Optimization of the central core of indolinone-acetic acid-based CRTH2 (DP2) receptor antagonists

ACS Medicinal Chemistry Letters

Volumn 2, Issue 8, 2011, Pages 644-649

  Crosignani, Stefano ^a   Jorand Lebrun, Catherine ^a   Page, Patrick ^a   Campbell, Gordon ^a   Colovray, Véronique ^a   Missotten, Marc ^a   Humbert, Yves ^a   Cleva, Christophe ^a   Arrighi, Jean François ^a   Gaudet, Marilène ^a   Johnson, Zoe ^a   Ferro, Pamela ^a   Chollet, André ^a  

^a MERCK SERONO S A   (Switzerland)

Author keywords

antagonist; asthma; atopic dermatitis; CRTH2 receptor; indolinone; prostaglandin D2

Indexed keywords

ACETIC ACID DERIVATIVE; DEXAMETHASONE; INDOLE DERIVATIVE; PROSTAGLANDIN D2 RECEPTOR ANTAGONIST; PROSTAGLANDIN RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG PENETRATION; DRUG POTENCY; DRUG STABILITY; EOSINOPHIL; EXPERIMENTAL DOG; EXPERIMENTAL GUINEA PIG; EXPERIMENTAL MONKEY; HUMAN; HUMAN CELL; IC 50; LOEFFLER PNEUMONIA; MOUSE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PH; PLASMA; PLASMA PROTEIN BINDING; PRIORITY JOURNAL; PROCESS OPTIMIZATION; RAT; STRUCTURE ACTIVITY RELATION;

RATTUS; RODENTIA;

EID: 80051763689     PISSN: None     EISSN: 19485875     Source Type: Journal    
DOI: 10.1021/ml2001196     Document Type: Article

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