local anesthetic intoxication by lipid emulsion injection. Anesth Analg 106: 1575-1577.
14. Weinberg GL, Palmer JW, VadeBoncouer TR, et al (2000) Bupivacaine inhibits acylcarnitine exchange in cardiac mitochondria. Anesthesiology 92: 523-528.
15. Edelman LB, Ripper R, Kelly K, et al (2008) Metabolic context affects hemodynamic response to bupivacaine in the isolated rat heart. Chem Biol Interact 172: 48-53.
16. van de Velde M, DeWolff M, Leather HA, Wouters PF (2000) Effects of lipids on the functional and metabolic recovery from global myocardial stunning in isolated rabbit hearts. Cardiovasc Res 48: 129-137.
17. Cho S, Lee JJ, Chung IS, et al (2000) Insulin reverses bupivacaininduced cardiac depression in dogs. Anesth Analg 91: 1096-1102.
18. Mégarbane B, Karyo S, Baud FJ (2004) The role of insulin and glucose (hyperinsulinaemia/euglycaemia) therapy in acute calcium channel antagonist and beta-blocker poisoning. Toxicol Rev 23: 215-222.
19. Huang JM, Xian H, Bacaner M (1992) Long-chain fatty acids activate calcium channels in ventricular myocytes. Proc Natl Acad Sci USA 89: 6452-6456.
20. Yoav G, Odelia G, Shaltiel C (2002) A lipid emulsion reduces mortality from clomipramine overdose in rats. Vet Hum Toxicol 44: 30.
21. Harvey M, Cave G (2007) Intralipid outperforms sodium bicarbonate in a rabbit model of clomipramine toxicity. Ann Emerg Med 49: 178-185.
22. Harvey G, Cave G, Hoggett K (2009) Correlation of plasma and peritoneal dialysate clomipramine concentration with hemodynamic recovery after intralipid infusion in rabbits. Acad Emerg Med 16: 151-156.
23. Tebbutt S, Harvey M, Nicholson T, Cave G (2006) Intralipid prolongs survival in a rat model of verapamil toxicity. Acad Emerg Med 13: 134-139.
24. Bania TC (2007) Hemodynamic effects of intravenous fat emulsion in an animal model of severe verapamil toxicity resuscitated with atropine, calcium and normal saline. Acad Emerg Med 14: 105-111.
25. Perez E, Bania T, Medlej K, et al (2008) Determining the optimal dose of intravenous fat emulsion in an animal model of severe verapamil toxicity resuscitated with atropine, calcium and saline. Acad Emerg Med 15: 1284-129.
26. Bania T, Chu J, Perez E, et al (2008) Hemodynamic effects of intravenous fat emulsion versus high-dose insulin euglycemia in a model of severe verapamil toxicity. Acad Emerg Med 15: S93.
27. Chu J, Medlej K, Bania T, et al (2009) Hemodynamic effects of intravenous fat emulsions in nifedipine toxicity. Acad Emerg Med 16: S226.
28. Cave G, Harvey M, Castle C (2006) The role of fat emulsion therapy in a rodent model of propanolol toxicity: a preliminary study? J Med Toxicol 2: 4-7.
29. Bania T, Chu J, Wesolowski M (2006) The hemodynamic effect of intralipid on propranolol toxicity. Acad Emerg Med 13: S109.
30. Harvey MG, Cave GR (2008) Intralipid infusion ameliorates propranolol-induced hypotension in rabbits. J Med Toxicol 4: 71-76.
31. Browne A, Harvey M, Cave G (2010) Intravenous lipid emulsion does not augment blood pressure recovery in a rabbit model of metoprolol toxicity. J Med Toxicol 2010 DOI 10. 1007/s13181-010-0049-y.
32. Guy Weinberg (2007) LipidRescue. http://www. lipidrescue. org.
33. Harchelroad FP, Palma A (2008) Efficacy and safety of intravenous lipid therapy in a β-blocker overdose. Clin Toxicol 46: 620.
34. Stellpflug SJ, Harris CR, Engebretsen KM, et al (2010) Intentional overdose with cardiac arrest treated with intravenous fat emulsion and high-dose insulin. Clin Toxicol 48: 227-229.
35. Young AC, Velez LI, Kleinschmidt KC (2009) Intravenous fat emulsion therapy for the intentional sustained-release verapamil overdose. Resuscitation 80: 591-593.
36. Cooper G, Dyas J, Krishna CV, Thompson JP (2010) Successful use of intravenous fat emulsion following ingestion of lipid soluble drugs. Clin Toxicol 48: 298.
37. Dolcourt B, Aaron C (2008) Intravenous fat emulsion for refractory verapamil and atenolol induced-shock: a human case report. Clin Toxicol 46: 620.
38. Al-Duaij N, George M, O'Donnell K, Burns Ewald M (2009) Lipid emulsion in massive imipramine overdose. Clin Toxicol 47: 460.
39. Weinberg G, DiGregorio G, Hiller G, et al (2009) Lipid emulsion reversal of haloperidol-induced cardiac arrest. Ann Intern Med 150: 737-738.
40. Sirianni AJ, Osterhoudt KC, Calello DP, et al (2008) Use of lipid emulsion in the resuscitation of a patient with prolonged cardiovascular collapse after overdose of bupropion and lamotrigine. Ann Emerg Med 51: 412-415.
41. Finn SDH, Uncles DR, Willers J, Sable N (2009) Early treatment of quetiapine and sertraline overdose with Intralipid. Anaesthesia 64: 191-194.
42. Hillyard SG, Barrera-Groba C, Tighe R (2010) Intralipid reverses coma associated with zopiclone and venlafaxine overdose. Eur J Anesthesiol 27: 582-583.
43. Han SK, Jeong J, Yeom S, et al (2010) Use of a lipid emulsion in a refractory hypotension caused by glyphosate-surfactant herbicide. Clin Toxicol, DOI: 10. 3109/15563650. 2010. 496730.
44. West PL, McKeown NJ, Hendrickson RG (2010) Iatrogenic lipid emulsion overdose in a case of amlodipine poisoning. Clin Toxicol 48: 393-396.
45. Hiller DB, DiGregorio G, Kelly K, et al (2010) Safety of high volume lipid emulsion infusion - a first approximation of LD50 in rats. Reg Anesth Pain Med 35: 140-144.
46. Candela D, Louart G, Bousquet PJ, et al (2009) Reversal of bupivacaine-induced cardiac electrophysiologic changes by two lipid emulsions in anesthetized mechanically ventilated piglets. Anesth Analg 110: 1473-1479.
47. Hiller DB, DiGregorio G, Ripper R, et al (2009) Epinephrine impairs lipid resuscitation from bupivacaine overdose. Anesthesiology 111: 498-505.